MX363961B - Nanoparticulas polimericas de finasterida y minoxidil, metodo para preparar las mismas, suspension acuosa que contiene las mismas, composicion farmaceutica y su uso. - Google Patents
Nanoparticulas polimericas de finasterida y minoxidil, metodo para preparar las mismas, suspension acuosa que contiene las mismas, composicion farmaceutica y su uso.Info
- Publication number
- MX363961B MX363961B MX2015002300A MX2015002300A MX363961B MX 363961 B MX363961 B MX 363961B MX 2015002300 A MX2015002300 A MX 2015002300A MX 2015002300 A MX2015002300 A MX 2015002300A MX 363961 B MX363961 B MX 363961B
- Authority
- MX
- Mexico
- Prior art keywords
- minoxidil
- finasteride
- nanoparticles
- pharmaceutical composition
- polymeric
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
La presente invención se relaciona a una composición farmacéutica de aplicación tópica para el tratamiento de alopecia, la composición que comprende nanopartículas poliméricas, de preferencia nanocápsulas, que contienen dos principios activos, finasterida y minoxidil, y aditivos y portadores farmacéuticamente aceptables. La invención además incluye un método para preparar nanopartículas poliméricas de finasterida y minoxidil, de preferencia nanocápsulas, adecuadas para una composición de aplicación tópica para el tratamiento de alopecia, así como el uso de las nanocápsulas para preparar una composición farmacéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102012022036-9A BR102012022036B1 (pt) | 2012-08-31 | 2012-08-31 | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
PCT/BR2013/000335 WO2014032152A1 (pt) | 2012-08-31 | 2013-08-30 | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015002300A MX2015002300A (es) | 2016-02-10 |
MX363961B true MX363961B (es) | 2019-04-09 |
Family
ID=50182296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002300A MX363961B (es) | 2012-08-31 | 2013-08-30 | Nanoparticulas polimericas de finasterida y minoxidil, metodo para preparar las mismas, suspension acuosa que contiene las mismas, composicion farmaceutica y su uso. |
Country Status (23)
Country | Link |
---|---|
US (1) | US9687554B2 (es) |
EP (1) | EP2891486B1 (es) |
JP (1) | JP6352265B2 (es) |
KR (1) | KR102118582B1 (es) |
CN (1) | CN104755075B (es) |
AR (1) | AR092403A1 (es) |
AU (1) | AU2013308356B2 (es) |
BR (1) | BR102012022036B1 (es) |
CA (1) | CA2883998C (es) |
CL (1) | CL2015000501A1 (es) |
CO (1) | CO7310520A2 (es) |
DK (1) | DK2891486T3 (es) |
ES (1) | ES2683418T3 (es) |
IN (1) | IN2015DN01728A (es) |
MX (1) | MX363961B (es) |
MY (1) | MY174692A (es) |
PE (2) | PE20191714A1 (es) |
SA (1) | SA515360084B1 (es) |
TR (1) | TR201810389T4 (es) |
UA (1) | UA113774C2 (es) |
UY (1) | UY35002A (es) |
WO (1) | WO2014032152A1 (es) |
ZA (1) | ZA201501255B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150174254A1 (en) * | 2013-12-23 | 2015-06-25 | Mcneil-Ppc, Inc. | Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent |
US9675537B2 (en) * | 2014-06-30 | 2017-06-13 | Johnson & Johnson Consumer Inc. | Hair growth composition and method |
CN104887685A (zh) * | 2015-05-05 | 2015-09-09 | 谢秉权 | 一种治疗和/或预防男性型脱发的复方外用药 |
ES2613888B1 (es) * | 2016-08-19 | 2017-11-16 | Enrique Blanxart Sena | Composición farmacéutica para el tratamiento de la alopecia |
WO2018206077A1 (en) * | 2017-05-08 | 2018-11-15 | Merz Pharma Gmbh & Co. Kgaa | Emulsion comprising finasteride |
