EP2863897A4 - Nanoparticles of indirubin, derivatives thereof and methods of making and using same - Google Patents

Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Info

Publication number
EP2863897A4
EP2863897A4 EP13806153.6A EP13806153A EP2863897A4 EP 2863897 A4 EP2863897 A4 EP 2863897A4 EP 13806153 A EP13806153 A EP 13806153A EP 2863897 A4 EP2863897 A4 EP 2863897A4
Authority
EP
European Patent Office
Prior art keywords
indirubin
nanoparticles
derivatives
making
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13806153.6A
Other languages
German (de)
French (fr)
Other versions
EP2863897A1 (en
EP2863897B1 (en
Inventor
Bin Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phosphorex Inc
Original Assignee
Phosphorex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phosphorex Inc filed Critical Phosphorex Inc
Priority to EP19180122.4A priority Critical patent/EP3597178A1/en
Publication of EP2863897A1 publication Critical patent/EP2863897A1/en
Publication of EP2863897A4 publication Critical patent/EP2863897A4/en
Application granted granted Critical
Publication of EP2863897B1 publication Critical patent/EP2863897B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP13806153.6A 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same Active EP2863897B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP19180122.4A EP3597178A1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662469P 2012-06-21 2012-06-21
PCT/US2013/046981 WO2013192493A1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP19180122.4A Division EP3597178A1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Publications (3)

Publication Number Publication Date
EP2863897A1 EP2863897A1 (en) 2015-04-29
EP2863897A4 true EP2863897A4 (en) 2016-01-27
EP2863897B1 EP2863897B1 (en) 2019-06-19

Family

ID=49769412

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19180122.4A Withdrawn EP3597178A1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same
EP13806153.6A Active EP2863897B1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP19180122.4A Withdrawn EP3597178A1 (en) 2012-06-21 2013-06-21 Nanoparticles of indirubin, derivatives thereof and methods of making and using same

Country Status (6)

Country Link
US (3) US10039829B2 (en)
EP (2) EP3597178A1 (en)
JP (5) JP6382187B2 (en)
CN (2) CN110123763A (en)
CA (1) CA2914782C (en)
WO (1) WO2013192493A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6382187B2 (en) * 2012-06-21 2018-08-29 フォスフォレックス，インコーポレーテッド Nanoparticles of indirubin, their derivatives and methods for making and using them
CN106029065A (en) * 2013-12-20 2016-10-12 法斯瑞斯公司 Indirubin solid dispersion composition
RU2630561C2 (en) * 2015-10-20 2017-09-11 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России Method for production of fullerene water-salt dispersions
WO2018183631A1 (en) * 2017-03-29 2018-10-04 Phosphorex, Inc. Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same
RU2721318C1 (en) * 2019-02-28 2020-05-18 Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" Method of producing sols and suspensions
CN114340600A (en) * 2019-05-03 2022-04-12 阿佐拉治疗股份有限公司 Compositions comprising indigo and/or indigo derivatives and methods of use thereof
CN114668744A (en) * 2022-03-23 2022-06-28 成都大学 Indirubin solid lipid nanoparticle and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051900A1 (en) * 2001-12-13 2003-06-26 Natrogen Therapeutics, Inc. Derivatives of isoindigo, indigo and indirubin and use in treating cancer
CN1615852A (en) * 2003-11-10 2005-05-18 许军 Indirubin oral dripping pill and preparing process
CN101362066A (en) * 2008-09-27 2009-02-11 同济大学 Preparation method of liposome embedded quantum dots silicon dioxide microspheres and products thereof
CN101775082A (en) * 2010-02-09 2010-07-14 中国药科大学 Amphoteric ion-based charge reversal chitosan derivative and application thereof in medicament
CN102228433A (en) * 2011-06-29 2011-11-02 上海中医药大学 Supersaturated self-microemulsion as well as preparation method and application thereof
CN102018736B (en) * 2010-11-19 2012-03-28 成都中医药大学 Natural indigo decoction piece and preparation method thereof

