PE20191714A1 - Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso - Google Patents

Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso

Info

Publication number
PE20191714A1
PE20191714A1 PE2019001935A PE2019001935A PE20191714A1 PE 20191714 A1 PE20191714 A1 PE 20191714A1 PE 2019001935 A PE2019001935 A PE 2019001935A PE 2019001935 A PE2019001935 A PE 2019001935A PE 20191714 A1 PE20191714 A1 PE 20191714A1
Authority
PE
Peru
Prior art keywords
minoxidil
finasteride
polymeric
nanoparticula
pharmaceutical composition
Prior art date
Application number
PE2019001935A
Other languages
English (en)
Spanish (es)
Inventor
Ludmila Pinheiro Do Nascimento
Adriana Raffin Pohlmann
Silvia Stanisçuaski Guterres
Denise Soledade Jornada
Original Assignee
Biolab Sanus Farmaceutica Ltda
Univ Federal Do Rio Grande Do Sul Ufrgs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50182296&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20191714(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biolab Sanus Farmaceutica Ltda, Univ Federal Do Rio Grande Do Sul Ufrgs filed Critical Biolab Sanus Farmaceutica Ltda
Publication of PE20191714A1 publication Critical patent/PE20191714A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
PE2019001935A 2012-08-31 2013-08-30 Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso PE20191714A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR102012022036-9A BR102012022036B1 (pt) 2012-08-31 2012-08-31 Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso
PCT/BR2013/000335 WO2014032152A1 (pt) 2012-08-31 2013-08-30 Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso

Publications (1)

Publication Number Publication Date
PE20191714A1 true PE20191714A1 (es) 2019-12-05

Family

ID=50182296

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2019001935A PE20191714A1 (es) 2012-08-31 2013-08-30 Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso
PE2015000270A PE20150732A1 (es) 2012-08-31 2013-08-30 Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2015000270A PE20150732A1 (es) 2012-08-31 2013-08-30 Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso

Country Status (24)

