PE20210096A1 - Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret - Google Patents
Inhibidor de ret para uso en tratar cancer que tiene una alteracion de retInfo
- Publication number
- PE20210096A1 PE20210096A1 PE2020001523A PE2020001523A PE20210096A1 PE 20210096 A1 PE20210096 A1 PE 20210096A1 PE 2020001523 A PE2020001523 A PE 2020001523A PE 2020001523 A PE2020001523 A PE 2020001523A PE 20210096 A1 PE20210096 A1 PE 20210096A1
- Authority
- PE
- Peru
- Prior art keywords
- ret
- alteration
- inhibitor
- treating cancer
- pyrazol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652284P | 2018-04-03 | 2018-04-03 | |
| US201862656297P | 2018-04-11 | 2018-04-11 | |
| US201862657605P | 2018-04-13 | 2018-04-13 | |
| US201862741683P | 2018-10-05 | 2018-10-05 | |
| PCT/US2019/025655 WO2019195471A1 (en) | 2018-04-03 | 2019-04-03 | Ret inhibitor for use in treating cancer having a ret alteration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20210096A1 true PE20210096A1 (es) | 2021-01-12 |
Family
ID=66223846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001523A PE20210096A1 (es) | 2018-04-03 | 2019-04-03 | Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US20210100795A1 (enExample) |
| EP (2) | EP3773589B1 (enExample) |
| JP (3) | JP7422084B2 (enExample) |
| KR (1) | KR20200139749A (enExample) |
| AU (1) | AU2019247766A1 (enExample) |
| BR (1) | BR112020020273A2 (enExample) |
| CA (1) | CA3096043A1 (enExample) |
| CL (1) | CL2020002544A1 (enExample) |
| CR (1) | CR20200522A (enExample) |
| DK (1) | DK3773589T3 (enExample) |
| ES (1) | ES2970041T3 (enExample) |
| FI (1) | FI3773589T3 (enExample) |
| HR (1) | HRP20240124T1 (enExample) |
| HU (1) | HUE065374T2 (enExample) |
| IL (1) | IL277629A (enExample) |
| LT (1) | LT3773589T (enExample) |
| MX (1) | MX2020010417A (enExample) |
| MY (1) | MY203645A (enExample) |
| PE (1) | PE20210096A1 (enExample) |
| PL (1) | PL3773589T3 (enExample) |
| PT (1) | PT3773589T (enExample) |
| RS (1) | RS65127B1 (enExample) |
| SG (1) | SG11202009681YA (enExample) |
| SI (1) | SI3773589T1 (enExample) |
| WO (1) | WO2019195471A1 (enExample) |
| ZA (1) | ZA202006072B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| IL302209B2 (en) | 2015-11-02 | 2024-06-01 | Blueprint Medicines Corp | Inhibitors of ret |
| PT3773589T (pt) | 2018-04-03 | 2024-02-06 | Blueprint Medicines Corp | Inibidor de ret para utilização no tratamento de cancro com alteração de ret |
| US11666570B2 (en) * | 2019-07-11 | 2023-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnosis and regulation of epidermal differentiation and cancer cell activity |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| US11946935B2 (en) * | 2020-08-25 | 2024-04-02 | Regents Of The University Of Minnesota | Circulating tumor markers for meningiomas |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| CA2493000A1 (en) | 2002-07-24 | 2004-01-29 | University Of Cincinnati | 4-4(methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide for treating mutated-ret kinase associated diseases |
| US7504509B2 (en) | 2003-12-19 | 2009-03-17 | Plexxikon, Inc. | Compounds and methods for development of Ret modulators |
| US8227455B2 (en) | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
| WO2006122011A2 (en) | 2005-05-09 | 2006-11-16 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
