PL146890B1 - Process for preparing novel derivatives of silibinin - Google Patents

Process for preparing novel derivatives of silibinin Download PDF

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Publication number
PL146890B1
PL146890B1 PL1985256374A PL25637485A PL146890B1 PL 146890 B1 PL146890 B1 PL 146890B1 PL 1985256374 A PL1985256374 A PL 1985256374A PL 25637485 A PL25637485 A PL 25637485A PL 146890 B1 PL146890 B1 PL 146890B1
Authority
PL
Poland
Prior art keywords
silibinin
animals
acid
silybin
burned
Prior art date
Application number
PL1985256374A
Other languages
English (en)
Polish (pl)
Other versions
PL256374A1 (en
Inventor
Reinhard Braatz
Klaus Goerler
Guenter Halbach
Hartwig Soicke
Karlheinz Schmidt
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of PL256374A1 publication Critical patent/PL256374A1/xx
Publication of PL146890B1 publication Critical patent/PL146890B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
PL1985256374A 1984-11-22 1985-11-21 Process for preparing novel derivatives of silibinin PL146890B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
PL256374A1 PL256374A1 (en) 1986-12-02
PL146890B1 true PL146890B1 (en) 1989-03-31

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1985256374A PL146890B1 (en) 1984-11-22 1985-11-21 Process for preparing novel derivatives of silibinin

Country Status (29)

Country Link
JP (1) JPS61143377A (cs)
KR (1) KR870001020B1 (cs)
AR (1) AR240931A1 (cs)
AT (1) AT393268B (cs)
BE (1) BE903693A (cs)
CA (1) CA1337124C (cs)
CH (1) CH659473A5 (cs)
CS (1) CS273610B2 (cs)
DD (1) DD259191A1 (cs)
DE (1) DE3442639A1 (cs)
DK (1) DK164865C (cs)
EG (1) EG19424A (cs)
ES (1) ES8609311A1 (cs)
FI (1) FI84064C (cs)
FR (1) FR2573427B1 (cs)
GB (1) GB2167414B (cs)
HU (1) HU195503B (cs)
IE (1) IE58791B1 (cs)
IT (1) IT1190426B (cs)
LU (1) LU86163A1 (cs)
MX (1) MX168415B (cs)
NL (1) NL192387C (cs)
NO (1) NO160205C (cs)
PL (1) PL146890B1 (cs)
PT (1) PT81532B (cs)
SE (1) SE465676B (cs)
SU (1) SU1436875A3 (cs)
YU (1) YU43689B (cs)
ZA (1) ZA858951B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
CN101137639B (zh) * 2005-03-11 2012-05-23 霍华德弗洛里生理医学实验研究所 类黄酮化合物及其用途
KR101435242B1 (ko) 2007-11-15 2014-08-29 마다우스 게엠베하 간염치료용 실리비닌 성분
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
PT2430017T (pt) * 2009-05-14 2016-10-12 Madaus Gmbh Método para a preparação de silibinina amorfa
US20150174213A1 (en) 2012-07-05 2015-06-25 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
IE852808L (en) 1986-05-22
NO160205C (no) 1989-03-22
SE8505487D0 (sv) 1985-11-20
CS837885A2 (en) 1990-08-14
ATA337185A (de) 1991-02-15
PT81532A (de) 1985-12-01
DK164865C (da) 1993-01-18
NL8503171A (nl) 1986-06-16
SE465676B (sv) 1991-10-14
GB2167414B (en) 1989-01-11
DE3442639A1 (de) 1986-05-22
BE903693A (fr) 1986-05-22
NL192387C (nl) 1997-07-04
LU86163A1 (de) 1986-03-24
IE58791B1 (en) 1993-11-17
GB8528226D0 (en) 1985-12-18
EG19424A (en) 1995-02-28
AT393268B (de) 1991-09-25
AR240931A2 (es) 1991-03-27
PL256374A1 (en) 1986-12-02
FI854535A0 (fi) 1985-11-18
YU178685A (en) 1988-02-29
NL192387B (nl) 1997-03-03
JPS61143377A (ja) 1986-07-01
AR240931A1 (es) 1991-03-27
FI854535A7 (fi) 1986-05-23
DE3442639C2 (cs) 1989-08-10
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
FR2573427A1 (fr) 1986-05-23
DD259191A1 (de) 1988-08-17
IT8522932A0 (it) 1985-11-21
CA1337124C (en) 1995-09-26
IT1190426B (it) 1988-02-16
FI84064B (fi) 1991-06-28
KR860004056A (ko) 1986-06-16
ES549116A0 (es) 1986-09-01
HUT40114A (en) 1986-11-28
DK537785D0 (da) 1985-11-21
KR870001020B1 (ko) 1987-05-23
ES8609311A1 (es) 1986-09-01
SU1436875A3 (ru) 1988-11-07
GB2167414A (en) 1986-05-29
NO854655L (no) 1986-05-23
DK164865B (da) 1992-08-31
HU195503B (en) 1988-05-30
NO160205B (no) 1988-12-12
PT81532B (pt) 1987-11-11
FI84064C (fi) 1991-10-10
FR2573427B1 (fr) 1989-03-10
JPH0432073B2 (cs) 1992-05-28
MX168415B (es) 1993-05-24
CH659473A5 (de) 1987-01-30
ZA858951B (en) 1986-08-27
CS273610B2 (en) 1991-03-12
DK537785A (da) 1986-05-23

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