MX2020006490A - Compuestos macrociclicos para tratar enfermedades. - Google Patents

Compuestos macrociclicos para tratar enfermedades.

Info

Publication number
MX2020006490A
MX2020006490A MX2020006490A MX2020006490A MX2020006490A MX 2020006490 A MX2020006490 A MX 2020006490A MX 2020006490 A MX2020006490 A MX 2020006490A MX 2020006490 A MX2020006490 A MX 2020006490A MX 2020006490 A MX2020006490 A MX 2020006490A
Authority
MX
Mexico
Prior art keywords
treating disease
macrocyclic compounds
cancer
methods
present disclosure
Prior art date
Application number
MX2020006490A
Other languages
English (en)
Inventor
Han Zhang
Wei Deng
Jane Ung
Jingrong Jean Cui
Evan W Rogers
Dayong Zhai
Jeffrey Whitten
Original Assignee
Turning Point Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Turning Point Therapeutics Inc filed Critical Turning Point Therapeutics Inc
Publication of MX2020006490A publication Critical patent/MX2020006490A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente descripción se refiere a ciertos derivados macrocíclicos, las composiciones farmacéuticas que los contienen y los métodos para usarlos para tratar enfermedades, como el cáncer.
MX2020006490A 2017-12-19 2018-12-18 Compuestos macrociclicos para tratar enfermedades. MX2020006490A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762607528P 2017-12-19 2017-12-19
US201862727124P 2018-09-05 2018-09-05
US201862779283P 2018-12-13 2018-12-13
PCT/US2018/066158 WO2019126121A1 (en) 2017-12-19 2018-12-18 Macrocyclic compounds for treating disease

Publications (1)

Publication Number Publication Date
MX2020006490A true MX2020006490A (es) 2020-08-17

Family

ID=66992951

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006490A MX2020006490A (es) 2017-12-19 2018-12-18 Compuestos macrociclicos para tratar enfermedades.

Country Status (26)

Country Link
US (3) US10745416B2 (es)
EP (2) EP4151641A1 (es)
JP (2) JP7194188B2 (es)
KR (1) KR20200101358A (es)
CN (1) CN111511746B (es)
AU (1) AU2018392332B2 (es)
BR (1) BR112020012319A2 (es)
CA (1) CA3083674A1 (es)
CL (1) CL2020001632A1 (es)
DK (1) DK3728271T3 (es)
EC (1) ECSP20033467A (es)
ES (1) ES2929467T3 (es)
HR (1) HRP20221502T1 (es)
HU (1) HUE060711T2 (es)
IL (1) IL275265B2 (es)
JO (1) JOP20200152A1 (es)
LT (1) LT3728271T (es)
MX (1) MX2020006490A (es)
PH (1) PH12020550901A1 (es)
PL (1) PL3728271T3 (es)
PT (1) PT3728271T (es)
RS (1) RS63787B1 (es)
SG (1) SG11202005590PA (es)
SI (1) SI3728271T1 (es)
TW (1) TW201930312A (es)
WO (1) WO2019126121A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ742351A (en) 2015-11-02 2023-03-31 Blueprint Medicines Corp Inhibitors of ret
JP7244504B2 (ja) 2017-10-18 2023-03-22 インサイト・コーポレイション ＰＩ３Ｋ－γ阻害剤としての三級ヒドロキシ基で置換された縮合イミダゾール誘導体
HRP20211918T8 (hr) 2017-12-19 2022-04-15 Bristol-Myers Squibb Company Triazol n-vezane karbamoil cikloheksil kiseline kao lpa antagonisti
PL3728271T3 (pl) 2017-12-19 2023-01-23 Turning Point Therapeutics, Inc. Związki makrocykliczne do leczenia chorób
HRP20240124T1 (hr) 2018-04-03 2024-04-12 Blueprint Medicines Corporation Inhibitori za ret za uporabu u liječenju raka koji ima ret alteraciju
CN112703014A (zh) 2018-08-10 2021-04-23 缆图药品公司 Egfr突变型癌症的治疗
EP3870579A4 (en) 2018-10-22 2022-10-19 Alumis Inc. TYK2 INHIBITORS AND THEIR USES
AU2020294627A1 (en) * 2019-06-19 2022-02-17 Turning Point Therapeutics, Inc. Polymorphs of a macrocyclic kinase inhibitor
WO2020257189A1 (en) * 2019-06-19 2020-12-24 Turning Point Therapeutics, Inc. Macrocycles for treating disease
WO2020257165A1 (en) * 2019-06-19 2020-12-24 Turning Point Therapeutics, Inc. Macrocycles for use in treating disease
WO2021027503A1 (zh) * 2019-08-12 2021-02-18 罗欣药业(上海)有限公司 三环类化合物、其制备方法、中间体及应用
CA3163735A1 (en) * 2019-12-03 2021-06-10 Turning Point Therapeutics, Inc. Macrocycles for use in treating disease
CN113754682B (zh) 2020-06-04 2023-01-06 赛诺哈勃药业（成都）有限公司 具有大环结构的化合物及其用途
WO2023060022A1 (en) * 2021-10-05 2023-04-13 Turning Point Therapeutics, Inc. Synthesis of macrocyclic compounds
WO2024017380A1 (zh) * 2022-07-22 2024-01-25 南京明德新药研发有限公司 含三并环的大环类化合物及其应用
WO2024040131A1 (en) * 2022-08-17 2024-02-22 Treeline Biosciences, Inc. Pyridopyrimidine kras inhibitors