| US20100047777A1 (en) | 2005-05-26 | 2010-02-25 | The Johns Hopkins University | Methods for identifying mutations in coding and non-coding dna |
| WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
| EP1978958A4 (en) | 2006-01-24 | 2009-12-02 | Merck & Co Inc | RET tyrosine kinase Inhibition |
| AU2007252506C1 (en) | 2006-05-18 | 2012-07-19 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| US20090048214A1 (en) | 2006-11-15 | 2009-02-19 | Rigel Pharmaceuticals, Inc | Methods for Treating Renal Tumors Using 2, 4-Pyrimidinediamine Drug and Prodrug Compounds |
| WO2009003136A1 (en) | 2007-06-26 | 2008-12-31 | Rigel Pharmaceuticals, Inc. | Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders |
| AU2008273889B2 (en) | 2007-07-09 | 2012-03-08 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| RU2474580C2 (ru) | 2007-07-19 | 2013-02-10 | Шеринг Корпорейшн | Гетероциклические амидные соединения как ингибиторы протеинкиназ |
| WO2009100536A1 (en) | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
| WO2010006432A1 (en) | 2008-07-14 | 2010-01-21 | Queen's University At Kingston | Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer |
| CA2755953A1 (en) | 2009-03-24 | 2010-09-30 | Vertex Pharmaceuticals Incorporated | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| US20120172361A1 (en) | 2009-06-08 | 2012-07-05 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| JP2012529517A (ja) | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ベンジル置換トリアジン誘導体類及びそれらの治療応用 |
| JP2013509444A (ja) | 2009-10-30 | 2013-03-14 | アリアド・ファーマシューティカルズ・インコーポレイテッド | がんの治療方法及び治療用組成物 |
| KR101663637B1 (ko) | 2009-11-13 | 2016-10-07 | 제노스코 | 키나아제 억제제 |
| KR20140047138A (ko) | 2011-08-04 | 2014-04-21 | 도쿠리츠교세이호진 고쿠리츠간켄큐센터 | Ｋｉｆ5ｂ 유전자와 ｒｅｔ 유전자와의 융합 유전자, 및 당해 융합 유전자를 표적으로 한 암 치료의 유효성을 판정하는 방법 |
| BR112014004213A2 (pt) | 2011-08-23 | 2017-06-20 | Found Medicine Inc | novas moléculas de fusão kif5b-ret e usos das mesmas |
| WO2013077921A2 (en) | 2011-09-02 | 2013-05-30 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
| US20130096136A1 (en) | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| US10023855B2 (en) | 2011-10-31 | 2018-07-17 | Macrogen, Inc. | Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| WO2013133367A1 (ja) | 2012-03-09 | 2013-09-12 | カルナバイオサイエンス株式会社 | 新規トリアジン誘導体 |
| JP2015109806A (ja) | 2012-03-22 | 2015-06-18 | アステラス製薬株式会社 | 新規ｒｅｔ融合体の検出法 |
| ES2645984T3 (es) | 2012-04-25 | 2017-12-11 | Raqualia Pharma Inc | Derivados de pirrolopiridinona como bloqueadores de TTX-S |
| US20150099721A1 (en) | 2012-05-10 | 2015-04-09 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
| SMT202100451T1 (it) | 2012-07-11 | 2021-09-14 | Blueprint Medicines Corp | Inibitori del recettore di crescita dei fibroblasti |
| JPWO2014017491A1 (ja) | 2012-07-26 | 2016-07-11 | 国立研究開発法人国立がん研究センター | Ｃｅｐ５５遺伝子とｒｅｔ遺伝子との融合遺伝子 |
| US20150238477A1 (en) | 2012-09-07 | 2015-08-27 | Exelixis, Inc. | Method of Treating Lung Adenocarcinoma |
| SG11201502211QA (en) | 2012-09-25 | 2015-05-28 | Chugai Pharmaceutical Co Ltd | Ret inhibitor |
| WO2014072220A1 (en) | 2012-11-07 | 2014-05-15 | Nerviano Medical Sciences S.R.L. | Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors |
| TWI629266B (zh) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | 纖維母細胞生長因子受體之抑制劑 |
| WO2014130810A1 (en) | 2013-02-25 | 2014-08-28 | Bristol-Myers Squibb Company | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv |
