PE20191713A1 - Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su uso - Google Patents
Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su usoInfo
- Publication number
- PE20191713A1 PE20191713A1 PE2019001938A PE2019001938A PE20191713A1 PE 20191713 A1 PE20191713 A1 PE 20191713A1 PE 2019001938 A PE2019001938 A PE 2019001938A PE 2019001938 A PE2019001938 A PE 2019001938A PE 20191713 A1 PE20191713 A1 PE 20191713A1
- Authority
- PE
- Peru
- Prior art keywords
- composition
- finasteride
- polymeric
- alopecia
- preparing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/654—The particulate/core comprising macromolecular material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
La presente invencion se refiere a una composicion de nanoparticulas polimericas en forma de nanocapsulas que contienen finasterida como principio activo, donde las nanoparticulas polimericas comprenden un nucleo interno liquido o semisolido encapsulado por una membrana solida polimerica, que comprende: a) 0,05% a 20,0% (p/p) de un polimero hidrofobico seleccionado de poli (?-caprolactona); b) 0,05% a 20,0% (p/p) de una mezcla de aceites seleccionado de trigliceridos de los acidos caprico y caprilico, con linalol y farnesol; c) 0,05% a 20,0% (p/p) de un tensoactivo lipofilico de bajo EHL (Equilibrio Hidrofilo Lipofilo) seleccionado de monoestearato de sorbitan; d) 10% a 80% de un solvente organico seleccionado de acetona; e) 0,005% a 50% (p/p) de finasterida; f) 0,05% a 20,0% (p/p) de un tensioactivo hidrofilico neutro seleccionado de polisorbato 80; g) 10% a 90% (p/p) de agua. Dicha composicion es de aplicacion topica, siendo util para el tratamiento de la alopecia. Tambien se refiere a un proceso de preparacion de dicha composicion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102012022034-2A BR102012022034B1 (pt) | 2012-08-31 | 2012-08-31 | Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso |
| PCT/BR2013/000334 WO2014032151A1 (pt) | 2012-08-31 | 2013-08-30 | Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191713A1 true PE20191713A1 (es) | 2019-12-05 |
Family
ID=50182295
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001938A PE20191713A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su uso |
| PE2015000269A PE20150731A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su uso |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015000269A PE20150731A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida, suspension acuosa conteniendo a la misma, composicion para tratamiento de alopecia, proceso de preparacion de dicha composicion, y su uso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9895302B2 (es) |
| EP (1) | EP2891487B1 (es) |
| JP (1) | JP6235018B2 (es) |
| KR (1) | KR102128478B1 (es) |
| CN (1) | CN104768539B (es) |
| AR (1) | AR092402A1 (es) |
| AU (1) | AU2013308355B2 (es) |
| BR (1) | BR102012022034B1 (es) |
| CA (1) | CA2883996C (es) |
| CL (1) | CL2015000502A1 (es) |
| DK (1) | DK2891487T3 (es) |
| ES (1) | ES2702577T3 (es) |
| IN (1) | IN2015DN01727A (es) |
| MX (1) | MX357601B (es) |
| PE (2) | PE20191713A1 (es) |
| SA (1) | SA515360083B1 (es) |
| TR (1) | TR201818992T4 (es) |
| UA (1) | UA116993C2 (es) |
| UY (1) | UY35003A (es) |
| WO (1) | WO2014032151A1 (es) |
| ZA (1) | ZA201501254B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2596720B1 (es) * | 2015-07-10 | 2018-01-29 | Juvilis Cosmetics S.L. | Composiciones para uso tópico |
| KR102429536B1 (ko) * | 2015-09-30 | 2022-08-04 | (주)아모레퍼시픽 | 열안정성 현탁 화장료 조성물 |
| CN109071750B (zh) | 2016-03-08 | 2022-08-02 | 生活实验公司 | 持久化妆品组合物 |
| BR112018068886A2 (pt) | 2016-03-18 | 2019-01-22 | Caregen Co Ltd | conjugado de finasterida com peptídeo |
| CN110325272A (zh) * | 2017-03-28 | 2019-10-11 | 富士胶片株式会社 | 微胶囊及其制造方法 |
| WO2018206077A1 (en) * | 2017-05-08 | 2018-11-15 | Merz Pharma Gmbh & Co. Kgaa | Emulsion comprising finasteride |
| WO2019055445A2 (en) | 2017-09-13 | 2019-03-21 | Living Proof, Inc. | COLOR PROTECTION COMPOSITIONS |
| CA3074843A1 (en) | 2017-09-13 | 2019-03-21 | Living Proof, Inc. | Long lasting cosmetic compositions |
| CN110448525A (zh) * | 2018-05-08 | 2019-11-15 | 无锡派列博生物医药科技有限公司 | 一种预防脱发和促生发的外用非那雄胺脂质纳米制剂及其制备方法 |
| KR102644611B1 (ko) | 2018-11-29 | 2024-03-07 | (주)아모레퍼시픽 | 탈모 또는 피부 염증 억제용 조성물 |
| KR20200099901A (ko) * | 2019-02-15 | 2020-08-25 | (주)인벤티지랩 | 피나스테라이드를 포함하는 마이크로 입자를 함유한 피하 주사용 조성물 |
| KR102157124B1 (ko) * | 2019-12-23 | 2020-09-18 | (주)인벤티지랩 | 피나스테라이드를 포함하는 서방성 주사용 조성물 |