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT690843E (pt) * 1993-03-25 2001-01-31 Upjohn Co Derivados de indolo substituidos com formilo ou ciano possuindo actividade dopaminergica
RU2147304C1 (ru) 1993-12-07 2000-04-10 Эли Лилли Энд Компани Бис-индолмалеимидные макроциклические производные, способ их получения (варианты) и фармацевтическая композиция
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
MXPA03005139A (es) 2000-12-08 2004-01-29 Ortho Mcneil Pharm Inc Compuestos macroheterociclicos utiles como inhibidores de cinasa.
CA2735420C (en) 2008-09-08 2016-06-28 Merck Patent Gmbh Macrocyclic pyrimidines as protein kinase inhibitors
RS53350B (en) 2008-09-22 2014-10-31 Array Biopharma, Inc. SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS
TWI577680B (zh) 2008-10-22 2017-04-11 亞雷生物製藥股份有限公司 作為ＴＲＫ激酶抑制劑之經取代吡唑并〔１，５－ａ〕嘧啶化合物
CN102271515B (zh) 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
AU2010305805B2 (en) 2009-10-13 2014-04-03 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors
SA111320200B1 (ar) 2010-02-17 2014-02-16 ديبيوفارم اس ايه مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
ES2534335T3 (es) * 2010-05-20 2015-04-21 Array Biopharma, Inc. Compuestos macrocíclicos como inhibidores de la Trk cinasa
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
EP2508607A1 (en) 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medicament for liver regeneration and for treatment of liver failure
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
WO2013028470A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
DK2760867T3 (en) 2011-09-30 2016-04-11 Oncodesign Sa Macrocyclic FLT3 kinase inhibitors
HUE034118T2 (en) 2012-03-06 2018-01-29 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
RU2014140735A (ru) 2012-03-09 2016-04-27 Лексикон Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ ПИРАЗОЛО[1, 5-a]ПИРИМИДИНА, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
SG11201405563VA (en) 2012-03-09 2014-10-30 Lexicon Pharmaceuticals Inc Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
GB201205669D0 (en) 2012-03-30 2012-05-16 Agency Science Tech & Res Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof
PT3636649T (pt) * 2014-01-24 2024-04-09 Turning Point Therapeutics Inc Diaril macrociclos como moduladores das proteínas quinases
AU2015292827B2 (en) * 2014-07-21 2019-11-14 Dana-Farber Cancer Institute, Inc. Macrocyclic kinase inhibitors and uses thereof
WO2017004342A1 (en) 2015-07-02 2017-01-05 Tp Therapeutics, Inc. Chiral diaryl macrocycles as modulators of protein kinases
DK3319969T3 (da) 2015-07-06 2024-07-08 Turning Point Therapeutics Inc Diaryl-makrocyklus-polymorf
MX2018000718A (es) 2015-07-21 2020-01-20 Turning Point Therapeutics Inc Macrociclos de diarilo quirales y usos de los mismos.
ES2812336T3 (es) * 2016-03-03 2021-03-16 Shenzhen Targetrx Inc Macrocíclico y composición que comprende el mismo
CN106008531B (zh) * 2016-05-30 2019-01-11 上海交通大学 多环稠合大环内酰胺类化合物的抗胰腺癌用途
RU2019105587A (ru) 2016-07-28 2020-08-28 Тёрнинг Поинт Терапьютикс, Инк. Макроциклические ингибиторы киназ
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
US11286264B2 (en) 2017-07-28 2022-03-29 Turning Point Therapeutics, Inc. Macrocyclic compounds and uses thereof
JP7244504B2 (ja) 2017-10-18 2023-03-22 インサイト・コーポレイション ＰＩ３Ｋ－γ阻害剤としての三級ヒドロキシ基で置換された縮合イミダゾール誘導体
EP3728270A4 (en) * 2017-12-19 2021-06-23 Turning Point Therapeutics, Inc. MACROCYCLIC KINASE INHIBITORS AND THEIR USES
PL3728271T3 (pl) 2017-12-19 2023-01-23 Turning Point Therapeutics, Inc. Związki makrocykliczne do leczenia chorób
HRP20211918T8 (hr) 2017-12-19 2022-04-15 Bristol-Myers Squibb Company Triazol n-vezane karbamoil cikloheksil kiseline kao lpa antagonisti
GB201721235D0 (en) 2017-12-19 2018-01-31 Syngenta Participations Ag Polymorphs
WO2019120267A1 (zh) 2017-12-22 2019-06-27 成都先导药物开发股份有限公司 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂
CA3099493C (en) 2018-04-18 2023-08-22 Hitgen Inc. Macrocyclic kinase inhibitor