Country Link
US (1) US9687554B2 (enExample)
EP (1) EP2891486B1 (enExample)
JP (1) JP6352265B2 (enExample)
KR (1) KR102118582B1 (enExample)
CN (1) CN104755075B (enExample)
AR (1) AR092403A1 (enExample)
AU (1) AU2013308356B2 (enExample)
BR (1) BR102012022036B1 (enExample)
CA (1) CA2883998C (enExample)
CL (1) CL2015000501A1 (enExample)
CO (1) CO7310520A2 (enExample)
DK (1) DK2891486T3 (enExample)
ES (1) ES2683418T3 (enExample)
IN (1) IN2015DN01728A (enExample)
MX (1) MX363961B (enExample)
MY (1) MY174692A (enExample)
PE (2) PE20191714A1 (enExample)
PY (1) PY1340780A (enExample)
SA (1) SA515360084B1 (enExample)
TR (1) TR201810389T4 (enExample)
UA (1) UA113774C2 (enExample)
UY (1) UY35002A (enExample)
WO (1) WO2014032152A1 (enExample)
ZA (1) ZA201501255B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150174254A1 (en) * 2013-12-23 2015-06-25 Mcneil-Ppc, Inc. Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent
US9675537B2 (en) * 2014-06-30 2017-06-13 Johnson & Johnson Consumer Inc. Hair growth composition and method
CN104887685A (zh) * 2015-05-05 2015-09-09 谢秉权 一种治疗和/或预防男性型脱发的复方外用药
ES2613888B1 (es) * 2016-08-19 2017-11-16 Enrique Blanxart Sena Composición farmacéutica para el tratamiento de la alopecia
WO2018206077A1 (en) * 2017-05-08 2018-11-15 Merz Pharma Gmbh & Co. Kgaa Emulsion comprising finasteride
EP3638198B1 (de) * 2017-06-16 2021-08-18 Capilli Med GmbH Zusammensetzung zur verhinderung von haarausfall und wachstumsförderung von haaren
MX390288B (es) * 2018-02-06 2025-03-20 Centro Int De Cosmiatria S A P I De C V Formulación y método para el tratamiento de la alopecia androgénica.
CN110448525A (zh) * 2018-05-08 2019-11-15 无锡派列博生物医药科技有限公司 一种预防脱发和促生发的外用非那雄胺脂质纳米制剂及其制备方法
WO2020097284A1 (en) * 2018-11-08 2020-05-14 Jindal Vinay K TOPICAL FORMULATIONS OF 5-α-REDUCTASE INHIBITORS AND USES THEREOF
WO2020121329A1 (en) * 2018-12-11 2020-06-18 Dr Rathod Sudha Suresh Minoxidil and castor oil nanoemulgel for alopecia
CN112773776B (zh) * 2019-11-11 2023-06-20 上海胜联医药科技有限公司 一种载药纳米粒体系
CN111329832B (zh) * 2020-02-08 2021-07-16 中山大学 一种治疗脱发的纳米脂质载体微针及其应用
EP4114362A4 (en) * 2020-03-05 2024-03-20 University of Miami NANODRUG FORMULATIONS OF CANNABIDIOL AND THEIR METHODS OF USE
KR102244368B1 (ko) 2020-03-30 2021-04-27 현대바이오사이언스 주식회사 비타민과 덱스판테놀이 봉입된 에토좀 조성물 및 이의 제조방법
US11311556B2 (en) 2020-05-13 2022-04-26 Varsona Therapeutics, Inc. Topical dutasteride emulsions for treating endocrine therapy-induced alopecia
EP4216938A4 (en) * 2020-09-24 2024-12-18 Pro Transit Nanotherapy LLC COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS AND OTHER CONDITIONS
CN114910567B (zh) * 2021-02-07 2023-11-24 株洲千金药业股份有限公司 一种检测非那雄胺中遗传毒性杂质的方法及其应用
CN113425845B (zh) * 2021-08-10 2022-12-02 成都倍特药业股份有限公司 一种预防和/或治疗脱发症的传递体制剂及其制备方法和用途
CN113797208B (zh) * 2021-11-17 2022-02-25 山东谷雨春生物科技有限公司 一种含米诺地尔的制剂及其制备方法和应用
KR20230113871A (ko) 2022-01-24 2023-08-01 (주) 해피론이엔지 발포폴리에틸렌메시를 이용한 건축물 층간소음방지 시공방법 및 구조.
KR102623083B1 (ko) 2022-05-02 2024-01-10 (주) 해피론이엔지 공명공간을 제거한 1차 몰탈 타설식 소음방지 시공공법 및 시공구조
CN115006712B (zh) * 2022-06-28 2024-01-09 广州汇元医药科技有限公司 一种米诺地尔的脂质纳米粒微针及其制备方法和应用
CN115252549B (zh) * 2022-07-12 2023-09-08 科辉智药生物科技（无锡）有限公司 提高生发活性物质药效的组合物及其制备方法
CN115400085A (zh) * 2022-09-02 2022-11-29 南昌大学 一种非那雄胺类脂囊泡及其制备方法和应用
CN116870169A (zh) * 2023-07-20 2023-10-13 华南理工大学 一种防脱发纳米组合物及其制备方法
CN118831088B (zh) * 2023-09-06 2025-04-29 北京辰光医药科技有限公司 治疗脱发的药物制剂及其制备方法与用途
EP4702983A1 (en) * 2024-09-02 2026-03-04 Lacer, S.A.U. Compositions for hair loss
CN118831050B (zh) * 2024-09-12 2025-01-28 晨笛医药科技(上海)有限公司 一种5α-还原酶抑制剂的含醇乳液及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
US6284234B1 (en) * 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
EP1154783A4 (en) * 1999-07-06 2005-01-19 Raziel Lurie RELAXIN-CONTAINING MEDICAMENTS AND ITS USE
KR100463167B1 (ko) * 2001-04-13 2004-12-23 주식회사 태평양 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물
WO2005000258A1 (en) 2003-06-27 2005-01-06 Amorepacific Corporation Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles
CN100539988C (zh) * 2003-06-27 2009-09-16 株式会社太平洋 含有生理活性成分的自聚集聚合物纳米颗粒和含有该纳米颗粒的外用搽剂
JP4939936B2 (ja) * 2003-06-27 2012-05-30 株式會社アモーレパシフィック 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物
US20060204588A1 (en) 2005-03-10 2006-09-14 Elan Pharma International Limited Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof
CL2007002336A1 (es) * 2006-08-11 2008-02-08 M S Panacea Biotec Ltd Composicion que tiene particulas que comprende elementos inorganicos, uno o mas ingredientes activos y opcionalmente, agentes moduladores de la tasa de liberacion; procedimiento para prepararla; las particulas, util para la entrega de ingredientes ac
US20080175807A1 (en) 2007-01-24 2008-07-24 Fujifilm Corporation Composition for hair
BRPI0700832B8 (pt) * 2007-03-16 2021-05-25 Biolab Sanus Farmaceutica Ltda composição anestésica tópica compreendendo suspensão de nanocápsulas poliméricas de lidocaína e prilocaína
WO2009058135A1 (en) 2007-10-30 2009-05-07 Celonova Biosciences, Inc. Loadable polymeric microparticles for therapeutic use in alopecia and methods of preparing and using the same
PL2344198T3 (pl) 2008-09-27 2021-05-31 Jina Pharmaceuticals Inc. Preparaty farmaceutyczne na bazie lipidów do stosowania miejscowego
KR20120113211A (ko) 2009-09-11 2012-10-12 폴리카 인코포레이티드 모발 성장을 조절하기 위한 간헐 리튬 치료 및 펄스 리튬 치료
ES2384060B1 (es) * 2010-03-24 2013-09-23 Lipotec S.A. Cápsulas de nanopartículas lipídicas.
BRPI1002601E2 (pt) * 2010-06-01 2020-06-30 Embrapa Pesquisa Agropecuaria composição nanoestruturada de uso veterinário para administração de fármacos

