PE20150686A1 - Piridinonas biciclicas novedosas - Google Patents

Piridinonas biciclicas novedosas

Info

Publication number
PE20150686A1
PE20150686A1 PE2015000380A PE2015000380A PE20150686A1 PE 20150686 A1 PE20150686 A1 PE 20150686A1 PE 2015000380 A PE2015000380 A PE 2015000380A PE 2015000380 A PE2015000380 A PE 2015000380A PE 20150686 A1 PE20150686 A1 PE 20150686A1
Authority
PE
Peru
Prior art keywords
hydrogen
alkyl
pyridinones
new bicycle
cyano
Prior art date
Application number
PE2015000380A
Other languages
English (en)
Spanish (es)
Inventor
Ende Christopher William Am
Michael Eric Green
Douglas Scott Jhonson
Gregory Wayne Kauffman
Christopher John O'donnell
Nandini Chaturbhai Patel
Martin Youngjin Petterson
Antonia Friederike Stepan
Cory Michael Stiff
Chakrapani Subramanyam
Tuan Phong Tran
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20150686A1 publication Critical patent/PE20150686A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PE2015000380A 2012-09-21 2013-09-06 Piridinonas biciclicas novedosas PE20150686A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21

Publications (1)

Publication Number Publication Date
PE20150686A1 true PE20150686A1 (es) 2015-05-23

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015000380A PE20150686A1 (es) 2012-09-21 2013-09-06 Piridinonas biciclicas novedosas

Country Status (46)