Also Published As

Publication number Publication date
EP3728271A1 (en) 2020-10-28
RS63787B1 (sr) 2022-12-30
DK3728271T3 (da) 2022-12-19
CL2020001632A1 (es) 2020-11-20
HRP20221502T1 (hr) 2023-03-31
AU2018392332A1 (en) 2020-06-11
CN111511746A (zh) 2020-08-07
CA3083674A1 (en) 2019-06-27
US10745416B2 (en) 2020-08-18
US20220306652A1 (en) 2022-09-29
BR112020012319A2 (pt) 2020-11-24
EP3728271B1 (en) 2022-09-28
AU2018392332B2 (en) 2023-08-03
ECSP20033467A (es) 2020-09-30
JP2023027237A (ja) 2023-03-01
WO2019126121A1 (en) 2019-06-27
EP3728271A4 (en) 2021-06-23
LT3728271T (lt) 2022-12-12
US20200392160A1 (en) 2020-12-17
US11286265B2 (en) 2022-03-29
HUE060711T2 (hu) 2023-04-28
EP4151641A1 (en) 2023-03-22
ES2929467T3 (es) 2022-11-29
IL275265B2 (en) 2023-07-01
PH12020550901A1 (en) 2021-05-17
IL275265B1 (en) 2023-03-01
SI3728271T1 (sl) 2023-01-31
JP7194188B2 (ja) 2022-12-21
JOP20200152A1 (ar) 2022-10-30
SG11202005590PA (en) 2020-07-29
JP2021506850A (ja) 2021-02-22
TW201930312A (zh) 2019-08-01
PT3728271T (pt) 2022-10-06
PL3728271T3 (pl) 2023-01-23
US20200190110A1 (en) 2020-06-18
KR20200101358A (ko) 2020-08-27
IL275265A (en) 2020-07-30
CN111511746B (zh) 2024-01-09

Similar Documents

Publication Publication Date Title
PH12020550901A1 (en) Macrocyclic compounds for treating disease
PH12019501443A1 (en) Benzooxazole derivatives as immunomodulators
ZA202004100B (en) Diaryl macrocycles as modulators of protein kinases
PH12020500033A1 (en) Macrocyclic compounds and uses thereof
MX2019001125A (es) Inhibidores de cinasa macrociclica.
PH12018501084A1 (en) Heterocyclic compounds as immunomodulators
PH12018502535A1 (en) Substituted carbonucleoside derivatives useful as anticancer agents
PH12016502179A1 (en) Inhibitors of lysine specific demethylase-1
MY198613A (en) Nitrobenzyl derivatives of anti-cancer agents
JO3512B1 (ar) مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
PH12015502414A1 (en) Enhancer of zeste homolog 2 inhibitors
PH12018502497A1 (en) Adenosine derivatives for use in the treatment of cancer
NZ731696A (en) Method for treating cancer
MX2022008523A (es) Compuestos que interactuan con glicanos y metodos de uso.
PH12019502363A1 (en) Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
MX2019013808A (es) Compuestos desestabilizadores de microtubulina para usarse en el tratamiento del cancer.
WO2019036417A3 (en) Inhibition of ngly1 for the treatment of cancer
MX2017009608A (es) Compuestos anticancerigenos.
MX2017007318A (es) Metodos de prevencion, reduccion o tratamiento de degeneracion macular.
MX2016004094A (es) Composicion farmaceutica que comprende capecitabina y ciclofosfamida.
TW201612183A (en) Diaryl macrocycles as modulators of protein kinases
EA202091327A1 (ru) Макроциклические соединения для лечения заболеваний