| US9499522B2 (en) | 2013-03-15 | 2016-11-22 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| PT2970191T (pt) | 2013-03-15 | 2017-03-23 | Glaxosmithkline Ip Dev Ltd | Derivados de piridina como inibidores da quinase rearranjada durante transfecção(ret) |
| IN2013MU00848A (enExample) | 2013-03-19 | 2015-05-01 | Glenmark Generics Ltd | |
| WO2015006875A1 (en) | 2013-07-18 | 2015-01-22 | Methylgene Inc. | Process for the preparation of substituted pyrimidines |
| WO2015025866A1 (ja) | 2013-08-20 | 2015-02-26 | 独立行政法人国立がん研究センター | 肺がんで見出された新規融合遺伝子 |
| US9334263B2 (en) | 2013-10-17 | 2016-05-10 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| BR112016008541B1 (pt) | 2013-10-17 | 2022-11-22 | Blueprint Medicines Corporation | Composto ou sal farmaceuticamente aceitável, uso do mesmo para tratar mastocistose, tumor do estroma gastrointestinal e leucemia, e composição farmacêutica |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| WO2016022569A1 (en) | 2014-08-04 | 2016-02-11 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| PT3191450T (pt) | 2014-09-10 | 2019-05-29 | Glaxosmithkline Ip Dev Ltd | Derivados de piridona como inibidores da quinase rearranjada durante a transfecção (ret) |
| EA032030B1 (ru) | 2014-09-10 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы |
| EA039885B1 (ru) | 2014-11-14 | 2022-03-23 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Производные 6-амино-7-бицикло-7-деазапурина в качестве ингибиторов протеинкиназы |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| CN104844567B (zh) | 2015-04-23 | 2017-03-29 | 暨南大学 | 一种中间体1‑(3‑氯‑2‑吡啶基)‑3‑溴‑1h‑5‑吡唑甲酸的合成方法 |
| RS61485B1 (sr) | 2015-07-16 | 2021-03-31 | Array Biopharma Inc | Supstituisana pirazolo [1,5-a] piridinska jedinjenja kao inhibitori ret kinaze |
| KR20180048635A (ko) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물 |
| RU2744974C2 (ru) | 2015-08-26 | 2021-03-17 | Блюпринт Медсинс Корпорейшн | Соединения и композиции, применяемые для лечения расстройств, связанных с ntrk |
| CN105255927B (zh) | 2015-09-30 | 2018-07-27 | 温州医科大学附属第一医院 | 一种kiaa1217-ret融合基因 |
| BR112018008865A8 (pt) | 2015-11-02 | 2019-02-26 | Five Prime Therapeutics Inc | polipeptídeos do domínio extracelular cd80 e seu uso no tratamento do câncer |
| IL302209B2 (en) | 2015-11-02 | 2024-06-01 | Blueprint Medicines Corp | Inhibitors of ret |
| EA201891084A1 (ru) | 2015-11-02 | 2019-10-31 | Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение | |
| CA3005741A1 (en) | 2015-11-19 | 2017-05-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| JP2018536682A (ja) | 2015-12-11 | 2018-12-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｅｇｆｒ及び／またはｅｒｂｂ３遮断に耐性のある腫瘍の成長を低減または防止するための方法 |
| WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
| WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
| EP3436018A4 (en) | 2016-04-01 | 2019-11-13 | Signal Pharmaceuticals, LLC | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS AND METHOD FOR TREATING THEREOF |
| LT3442535T (lt) | 2016-04-15 | 2022-10-25 | Cancer Research Technology Limited | Heterocikliniai junginiai kaip ret kinazės inhibitoriai |
| RS62322B1 (sr) | 2016-04-15 | 2021-10-29 | Cancer Research Tech Ltd | Heterociklična jedinjenja kao inhibitori ret kinaze |
| EP4285996A3 (en) | 2016-04-15 | 2024-01-10 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| US10035789B2 (en) | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US20190192522A1 (en) | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