Country Link
US (3) US8916564B2 (cg-RX-API-DMAC7.html)
EP (1) EP2897956B1 (cg-RX-API-DMAC7.html)
JP (1) JP5844018B2 (cg-RX-API-DMAC7.html)
KR (1) KR101725696B1 (cg-RX-API-DMAC7.html)
CN (1) CN104662021B (cg-RX-API-DMAC7.html)
AP (1) AP2015008277A0 (cg-RX-API-DMAC7.html)
AR (1) AR092628A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013319845B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015006436A2 (cg-RX-API-DMAC7.html)
CA (1) CA2882386C (cg-RX-API-DMAC7.html)
CL (1) CL2015000717A1 (cg-RX-API-DMAC7.html)
CR (1) CR20150053A (cg-RX-API-DMAC7.html)
CU (1) CU20150021A7 (cg-RX-API-DMAC7.html)
CY (1) CY1118662T1 (cg-RX-API-DMAC7.html)
DK (1) DK2897956T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2015000069A (cg-RX-API-DMAC7.html)
EA (1) EA026668B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP15015594A (cg-RX-API-DMAC7.html)
ES (1) ES2609987T3 (cg-RX-API-DMAC7.html)
GE (1) GEP201706659B (cg-RX-API-DMAC7.html)
GT (1) GT201500069A (cg-RX-API-DMAC7.html)
HR (1) HRP20161558T1 (cg-RX-API-DMAC7.html)
HU (1) HUE031248T2 (cg-RX-API-DMAC7.html)
IL (1) IL237163A (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01119A (cg-RX-API-DMAC7.html)
LT (1) LT2897956T (cg-RX-API-DMAC7.html)
MA (1) MA37886B1 (cg-RX-API-DMAC7.html)
MD (1) MD4583B1 (cg-RX-API-DMAC7.html)
ME (1) ME02571B (cg-RX-API-DMAC7.html)
MX (1) MX360599B (cg-RX-API-DMAC7.html)
MY (1) MY181891A (cg-RX-API-DMAC7.html)
NI (1) NI201500038A (cg-RX-API-DMAC7.html)
NZ (1) NZ704863A (cg-RX-API-DMAC7.html)
PE (1) PE20150686A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015500376A1 (cg-RX-API-DMAC7.html)
PL (1) PL2897956T3 (cg-RX-API-DMAC7.html)
PT (1) PT2897956T (cg-RX-API-DMAC7.html)
RS (1) RS55426B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201501074WA (cg-RX-API-DMAC7.html)
SI (1) SI2897956T1 (cg-RX-API-DMAC7.html)
TN (1) TN2015000084A1 (cg-RX-API-DMAC7.html)
TW (1) TWI500616B (cg-RX-API-DMAC7.html)
UA (1) UA110688C2 (cg-RX-API-DMAC7.html)
UY (1) UY35039A (cg-RX-API-DMAC7.html)
WO (1) WO2014045156A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201501195B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
EP2953949B1 (en) 2012-12-20 2016-09-28 Janssen Pharmaceutica NV Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
EP2945944B1 (en) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
EP3052495B1 (en) * 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
WO2015150957A1 (en) * 2014-04-01 2015-10-08 Pfizer Inc. Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
WO2016125048A1 (en) * 2015-02-03 2016-08-11 Pfizer Inc. Novel cyclopropabenzofuranyl pyridopyrazinediones
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof
CN109311876B (zh) 2016-06-16 2022-05-03 豪夫迈·罗氏有限公司 杂芳基雌激素受体调节剂及其用途
US10925872B2 (en) 2016-12-16 2021-02-23 Pipeline Therapeutics, Inc. Methods of treating cochlear synaptopathy
CN113164381A (zh) 2018-10-02 2021-07-23 频率医疗公司 有关耳用治疗剂的药物组合物及方法
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
MX2021012258A (es) 2019-04-08 2022-01-04 Frequency Therapeutics Inc Combinacion de chir99021 y acido valproico para tratar la perdida auditiva.
PT4069691T (pt) 2019-12-06 2024-12-18 Vertex Pharma Tetrahidrofuranos substituídos como moduladores dos canais de sódio
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1，2，6，7-四氢-8H-茚并[5，4-b]呋喃-8-酮的制备方法
GEAP202416430A (en) 2021-06-04 2024-03-25 Vertex Pharma N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CN114034792B (zh) * 2021-11-09 2024-06-25 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
WO1992000075A1 (en) 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
EP0585913B1 (en) 1992-09-04 1997-12-29 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
ATE239797T1 (de) 1993-01-25 2003-05-15 Takeda Chemical Industries Ltd Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
EP0733632B1 (en) 1995-03-24 2003-06-04 Takeda Chemical Industries, Ltd. Cyclic compounds, their production and use as tachykinin receptor antagonists
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
JP3816111B2 (ja) 1997-04-09 2006-08-30 インテレクト・ニューロサイエンシズ・インコーポレーテッド β−アミロイド末端に特異的な組換え抗体、それをコードするＤＮＡ及びその使用法
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
EP1060141B1 (en) 1998-03-03 2002-10-30 PPG Industries Ohio, Inc. Impregnated glass fiber strands and products including the same
US20020132817A1 (en) 1998-03-19 2002-09-19 Hideaki Natsugari Heterocyclic compounds, their production and use
AU1409100A (en) 1998-11-27 2000-06-19 Takeda Chemical Industries Ltd. Drugs
SI1481992T1 (sl) 2000-02-24 2017-01-31 Washington University St. Louis Humanizirana protitelesa, ki vežejo amiloidni peptid beta
