PH25055A - 6,7-disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids,pharmaceutical compositions containing them and method of use thereof - Google Patents

6,7-disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids,pharmaceutical compositions containing them and method of use thereof

Info

Publication number
PH25055A
PH25055A PH33280A PH33280A PH25055A PH 25055 A PH25055 A PH 25055A PH 33280 A PH33280 A PH 33280A PH 33280 A PH33280 A PH 33280A PH 25055 A PH25055 A PH 25055A
Authority
PH
Philippines
Prior art keywords
naphthyridine
disubstituted
cyclopropyl
dihydro
oxo
Prior art date
Application number
PH33280A
Other languages
English (en)
Inventor
Uwe Petersen
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PH25055A publication Critical patent/PH25055A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PH33280A 1985-01-10 1986-01-10 6,7-disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids,pharmaceutical compositions containing them and method of use thereof PH25055A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3500562 1985-01-10
DE19853508816 DE3508816A1 (de) 1985-01-10 1985-03-13 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren

Publications (1)

Publication Number Publication Date
PH25055A true PH25055A (en) 1991-01-28

Family

ID=25828438

Family Applications (2)

Application Number Title Priority Date Filing Date
PH33280A PH25055A (en) 1985-01-10 1986-01-10 6,7-disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids,pharmaceutical compositions containing them and method of use thereof
PH35094A PH24769A (en) 1985-01-10 1987-04-01 2,6-dichloro-5-fluoro-pyridine-3-carboxylic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH35094A PH24769A (en) 1985-01-10 1987-04-01 2,6-dichloro-5-fluoro-pyridine-3-carboxylic acid derivatives

Country Status (21)

Country Link
US (1) US4840954A (ko)
EP (1) EP0187376B1 (ko)
JP (1) JPH0653741B2 (ko)
KR (1) KR910002645B1 (ko)
CN (1) CN1003236B (ko)
AT (1) ATE76076T1 (ko)
AU (3) AU574550B2 (ko)
CA (2) CA1339373C (ko)
DE (2) DE3508816A1 (ko)
DK (1) DK168439B1 (ko)
ES (5) ES8802520A1 (ko)
FI (2) FI86721C (ko)
GR (1) GR860031B (ko)
HU (1) HU193623B (ko)
IE (1) IE58412B1 (ko)
IL (2) IL77538A (ko)
NO (2) NO163331C (ko)
NZ (2) NZ229861A (ko)
PH (2) PH25055A (ko)
PL (2) PL148759B1 (ko)
PT (1) PT81810B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2650276B1 (fr) * 1989-07-28 1991-10-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
BR9407806A (pt) * 1993-10-14 1997-08-19 Abbott Lab Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético
HUP9801057A3 (en) * 1995-05-26 2000-06-28 Bayer Ag Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms
US5739342A (en) * 1997-03-03 1998-04-14 Abbott Laboratories Process for the preparation of nicotinic acids
EP0978516A4 (en) * 1998-01-29 2001-01-10 Suntory Ltd 1-CYCLOALKYL-1,8-NAPHTHYRIDINE-4-ONE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITING ACTIVITY
KR100364226B1 (ko) * 1998-03-18 2003-01-24 주식회사 엘지생명과학 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법
KR20040041177A (ko) * 2001-09-26 2004-05-14 바이엘 파마슈티칼스 코포레이션 당뇨병 치료제로서의 1,6-나프티리딘 유도체
KR100589966B1 (ko) 2001-10-15 2006-06-15 주식회사 엘지생명과학 베타-케토에스테르 화합물의 제조방법
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
EP3296298A1 (de) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung
CN109206424A (zh) * 2018-09-18 2019-01-15 佳木斯大学 依诺沙星-邻苯二甲酸药物盐单晶体及其制备方法

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Publication number Priority date Publication date Assignee Title
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5531042A (en) * 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5649382A (en) * 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
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JPS60197686A (ja) * 1984-03-19 1985-10-07 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
JPS60172981A (ja) * 1984-02-17 1985-09-06 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
EP0160578B1 (en) * 1984-02-17 1989-11-23 Daiichi Seiyaku Co., Ltd. 1,8-naphthyridine derivatives
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6172753A (ja) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd ピリジルケトン誘導体
US4663457A (en) * 1985-01-23 1987-05-05 Warner-Lambert Company 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
DE3685157D1 (de) * 1985-06-26 1992-06-11 Daiichi Seiyaku Co Pyridoncarbonsaeurederivate.
JP2960257B2 (ja) * 1992-06-04 1999-10-06 ピーイーバイオシステムズジャパン株式会社 ビオチン導入試薬およびそれを用いる合成ペプチド精製法

Also Published As

Publication number Publication date
AU7311887A (en) 1987-09-10
ES557785A0 (es) 1988-04-16
AU5216486A (en) 1987-01-22
ES557515A0 (es) 1988-02-16
ES557516A0 (es) 1987-10-16
ES8800222A1 (es) 1987-10-16
NZ229861A (en) 1989-10-27
ES8802225A1 (es) 1988-04-16
CA1339373C (en) 1997-08-26
PL148759B1 (en) 1989-11-30
JPS61161284A (ja) 1986-07-21
JPH0653741B2 (ja) 1994-07-20
KR910002645B1 (ko) 1991-04-27
GR860031B (en) 1986-04-29
EP0187376B1 (de) 1992-05-13
PT81810B (pt) 1988-05-27
HUT40126A (en) 1986-11-28
DE3508816A1 (de) 1986-07-10
FI86721B (fi) 1992-06-30
ATE76076T1 (de) 1992-05-15
PL257419A1 (en) 1987-07-27
PL148191B1 (en) 1989-09-30
IE58412B1 (en) 1993-09-22
PT81810A (en) 1986-02-01
CN1003236B (zh) 1989-02-08
AU574550B2 (en) 1988-07-07
PL264565A1 (en) 1988-01-07
ES557514A0 (es) 1988-03-01
IL77538A (en) 1992-05-25
FI892675A0 (fi) 1989-06-01
DK9186A (da) 1986-07-11
NO163331C (no) 1990-05-09
ES550767A0 (es) 1988-06-16
HU193623B (en) 1987-11-30
ES8801919A1 (es) 1988-03-01
CN86100126A (zh) 1986-07-09
FI860073A0 (fi) 1986-01-08
DK168439B1 (da) 1994-03-28
NO163331B (no) 1990-01-29
IE860062L (en) 1986-07-10
ES8801796A1 (es) 1988-02-16
DK9186D0 (da) 1986-01-09
FI860073A (fi) 1986-07-11
FI892675A (fi) 1989-06-01
EP0187376A2 (de) 1986-07-16
EP0187376A3 (en) 1988-05-04
CA1320206C (en) 1993-07-13
AU576449B2 (en) 1988-08-25
KR860005818A (ko) 1986-08-13
PH24769A (en) 1990-10-01
IL89168A0 (en) 1989-09-10
DE3586048D1 (en) 1992-06-17
NO855134L (no) 1986-07-11
NZ214746A (en) 1989-10-27
AU1835988A (en) 1988-09-15
FI86721C (fi) 1992-10-12
ES8802520A1 (es) 1988-06-16
NO860199L (no) 1986-07-11
US4840954A (en) 1989-06-20

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