PL111422B1 - Process for the preparation of novel derivatives of quinazolone - Google Patents

Process for the preparation of novel derivatives of quinazolone Download PDF

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Publication number
PL111422B1
PL111422B1 PL1976209361A PL20936176A PL111422B1 PL 111422 B1 PL111422 B1 PL 111422B1 PL 1976209361 A PL1976209361 A PL 1976209361A PL 20936176 A PL20936176 A PL 20936176A PL 111422 B1 PL111422 B1 PL 111422B1
Authority
PL
Poland
Prior art keywords
group
formula
quinazoline
keto
compounds
Prior art date
Application number
PL1976209361A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL111422B1 publication Critical patent/PL111422B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL1976209361A 1975-12-19 1976-12-18 Process for the preparation of novel derivatives of quinazolone PL111422B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2557425A DE2557425C2 (de) 1975-12-19 1975-12-19 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel

Publications (1)

Publication Number Publication Date
PL111422B1 true PL111422B1 (en) 1980-08-30

Family

ID=5964943

Family Applications (5)

Application Number Title Priority Date Filing Date
PL1976201603A PL103556B1 (pl) 1975-12-19 1976-12-18 Sposob wytwarzania nowych pochodnych chinazolonu
PL1976201604A PL102308B1 (pl) 1975-12-19 1976-12-18 A method of producing new derivatives of quinazolone
PL1976194519A PL101141B1 (pl) 1975-12-19 1976-12-18 Sposob wytwarzania nowych pochodnych chinazolonu
PL1976209362A PL110780B1 (en) 1975-12-19 1976-12-18 Method of producing new derivatives of quinazolone
PL1976209361A PL111422B1 (en) 1975-12-19 1976-12-18 Process for the preparation of novel derivatives of quinazolone

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PL1976201603A PL103556B1 (pl) 1975-12-19 1976-12-18 Sposob wytwarzania nowych pochodnych chinazolonu
PL1976201604A PL102308B1 (pl) 1975-12-19 1976-12-18 A method of producing new derivatives of quinazolone
PL1976194519A PL101141B1 (pl) 1975-12-19 1976-12-18 Sposob wytwarzania nowych pochodnych chinazolonu
PL1976209362A PL110780B1 (en) 1975-12-19 1976-12-18 Method of producing new derivatives of quinazolone

Country Status (36)

Country Link
US (2) US4083980A (enrdf_load_stackoverflow)
JP (1) JPS5831350B2 (enrdf_load_stackoverflow)
AT (1) AT352736B (enrdf_load_stackoverflow)
AU (1) AU513469B2 (enrdf_load_stackoverflow)
BE (1) BE849542A (enrdf_load_stackoverflow)
BG (3) BG25092A3 (enrdf_load_stackoverflow)
CA (1) CA1199914A (enrdf_load_stackoverflow)
CH (4) CH627754A5 (enrdf_load_stackoverflow)
CS (1) CS198222B2 (enrdf_load_stackoverflow)
DD (1) DD128812A5 (enrdf_load_stackoverflow)
DE (1) DE2557425C2 (enrdf_load_stackoverflow)
DK (1) DK149107C (enrdf_load_stackoverflow)
ES (3) ES454405A1 (enrdf_load_stackoverflow)
FI (1) FI64159C (enrdf_load_stackoverflow)
FR (1) FR2335229A1 (enrdf_load_stackoverflow)
GB (1) GB1572707A (enrdf_load_stackoverflow)
GR (1) GR62109B (enrdf_load_stackoverflow)
HK (1) HK12984A (enrdf_load_stackoverflow)
HU (1) HU172929B (enrdf_load_stackoverflow)
IE (1) IE45256B1 (enrdf_load_stackoverflow)
IL (1) IL51124A (enrdf_load_stackoverflow)
LU (1) LU76417A1 (enrdf_load_stackoverflow)
MX (1) MX4488E (enrdf_load_stackoverflow)
MY (1) MY8500078A (enrdf_load_stackoverflow)
NL (1) NL182535C (enrdf_load_stackoverflow)
NO (1) NO147450C (enrdf_load_stackoverflow)
NZ (1) NZ182915A (enrdf_load_stackoverflow)
PH (1) PH16310A (enrdf_load_stackoverflow)
PL (5) PL103556B1 (enrdf_load_stackoverflow)
PT (1) PT65981A (enrdf_load_stackoverflow)
RO (3) RO75248A (enrdf_load_stackoverflow)
SE (1) SE431456B (enrdf_load_stackoverflow)
SG (1) SG55483G (enrdf_load_stackoverflow)
SU (4) SU645571A3 (enrdf_load_stackoverflow)
YU (2) YU39048B (enrdf_load_stackoverflow)
ZA (1) ZA767490B (enrdf_load_stackoverflow)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337255A (en) * 1977-07-29 1982-06-29 E. R. Squibb & Sons, Inc. Pyrazolo[1,5-c]quinazoline derivatives and related compounds
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2739020A1 (de) 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4348396A (en) * 1978-01-23 1982-09-07 Hoffmann-La Roche Inc. Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
DE3065963D1 (en) * 1979-01-24 1984-02-02 Warner Lambert Co Pyrazolo (5,1-b) quinazolin-9(4h)-one derivatives, process for their preparation and pharmaceutical compositions containing them
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4302585A (en) 1980-12-22 1981-11-24 American Home Products Corporation 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic acids and their lactones
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
DE3142728A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums
DE3142727A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums
ES521739A0 (es) * 1982-04-29 1984-07-01 Erba Farmitalia Procedimiento para preparar derivados cicloalifaticos condensados de pirido(1,2-a)pirimidinas sustituidas.
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US4455312A (en) * 1982-08-19 1984-06-19 Portnyagina Vera A 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
EP0142057A3 (en) * 1983-11-04 1988-03-30 F. Hoffmann-La Roche Ag Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same
US4738964A (en) * 1984-05-30 1988-04-19 Pennwalt Corporation Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
US4588812A (en) * 1984-05-30 1986-05-13 Pennwalt Corporation Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
DE3704203A1 (de) * 1987-02-11 1988-08-25 Boehringer Ingelheim Kg Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie
US4904667A (en) * 1989-02-24 1990-02-27 Ortho Pharmaceutical Corporation 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them
AU2001234420A1 (en) 2000-02-03 2001-08-14 Eli Lilly And Company Potentiators of glutamate receptors
US8946223B2 (en) 2010-04-12 2015-02-03 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8765773B2 (en) 2010-10-18 2014-07-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
WO2016126725A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242863A (en) * 1968-05-10 1971-08-18 Pharmacia As 2,3-DIHYDRO-5H-THIAZOLO[2,3-b]QUINAZOLINES AND PROCESSES FOR THE PREPARATION THEREOF
US3598823A (en) * 1969-05-28 1971-08-10 Sandoz Ag Tricyclic quinazolinones
US3833588A (en) * 1972-04-25 1974-09-03 Sandoz Ag Unsaturated-substituted tricyclic quinazolinones
JPS5752352B2 (enrdf_load_stackoverflow) * 1974-02-28 1982-11-06
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation
US4142049A (en) * 1976-10-18 1979-02-27 Warner-Lambert Company Benzo[g]pyrido[2,1-b]quinazolinones
US4066767A (en) * 1976-11-01 1978-01-03 Warner-Lambert Company 8-(1H-Tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones and method of treating bronchial asthma using them
ES468126A1 (es) * 1977-03-24 1979-09-01 Hoffmann La Roche Un procedimiento para la preparacion de nuevos derivados de pirido(2,1b) quinazolina
DE2739020A1 (de) * 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