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
JP4708675B2 (ja) 2000-11-03 2011-06-22 プロテオテック・インコーポレーテッド ウンカリア・トメントーサおよび関連植物からアミロイド阻害化合物を単離する方法ならびに単離した化合物の使用
WO2003016466A2 (en) 2001-08-17 2003-02-27 Eli Lilly And Company ANTI-Aβ ANTIBODIES
US20030195205A1 (en) 2001-11-02 2003-10-16 Pfizer Inc. PDE9 inhibitors for treating cardiovascular disorders
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
EP1549315A4 (en) 2002-09-11 2007-05-23 Merck & Co Inc DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS
WO2004033434A1 (en) 2002-10-09 2004-04-22 Pfizer Products Inc. Pyrazole compounds for treatment of neurodegenerative disorders
CA2501945A1 (en) 2002-10-09 2004-04-22 Rinat Neuroscience Corp. Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EP1638935A1 (en) 2003-06-19 2006-03-29 Pfizer Products Inc. Nk1 antagonist
BRPI0413709A (pt) 2003-08-21 2006-10-17 Pfizer Prod Inc compostos para o tratamento de distúrbios neurodegenerativos
CA2538220A1 (en) 2003-09-09 2005-03-24 Takeda Pharmaceutical Company Limited Use of antibody
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US20070155731A1 (en) 2004-01-28 2007-07-05 Gabor Butora Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
BRPI0507374A (pt) 2004-02-02 2007-07-10 Pfizer Prod Inc moduladores do receptor de histamina-3
CN1929737A (zh) 2004-03-09 2007-03-14 默克公司 Hiv整合酶抑制剂
AP2379A (en) 2004-03-23 2012-03-08 Pfizer Prod Inc Imidazole compounds for the treatment of neurodegenerative disorders.
CA2562713A1 (en) 2004-04-14 2005-12-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
TWI355389B (en) 2004-07-30 2012-01-01 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide a
FR2877015B1 (fr) 2004-10-21 2007-10-26 Commissariat Energie Atomique Revetement nanostructure et procede de revetement.
GB0423356D0 (en) 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
WO2006069081A2 (en) 2004-12-22 2006-06-29 Washington University In St. Louis USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
UY29504A1 (es) 2005-04-29 2006-10-31 Rinat Neuroscience Corp Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
EP1881825B1 (en) 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
PL1881985T3 (pl) 2005-05-12 2011-05-31 Pfizer Bezwodne krystaliczne postacie N-[1-(2-etoksyetylo)-5-(N-etylo-N-metyloamino)-7-(4-metylopirydyn-2-yloamino)-1H-pirazolo[4,3-d]pirymidyno-3-karbonylo]metano-sulfonoamidu
WO2006126083A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
CA2603830A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Co Llc PYRIDINE [2,3-B] PYRAZINONES
WO2006126082A2 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
WO2006136924A1 (en) 2005-06-22 2006-12-28 Pfizer Products Inc. Histamine-3 receptor antagonists
US20070060534A1 (en) 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
JP2009514846A (ja) 2005-11-04 2009-04-09 ファイザー・リミテッド テトラヒドロナフチリジン誘導体
US20070197532A1 (en) 2005-11-18 2007-08-23 Cao Sheldon X Glucokinase activators
US20080275251A1 (en) 2005-11-18 2008-11-06 Glaxo Group Limited Novel Intermediates and Their Use
AU2006317457B2 (en) 2005-11-24 2011-09-08 Eisai R & D Management Co., Ltd. Morpholine type cinnamide compound
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
WO2007063385A2 (en) 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
WO2007069053A1 (en) 2005-12-14 2007-06-21 Pfizer Products Inc. Benzimidazole antagonists of the h-3 receptor
PE20071321A1 (es) * 2006-01-20 2007-12-29 Schering Corp Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
WO2007088462A1 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Spirochromane antagonists of the h-3 receptor
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2007749A2 (en) 2006-03-13 2008-12-31 Pfizer Products Inc. Tetralines antagonists of the h-3 receptor
CA2649775C (en) 2006-04-21 2011-05-31 Pfizer Products Inc. Pyridine[3,4-b]pyrazinones
EP2021327B1 (en) 2006-05-15 2012-04-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
AU2007254190A1 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
EP2019093A4 (en) 2006-05-19 2011-02-23 Eisai R&D Man Co Ltd CINEMA ACID AMID DERIVATIVE FROM THE UREA TYPE
WO2007138431A2 (en) 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
WO2008090429A1 (en) 2007-01-22 2008-07-31 Pfizer Products Inc. Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
WO2008100412A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperidine derivatives
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ａｄおよび関連状態の治療のためのピペラジン誘導体
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
KR20100017573A (ko) 2007-05-07 2010-02-16 쉐링 코포레이션 감마 세크레타제 조정인자
