PE20130150A1 - Inhibidores de las iap - Google Patents
Inhibidores de las iapInfo
- Publication number
- PE20130150A1 PE20130150A1 PE2012001805A PE2012001805A PE20130150A1 PE 20130150 A1 PE20130150 A1 PE 20130150A1 PE 2012001805 A PE2012001805 A PE 2012001805A PE 2012001805 A PE2012001805 A PE 2012001805A PE 20130150 A1 PE20130150 A1 PE 20130150A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- independently
- hydroxyl
- amino
- members
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA U1-M-U2, DONDE U1 Y U2 TIENEN LA FORMULA (I) DONDE: X1 Y X2 SON INDEPENDIENTEMENTE O O S; R2 ES ALQUILO C1-10, CARBOCICLO, CARBOCICLILALQUILO, HETEROCICLO O HETEROCICLILALQUILO, OPCIONALMENTE SUSTITUIDO CON NITRO, AMINO, OXO, ENTRE OTROS; R3 ES H O ALQUILO C1-10 OPCIONALMENTE SUSTITUIDO POR HALOGENO O HIDROXILO; R3 Y R4 FORMAN HETEROCICLO DE 3 A 6 MIEMBROS; R3´ ES H; R3 Y R3´ FORMAN UN CARBOCICLO DE 3 A 6 MIEMBROS; R4 Y R4´ SON INDEPENDIENTEMENTE H, AMINO, HIDROXILO, CARBOCICLO, ENTRE OTROS; R5 ES H O ALQUILO C1-10; M ES UN GRUPO ENLAZADOR QUE UNE COVALENTEMENTE U1 Y U2; G ES (IVa), (IVb), ENTRE OTROS, DONDE R1 ES H, OH O ALQUILO C1-10; R5´ ES H O ALQUILO C1-10; R6 Y R6´ SON INDEPENDIENTEMENTE H, ALQUILO C1-10, ARILO O ARALQUILO; A1 ES HETEROCICLO DE 5 MIEMBROS CON 1 A 4 HETEROATOMOS OPCIONALMENTE SUSTITUIDOS CON AMINO, MERCAPTO, HIDROXILO, ENTRE OTROS; L ES UN ENLACE, -C(X3)-, -C(X3)O-, ENTRE OTROS; X3 ES O O S; Y ES UN ENLACE, O, S, ENTRE OTROS; R9´ ES Q1 Y Q2; Q1 Y Q2 SON INDEPENDIENTEMENTE H, ALQUILO, ENTRE OTROS; DICHO COMPUESTO ES INHIBIDOR DE LAS PROTEINAS DE APOPTOSIS (IAP) SIENDO UTILES EN EL TRATAMIENTO DE NEOPLASIAS MALIGNAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91501007P | 2007-04-30 | 2007-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130150A1 true PE20130150A1 (es) | 2013-02-27 |
Family
ID=39926122
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000757A PE20090211A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
PE2012001805A PE20130150A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000757A PE20090211A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
Country Status (18)
Country | Link |
---|---|
US (1) | US8907092B2 (es) |
EP (1) | EP2148858A4 (es) |
JP (1) | JP5368428B2 (es) |
KR (1) | KR20100024923A (es) |
CN (1) | CN101687787A (es) |
AR (1) | AR066348A1 (es) |
AU (1) | AU2008245447C1 (es) |
BR (1) | BRPI0809867A2 (es) |
CA (1) | CA2683392A1 (es) |
CL (1) | CL2008001234A1 (es) |
IL (1) | IL201379A0 (es) |
MX (1) | MX2009011783A (es) |
NZ (2) | NZ598890A (es) |
PE (2) | PE20090211A1 (es) |
RU (1) | RU2491276C2 (es) |
TW (1) | TWI432212B (es) |
WO (1) | WO2008134679A1 (es) |
ZA (1) | ZA200906946B (es) |
Families Citing this family (88)
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US7985735B2 (en) | 2006-07-24 | 2011-07-26 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
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-
2008
- 2008-04-29 CA CA002683392A patent/CA2683392A1/en not_active Abandoned
- 2008-04-29 PE PE2008000757A patent/PE20090211A1/es not_active Application Discontinuation
- 2008-04-29 BR BRPI0809867-0A patent/BRPI0809867A2/pt not_active IP Right Cessation
- 2008-04-29 TW TW097115740A patent/TWI432212B/zh not_active IP Right Cessation
- 2008-04-29 EP EP08747109A patent/EP2148858A4/en not_active Withdrawn
- 2008-04-29 JP JP2010506573A patent/JP5368428B2/ja not_active Expired - Fee Related
- 2008-04-29 WO PCT/US2008/061891 patent/WO2008134679A1/en active Application Filing
- 2008-04-29 MX MX2009011783A patent/MX2009011783A/es not_active Application Discontinuation
- 2008-04-29 CL CL200801234A patent/CL2008001234A1/es unknown
- 2008-04-29 NZ NZ598890A patent/NZ598890A/xx not_active IP Right Cessation
- 2008-04-29 US US12/598,027 patent/US8907092B2/en not_active Expired - Fee Related
- 2008-04-29 NZ NZ580226A patent/NZ580226A/xx not_active IP Right Cessation
- 2008-04-29 RU RU2009144094/04A patent/RU2491276C2/ru not_active IP Right Cessation
- 2008-04-29 AR ARP080101812A patent/AR066348A1/es not_active Application Discontinuation
- 2008-04-29 PE PE2012001805A patent/PE20130150A1/es not_active Application Discontinuation
- 2008-04-29 AU AU2008245447A patent/AU2008245447C1/en not_active Ceased
- 2008-04-29 KR KR1020097024828A patent/KR20100024923A/ko active IP Right Grant
- 2008-04-29 CN CN200880022901A patent/CN101687787A/zh active Pending
-
2009
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Also Published As
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WO2008134679A1 (en) | 2008-11-06 |
US8907092B2 (en) | 2014-12-09 |
NZ580226A (en) | 2012-11-30 |
RU2491276C2 (ru) | 2013-08-27 |
JP2010526079A (ja) | 2010-07-29 |
AU2008245447B2 (en) | 2014-01-23 |
BRPI0809867A2 (pt) | 2014-09-30 |
CA2683392A1 (en) | 2008-11-06 |
AU2008245447A1 (en) | 2008-11-06 |
JP5368428B2 (ja) | 2013-12-18 |
KR20100024923A (ko) | 2010-03-08 |
RU2009144094A (ru) | 2011-06-10 |
CN101687787A (zh) | 2010-03-31 |
ZA200906946B (en) | 2011-05-25 |
IL201379A0 (en) | 2010-05-31 |
AU2008245447C1 (en) | 2014-11-20 |
TW200902067A (en) | 2009-01-16 |
MX2009011783A (es) | 2009-12-04 |
TWI432212B (zh) | 2014-04-01 |
PE20090211A1 (es) | 2009-04-02 |
AR066348A1 (es) | 2009-08-12 |
CL2008001234A1 (es) | 2008-09-22 |
US20110077265A1 (en) | 2011-03-31 |
EP2148858A1 (en) | 2010-02-03 |
NZ598890A (en) | 2013-10-25 |
EP2148858A4 (en) | 2011-01-26 |
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