| JP2018052878A (ja) | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| CN106749231B (zh) | 2016-10-09 | 2019-03-01 | 南京纳丁菲医药科技有限公司 | 萘啶化合物和药物组合物及它们的应用 |
| TWI704148B (zh) * | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| WO2018102455A1 (en) | 2016-12-01 | 2018-06-07 | Ignyta, Inc. | Methods for the treatment of cancer |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| US11040979B2 (en) | 2017-03-31 | 2021-06-22 | Blueprint Medicines Corporation | Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| CN110891573A (zh) * | 2017-05-15 | 2020-03-17 | 缆图药品公司 | Ret抑制剂和mtorc1抑制剂的组合及其用于治疗由异常ret活性介导的癌症的用途 |
| WO2018237134A1 (en) | 2017-06-23 | 2018-12-27 | San Diego State University Research Foundation | Atropisomerism for enhanced kinase inhibitor selectivity |
| CN109180677A (zh) | 2017-06-30 | 2019-01-11 | 厦门大学 | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 |
| US12435374B2 (en) | 2017-07-07 | 2025-10-07 | Nipd Genetics Public Company Limited | Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers |
| CN107980784B (zh) | 2017-12-13 | 2020-05-26 | 中国农业大学 | 5-氨基吡唑类化合物在调节植物生长方面的应用 |
| MX2020006490A (es) | 2017-12-19 | 2020-08-17 | Turning Point Therapeutics Inc | Compuestos macrociclicos para tratar enfermedades. |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CN108341782A (zh) | 2018-03-30 | 2018-07-31 | 南京哈柏医药科技有限公司 | 3-氨基-5-甲基吡唑的合成工艺 |
| PT3773589T (pt) | 2018-04-03 | 2024-02-06 | Blueprint Medicines Corp | Inibidor de ret para utilização no tratamento de cancro com alteração de ret |
| WO2020033838A2 (en) | 2018-08-10 | 2020-02-13 | Blueprint Medicines Corporation | Treatment of egfr-mutant cancer |
| CN111362923A (zh) | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
| CN111440151A (zh) | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| IL298525A (en) | 2020-05-29 | 2023-01-01 | Blueprint Medicines Corp | Pralsetinib pharmaceutical compositions |
| EP4255892A1 (en) | 2020-12-04 | 2023-10-11 | Blueprint Medicines Corporation | Method of preparing pralsetinib |
-
2019
- 2019-04-03 PT PT197185317T patent/PT3773589T/pt unknown
- 2019-04-03 WO PCT/US2019/025655 patent/WO2019195471A1/en not_active Ceased
- 2019-04-03 CR CR20200522A patent/CR20200522A/es unknown
- 2019-04-03 DK DK19718531.7T patent/DK3773589T3/da active
- 2019-04-03 SI SI201930702T patent/SI3773589T1/sl unknown
- 2019-04-03 EP EP19718531.7A patent/EP3773589B1/en active Active
- 2019-04-03 MX MX2020010417A patent/MX2020010417A/es unknown
- 2019-04-03 JP JP2020553633A patent/JP7422084B2/ja active Active
- 2019-04-03 PL PL19718531.7T patent/PL3773589T3/pl unknown
- 2019-04-03 RS RS20240107A patent/RS65127B1/sr unknown
- 2019-04-03 EP EP23199171.2A patent/EP4353317A3/en not_active Withdrawn
- 2019-04-03 FI FIEP19718531.7T patent/FI3773589T3/fi active
- 2019-04-03 ES ES19718531T patent/ES2970041T3/es active Active
- 2019-04-03 KR KR1020207031426A patent/KR20200139749A/ko not_active Withdrawn
- 2019-04-03 HU HUE19718531A patent/HUE065374T2/hu unknown
- 2019-04-03 US US17/044,884 patent/US20210100795A1/en not_active Abandoned
- 2019-04-03 MY MYPI2020005148A patent/MY203645A/en unknown
- 2019-04-03 HR HRP20240124TT patent/HRP20240124T1/hr unknown
- 2019-04-03 SG SG11202009681YA patent/SG11202009681YA/en unknown
- 2019-04-03 AU AU2019247766A patent/AU2019247766A1/en not_active Withdrawn