CA2686754C (en) 2007-05-11 2014-10-28 F. Hoffmann-La Roche Ag Hetarylanilines as modulators for amyloid beta
CL2008001540A1 (es) 2007-05-29 2009-05-22 Sgx Pharmaceuticals Inc Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer.
AU2008263207B2 (en) 2007-06-01 2013-10-03 Merck Sharp & Dohme Corp. Gamma secretase modulators
US8580956B2 (en) 2007-06-01 2013-11-12 Merck Sharp & Dohme Corp. Gamma secretase modulators
WO2008156580A1 (en) 2007-06-13 2008-12-24 Merck & Co., Inc. Triazole derivatives for treating alzheimer's disease and related conditions
WO2009005729A1 (en) 2007-06-29 2009-01-08 Schering Corporation Gamma secretase modulators
EP2185522A1 (en) 2007-08-06 2010-05-19 Schering Corporation Gamma secretase modulators
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
EP2200990A1 (en) 2007-09-06 2010-06-30 Schering Corporation Gamma secretase modulators
US20100298381A1 (en) 2007-09-28 2010-11-25 Schering Corporation Gamma secretase modulators
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
US8487099B2 (en) 2007-11-05 2013-07-16 Merck Sharp & Dohme Corp. Gamma secretase modulators
JP2011506336A (ja) 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
MX2010006379A (es) 2007-12-11 2010-09-07 Schering Corp Moduladores de la secretasa gamma.
WO2009076352A1 (en) 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
AU2008335709A1 (en) 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
BRPI0906799A2 (pt) 2008-01-11 2015-07-14 Hoffmann La Roche Moduladores para amiloide beta
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
CA2716747A1 (en) 2008-02-29 2009-09-03 Schering Corporation Gamma secretase modulators for the treatment of alzheimer's disease
CA2722606A1 (en) 2008-05-05 2009-11-12 Amgen Inc. Urea compounds as gamma secretase modulators
FR2933700B1 (fr) * 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
WO2010019393A1 (en) 2008-08-13 2010-02-18 Merck Sharp & Dohme Corp. Pyrimidine derivatives for treatment of alzheimer's disease
US20110251172A1 (en) 2008-08-13 2011-10-13 Rivkin Alexey A Purine derivatives for treatment of alzheimer's disease
CA2733606A1 (en) 2008-08-27 2010-03-04 Eisai R&D Management Co., Ltd. Process for preparing certain cinnamide compounds
MX2011003246A (es) 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
AU2009313524A1 (en) 2008-11-06 2010-05-14 Merck Sharp & Dohme Corp. Gamma secretase modulators
WO2010054078A1 (en) 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
EP2367826A4 (en) 2008-11-06 2012-07-04 Astrazeneca Ab MODULATORS OF THE PROTEIN -AMYLOID
KR101293421B1 (ko) 2008-11-10 2013-08-05 에프. 호프만-라 로슈 아게 헤테로사이클릭 감마 분비효소 조절제
EP2379075A4 (en) 2008-12-16 2012-05-30 Merck Sharp & Dohme TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
WO2010071741A1 (en) 2008-12-16 2010-06-24 Merck Sharp & Dohme Corp. Triazole derivatives for treatment of alzheimer's disease
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
MX2011005150A (es) 2008-12-19 2011-05-30 Boehringer Ingelheim Int Pirimidin-4-carboxamidas ciclicas como antagonistas del receptor ccr2 para el tratamiento de inflamacion, asma y epoc.
US8759337B2 (en) 2008-12-22 2014-06-24 Merck Sharp & Dohme Corp. Gamma secretase modulators
TW201035103A (en) 2008-12-22 2010-10-01 Schering Corp Gamma secretase modulators
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
BRPI1008473A2 (pt) 2009-02-06 2019-04-02 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
BRPI1007883A2 (pt) 2009-02-26 2016-02-23 Eisai R&D Man Co Ltd sal, e, cristal.
JP2012121809A (ja) 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
CA2751534A1 (en) 2009-03-03 2010-09-10 Pfizer Inc. Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
AU2010279377B2 (en) 2009-08-07 2014-07-03 Dow Agrosciences Llc Pesticidal compositions
WO2011048525A1 (en) * 2009-10-20 2011-04-28 Pfizer Inc. Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
NZ600954A (en) * 2009-12-22 2013-11-29 Isoindolinone inhibitors of phosphatidylinositol 3-kinase
ES2602794T3 (es) * 2011-03-31 2017-02-22 Pfizer Inc Piridinonas bicíclicas novedosas
AU2013261023B2 (en) * 2012-05-16 2016-11-24 Cellzome Limited Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
EP2953949B1 (en) 2012-12-20 2016-09-28 Janssen Pharmaceutica NV Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
EP2945944B1 (en) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
EP3052495B1 (en) 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
US11497586B2 (en) 2014-03-21 2022-11-15 Align Technology, Inc. Segmented orthodontic appliance with elastics
WO2015150957A1 (en) 2014-04-01 2015-10-08 Pfizer Inc. Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators

