PE20191714A1 - Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso - Google Patents
Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su usoInfo
- Publication number
- PE20191714A1 PE20191714A1 PE2019001935A PE2019001935A PE20191714A1 PE 20191714 A1 PE20191714 A1 PE 20191714A1 PE 2019001935 A PE2019001935 A PE 2019001935A PE 2019001935 A PE2019001935 A PE 2019001935A PE 20191714 A1 PE20191714 A1 PE 20191714A1
- Authority
- PE
- Peru
- Prior art keywords
- minoxidil
- finasteride
- polymeric
- nanoparticula
- pharmaceutical composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
La presente invencion se refiere a una composicion de nanoparticulas polimericas en forma de nanocapsoides que contienen finasterida y minoxidil como principios activos, donde las nanoparticulas polimericas comprenden un nucleo interno liquido o semisolido encapsulado por una membrana solida polimerica, que comprende: a) 0,05% a 20,0% (p/p) de un polimero hidrofobico, seleccionado de poli (?-caprolactona); b) 0,05% a 20,0% (p/p) de un aceite fijo seleccionado de trigliceridos de los acidos caprico y caprilico; c) 0,05% a 20,0% (p/p) de un tensoactivo lipofilico de bajo EHL (Equilibrio Hidrofilo Lipofilo) seleccionado de monoestearato de sorbitan; d) 10% a 80% de un solvente organico seleccionado de acetona; e) 0,001% a 50% (p/p) de un co-solvente seleccionado de etanol; f) 0,005% a 50% (p/p) de finasterida; g) 0,05% a 20,0% (p/p) de un tensioactivo hidrofilico seleccionado de polisorbato 80; h) 0,005% a 50% (p/p) de minoxidil; y i) 10% a 90% (p/p) de agua. Dicha composicion es de aplicacion topica, siendo util para el tratamiento de la alopecia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102012022036-9A BR102012022036B1 (pt) | 2012-08-31 | 2012-08-31 | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
| PCT/BR2013/000335 WO2014032152A1 (pt) | 2012-08-31 | 2013-08-30 | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191714A1 true PE20191714A1 (es) | 2019-12-05 |
Family
ID=50182296
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015000270A PE20150732A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso |
| PE2019001935A PE20191714A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015000270A PE20150732A1 (es) | 2012-08-31 | 2013-08-30 | Nanoparticula polimerica de finasterida y minoxidil, proceso de preparacion, suspension acuosa conteniendo la misma, composicion farmaceutica, y su uso |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9687554B2 (es) |
| EP (1) | EP2891486B1 (es) |
| JP (1) | JP6352265B2 (es) |
| KR (1) | KR102118582B1 (es) |
| CN (1) | CN104755075B (es) |
| AR (1) | AR092403A1 (es) |
| AU (1) | AU2013308356B2 (es) |
| BR (1) | BR102012022036B1 (es) |
| CA (1) | CA2883998C (es) |
| CL (1) | CL2015000501A1 (es) |
| CO (1) | CO7310520A2 (es) |
| DK (1) | DK2891486T3 (es) |
| ES (1) | ES2683418T3 (es) |
| IN (1) | IN2015DN01728A (es) |
| MX (1) | MX363961B (es) |
| MY (1) | MY174692A (es) |
| PE (2) | PE20150732A1 (es) |
| SA (1) | SA515360084B1 (es) |
| TR (1) | TR201810389T4 (es) |
| UA (1) | UA113774C2 (es) |
| UY (1) | UY35002A (es) |
| WO (1) | WO2014032152A1 (es) |
| ZA (1) | ZA201501255B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150174254A1 (en) * | 2013-12-23 | 2015-06-25 | Mcneil-Ppc, Inc. | Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent |
| US9675537B2 (en) * | 2014-06-30 | 2017-06-13 | Johnson & Johnson Consumer Inc. | Hair growth composition and method |
| CN104887685A (zh) * | 2015-05-05 | 2015-09-09 | 谢秉权 | 一种治疗和/或预防男性型脱发的复方外用药 |
