PL143281B1 - Process for preparing 4"-api-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a - Google Patents

Process for preparing 4"-api-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a Download PDF

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Publication number
PL143281B1
PL143281B1 PL1983244557A PL24455783A PL143281B1 PL 143281 B1 PL143281 B1 PL 143281B1 PL 1983244557 A PL1983244557 A PL 1983244557A PL 24455783 A PL24455783 A PL 24455783A PL 143281 B1 PL143281 B1 PL 143281B1
Authority
PL
Poland
Prior art keywords
formula
aza
compound
erythromycin
epi
Prior art date
Application number
PL1983244557A
Other languages
English (en)
Polish (pl)
Other versions
PL244557A1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PL244557A1 publication Critical patent/PL244557A1/xx
Publication of PL143281B1 publication Critical patent/PL143281B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Cosmetics (AREA)
PL1983244557A 1982-11-15 1983-11-14 Process for preparing 4"-api-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a PL143281B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15

Publications (2)

Publication Number Publication Date
PL244557A1 PL244557A1 (en) 1985-03-26
PL143281B1 true PL143281B1 (en) 1988-01-30

Family

ID=23755068

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1983244557A PL143281B1 (en) 1982-11-15 1983-11-14 Process for preparing 4"-api-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a
PL1983250350A PL142601B1 (en) 1982-11-15 1983-11-14 Process for preparing 4"-epi-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL1983250350A PL142601B1 (en) 1982-11-15 1983-11-14 Process for preparing 4"-epi-9-desketo-9a-methyl-9a-aza-9a-homoerythromycin a

Country Status (26)

Country Link
EP (1) EP0109253B1 (enExample)
JP (1) JPS59104398A (enExample)
KR (1) KR850000968B1 (enExample)
AT (1) ATE30237T1 (enExample)
AU (1) AU544790B2 (enExample)
CA (1) CA1239639A (enExample)
CS (1) CS241069B2 (enExample)
DD (1) DD216017A5 (enExample)
DE (1) DE3374065D1 (enExample)
DK (1) DK159322C (enExample)
EG (1) EG16641A (enExample)
ES (2) ES8600327A1 (enExample)
FI (1) FI72980C (enExample)
GR (1) GR79425B (enExample)
GT (1) GT198304062A (enExample)
HU (1) HU193886B (enExample)
IE (1) IE56234B1 (enExample)
IL (1) IL70228A (enExample)
NO (1) NO160262C (enExample)
NZ (1) NZ206259A (enExample)
PH (2) PH19293A (enExample)
PL (2) PL143281B1 (enExample)
PT (1) PT77645B (enExample)
SU (1) SU1272996A3 (enExample)
YU (2) YU43198B (enExample)
ZA (1) ZA838460B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3475073D1 (en) * 1983-09-06 1988-12-15 Pfizer Azahomoerythromycin b derivatives and intermediates thereof
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
SI8911498B (sl) * 1989-07-26 1998-10-31 Pliva Postopek za pripravo derivatov tilozina
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
SI9520049A (en) * 1994-05-06 1997-12-31 Pfizer Controlled-release dosage forms of azithromycin
UA52607C2 (uk) * 1995-06-29 2003-01-15 Тексіс Байотекнолоджі Корпорейшн Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти)
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
PT1206476E (pt) * 1999-08-24 2006-05-31 Abbott Lab 9a-azalidos com actividade antibacteriana
EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
WO2005053655A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417348A (pt) 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
JP2007513139A (ja) 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
RU2256665C1 (ru) * 2004-01-29 2005-07-20 Открытое акционерное общество Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Способ получения оксима эритромицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
DK159322B (da) 1990-10-01
FI72980B (fi) 1987-04-30
DK518683D0 (da) 1983-11-14
IE56234B1 (en) 1991-05-22
CS845583A2 (en) 1985-07-16
YU43198B (en) 1989-04-30
HU193886B (en) 1987-12-28
DK159322C (da) 1991-02-25
ZA838460B (en) 1985-06-26
JPH0140038B2 (enExample) 1989-08-24
EP0109253B1 (en) 1987-10-14
YU43425B (en) 1989-06-30
FI834163A0 (fi) 1983-11-14
KR840006673A (ko) 1984-12-01
SU1272996A3 (ru) 1986-11-23
JPS59104398A (ja) 1984-06-16
DK518683A (da) 1984-05-16
DD216017A5 (de) 1984-11-28
PH19293A (en) 1986-03-04
ES543638A0 (es) 1986-01-16
FI72980C (fi) 1987-08-10
NO160262B (no) 1988-12-19
NZ206259A (en) 1986-08-08
KR850000968B1 (ko) 1985-07-02
CS241069B2 (en) 1986-03-13
ES8604257A1 (es) 1986-01-16
GR79425B (enExample) 1984-10-22
AU544790B2 (en) 1985-06-13
ATE30237T1 (de) 1987-10-15
IL70228A (en) 1987-03-31
IE832652L (en) 1984-05-15
ES527249A0 (es) 1985-10-01
PL250350A1 (en) 1985-04-24
PT77645A (en) 1983-12-01
PL142601B1 (en) 1987-11-30
HUT35273A (en) 1985-06-28
YU224383A (en) 1986-04-30
NO160262C (no) 1989-03-29
ES8600327A1 (es) 1985-10-01
PL244557A1 (en) 1985-03-26
IL70228A0 (en) 1984-02-29
YU197285A (en) 1986-08-31
EP0109253A2 (en) 1984-05-23
FI834163L (fi) 1984-05-16
EP0109253A3 (en) 1984-09-12
CA1239639A (en) 1988-07-26
NO834146L (no) 1984-05-16
AU2130983A (en) 1984-05-24
DE3374065D1 (en) 1987-11-19
GT198304062A (es) 1985-05-04
EG16641A (en) 1990-08-30
PH21560A (en) 1987-12-11
PT77645B (en) 1986-05-12

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