PE20080339A1 - Polipeptidos del factor de coagulacion ix modificados y uso de los mismos para tratamiento - Google Patents
Polipeptidos del factor de coagulacion ix modificados y uso de los mismos para tratamientoInfo
- Publication number
- PE20080339A1 PE20080339A1 PE2007000780A PE2007000780A PE20080339A1 PE 20080339 A1 PE20080339 A1 PE 20080339A1 PE 2007000780 A PE2007000780 A PE 2007000780A PE 2007000780 A PE2007000780 A PE 2007000780A PE 20080339 A1 PE20080339 A1 PE 20080339A1
- Authority
- PE
- Peru
- Prior art keywords
- modified
- proteepine
- coagulation factor
- treatment
- same
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UN POLIPEPTIDO DE FIX (FACTOR DE COAGULACION IX) MODIFICADO QUE CONSTA DE UNA MODIFICACION AMINOACIDICA EN UN POLIPEPTIDO DE FIX MADURO ESTABLECIDO EN SEQ ID NO:2 o 1035. LAS MODIFICACIONES AMINOACIDICAS CORRESPONDEN A MODIFICACIONES SELECCIONADAS ENTRE S174Q/F192I/D203Q, S174H/D186N/F192I Y T179Q/F192I/D203Q. DICHO POLIPEPTIDO MODIFICADO ESTA GLICOSILADO, CARBOXILADO, HIDROXILADO, SULFATADO, FOSFORILADO, ALBUMINADO O CONJUGADO A UN GRUPO FUNCIONAL POLIETILENGLICOL (PEG), MANTIENE LA ACTIVIDAD ADEMAS, AUMENTA LA RESISTENCIA A PROTEASAS EN EL TRACTO DIGESTIVO O EN EL FLUJO SANGUINEO COMPARADA CON EL POLIPEPTIDO NO MODIFICADO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81511306P | 2006-06-19 | 2006-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080339A1 true PE20080339A1 (es) | 2008-06-06 |
Family
ID=38834052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000780A PE20080339A1 (es) | 2006-06-19 | 2007-06-19 | Polipeptidos del factor de coagulacion ix modificados y uso de los mismos para tratamiento |
Country Status (6)
Country | Link |
---|---|
US (2) | US8383388B2 (es) |
EP (4) | EP2423305A1 (es) |
CL (1) | CL2012000063A1 (es) |
PE (1) | PE20080339A1 (es) |
TW (1) | TW200804416A (es) |
WO (1) | WO2007149406A2 (es) |
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-
2007
- 2007-06-15 EP EP11189828A patent/EP2423305A1/en not_active Withdrawn
- 2007-06-15 WO PCT/US2007/014219 patent/WO2007149406A2/en active Application Filing
- 2007-06-15 US US11/818,985 patent/US8383388B2/en active Active
- 2007-06-15 EP EP07809648A patent/EP2084274A2/en not_active Withdrawn
- 2007-06-15 EP EP11189834A patent/EP2423306A1/en not_active Withdrawn
- 2007-06-15 TW TW096121694A patent/TW200804416A/zh unknown
- 2007-06-15 EP EP11189837A patent/EP2423307A1/en not_active Withdrawn
- 2007-06-19 PE PE2007000780A patent/PE20080339A1/es not_active Application Discontinuation
-
2012
- 2012-01-09 CL CL2012000063A patent/CL2012000063A1/es unknown
- 2012-11-14 US US13/694,290 patent/US20130243855A1/en not_active Abandoned
Also Published As
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EP2423307A1 (en) | 2012-02-29 |
WO2007149406A9 (en) | 2008-03-13 |
US8383388B2 (en) | 2013-02-26 |
TW200804416A (en) | 2008-01-16 |
EP2423305A1 (en) | 2012-02-29 |
EP2084274A2 (en) | 2009-08-05 |
CL2012000063A1 (es) | 2012-08-24 |
WO2007149406A8 (en) | 2008-09-25 |
US20080102115A1 (en) | 2008-05-01 |
WO2007149406A3 (en) | 2008-07-10 |
EP2423306A1 (en) | 2012-02-29 |
WO2007149406A2 (en) | 2007-12-27 |
US20130243855A1 (en) | 2013-09-19 |
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