MX2018011209A - Conjugado de finasterida con péptido. - Google Patents

Conjugado de finasterida con péptido.

Info

Publication number
MX2018011209A
MX2018011209A MX2018011209A MX2018011209A MX2018011209A MX 2018011209 A MX2018011209 A MX 2018011209A MX 2018011209 A MX2018011209 A MX 2018011209A MX 2018011209 A MX2018011209 A MX 2018011209A MX 2018011209 A MX2018011209 A MX 2018011209A
Authority
MX
Mexico
Prior art keywords
finasteride
peptide
hair loss
composition
linked
Prior art date
Application number
MX2018011209A
Other languages
English (en)
Inventor
Ji Chung Yong
Mi Kim Eun
Original Assignee
Caregen Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caregen Co Ltd filed Critical Caregen Co Ltd
Publication of MX2018011209A publication Critical patent/MX2018011209A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con una composición para evitar la pérdida de cabello y, de manera más específica, con un compuesto que tiene una estructura en la cual la finasterida y un péptido están enlazados a través de un enlace covalente y una composición farmacéutica o una composición cosmética para evitar la pérdida de cabello o promover el crecimiento de cabello que comprende la misma. El compuesto de la presente invención tiene una estructura en la cual la finasterida y un péptido están enlazados a través de un enlace covalente, es excelente en actividades fisiológicas como por ejemplo mejoramiento en la pérdida de cabello, promoción del crecimiento de cabello, promoción de crecimiento celular, etc., es excelente en estabilidad en agua y permeación de la piel, y por lo tanto se puede utilizar eficazmente como una composición para evitar la pérdida de cabello y para promover el crecimiento de cabello.
MX2018011209A 2016-03-18 2016-05-20 Conjugado de finasterida con péptido. MX2018011209A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160032988 2016-03-18
PCT/KR2016/005405 WO2017159922A1 (ko) 2016-03-18 2016-05-20 피나스테라이드와 펩타이드의 결합체

Publications (1)

Publication Number Publication Date
MX2018011209A true MX2018011209A (es) 2019-05-16

Family

ID=59852267

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011209A MX2018011209A (es) 2016-03-18 2016-05-20 Conjugado de finasterida con péptido.

Country Status (17)

Country Link
US (1) US11357783B2 (es)
EP (1) EP3431505B1 (es)
JP (2) JP6835867B2 (es)
KR (1) KR102160565B1 (es)
CN (1) CN107428841B (es)
AU (1) AU2016397332B2 (es)
BR (1) BR112018068886A2 (es)
CA (1) CA3018193C (es)
CL (1) CL2018002629A1 (es)
EA (1) EA039431B1 (es)
ES (1) ES2928882T3 (es)
MX (1) MX2018011209A (es)
MY (1) MY189759A (es)
PH (1) PH12018501993A1 (es)
SA (1) SA518400042B1 (es)
WO (1) WO2017159922A1 (es)
ZA (1) ZA201806245B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102293250B1 (ko) * 2017-09-18 2021-08-26 애니젠 주식회사 활성물질-헥사펩타이드 복합체 및 이를 포함하는 화장료 조성물
CN111465611A (zh) * 2017-12-01 2020-07-28 古德T细胞有限公司 预防或治疗脱发的组合物
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
KR102157124B1 (ko) * 2019-12-23 2020-09-18 (주)인벤티지랩 피나스테라이드를 포함하는 서방성 주사용 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3596835B2 (ja) 1996-08-13 2004-12-02 株式会社ノエビア 養毛剤
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
NZ601780A (en) * 2003-07-29 2012-10-26 Signature R & D Holdings Llc Amino Acid Prodrugs
CN100415239C (zh) * 2005-05-16 2008-09-03 济南百诺医药科技开发有限公司 非那雄胺高浓度溶液及用途
KR100804494B1 (ko) 2006-07-18 2008-02-20 김준현 악취 제거 장치
KR20080077762A (ko) 2007-02-21 2008-08-26 주식회사 웰코스 탈모방지 및 모발생장 촉진 효과를 가지는 생약화장료조성물
KR101386570B1 (ko) 2007-07-24 2014-04-21 엘지디스플레이 주식회사 액정표시장치
KR101021197B1 (ko) * 2008-04-11 2011-03-11 (주)케어젠 성장인자―미미킹 펩타이드 및 그의 용도
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
KR101163171B1 (ko) * 2009-01-20 2012-07-19 (주)케어젠 노긴?유래 펩타이드 및 그의 용도
KR101198918B1 (ko) * 2009-09-01 2012-11-07 (주)케어젠 Ｗｎｔ１０?유래 펩타이드 및 그의 용도
CN103547282A (zh) 2011-01-21 2014-01-29 Igisu株式会社 秃头症治疗剂
CN103596550A (zh) * 2011-04-25 2014-02-19 朴俊炯 用于预防脱发和促进毛发生长的局部施用的组合物
KR101205209B1 (ko) 2011-04-25 2012-11-27 박준형 탈모방지 및 발모촉진용 외용제 조성물
BR102012022034B1 (pt) 2012-08-31 2020-02-18 Biolab Sanus Farmacêutica Ltda. Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso
US9700633B2 (en) * 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
US20150118292A1 (en) * 2013-10-24 2015-04-30 Daniel Khesin Compositions and methods for treatment of hair loss

Also Published As

Publication number Publication date
ES2928882T3 (es) 2022-11-23
ZA201806245B (en) 2019-07-31
WO2017159922A1 (ko) 2017-09-21
CN107428841A (zh) 2017-12-01
CA3018193C (en) 2023-04-04
JP2019512502A (ja) 2019-05-16
KR102160565B1 (ko) 2020-09-28
JP2021011507A (ja) 2021-02-04
AU2016397332B2 (en) 2020-04-30
US20200289526A1 (en) 2020-09-17
AU2016397332A1 (en) 2018-10-18
JP6835867B2 (ja) 2021-02-24
EA039431B1 (ru) 2022-01-26
CN107428841B (zh) 2021-06-11
PH12018501993A1 (en) 2019-06-17
EP3431505A1 (en) 2019-01-23
BR112018068886A2 (pt) 2019-01-22
US11357783B2 (en) 2022-06-14
EP3431505B1 (en) 2022-09-07
EA201892112A1 (ru) 2019-03-29
EP3431505A4 (en) 2019-01-23
CL2018002629A1 (es) 2019-03-22
MY189759A (en) 2022-03-02
SA518400042B1 (ar) 2022-02-08
CA3018193A1 (en) 2017-09-21
KR20180112003A (ko) 2018-10-11

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