Also Published As

Publication number Publication date
DE2557425C2 (de) 1987-03-19
IL51124A (en) 1980-06-30
ES454405A1 (es) 1978-01-16
ZA767490B (en) 1978-08-30
ES464136A1 (es) 1978-09-01
IE45256L (en) 1977-06-19
PL102308B1 (pl) 1979-03-31
ATA883976A (de) 1979-03-15
YU115282A (en) 1983-12-31
JPS5831350B2 (ja) 1983-07-05
ES464162A1 (es) 1978-09-01
BE849542A (fr) 1977-06-17
FI64159B (fi) 1983-06-30
CH631983A5 (de) 1982-09-15
FR2335229B1 (enrdf_load_stackoverflow) 1980-04-11
LU76417A1 (enrdf_load_stackoverflow) 1978-01-18
RO75734A (ro) 1982-07-06
BG24673A3 (bg) 1978-04-12
DK567376A (da) 1977-06-20
SG55483G (en) 1984-07-27
PL103556B1 (pl) 1979-06-30
SU652894A3 (ru) 1979-03-15
SU784776A3 (ru) 1980-11-30
MX4488E (es) 1982-05-21
CH627754A5 (de) 1982-01-29
IL51124A0 (en) 1977-02-28
SE431456B (sv) 1984-02-06
BG25092A3 (bg) 1978-07-12
PL101141B1 (pl) 1978-12-30
NL7614013A (nl) 1977-06-21
DD128812A5 (de) 1977-12-14
YU308276A (en) 1982-08-31
DK149107B (da) 1986-01-27
JPS5277096A (en) 1977-06-29
MY8500078A (en) 1985-12-31
FI763469A7 (enrdf_load_stackoverflow) 1977-06-20
GR62109B (en) 1979-02-26
SU645571A3 (ru) 1979-01-30
PL110780B1 (en) 1980-07-31
NL182535C (nl) 1988-04-05
CS198222B2 (en) 1980-05-30
NL182535B (nl) 1987-11-02
BG25093A3 (bg) 1978-07-12
HK12984A (en) 1984-02-24
AT352736B (de) 1979-10-10
NO764303L (enrdf_load_stackoverflow) 1977-06-21
SE7614258L (sv) 1977-06-20
RO75248A (ro) 1980-11-30
AU2069576A (en) 1978-06-22
AU513469B2 (en) 1980-12-04
NO147450B (no) 1983-01-03
RO69411A (ro) 1982-02-01
DK149107C (da) 1986-06-09
GB1572707A (en) 1980-07-30
HU172929B (hu) 1979-01-28
YU40078B (en) 1985-06-30
CA1199914A (en) 1986-01-28
CH625243A5 (enrdf_load_stackoverflow) 1981-09-15
IE45256B1 (en) 1982-07-28
NO147450C (no) 1983-04-13
YU39048B (en) 1984-02-29
FI64159C (fi) 1983-10-10
PH16310A (en) 1983-09-05
PT65981A (pt) 1977-01-01
FR2335229A1 (fr) 1977-07-15
SU733516A3 (ru) 1980-05-05
NZ182915A (en) 1979-07-11
US4332802A (en) 1982-06-01
CH625522A5 (enrdf_load_stackoverflow) 1981-09-30
US4083980A (en) 1978-04-11
DE2557425A1 (de) 1977-06-30

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