BR112018068886A2 - conjugado de finasterida com peptídeo - Google Patents

conjugado de finasterida com peptídeo

Info

Publication number
BR112018068886A2
BR112018068886A2 BR112018068886A BR112018068886A BR112018068886A2 BR 112018068886 A2 BR112018068886 A2 BR 112018068886A2 BR 112018068886 A BR112018068886 A BR 112018068886A BR 112018068886 A BR112018068886 A BR 112018068886A BR 112018068886 A2 BR112018068886 A2 BR 112018068886A2
Authority
BR
Brazil
Prior art keywords
finasteride
peptide
hair
hair loss
growth
Prior art date
Application number
BR112018068886A
Other languages
English (en)
Inventor
Mi Kim Eun
Ji Chung Yong
Original Assignee
Caregen Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caregen Co Ltd filed Critical Caregen Co Ltd
Publication of BR112018068886A2 publication Critical patent/BR112018068886A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção se refere a uma composição para prevenir a queda dos cabelos e, mais especificamente, a um composto com uma estrutura na qual a finasterida e um peptídeo estão ligados através de uma ligação covalente e uma composição farmacêutica ou composição cosmética para prevenir a queda dos cabelos ou promover o crescimento capilar compreendendo os mesmos. o composto da presente invenção que apresenta uma estrutura na qual a finasterida e um peptídeo estão ligados através de uma ligação covalente é excelente nas atividades fisiológicas, tais como, melhoria da queda dos cabelos, promoção do crescimento dos cabelos, promoção do crescimento celular, etc., sendo excelente em estabilidade em água e permeação da pele, e, portanto, podendo ser efetivamente usado como uma composição para prevenir a queda dos cabelos e promover o crescimento dos mesmos.
BR112018068886A 2016-03-18 2016-05-20 conjugado de finasterida com peptídeo BR112018068886A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160032988 2016-03-18
PCT/KR2016/005405 WO2017159922A1 (ko) 2016-03-18 2016-05-20 피나스테라이드와 펩타이드의 결합체

Publications (1)

Publication Number Publication Date
BR112018068886A2 true BR112018068886A2 (pt) 2019-01-22

Family

ID=59852267

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018068886A BR112018068886A2 (pt) 2016-03-18 2016-05-20 conjugado de finasterida com peptídeo

Country Status (17)

Country Link
US (1) US11357783B2 (pt)
EP (1) EP3431505B1 (pt)
JP (2) JP6835867B2 (pt)
KR (1) KR102160565B1 (pt)
CN (1) CN107428841B (pt)
AU (1) AU2016397332B2 (pt)
BR (1) BR112018068886A2 (pt)
CA (1) CA3018193C (pt)
CL (1) CL2018002629A1 (pt)
EA (1) EA039431B1 (pt)
ES (1) ES2928882T3 (pt)
MX (1) MX2018011209A (pt)
MY (1) MY189759A (pt)
PH (1) PH12018501993A1 (pt)
SA (1) SA518400042B1 (pt)
WO (1) WO2017159922A1 (pt)
ZA (1) ZA201806245B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019054822A1 (ko) * 2017-09-18 2019-03-21 애니젠 주식회사 활성물질-헥사펩타이드 복합체 및 이를 포함하는 화장료 조성물
JP2021504407A (ja) * 2017-12-01 2021-02-15 グッド ティー セルズ、 インコーポレイテッド 脱毛の予防または治療用組成物
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
KR102157124B1 (ko) * 2019-12-23 2020-09-18 (주)인벤티지랩 피나스테라이드를 포함하는 서방성 주사용 조성물

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JP3596835B2 (ja) * 1996-08-13 2004-12-02 株式会社ノエビア 養毛剤
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
CA2534342C (en) 2003-07-29 2016-05-10 V. Ravi Chandran Amino acid prodrugs
CN100415239C (zh) 2005-05-16 2008-09-03 济南百诺医药科技开发有限公司 非那雄胺高浓度溶液及用途
KR100804494B1 (ko) 2006-07-18 2008-02-20 김준현 악취 제거 장치
KR20080077762A (ko) 2007-02-21 2008-08-26 주식회사 웰코스 탈모방지 및 모발생장 촉진 효과를 가지는 생약화장료조성물
KR101386570B1 (ko) 2007-07-24 2014-04-21 엘지디스플레이 주식회사 액정표시장치
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Also Published As

Publication number Publication date
CL2018002629A1 (es) 2019-03-22
ES2928882T3 (es) 2022-11-23
KR102160565B1 (ko) 2020-09-28
SA518400042B1 (ar) 2022-02-08
CA3018193C (en) 2023-04-04
CA3018193A1 (en) 2017-09-21
AU2016397332B2 (en) 2020-04-30
EA039431B1 (ru) 2022-01-26
JP2019512502A (ja) 2019-05-16
MX2018011209A (es) 2019-05-16
JP6835867B2 (ja) 2021-02-24
WO2017159922A1 (ko) 2017-09-21
JP2021011507A (ja) 2021-02-04
EA201892112A1 (ru) 2019-03-29
CN107428841A (zh) 2017-12-01
AU2016397332A1 (en) 2018-10-18
EP3431505B1 (en) 2022-09-07
CN107428841B (zh) 2021-06-11
KR20180112003A (ko) 2018-10-11
US11357783B2 (en) 2022-06-14
EP3431505A1 (en) 2019-01-23
ZA201806245B (en) 2019-07-31
EP3431505A4 (en) 2019-01-23
MY189759A (en) 2022-03-02
US20200289526A1 (en) 2020-09-17
PH12018501993A1 (en) 2019-06-17

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