PL119416B1 - Process for preparing novel derivatives of 4-desacetylvinblastineastina - Google Patents

Process for preparing novel derivatives of 4-desacetylvinblastineastina Download PDF

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Publication number
PL119416B1
PL119416B1 PL1979215011A PL21501179A PL119416B1 PL 119416 B1 PL119416 B1 PL 119416B1 PL 1979215011 A PL1979215011 A PL 1979215011A PL 21501179 A PL21501179 A PL 21501179A PL 119416 B1 PL119416 B1 PL 119416B1
Authority
PL
Poland
Prior art keywords
vlb
formula
compounds
desacetyl
radical
Prior art date
Application number
PL1979215011A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL119416B1 publication Critical patent/PL119416B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL1979215011A 1978-04-20 1979-04-19 Process for preparing novel derivatives of 4-desacetylvinblastineastina PL119416B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
PL119416B1 true PL119416B1 (en) 1981-12-31

Family

ID=25410402

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1979215011A PL119416B1 (en) 1978-04-20 1979-04-19 Process for preparing novel derivatives of 4-desacetylvinblastineastina
PL1979230538A PL125470B1 (en) 1978-04-20 1979-04-19 Process for preparing novel derivatives of 4-deacetylvinblastine
PL21591179A PL215911A1 (OSRAM) 1978-04-20 1979-04-19

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL1979230538A PL125470B1 (en) 1978-04-20 1979-04-19 Process for preparing novel derivatives of 4-deacetylvinblastine
PL21591179A PL215911A1 (OSRAM) 1978-04-20 1979-04-19

Country Status (32)

Country Link
US (1) US4166810A (OSRAM)
EP (1) EP0005051B1 (OSRAM)
JP (1) JPS54141798A (OSRAM)
AR (1) AR228940A1 (OSRAM)
AT (1) AT369010B (OSRAM)
AU (1) AU527109B2 (OSRAM)
BE (1) BE875652A (OSRAM)
BG (3) BG33296A3 (OSRAM)
CA (1) CA1097629A (OSRAM)
CH (1) CH643269A5 (OSRAM)
CS (3) CS218583B2 (OSRAM)
DD (1) DD143075A5 (OSRAM)
DE (1) DE2964130D1 (OSRAM)
DK (1) DK147484C (OSRAM)
EG (1) EG14867A (OSRAM)
ES (2) ES479753A1 (OSRAM)
FI (1) FI791286A7 (OSRAM)
FR (1) FR2423495A1 (OSRAM)
GB (1) GB2019396B (OSRAM)
GR (1) GR69987B (OSRAM)
HU (1) HU181431B (OSRAM)
IE (1) IE48213B1 (OSRAM)
IL (1) IL57168A (OSRAM)
LU (1) LU81166A1 (OSRAM)
NZ (1) NZ190213A (OSRAM)
PH (1) PH14163A (OSRAM)
PL (3) PL119416B1 (OSRAM)
PT (1) PT69496A (OSRAM)
RO (3) RO80084A (OSRAM)
SU (3) SU893135A3 (OSRAM)
YU (1) YU93179A (OSRAM)
ZA (1) ZA791856B (OSRAM)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
US4596676A (en) * 1983-03-30 1986-06-24 Lilly Industries Limited Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
WO2002085908A1 (en) 2001-04-24 2002-10-31 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
ATE426414T1 (de) * 2002-05-15 2009-04-15 Endocyte Inc Vitamin-mitomycin-konjugate
EP2517729A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
CN101098854B (zh) * 2004-07-23 2012-12-05 恩多塞特公司 二价连接体及其轭合物
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
CN103893778A (zh) 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
JP2009504783A (ja) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2139523B1 (en) * 2007-03-14 2014-10-22 Endocyte, Inc. Conjugates of folate and tubulysin for targeted drug delivery
JP5690589B2 (ja) 2007-06-25 2015-03-25 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 親水性スペーサーリンカーを含有する結合体
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
WO2009055562A1 (en) 2007-10-25 2009-04-30 Endocyte, Inc. Tubulysins and processes for preparing
RU2543639C2 (ru) * 2009-09-07 2015-03-10 Нипро Пэтч Ко., Лтд. Чрескожно всасывающийся препарат
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
SG11201502896XA (en) 2012-10-16 2015-05-28 Endocyte Inc Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
IE790795L (en) 1979-10-20
BE875652A (fr) 1979-10-18
AU4609779A (en) 1979-10-25
EG14867A (en) 1986-09-30
CS218585B2 (en) 1983-02-25
SU1225490A3 (ru) 1986-04-15
RO81037A (ro) 1983-02-01
CH643269A5 (fr) 1984-05-30
NZ190213A (en) 1982-12-21
IE48213B1 (en) 1984-10-31
CA1097629A (en) 1981-03-17
EP0005051B1 (en) 1982-12-01
HU181431B (en) 1983-07-28
EP0005051A1 (en) 1979-10-31
IL57168A (en) 1983-10-31
PT69496A (en) 1979-05-01
PH14163A (en) 1981-03-19
ES479753A1 (es) 1980-08-16
LU81166A1 (fr) 1979-09-07
SU893135A3 (ru) 1981-12-23
GB2019396A (en) 1979-10-31
DK147484B (da) 1984-08-27
BG33294A3 (bg) 1983-01-14
DK147484C (da) 1985-03-25
GR69987B (OSRAM) 1982-07-22
FI791286A7 (fi) 1981-01-01
CS218583B2 (en) 1983-02-25
AU527109B2 (en) 1983-02-17
US4166810A (en) 1979-09-04
JPS6245873B2 (OSRAM) 1987-09-29
RO81037B (ro) 1983-01-30
FR2423495B1 (OSRAM) 1983-02-11
YU93179A (en) 1983-01-21
DD143075A5 (de) 1980-07-30
SU1061698A3 (ru) 1983-12-15
FR2423495A1 (fr) 1979-11-16
RO81114A (ro) 1983-02-01
ZA791856B (en) 1980-11-26
BG33296A3 (bg) 1983-01-14
ATA291279A (de) 1982-04-15
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
CS218584B2 (en) 1983-02-25
RO80084A (ro) 1983-02-01
PL125470B1 (en) 1983-05-31
PL215911A1 (OSRAM) 1980-03-24
AT369010B (de) 1982-11-25
RO80084B (ro) 1983-01-30
RO81114B (ro) 1983-01-30
JPS54141798A (en) 1979-11-05
IL57168A0 (en) 1979-07-25
BG33297A3 (bg) 1983-01-14
DE2964130D1 (en) 1983-01-05
GB2019396B (en) 1982-09-15
AR228940A1 (es) 1983-05-13

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