PE20080771A1 - Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico - Google Patents

Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico

Info

Publication number
PE20080771A1
PE20080771A1 PE2007001203A PE2007001203A PE20080771A1 PE 20080771 A1 PE20080771 A1 PE 20080771A1 PE 2007001203 A PE2007001203 A PE 2007001203A PE 2007001203 A PE2007001203 A PE 2007001203A PE 20080771 A1 PE20080771 A1 PE 20080771A1
Authority
PE
Peru
Prior art keywords
preparation
substituted
methyl ester
processes
stages
Prior art date
Application number
PE2007001203A
Other languages
English (en)
Inventor
Neil G Almstead
Seemon Pines
James J Takasugi
Peter Seongwoo Hwang
Young-Choon Moon
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of PE20080771A1 publication Critical patent/PE20080771A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO SUSTITUIDO O NO, CICLOALQUILO SUSTITUIDO O NO, HETEROARILO SUSTITUIDO O NO, ENTRE OTROS; X ES F, Cl, Br, I; m ES DE 1-5. DICHO PROCESO COMPRENDE: a) REACCIONAR UN METIL ESTER DE ACIDO CIANOBENZOICO CON HIDROXILAMINA; b) ACILACION CON CLORURO DE HALOBENZOILO; c) CONDENSACION; d) HIDROLISIS DEL METIL ESTER; DONDE CADA UNA DE LAS ETAPAS SON LLEVADAS A CABO EN UN SOLVENTE SELECCIONADO DE TETRAHIDROFURANO, DIOXANO, ACETATO DE ISOBUTILO, ACETATO DE ISOPROPILO, ENTRE OTROS. UN COMPUESTO OBTENIDO MEDIANTE DICHO PROCESO ES: ACIDO 3-[5-(2-FLUOROFENIL)-[1,2,4]OXADIAZOL-3-IL]-BENZOICO. DICHO PROCESO DE SINTESIS TIENE MENOS ETAPAS DE AISLAMIENTO Y COMPRENDEN MENOS SOLVENTES UTILES PARA EL TRATAMIENTO O PREVENCION DE ENFERMEDADES ASOCIADAS CON UNA MUTACION EN SENTIDO CONTRARIO, PRESENTE EN ENFERMEDADES HEREDITARIAS
PE2007001203A 2006-09-08 2007-09-07 Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico PE20080771A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08

Publications (1)

Publication Number Publication Date
PE20080771A1 true PE20080771A1 (es) 2008-06-13

Family

ID=38935880

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007001203A PE20080771A1 (es) 2006-09-08 2007-09-07 Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico
PE2011001405A PE20120669A1 (es) 2006-09-08 2007-09-07 Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011001405A PE20120669A1 (es) 2006-09-08 2007-09-07 Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoico

Country Status (25)

