PE20142404A1 - Compuestos de microarn y metodos de modulacion de la actividad de mir-21 - Google Patents

Compuestos de microarn y metodos de modulacion de la actividad de mir-21

Info

Publication number
PE20142404A1
PE20142404A1 PE2014001895A PE2014001895A PE20142404A1 PE 20142404 A1 PE20142404 A1 PE 20142404A1 PE 2014001895 A PE2014001895 A PE 2014001895A PE 2014001895 A PE2014001895 A PE 2014001895A PE 20142404 A1 PE20142404 A1 PE 20142404A1
Authority
PE
Peru
Prior art keywords
mir
activity
modulation methods
microrna compounds
microrna
Prior art date
Application number
PE2014001895A
Other languages
English (en)
Spanish (es)
Inventor
Balkrishen Bhat
Eric Marcusson
Original Assignee
Regulus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of PE20142404A1 publication Critical patent/PE20142404A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/32—Chemical structure of the sugar
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PE2014001895A 2012-04-25 2013-04-24 Compuestos de microarn y metodos de modulacion de la actividad de mir-21 PE20142404A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US201361779913P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
PE20142404A1 true PE20142404A1 (es) 2015-02-02

Family

ID=48289681

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001895A PE20142404A1 (es) 2012-04-25 2013-04-24 Compuestos de microarn y metodos de modulacion de la actividad de mir-21

Country Status (28)

Country Link
US (5) US8969317B2 (enExample)
EP (1) EP2841579B1 (enExample)
JP (1) JP6322189B2 (enExample)
KR (4) KR20230037703A (enExample)
CN (1) CN104254607B (enExample)
AR (1) AR090825A1 (enExample)
AU (1) AU2013251696B2 (enExample)
BR (1) BR112014026639A8 (enExample)
CA (1) CA2869639A1 (enExample)
CL (3) CL2014002844A1 (enExample)
CO (1) CO7111303A2 (enExample)
CR (1) CR20140524A (enExample)
DO (1) DOP2014000233A (enExample)
EA (1) EA030211B1 (enExample)
EC (1) ECSP14028612A (enExample)
GT (1) GT201400221A (enExample)
IL (1) IL234904B (enExample)
IN (1) IN2014DN09134A (enExample)
MX (1) MX353562B (enExample)
MY (1) MY173600A (enExample)
NZ (1) NZ630591A (enExample)
PE (1) PE20142404A1 (enExample)
PH (2) PH12023550488A1 (enExample)
SG (1) SG11201406931XA (enExample)
TW (1) TWI647235B (enExample)
UA (1) UA117098C2 (enExample)
WO (1) WO2013163258A1 (enExample)
ZA (1) ZA201407228B (enExample)

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CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
EP2702155B9 (en) 2011-04-25 2020-01-01 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
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KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
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JP2015518475A (ja) * 2012-04-10 2015-07-02 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 非アルコール性脂肪性肝炎の治療方法
PH12023550488A1 (en) 2012-04-25 2024-06-24 Sanofi Sa Microrna compounds and methods for modulating mir-21 activity
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
EP4086347A3 (en) * 2012-10-12 2023-01-11 Ionis Pharmaceuticals, Inc. Selective antisense compounds and uses thereof
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EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
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US20160289678A1 (en) * 2013-11-22 2016-10-06 Dcb-Usa Llc Use of microrna 146-a in the diagnosis, treatment and prevention of picornavirus infection and microrna 146-a antagonists
EP3105327A4 (en) * 2014-02-12 2017-10-18 Thomas Jefferson University Compositions and methods of using microrna inhibitors
WO2015154002A1 (en) * 2014-04-04 2015-10-08 Ohio State Innovation Foundation Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
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