LT3638198T (lt) * | 2017-06-16 | 2021-12-10 | Capilli Med Gmbh | Kompozicija, skirta plaukų slinkimo prevencijai ir plaukų augimo skatinimui |
MX2018001546A (es) | 2018-02-06 | 2019-08-07 | Centro Int De Cosmiatria S A P I De C V | Formulacion y metodo para el tratamiento de la alopecia androgenica. |
CN110448525A (zh) * | 2018-05-08 | 2019-11-15 | 无锡派列博生物医药科技有限公司 | 一种预防脱发和促生发的外用非那雄胺脂质纳米制剂及其制备方法 |
WO2020097284A1 (en) * | 2018-11-08 | 2020-05-14 | Jindal Vinay K | TOPICAL FORMULATIONS OF 5-α-REDUCTASE INHIBITORS AND USES THEREOF |
WO2020121329A1 (en) * | 2018-12-11 | 2020-06-18 | Dr Rathod Sudha Suresh | Minoxidil and castor oil nanoemulgel for alopecia |
CN112773776B (zh) * | 2019-11-11 | 2023-06-20 | 上海胜联医药科技有限公司 | 一种载药纳米粒体系 |
CN111329832B (zh) * | 2020-02-08 | 2021-07-16 | 中山大学 | 一种治疗脱发的纳米脂质载体微针及其应用 |
WO2021178871A1 (en) * | 2020-03-05 | 2021-09-10 | University Of Miami | Cannabidiol nanodrug formulations and methods for use the same |
KR102244368B1 (ko) | 2020-03-30 | 2021-04-27 | 현대바이오사이언스 주식회사 | 비타민과 덱스판테놀이 봉입된 에토좀 조성물 및 이의 제조방법 |
US11311556B2 (en) | 2020-05-13 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical dutasteride emulsions for treating endocrine therapy-induced alopecia |
CN114910567B (zh) * | 2021-02-07 | 2023-11-24 | 株洲千金药业股份有限公司 | 一种检测非那雄胺中遗传毒性杂质的方法及其应用 |
CN113425845B (zh) * | 2021-08-10 | 2022-12-02 | 成都倍特药业股份有限公司 | 一种预防和/或治疗脱发症的传递体制剂及其制备方法和用途 |
CN113797208B (zh) * | 2021-11-17 | 2022-02-25 | 山东谷雨春生物科技有限公司 | 一种含米诺地尔的制剂及其制备方法和应用 |
KR20230113871A (ko) | 2022-01-24 | 2023-08-01 | (주) 해피론이엔지 | 발포폴리에틸렌메시를 이용한 건축물 층간소음방지 시공방법 및 구조. |
KR102623083B1 (ko) | 2022-05-02 | 2024-01-10 | (주) 해피론이엔지 | 공명공간을 제거한 1차 몰탈 타설식 소음방지 시공공법 및 시공구조 |
CN115006712B (zh) * | 2022-06-28 | 2024-01-09 | 广州汇元医药科技有限公司 | 一种米诺地尔的脂质纳米粒微针及其制备方法和应用 |
CN115252549B (zh) * | 2022-07-12 | 2023-09-08 | 科辉智药生物科技(无锡)有限公司 | 提高生发活性物质药效的组合物及其制备方法 |
CN115400085A (zh) * | 2022-09-02 | 2022-11-29 | 南昌大学 | 一种非那雄胺类脂囊泡及其制备方法和应用 |
Family Cites Families (16)
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FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
WO2001001997A1 (en) * | 1999-07-06 | 2001-01-11 | Raziel Lurie | Medicaments comprising relaxin and their use |
KR100463167B1 (ko) * | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
WO2005000258A1 (en) * | 2003-06-27 | 2005-01-06 | Amorepacific Corporation | Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles |
JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
CN100539988C (zh) * | 2003-06-27 | 2009-09-16 | 株式会社太平洋 | 含有生理活性成分的自聚集聚合物纳米颗粒和含有该纳米颗粒的外用搽剂 |
WO2006099121A2 (en) | 2005-03-10 | 2006-09-21 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride and tamsulosin hydrochloride, and mixtures thereof |
CL2007002336A1 (es) * | 2006-08-11 | 2008-02-08 | M S Panacea Biotec Ltd | Composicion que tiene particulas que comprende elementos inorganicos, uno o mas ingredientes activos y opcionalmente, agentes moduladores de la tasa de liberacion; procedimiento para prepararla; las particulas, util para la entrega de ingredientes ac |
US20080175807A1 (en) | 2007-01-24 | 2008-07-24 | Fujifilm Corporation | Composition for hair |
BRPI0700832B8 (pt) * | 2007-03-16 | 2021-05-25 | Biolab Sanus Farmaceutica Ltda | composição anestésica tópica compreendendo suspensão de nanocápsulas poliméricas de lidocaína e prilocaína |
WO2009058135A1 (en) * | 2007-10-30 | 2009-05-07 | Celonova Biosciences, Inc. | Loadable polymeric microparticles for therapeutic use in alopecia and methods of preparing and using the same |