Also Published As

Publication number Publication date
AU2013308356B2 (en) 2017-09-28
MX363961B (es) 2019-04-09
IN2015DN01728A (enExample) 2015-05-29
CA2883998C (en) 2020-08-25
CN104755075A (zh) 2015-07-01
JP6352265B2 (ja) 2018-07-04
US20150216986A1 (en) 2015-08-06
EP2891486A4 (en) 2016-03-23
MY174692A (en) 2020-05-07
JP2015526484A (ja) 2015-09-10
PY1340780A (es) 2018-10-01
UA113774C2 (xx) 2017-03-10
CN104755075B (zh) 2019-07-26
CO7310520A2 (es) 2015-06-30
TR201810389T4 (tr) 2018-08-27
WO2014032152A1 (pt) 2014-03-06
US9687554B2 (en) 2017-06-27
BR102012022036B1 (pt) 2019-10-01
KR102118582B1 (ko) 2020-06-04
MX2015002300A (es) 2016-02-10
CA2883998A1 (en) 2014-03-06
SA515360084B1 (ar) 2016-10-03
ES2683418T3 (es) 2018-09-26
DK2891486T3 (en) 2018-07-23
EP2891486A1 (en) 2015-07-08
EP2891486B1 (en) 2018-05-16
PE20150732A1 (es) 2015-05-17
BR102012022036A2 (pt) 2014-11-25
AR092403A1 (es) 2015-04-22
UY35002A (es) 2014-03-31
AU2013308356A1 (en) 2015-04-16
CL2015000501A1 (es) 2015-07-03
KR20150044029A (ko) 2015-04-23
ZA201501255B (en) 2016-01-27

Similar Documents

Publication Publication Date Title
PE20191714A1 (es) Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso
PE20191713A1 (es) Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su uso
CL2018003452A1 (es) Formulaciones nasales semi-sólidas y líquidas visuales de cannabinoides.
AR086115A1 (es) Formulaciones parenterales mejoradas de agentes farmaceuticos lipofilos y los metodos para la preparacion y el uso de las mismas
MX2016007067A (es) Microcapsulas lipidicas que comprenden de preferencia un retinoide y composicion que las contiene, su procedimiento de preparacion y su uso en dermatologia.
ES2721325T3 (es) Método para producir de manera estéril partículas de lípido-ácido nucleico
MX2017004256A (es) Metodo para desinfectar semillas comestibles, particularmente semillas productoras de mucilago.
AR071123A1 (es) Composiciones para duchas y banos de inmersion
AR075284A1 (es) Formulaciones fitosanitarias liquidas acuosas
CL2013003365A1 (es) Formulacion farmaceutica que comprende diacilglicerol y/o tocoferol, fosfatidilcolina, solvente mono-alcoholico organico biocompatible que comprende etanol, solvente polar, y un analogo de somatostatina como principio activo; proceso para prepararla; kit farmaceutico; uso en el tratamiento de acromegalia y canceres, entre otros.
AR082051A1 (es) Composicion antimicrobial para enjuague bucal reducida en alcohol
MX2015011462A (es) Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.
AR072359A1 (es) Encapsulacion de agentes biologicamente activos
BR112012015433A2 (pt) composição farmacêutica substancialmente anidra para aplicação cutânea
DOP2015000303A (es) Letermovir amorfo y formulaciones farmacéuticas sólidas del mismo para administración por vía oral
AR053737A1 (es) Formulacion pediatrica de topiramato
DOP2016000007A (es) Pirazolpiridinas sustituidas
PE20171246A1 (es) Formulaciones farmaceuticas que comprenden cangrelor de alta pureza y metodos para la preparacion y uso de los mismos
EP2787071A4 (en) MEANS FOR INCREASING EQUOL CONCENTRATION WITH PSICOSE AS ACTIVE AGENT
AR107701A1 (es) Composición cosmética bifásica y su uso mediante aplicación tópica
CL2015000226A1 (es) Proceso para la concentracion de una suspension acuosa de particulas solidas que comprende la adicion de al menos un floculante polimerico organico a la suspension acuosa y en donde se añade al menos un agente activo a los solidos en la corriente de reciclado.
HK1222337A1 (zh) 用於施加药物活性成分或化妆品活性成分的局部组合物和载体
AR091526A1 (es) Composicion pesticida en la forma de emulsion acuosa
WO2013182998A4 (en) Cosmetic and / or pharmaceutical composition for the treatment of skin inflammation and related syndromes
BR112014014576A2 (pt) composição aquosa não-surfactante, composição de emulsão, método de deslocamento de um material de petróleo ativo não refinado em contato com um material sólido, e, método de conversão de um ácido de petróleo ativo não refinado em um surfactante