Country Link
US (2) US7678922B2 (es)
EP (1) EP2059513B1 (es)
JP (2) JP5955494B2 (es)
KR (1) KR101466368B1 (es)
CN (1) CN101535284B (es)
AR (3) AR062715A1 (es)
AU (1) AU2007292915B2 (es)
BR (1) BRPI0716996B8 (es)
CA (2) CA2662749C (es)
CL (1) CL2007002606A1 (es)
DK (1) DK2059513T3 (es)
ES (1) ES2404348T3 (es)
HK (1) HK1134094A1 (es)
IL (1) IL197445A (es)
MX (1) MX2009002439A (es)
MY (1) MY148598A (es)
NZ (2) NZ575511A (es)
PE (2) PE20080771A1 (es)
PL (1) PL2059513T3 (es)
PT (1) PT2059513E (es)
RU (1) RU2495030C2 (es)
TW (1) TWI482761B (es)
UA (1) UA99265C2 (es)
WO (1) WO2008030570A1 (es)
ZA (1) ZA200901782B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2770035T3 (es) 2003-04-11 2020-06-30 Ptc Therapeutics Inc Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
NZ562197A (en) 2005-04-08 2010-09-30 Ptc Therapeutics Inc Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
BRPI0710213A2 (pt) 2006-03-30 2011-04-12 Ptc Therapeutics Inc métodos para produzir uma quantidade efetiva de uma proteìna de transleitura funcional codificada por uma sequência de ácido nucleico que compreende uma mutação não-sentido e para tratar, controlar e/ou prevenir uma doença
CA2662749C (en) * 2006-09-08 2015-01-20 Ptc Therapeutics, Inc. Processes for the preparation of 1,2,4-oxadiazole benzoic acids
EP2068871B1 (en) 2006-09-25 2013-12-25 PTC Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression
MX2009003160A (es) 2006-09-25 2009-04-06 Ptc Therapeutics Inc Formas cristalinas del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol -3-il]-benzoico.
EP2460520B1 (en) 2006-10-12 2015-09-30 PTC Therapeutics, Inc. Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
EP2668951B9 (en) 2011-01-25 2017-03-15 Viviabiotech, S.L. 1,2,4-oxadiazole derivatives as drugs modulating the glp-1 peptide receptor
AU2013286860B2 (en) 2012-07-02 2017-10-26 Monsanto Technology Llc Processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
TWI695717B (zh) 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
BR112018008838A8 (pt) 2015-10-30 2019-02-26 Ptc Therapeutics Inc método para tratar, prevenir, melhorar ou administrar uma doença epiléptica
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
US20220071965A1 (en) 2018-12-20 2022-03-10 Pfizer Inc. Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
KR20040004705A (ko) * 2001-06-08 2004-01-13 시토비아 인크. 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도
MY151199A (en) * 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
JP2006506340A (ja) * 2002-08-09 2006-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
ES2770035T3 (es) * 2003-04-11 2020-06-30 Ptc Therapeutics Inc Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
WO2004110351A2 (en) * 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
NZ562197A (en) 2005-04-08 2010-09-30 Ptc Therapeutics Inc Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
CA2662749C (en) * 2006-09-08 2015-01-20 Ptc Therapeutics, Inc. Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Also Published As

Publication number Publication date
KR20090054464A (ko) 2009-05-29
JP5955494B2 (ja) 2016-07-20
BRPI0716996A2 (pt) 2013-10-08
RU2009113019A (ru) 2010-10-20
TWI482761B (zh) 2015-05-01
RU2495030C2 (ru) 2013-10-10
CA2842625A1 (en) 2008-03-13
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
CA2842625C (en) 2016-07-12
AR118922A2 (es) 2021-11-10
US20080139818A1 (en) 2008-06-12
US7678922B2 (en) 2010-03-16
HK1134094A1 (en) 2010-04-16
TW200823180A (en) 2008-06-01
BRPI0716996B8 (pt) 2021-05-25
MY148598A (en) 2013-05-15
PE20120669A1 (es) 2012-06-01
AR062715A1 (es) 2008-11-26
CN101535284A (zh) 2009-09-16
JP2010502715A (ja) 2010-01-28
UA99265C2 (ru) 2012-08-10
PL2059513T3 (pl) 2013-06-28
IL197445A0 (en) 2009-12-24
US8367841B2 (en) 2013-02-05
EP2059513B1 (en) 2013-01-23
ZA200901782B (en) 2010-06-30
ES2404348T3 (es) 2013-05-27
WO2008030570A1 (en) 2008-03-13
MX2009002439A (es) 2009-03-27
KR101466368B1 (ko) 2014-11-27
NZ575511A (en) 2012-02-24
AU2007292915B2 (en) 2012-07-26
EP2059513A1 (en) 2009-05-20
IL197445A (en) 2014-01-30
DK2059513T3 (da) 2013-05-06
AU2007292915A1 (en) 2008-03-13
CN101535284B (zh) 2014-12-10
JP2014193896A (ja) 2014-10-09
CA2662749C (en) 2015-01-20
CL2007002606A1 (es) 2008-04-18
CA2662749A1 (en) 2008-03-13
NZ598012A (en) 2013-08-30
US20100063297A1 (en) 2010-03-11
PT2059513E (pt) 2013-04-30

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