| ES2613888B1 (es) * | 2016-08-19 | 2017-11-16 | Enrique Blanxart Sena | Composición farmacéutica para el tratamiento de la alopecia |
| WO2018206077A1 (en) * | 2017-05-08 | 2018-11-15 | Merz Pharma Gmbh & Co. Kgaa | Emulsion comprising finasteride |
| DK3638198T3 (da) * | 2017-06-16 | 2021-11-22 | Capilli Med Gmbh | Sammensætning til at forebygge hårtab og fremme hårvækst |
| MX2018001546A (es) * | 2018-02-06 | 2019-08-07 | Centro Int De Cosmiatria S A P I De C V | Formulacion y metodo para el tratamiento de la alopecia androgenica. |
| CN110448525A (zh) * | 2018-05-08 | 2019-11-15 | 无锡派列博生物医药科技有限公司 | 一种预防脱发和促生发的外用非那雄胺脂质纳米制剂及其制备方法 |
| WO2020097284A1 (en) * | 2018-11-08 | 2020-05-14 | Jindal Vinay K | TOPICAL FORMULATIONS OF 5-α-REDUCTASE INHIBITORS AND USES THEREOF |
| WO2020121329A1 (en) * | 2018-12-11 | 2020-06-18 | Dr Rathod Sudha Suresh | Minoxidil and castor oil nanoemulgel for alopecia |
| CN112773776B (zh) * | 2019-11-11 | 2023-06-20 | 上海胜联医药科技有限公司 | 一种载药纳米粒体系 |
| CN111329832B (zh) * | 2020-02-08 | 2021-07-16 | 中山大学 | 一种治疗脱发的纳米脂质载体微针及其应用 |
| EP4114362A4 (en) * | 2020-03-05 | 2024-03-20 | Univ Miami | NANODRUG FORMULATIONS OF CANNABIDIOL AND THEIR METHODS OF USE |
| AU2020389480A1 (en) | 2020-03-30 | 2021-10-14 | Hyundaibioscience Co.,Ltd. | Ethosomal composition including ethosomes encapsulating vitamin and dexpanthenol and method for preparing the same |
| US11311556B2 (en) | 2020-05-13 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical dutasteride emulsions for treating endocrine therapy-induced alopecia |
| CN114910567B (zh) * | 2021-02-07 | 2023-11-24 | 株洲千金药业股份有限公司 | 一种检测非那雄胺中遗传毒性杂质的方法及其应用 |
| CN113425845B (zh) * | 2021-08-10 | 2022-12-02 | 成都倍特药业股份有限公司 | 一种预防和/或治疗脱发症的传递体制剂及其制备方法和用途 |
| CN113797208B (zh) * | 2021-11-17 | 2022-02-25 | 山东谷雨春生物科技有限公司 | 一种含米诺地尔的制剂及其制备方法和应用 |
| KR20230113871A (ko) | 2022-01-24 | 2023-08-01 | (주) 해피론이엔지 | 발포폴리에틸렌메시를 이용한 건축물 층간소음방지 시공방법 및 구조. |
| KR102623083B1 (ko) | 2022-05-02 | 2024-01-10 | (주) 해피론이엔지 | 공명공간을 제거한 1차 몰탈 타설식 소음방지 시공공법 및 시공구조 |
| CN115006712B (zh) * | 2022-06-28 | 2024-01-09 | 广州汇元医药科技有限公司 | 一种米诺地尔的脂质纳米粒微针及其制备方法和应用 |
| CN115252549B (zh) * | 2022-07-12 | 2023-09-08 | 科辉智药生物科技（无锡）有限公司 | 提高生发活性物质药效的组合物及其制备方法 |
| CN115400085A (zh) * | 2022-09-02 | 2022-11-29 | 南昌大学 | 一种非那雄胺类脂囊泡及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
| US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| EP1154783A4 (en) * | 1999-07-06 | 2005-01-19 | Raziel Lurie | RELAXIN-CONTAINING MEDICAMENTS AND ITS USE |
| KR100463167B1 (ko) * | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
| CN100539988C (zh) * | 2003-06-27 | 2009-09-16 | 株式会社太平洋 | 含有生理活性成分的自聚集聚合物纳米颗粒和含有该纳米颗粒的外用搽剂 |
| WO2005000258A1 (en) | 2003-06-27 | 2005-01-06 | Amorepacific Corporation | Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles |
| JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
| WO2006099121A2 (en) | 2005-03-10 | 2006-09-21 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride and tamsulosin hydrochloride, and mixtures thereof |
| CN101500937A (zh) * | 2006-08-11 | 2009-08-05 | 万能药生物有限公司 | 用于递送活性成分的粒子及其制备方法和组合物 |
| US20080175807A1 (en) | 2007-01-24 | 2008-07-24 | Fujifilm Corporation | Composition for hair |
| BRPI0700832B8 (pt) * | 2007-03-16 | 2021-05-25 | Biolab Sanus Farmaceutica Ltda | composição anestésica tópica compreendendo suspensão de nanocápsulas poliméricas de lidocaína e prilocaína |
| WO2009058135A1 (en) * | 2007-10-30 | 2009-05-07 | Celonova Biosciences, Inc. | Loadable polymeric microparticles for therapeutic use in alopecia and methods of preparing and using the same |
