SA518400042B1 - مترافق من فيناستيريد مع ببتيد - Google Patents

مترافق من فيناستيريد مع ببتيد

Info

Publication number
SA518400042B1
SA518400042B1 SA518400042A SA518400042A SA518400042B1 SA 518400042 B1 SA518400042 B1 SA 518400042B1 SA 518400042 A SA518400042 A SA 518400042A SA 518400042 A SA518400042 A SA 518400042A SA 518400042 B1 SA518400042 B1 SA 518400042B1
Authority
SA
Saudi Arabia
Prior art keywords
finasteride
peptide
hair loss
composition
linked
Prior art date
Application number
SA518400042A
Other languages
English (en)
Inventor
يونج جى شونج
اون مى كيم
Original Assignee
كاريجين كو. ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by كاريجين كو. ليمتد filed Critical كاريجين كو. ليمتد
Publication of SA518400042B1 publication Critical patent/SA518400042B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

يتعلق الاختراع الحالي بتركيبة لمنع تساقط الشعر و، بشكل أكثر تحديدا، إلى مركب له بنية حيث يتم ربط فيناستيريد finasteride وببتيد peptide خلال رابط تساهمي covalent bond وتركيبة صيدلانية pharmaceutical composition أو تركيبة تجميلية cosmetic composition لمنع تساقط الشعر أو تعزيز نمو الشعر تحتوي عليها. المركب وفقا للاختراع الحالي له بنية حيث يتم ربط فيناستيريد وببتيد خلال رابط تساهمي ممتاز في الأنشطة الفسيولوجية مثل تحسين تساقط الشعر، تعزيز نمو الشعر، تعزيز نمو الخلية، إلخ.، ممتاز في الثبات في الماء ونفاذية الجلد، وبالتالي يمكن استخدامها بفاعلية كتركيبة لمنع تساقط الشعر وتعزيز نمو الشعر. شكل1
SA518400042A 2016-03-18 2018-09-18 مترافق من فيناستيريد مع ببتيد SA518400042B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160032988 2016-03-18
PCT/KR2016/005405 WO2017159922A1 (ko) 2016-03-18 2016-05-20 피나스테라이드와 펩타이드의 결합체

Publications (1)

Publication Number Publication Date
SA518400042B1 true SA518400042B1 (ar) 2022-02-08

Family

ID=59852267

Family Applications (1)

Application Number Title Priority Date Filing Date
SA518400042A SA518400042B1 (ar) 2016-03-18 2018-09-18 مترافق من فيناستيريد مع ببتيد

Country Status (17)

Country Link
US (1) US11357783B2 (ar)
EP (1) EP3431505B1 (ar)
JP (2) JP6835867B2 (ar)
KR (1) KR102160565B1 (ar)
CN (1) CN107428841B (ar)
AU (1) AU2016397332B2 (ar)
BR (1) BR112018068886A2 (ar)
CA (1) CA3018193C (ar)
CL (1) CL2018002629A1 (ar)
EA (1) EA039431B1 (ar)
ES (1) ES2928882T3 (ar)
MX (1) MX2018011209A (ar)
MY (1) MY189759A (ar)
PH (1) PH12018501993A1 (ar)
SA (1) SA518400042B1 (ar)
WO (1) WO2017159922A1 (ar)
ZA (1) ZA201806245B (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019054822A1 (ko) * 2017-09-18 2019-03-21 애니젠 주식회사 활성물질-헥사펩타이드 복합체 및 이를 포함하는 화장료 조성물
KR20190065178A (ko) * 2017-12-01 2019-06-11 주식회사 굳티셀 탈모의 예방 또는 치료용 조성물
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
KR102157124B1 (ko) * 2019-12-23 2020-09-18 (주)인벤티지랩 피나스테라이드를 포함하는 서방성 주사용 조성물

Family Cites Families (19)

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JP3596835B2 (ja) * 1996-08-13 2004-12-02 株式会社ノエビア 養毛剤
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2003079972A2 (en) * 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
NZ601780A (en) 2003-07-29 2012-10-26 Signature R & D Holdings Llc Amino Acid Prodrugs
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
CN100415239C (zh) * 2005-05-16 2008-09-03 济南百诺医药科技开发有限公司 非那雄胺高浓度溶液及用途
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KR101386570B1 (ko) 2007-07-24 2014-04-21 엘지디스플레이 주식회사 액정표시장치
KR101021197B1 (ko) 2008-04-11 2011-03-11 (주)케어젠 성장인자―미미킹 펩타이드 및 그의 용도
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BR102012022034B1 (pt) 2012-08-31 2020-02-18 Biolab Sanus Farmacêutica Ltda. Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso
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US20150118292A1 (en) * 2013-10-24 2015-04-30 Daniel Khesin Compositions and methods for treatment of hair loss

Also Published As

Publication number Publication date
EA201892112A1 (ru) 2019-03-29
ES2928882T3 (es) 2022-11-23
US11357783B2 (en) 2022-06-14
AU2016397332A1 (en) 2018-10-18
MX2018011209A (es) 2019-05-16
JP2019512502A (ja) 2019-05-16
KR20180112003A (ko) 2018-10-11
BR112018068886A2 (pt) 2019-01-22
US20200289526A1 (en) 2020-09-17
AU2016397332B2 (en) 2020-04-30
CN107428841B (zh) 2021-06-11
JP2021011507A (ja) 2021-02-04
EA039431B1 (ru) 2022-01-26
WO2017159922A1 (ko) 2017-09-21
CN107428841A (zh) 2017-12-01
CA3018193A1 (en) 2017-09-21
CA3018193C (en) 2023-04-04
KR102160565B1 (ko) 2020-09-28
CL2018002629A1 (es) 2019-03-22
EP3431505B1 (en) 2022-09-07
MY189759A (en) 2022-03-02
JP6835867B2 (ja) 2021-02-24
EP3431505A4 (en) 2019-01-23
PH12018501993A1 (en) 2019-06-17
ZA201806245B (en) 2019-07-31
EP3431505A1 (en) 2019-01-23

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