| MX2022014226A (es) * | 2020-05-13 | 2023-04-14 | Follicle Pharma Ltd | Composiciones para la administracion de agentes bioactivos en foliculos pilosos. |
| EP4216938A1 (en) * | 2020-09-24 | 2023-08-02 | Pro Transit Nanotherapy LLC | Compositions and methods for the treatment of hair loss and other conditions |
| GB2624638A (en) * | 2022-11-22 | 2024-05-29 | Landa Labs 2012 Ltd | Nano-Carriers for Drug Delivery and Methods of Preparing the Same |
| CN115400085A (zh) * | 2022-09-02 | 2022-11-29 | 南昌大学 | 一种非那雄胺类脂囊泡及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4900984B2 (ja) * | 1997-07-15 | 2012-03-21 | 武田薬品工業株式会社 | 徐放性製剤の製造法 |
| WO2005000258A1 (en) * | 2003-06-27 | 2005-01-06 | Amorepacific Corporation | Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles |
| JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
| WO2006099121A2 (en) | 2005-03-10 | 2006-09-21 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride and tamsulosin hydrochloride, and mixtures thereof |
| US20080175807A1 (en) | 2007-01-24 | 2008-07-24 | Fujifilm Corporation | Composition for hair |
| JP2009096787A (ja) * | 2007-10-19 | 2009-05-07 | Fujifilm Corp | 血行促進剤を内包した水分散可能なナノ粒子 |
| FR2930176B1 (fr) * | 2008-04-18 | 2011-03-18 | Univ Claude Bernard Lyon | Nouveau procede de fabrication de nanocapsules, en l'absence de solvant organique, et nanocapsules ainsi obtenues |
| LT2344198T (lt) * | 2008-09-27 | 2021-02-25 | Jina Pharmaceuticals Inc. | Farmaciniai preparatai lipidų pagrindu, skirti vietiniam naudojimui |
| WO2010045292A2 (en) * | 2008-10-15 | 2010-04-22 | The University Of North Carolina At Chapel Hill | Nanoparticle compositions comprising liquid oil cores |
| CN102423297B (zh) * | 2011-12-23 | 2013-11-20 | 厦门金达威集团股份有限公司 | 一种自微乳液及其制备方法 |
-
2012
- 2012-08-31 BR BR102012022034-2A patent/BR102012022034B1/pt active IP Right Grant
-
2013
- 2013-08-30 KR KR1020157008182A patent/KR102128478B1/ko active IP Right Grant
- 2013-08-30 DK DK13832319.1T patent/DK2891487T3/en active
- 2013-08-30 CA CA2883996A patent/CA2883996C/en active Active
- 2013-08-30 PE PE2019001938A patent/PE20191713A1/es unknown
- 2013-08-30 CN CN201380057187.2A patent/CN104768539B/zh active Active
- 2013-08-30 PE PE2015000269A patent/PE20150731A1/es not_active Application Discontinuation
- 2013-08-30 EP EP13832319.1A patent/EP2891487B1/en active Active
- 2013-08-30 AR ARP130103102A patent/AR092402A1/es not_active Application Discontinuation
- 2013-08-30 ES ES13832319T patent/ES2702577T3/es active Active
- 2013-08-30 UY UY0001035003A patent/UY35003A/es not_active Application Discontinuation
- 2013-08-30 WO PCT/BR2013/000334 patent/WO2014032151A1/pt active Application Filing
- 2013-08-30 TR TR2018/18992T patent/TR201818992T4/tr unknown
- 2013-08-30 MX MX2015002299A patent/MX357601B/es active IP Right Grant
- 2013-08-30 UA UAA201502761A patent/UA116993C2/uk unknown
- 2013-08-30 IN IN1727DEN2015 patent/IN2015DN01727A/en unknown
- 2013-08-30 AU AU2013308355A patent/AU2013308355B2/en not_active Ceased
- 2013-08-30 US US14/424,662 patent/US9895302B2/en active Active
- 2013-08-30 JP JP2015528814A patent/JP6235018B2/ja active Active
-
2015
- 2015-02-24 ZA ZA2015/01254A patent/ZA201501254B/en unknown
- 2015-02-26 SA SA515360083A patent/SA515360083B1/ar unknown
- 2015-02-27 CL CL2015000502A patent/CL2015000502A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015526483A (ja) | 2015-09-10 |
| CA2883996C (en) | 2020-10-27 |
| KR20150046332A (ko) | 2015-04-29 |
| CA2883996A1 (en) | 2014-03-06 |
| IN2015DN01727A (es) | 2015-05-29 |
| ES2702577T3 (es) | 2019-03-04 |
| DK2891487T3 (en) | 2019-01-14 |
| CN104768539B (zh) | 2019-03-05 |
| MX2015002299A (es) | 2016-02-10 |
| MX357601B (es) | 2018-07-16 |
| EP2891487A4 (en) | 2016-04-20 |
| PE20150731A1 (es) | 2015-05-17 |
| AU2013308355A1 (en) | 2015-04-16 |
| BR102012022034B1 (pt) | 2020-02-18 |
| UY35003A (es) | 2014-03-31 |
| CN104768539A (zh) | 2015-07-08 |
| TR201818992T4 (tr) | 2019-01-21 |
| US9895302B2 (en) | 2018-02-20 |
| JP6235018B2 (ja) | 2017-11-22 |
| EP2891487B1 (en) | 2018-11-28 |
| AU2013308355B2 (en) | 2017-08-31 |
| KR102128478B1 (ko) | 2020-07-01 |
| US20150238406A1 (en) | 2015-08-27 |
| BR102012022034A2 (pt) | 2014-08-19 |
| UA116993C2 (uk) | 2018-06-11 |
| ZA201501254B (en) | 2016-05-25 |
| WO2014032151A1 (pt) | 2014-03-06 |
| EP2891487A1 (en) | 2015-07-08 |
| CL2015000502A1 (es) | 2015-10-16 |
| AR092402A1 (es) | 2015-04-22 |
| SA515360083B1 (ar) | 2017-03-01 |
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