| LT2344198T (lt) | 2008-09-27 | 2021-02-25 | Jina Pharmaceuticals Inc. | Farmaciniai preparatai lipidų pagrindu, skirti vietiniam naudojimui |
| WO2011031990A1 (en) * | 2009-09-11 | 2011-03-17 | Follica, Inc. | Intermittent and pulse lithium treatments for modulating hair growth |
| ES2384060B1 (es) * | 2010-03-24 | 2013-09-23 | Lipotec S.A. | Cápsulas de nanopartículas lipídicas. |
| BRPI1002601E2 (pt) * | 2010-06-01 | 2020-06-30 | Embrapa Pesquisa Agropecuaria | composição nanoestruturada de uso veterinário para administração de fármacos |
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2012
- 2012-08-31 BR BR102012022036-9A patent/BR102012022036B1/pt active IP Right Grant
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2013
- 2013-08-30 EP EP13832137.7A patent/EP2891486B1/en active Active
- 2013-08-30 JP JP2015528815A patent/JP6352265B2/ja active Active
- 2013-08-30 MY MYPI2015700620A patent/MY174692A/en unknown
- 2013-08-30 PE PE2015000270A patent/PE20150732A1/es not_active Application Discontinuation
- 2013-08-30 AU AU2013308356A patent/AU2013308356B2/en active Active
- 2013-08-30 ES ES13832137.7T patent/ES2683418T3/es active Active
- 2013-08-30 US US14/424,695 patent/US9687554B2/en active Active
- 2013-08-30 CA CA2883998A patent/CA2883998C/en active Active
- 2013-08-30 AR ARP130103103A patent/AR092403A1/es not_active Application Discontinuation
- 2013-08-30 CN CN201380057183.4A patent/CN104755075B/zh active Active
- 2013-08-30 IN IN1728DEN2015 patent/IN2015DN01728A/en unknown
- 2013-08-30 UA UAA201502698A patent/UA113774C2/uk unknown
- 2013-08-30 PE PE2019001935A patent/PE20191714A1/es unknown
- 2013-08-30 DK DK13832137.7T patent/DK2891486T3/en active
- 2013-08-30 MX MX2015002300A patent/MX363961B/es active IP Right Grant
- 2013-08-30 KR KR1020157008175A patent/KR102118582B1/ko active IP Right Grant
- 2013-08-30 TR TR2018/10389T patent/TR201810389T4/tr unknown
- 2013-08-30 WO PCT/BR2013/000335 patent/WO2014032152A1/pt active Application Filing
- 2013-08-30 UY UY0001035002A patent/UY35002A/es not_active Application Discontinuation
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2015
- 2015-02-24 ZA ZA2015/01255A patent/ZA201501255B/en unknown
- 2015-02-26 SA SA515360084A patent/SA515360084B1/ar unknown
- 2015-02-27 CL CL2015000501A patent/CL2015000501A1/es unknown
- 2015-03-06 CO CO15052121A patent/CO7310520A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX363961B (es) | 2019-04-09 |
| CA2883998C (en) | 2020-08-25 |
| CN104755075A (zh) | 2015-07-01 |
| MY174692A (en) | 2020-05-07 |
| KR20150044029A (ko) | 2015-04-23 |
| EP2891486A1 (en) | 2015-07-08 |
| BR102012022036A2 (pt) | 2014-11-25 |
| ES2683418T3 (es) | 2018-09-26 |
| AR092403A1 (es) | 2015-04-22 |
| CN104755075B (zh) | 2019-07-26 |
| IN2015DN01728A (es) | 2015-05-29 |
| PE20150732A1 (es) | 2015-05-17 |
| US9687554B2 (en) | 2017-06-27 |
| JP2015526484A (ja) | 2015-09-10 |
| CO7310520A2 (es) | 2015-06-30 |
| US20150216986A1 (en) | 2015-08-06 |
| KR102118582B1 (ko) | 2020-06-04 |
| AU2013308356A1 (en) | 2015-04-16 |
| JP6352265B2 (ja) | 2018-07-04 |
| MX2015002300A (es) | 2016-02-10 |
| EP2891486B1 (en) | 2018-05-16 |
| UY35002A (es) | 2014-03-31 |
| EP2891486A4 (en) | 2016-03-23 |
| UA113774C2 (xx) | 2017-03-10 |
| CL2015000501A1 (es) | 2015-07-03 |
| WO2014032152A1 (pt) | 2014-03-06 |
| CA2883998A1 (en) | 2014-03-06 |
| DK2891486T3 (en) | 2018-07-23 |
| BR102012022036B1 (pt) | 2019-10-01 |
| ZA201501255B (en) | 2016-01-27 |
| TR201810389T4 (tr) | 2018-08-27 |
| AU2013308356B2 (en) | 2017-09-28 |
| SA515360084B1 (ar) | 2016-10-03 |
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