CA2737025C (en) | 2008-09-27 | 2012-09-04 | Jina Pharmaceuticals, Inc. | Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof |
WO2011031990A1 (en) * | 2009-09-11 | 2011-03-17 | Follica, Inc. | Intermittent and pulse lithium treatments for modulating hair growth |
ES2384060B1 (es) * | 2010-03-24 | 2013-09-23 | Lipotec S.A. | Cápsulas de nanopartículas lipídicas. |
BRPI1002601E2 (pt) * | 2010-06-01 | 2020-06-30 | Embrapa Pesquisa Agropecuaria | composição nanoestruturada de uso veterinário para administração de fármacos |
-
2012
- 2012-08-31 BR BR102012022036-9A patent/BR102012022036B1/pt active IP Right Grant
-
2013
- 2013-08-30 TR TR2018/10389T patent/TR201810389T4/tr unknown
- 2013-08-30 WO PCT/BR2013/000335 patent/WO2014032152A1/pt active Application Filing
- 2013-08-30 UY UY0001035002A patent/UY35002A/es not_active Application Discontinuation
- 2013-08-30 MY MYPI2015700620A patent/MY174692A/en unknown
- 2013-08-30 PE PE2019001935A patent/PE20191714A1/es unknown
- 2013-08-30 CA CA2883998A patent/CA2883998C/en active Active
- 2013-08-30 JP JP2015528815A patent/JP6352265B2/ja active Active
- 2013-08-30 ES ES13832137.7T patent/ES2683418T3/es active Active
- 2013-08-30 IN IN1728DEN2015 patent/IN2015DN01728A/en unknown
- 2013-08-30 AR ARP130103103A patent/AR092403A1/es not_active Application Discontinuation
- 2013-08-30 PE PE2015000270A patent/PE20150732A1/es not_active Application Discontinuation
- 2013-08-30 AU AU2013308356A patent/AU2013308356B2/en active Active
- 2013-08-30 DK DK13832137.7T patent/DK2891486T3/en active
- 2013-08-30 EP EP13832137.7A patent/EP2891486B1/en active Active
- 2013-08-30 US US14/424,695 patent/US9687554B2/en active Active
- 2013-08-30 KR KR1020157008175A patent/KR102118582B1/ko active IP Right Grant
- 2013-08-30 MX MX2015002300A patent/MX363961B/es active IP Right Grant
- 2013-08-30 CN CN201380057183.4A patent/CN104755075B/zh active Active
- 2013-08-30 UA UAA201502698A patent/UA113774C2/uk unknown
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2015
- 2015-02-24 ZA ZA2015/01255A patent/ZA201501255B/en unknown
- 2015-02-26 SA SA515360084A patent/SA515360084B1/ar unknown
- 2015-02-27 CL CL2015000501A patent/CL2015000501A1/es unknown
- 2015-03-06 CO CO15052121A patent/CO7310520A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO7310520A2 (es) | 2015-06-30 |
KR20150044029A (ko) | 2015-04-23 |
DK2891486T3 (en) | 2018-07-23 |
KR102118582B1 (ko) | 2020-06-04 |
CA2883998C (en) | 2020-08-25 |
CA2883998A1 (en) | 2014-03-06 |
CL2015000501A1 (es) | 2015-07-03 |
UY35002A (es) | 2014-03-31 |
BR102012022036B1 (pt) | 2019-10-01 |
PE20191714A1 (es) | 2019-12-05 |
SA515360084B1 (ar) | 2016-10-03 |
CN104755075A (zh) | 2015-07-01 |
JP6352265B2 (ja) | 2018-07-04 |
UA113774C2 (xx) | 2017-03-10 |
EP2891486B1 (en) | 2018-05-16 |
BR102012022036A2 (pt) | 2014-11-25 |
US9687554B2 (en) | 2017-06-27 |
EP2891486A4 (en) | 2016-03-23 |
PE20150732A1 (es) | 2015-05-17 |
CN104755075B (zh) | 2019-07-26 |
TR201810389T4 (tr) | 2018-08-27 |
JP2015526484A (ja) | 2015-09-10 |
EP2891486A1 (en) | 2015-07-08 |
AU2013308356A1 (en) | 2015-04-16 |
WO2014032152A1 (pt) | 2014-03-06 |
US20150216986A1 (en) | 2015-08-06 |
AU2013308356B2 (en) | 2017-09-28 |
ES2683418T3 (es) | 2018-09-26 |
AR092403A1 (es) | 2015-04-22 |
ZA201501255B (en) | 2016-01-27 |
MX2015002300A (es) | 2016-02-10 |
MY174692A (en) | 2020-05-07 |
IN2015DN01728A (es) | 2015-05-29 |
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