- 2019-04-03 CA CA3096043A patent/CA3096043A1/en active Pending
- 2019-04-03 BR BR112020020273-8A patent/BR112020020273A2/pt not_active Application Discontinuation
- 2019-04-03 PE PE2020001523A patent/PE20210096A1/es unknown
- 2019-04-03 LT LTEPPCT/US2019/025655T patent/LT3773589T/lt unknown
-
2020
- 2020-09-27 IL IL277629A patent/IL277629A/en unknown
- 2020-09-30 ZA ZA2020/06072A patent/ZA202006072B/en unknown
- 2020-10-01 CL CL2020002544A patent/CL2020002544A1/es unknown
- 2020-10-02 US US17/061,743 patent/US11963958B2/en active Active
- 2020-12-18 US US17/127,041 patent/US11273160B2/en active Active
-
2021
- 2021-07-16 US US17/377,885 patent/US11872192B2/en active Active
- 2021-12-09 JP JP2021199945A patent/JP2022022391A/ja active Pending
-
2023
- 2023-09-28 JP JP2023167564A patent/JP2023165937A/ja not_active Withdrawn
-
2024
- 2024-03-15 US US18/606,346 patent/US20250041297A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20210096A1 (es) | Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret | |
| GEAP202516803A (en) | Bicyclic amines as cdk2 inhibitors | |
| CY1124789T1 (el) | Πυριμιδιν-2-υλαμινο-1η-πυραζολια ως αναστολεις lrrk2 για χρηση στη θεραπεια νευροεκφυλιστικων διαταραχων | |
| ZA202202097B (en) | Amino pyrimidine ssao inhibitors | |
| MX2024004332A (es) | Metodos de uso de inhibidores de ehmt2 para tratar o prevenir transtornos sanguíneos. | |
| MX2021003517A (es) | Composiciones de inhibidor de tirosina quinasa, metodos de fabricacion y metodos de uso. | |
| MX2020014245A (es) | Inhibidores de quinasas dependientes de ciclinas. | |
| MX2021005012A (es) | Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de su uso como inhibidores de la cinasa atr. | |
| EA201890001A1 (ru) | Замещенные гетероциклические производные как ингибиторы циклинзависимой киназы (cdk) | |
| PE20200796A1 (es) | Compuestos derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y composiciones que los comprenden | |
| MX2020012165A (es) | Derivados de bencimidazol como inhibidores de tirosina cinasa erbb para el tratamiento del cancer. | |
| CL2008003302A1 (es) | Uso de una proteina de funsion kinasa 1 similar al receptor de activina (alk-1) y fc (alk1.fc) porque sirve para preparar un medicamento contra tumor,cancer o desordenes proliferativos. | |
| ZA202204284B (en) | Inhibitors of raf kinases | |
| ECSP088387A (es) | Metodo de inhibicion de cinasa de tirosina cinasa 3 similar a fms | |
| MX373584B (es) | Tratamiento de cánceres utilizando moduladores de la isoforma pi3 cinasa. | |
| MX389961B (es) | Dispersiones sólidas que comprenden estimulador de heme guanilato ciclasa soluble (sgc). | |
| MX2016007111A (es) | Inhibidores de tirosina quinasa de bruton. | |
| NZ757929A (en) | Benzoazepine analogs as inhibiting agents for bruton’s tyrosine kinase | |
| BR112019006228A2 (pt) | tratamento de câncer de próstata | |
| BR112023006531A2 (pt) | Inibidores heterocílicos de egfr e/ou her2, para uso no tratamento de câncer | |
| MX2022006932A (es) | Combinaciones de inhibidores de diacilglicerol cinasas (dgk) y antagonistas de puntos de control. | |
| EA201692470A1 (ru) | Фармацевтические комбинации | |
| LT3972604T (lt) | Brutono tirozino kinazės inhibitorius, skirtas naudoti lėtinės spontaninės dilgėlinės gydymui | |
| BR112020016929A8 (pt) | Métodos de uso para derivados de benzotriazol trissubstituídos | |
| CL2024001756A1 (es) | Inhibidores de cinasa met |