Also Published As

Publication number Publication date
EP2897956B1 (en) 2016-11-09
JP2015529238A (ja) 2015-10-05
TWI500616B (zh) 2015-09-21
ES2609987T3 (es) 2017-04-25
EP2897956A1 (en) 2015-07-29
ECSP15015594A (es) 2017-08-31
DK2897956T3 (en) 2017-01-16
HK1206013A1 (zh) 2015-12-31
PH12015500376B1 (en) 2015-04-20
AU2013319845B2 (en) 2017-09-14
MD4583B1 (ro) 2018-07-31
DOP2015000069A (es) 2015-05-15
NZ704863A (en) 2017-03-31
HUE031248T2 (en) 2017-06-28
CR20150053A (es) 2015-03-25
US9751877B2 (en) 2017-09-05
US9193726B2 (en) 2015-11-24
ME02571B (me) 2017-06-20
CY1118662T1 (el) 2017-07-12
US8916564B2 (en) 2014-12-23
MD20150023A2 (ro) 2015-07-31
WO2014045156A1 (en) 2014-03-27
MX360599B (es) 2018-11-08
MY181891A (en) 2021-01-12
AP2015008277A0 (en) 2015-02-28
TW201425311A (zh) 2014-07-01
SG11201501074WA (en) 2015-05-28
MA37886A1 (fr) 2016-02-29
PH12015500376A1 (en) 2015-04-20
MX2015003637A (es) 2015-06-05
CN104662021B (zh) 2016-08-24
ZA201501195B (en) 2016-01-27
US20140088111A1 (en) 2014-03-27
CA2882386A1 (en) 2014-03-27
GEP201706659B (en) 2017-04-25
TN2015000084A1 (fr) 2016-06-29
PT2897956T (pt) 2017-01-13
NI201500038A (es) 2015-06-05
CL2015000717A1 (es) 2015-06-19
IL237163A0 (en) 2015-04-30
EA201590319A1 (ru) 2015-09-30
JP5844018B2 (ja) 2016-01-13
PL2897956T3 (pl) 2017-05-31
AR092628A1 (es) 2015-04-29
US20150072990A1 (en) 2015-03-12
US20160024088A1 (en) 2016-01-28
LT2897956T (lt) 2017-01-10
IN2015DN01119A (cg-RX-API-DMAC7.html) 2015-06-26
BR112015006436A2 (pt) 2017-07-04
KR101725696B1 (ko) 2017-04-10
RS55426B1 (sr) 2017-04-28
AU2013319845A1 (en) 2015-02-26
CU20150021A7 (es) 2015-08-27
IL237163A (en) 2016-12-29
UY35039A (es) 2014-04-30
MA37886B1 (fr) 2016-09-30
SI2897956T1 (sl) 2017-02-28
KR20150044948A (ko) 2015-04-27
GT201500069A (es) 2016-03-01
HRP20161558T1 (hr) 2016-12-30
UA110688C2 (uk) 2016-01-25
CA2882386C (en) 2017-11-28
EA026668B1 (ru) 2017-05-31
CN104662021A (zh) 2015-05-27

Similar Documents

Publication Publication Date Title
PE20150686A1 (es) Piridinonas biciclicas novedosas
CY1122707T1 (el) Ετεροκυκλικοι αναστολεις γλουταμινασης
CY1122601T1 (el) Αναστολεις gsk3 και μεθοδοι χρησης αυτων
CY1119105T1 (el) Παραγωγα διπυραζολιου ως αναστολεις jak
CY1116662T1 (el) Μεθοδοι χρησης αναστολεων alk
PE20180024A1 (es) Triazolopirazinonas como inhibidores de pde1
CL2016001733A1 (es) Compuestos intermediarios para la preparación de compuestos derivados de piperidinona como inhibidores mdm2 para el tratamiento de cáncer div. sol. 3415-12.
UY40181A (es) Pesticidas de azol bicíclico sustituido con heterociclos
AR084032A1 (es) Compuesto biciclico
MX359032B (es) Inhibidores de pirrolopirazina cinasa.
CY1116987T1 (el) Συμπυκνωμενα ιμιδαζολυλιμιδαζολια ως αντιϊικες ενωσεις
PE20141791A1 (es) Compuestos de enediino, conjugados de los mismos y sus usos y metodos
PE20142167A1 (es) Anticuerpos anti-lgr5 e inmunoconjugados
MX2011011875A (es) Compuesto de carboxamida heterociclica diamino.
EA201490269A1 (ru) Новое производное 1,2,3,4-тетрагидрохинолина, подходящее для лечения диабета
EA201591891A1 (ru) Пептидное соединение
UA110338C2 (xx) Хімічні сполуки
MX2016002368A (es) Compuestos de sulfonamida heterociclica sustituida utiles como moduladores del canal del receptor de potencial transitorio a1 (trpa1).
EA201490039A1 (ru) Химерные и гибридные полипептиды фактора viii и способы их применения
MX2012000413A (es) Metodos para tratar con compuestos anfotericos fluorados a las formaciones de carbonato que poseen hidrocarburos.
MX2017002328A (es) Analogos de dioxolano de uridina para el tratamiento del cancer.
EA201490195A1 (ru) Не содержащие аргинина композиции слитого fc-полипептида и способы их применения
MX2015007097A (es) Nuevas fenil-piridinas/pirazinas bi-anulares para el tratamiento de cancer.
EA201692150A1 (ru) Способ лечения аденокарциномы легкого
PE20200387A1 (es) Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer

Legal Events

Date Code Title Description
FD Application declared void or lapsed