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US4929242A (en) * 1986-11-26 1990-05-29 Baxter International Inc. Solution and method for maintaining patency of a catheter
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
TW384224B (en) * 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US7998507B2 (en) * 2000-09-21 2011-08-16 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
DE10129028A1 (en) * 2001-06-11 2003-01-02 Schering Ag Soluble Cdk-inhibitory Indirubin Derivatives
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
AU2003230691A1 (en) * 2002-03-20 2003-10-08 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same
US7230005B2 (en) * 2003-03-13 2007-06-12 Controlled Chemicals, Inc. Compounds and methods for lowering the abuse potential and extending the duration of action of a drug
KR100588803B1 (en) * 2004-01-27 2006-06-12 학교법인조선대학교 Indirubin derivatives having anticancer property against human cancer cell line
UA89513C2 (en) * 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Nanoparticulate raloxifene hydrochloride composition
JP2008524239A (en) * 2004-12-15 2008-07-10 エラン ファーマ インターナショナル リミティド Nanoparticulate tacrolimus formulation
US20060159767A1 (en) * 2004-12-22 2006-07-20 Elan Pharma International Limited Nanoparticulate bicalutamide formulations
CN101132770A (en) * 2005-01-06 2008-02-27 伊兰制药国际有限公司 Nanoparticulate candesartan formulations
KR20080003322A (en) * 2005-02-24 2008-01-07 엘란 파마 인터내셔널 리미티드 Nanoparticulate formulations of docetaxel and analogues thereof
US20060204588A1 (en) * 2005-03-10 2006-09-14 Elan Pharma International Limited Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof
NZ561666A (en) * 2005-03-17 2010-05-28 Elan Pharma Int Ltd Nanoparticulate biphosphonate compositions
CN101180038A (en) * 2005-03-23 2008-05-14 伊兰制药国际有限公司 Nanoparticulate corticosteroid and antihistamine formulations
CN101198314A (en) * 2005-04-12 2008-06-11 伊兰制药国际有限公司 Nanoparticulate quinazoline derivative formulations
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US8158582B2 (en) 2005-06-02 2012-04-17 Tercica, Inc. Methods for treatment of insulin-like growth factor-1 deficiency
CN101023944A (en) * 2006-02-23 2007-08-29 黎明涛 Use of indirubin derivative for preparing medicines for treating nerve retrograde affection
CN101074229B (en) * 2007-06-08 2010-09-01 无锡杰西医药科技有限公司 7-azaindirubin and 7-azaisoindigo derivative production and pharmaceutical use
EP2057982A1 (en) 2007-11-09 2009-05-13 Archimedes Development Limited Intranasal compositions
WO2009117042A1 (en) * 2008-03-21 2009-09-24 Adlyfe, Inc. Use of pyrene to carry non-peptide agents across the blood brain barrier
SI2113253T1 (en) 2008-04-30 2010-06-30 Immatics Biotechnologies Gmbh Novel formulations of tumour-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules for vaccines
JP6382187B2 (en) * 2012-06-21 2018-08-29 フォスフォレックス，インコーポレーテッド Nanoparticles of indirubin, their derivatives and methods for making and using them

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051900A1 (en) * 2001-12-13 2003-06-26 Natrogen Therapeutics, Inc. Derivatives of isoindigo, indigo and indirubin and use in treating cancer
CN1615852A (en) * 2003-11-10 2005-05-18 许军 Indirubin oral dripping pill and preparing process
CN101362066A (en) * 2008-09-27 2009-02-11 同济大学 Preparation method of liposome embedded quantum dots silicon dioxide microspheres and products thereof
CN101775082A (en) * 2010-02-09 2010-07-14 中国药科大学 Amphoteric ion-based charge reversal chitosan derivative and application thereof in medicament
CN102018736B (en) * 2010-11-19 2012-03-28 成都中医药大学 Natural indigo decoction piece and preparation method thereof
CN102228433A (en) * 2011-06-29 2011-11-02 上海中医药大学 Supersaturated self-microemulsion as well as preparation method and application thereof

Also Published As

Publication number Publication date
EP3597178A1 (en) 2020-01-22
JP2020073564A (en) 2020-05-14
US20220168423A1 (en) 2022-06-02
US20190054174A1 (en) 2019-02-21
US20150110878A1 (en) 2015-04-23
JP2015520241A (en) 2015-07-16
WO2013192493A1 (en) 2013-12-27
US10039829B2 (en) 2018-08-07
CN104602675B (en) 2019-06-28
US10675350B2 (en) 2020-06-09
JP6382187B2 (en) 2018-08-29
CN110123763A (en) 2019-08-16
EP2863897A1 (en) 2015-04-29
JP2023062070A (en) 2023-05-02
JP2018199685A (en) 2018-12-20
EP2863897B1 (en) 2019-06-19
CN104602675A (en) 2015-05-06
CA2914782A1 (en) 2013-12-27
JP2021181447A (en) 2021-11-25
CA2914782C (en) 2021-05-25

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