NO20093064L - Templatfikserte peptidhermere - Google Patents

Templatfikserte peptidhermere

Info

Publication number
NO20093064L
NO20093064L NO20093064A NO20093064A NO20093064L NO 20093064 L NO20093064 L NO 20093064L NO 20093064 A NO20093064 A NO 20093064A NO 20093064 A NO20093064 A NO 20093064A NO 20093064 L NO20093064 L NO 20093064L
Authority
NO
Norway
Prior art keywords
tyr
template
peptide mimics
dpro
cys
Prior art date
Application number
NO20093064A
Other languages
English (en)
Other versions
NO342598B1 (no
Inventor
John Anthony Robinson
Heiko Henze
Daniel Obrecht
Christian Ludin
Steven J Demarco
Frank Gombert
Jan Wim Vrijbloed
Kerstin Moehle
Reshimi Mukherjee
Barbara Romagnoli
Original Assignee
Polyphor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd filed Critical Polyphor Ltd
Publication of NO20093064L publication Critical patent/NO20093064L/no
Publication of NO342598B1 publication Critical patent/NO342598B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Reversible Transmitting Devices (AREA)

Abstract

Det er beskrevet templatfikserte ß- hårnålpeptidohermere syklo(-Tyr-His-X-Cys-Ser-Ala- DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), med disulfidbinding mellom Cys4 og Cys11, og farmasøytisk akseptable salter derav, hvor X er Ala eller Tyr, som har CXCR4 antagoniserende egenskaper og som kan anvendes til å forhindre HIV-infeksjoner i friske individer eller for å forsinke eller stoppe virusprogresjon i infiserte pasienter; eller hvor kreft er mediert eller resulterer fra CXCR4-reseptoraktivitet; eller hvor immunologiske sykdommer er mediert eller resulterer fra CXCR4-reseptoraktivitet; eller for og behandle immunundertrykkelse; eller særlig for stamcellemobilisering av perifere blodstamceller og/eller mesenchymale celler (MSC) og/eller andre stamceller hvor retensjonen avhenger av CXCR4- reseptoren. Disse ß-hårnålpeptidhermerne kan bli fremstilt ved en prosess som er basert på en blandet faststoff- og løsningsfase syntetisk strategi, ved å bruke fremgangsmåter som er velkjent for de med adekvat kunnskap i peptidkjemi.
NO20093064A 2007-02-28 2009-09-28 Templatfikserte peptidhermere NO342598B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2007/000101 WO2008104090A1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics

Publications (2)

Publication Number Publication Date
NO20093064L true NO20093064L (no) 2009-09-28
NO342598B1 NO342598B1 (no) 2018-06-18

Family

ID=37891752

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20093064A NO342598B1 (no) 2007-02-28 2009-09-28 Templatfikserte peptidhermere

Country Status (21)

Country Link
US (7) US8399611B2 (no)
EP (1) EP2132221B1 (no)
JP (1) JP5140686B2 (no)
KR (1) KR101479148B1 (no)
CN (1) CN101641372B (no)
AT (1) ATE475667T1 (no)
AU (1) AU2007348171B2 (no)
BR (1) BRPI0721259C1 (no)
CA (1) CA2679414C (no)
DE (1) DE602007008150D1 (no)
DK (1) DK2132221T3 (no)
EA (1) EA017583B1 (no)
ES (1) ES2349879T3 (no)
HK (1) HK1138011A1 (no)
IL (1) IL200312A (no)
MX (1) MX2009008843A (no)
NO (1) NO342598B1 (no)
NZ (1) NZ579875A (no)
PL (1) PL2132221T3 (no)
PT (1) PT2132221E (no)
WO (1) WO2008104090A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
AU2007345497B2 (en) 2007-01-29 2013-01-17 Polyphor Ltd. Template-fixed peptidomimetics
DE602007008150D1 (de) * 2007-02-28 2010-09-09 Polyphor Ltd Templat-fixierte peptidomimetika
EP2427476B1 (en) 2009-05-07 2018-08-08 Polyphor Ag Beta-hairpin peptidomimetics having cxcr4 antagonizing activity
US8716242B2 (en) 2009-12-04 2014-05-06 Polyphor Ag β-hairpin peptidomimetics
WO2012158707A1 (en) 2011-05-16 2012-11-22 Genzyme Corporation Use of cxcr4 antagonists
CN103703018B (zh) * 2011-06-07 2016-10-26 波利弗尔股份公司 作为CXC4拮抗剂的β-发夹肽模拟物
EP2764010B9 (en) * 2011-10-07 2017-01-18 Polyphor AG Template-fixed peptidomimetics as inhibitors of fpr1
WO2013182240A1 (en) * 2012-06-06 2013-12-12 Polyphor Ag Beta-hairpin peptidomimetics
US9775877B2 (en) * 2012-08-08 2017-10-03 Polyphor Ag Combinations with a backbone-cyclized peptide
CN113194978B (zh) * 2018-10-05 2024-03-08 斯特姆里姆有限公司 具有间充质干细胞的动员活性的肽
CA3199171A1 (en) 2020-11-19 2022-05-27 Spexis Ag Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4625603B2 (ja) 1999-08-30 2011-02-02 ポリファー アーゲー テンプレートを固定したβヘアピンループ類似物の合成
WO2002070547A1 (en) * 2001-02-23 2002-09-12 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
EP1483254A4 (en) * 2002-01-07 2005-06-08 Sequoia Pharmaceuticals INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
BRPI0215855B1 (pt) 2002-08-20 2016-12-13 Polyphor Ltd peptídeos cíclicos ligados à matriz com ação antimicrobiana
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
ES2306924T3 (es) 2003-05-02 2008-11-16 Polyphor Ag Peptidomimeticos fijados a una matriz como medicamentos contra el vih y el cancer.
US7681235B2 (en) 2003-05-19 2010-03-16 Radware Ltd. Dynamic network protection
EP1689863B1 (en) 2003-11-15 2014-05-28 Polyphor Ltd. Template fixed beta-hairpin loop mimetics and their use in phage display
BRPI0520016B1 (pt) 2005-02-17 2021-11-16 Polyphor Ltd. Composto, composiqao farmaceutica, uso de composto e processo para a fabricaqao de composto
WO2006117011A1 (en) 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
AU2007345497B2 (en) 2007-01-29 2013-01-17 Polyphor Ltd. Template-fixed peptidomimetics
DE602007008150D1 (de) 2007-02-28 2010-09-09 Polyphor Ltd Templat-fixierte peptidomimetika
AU2008360223B2 (en) 2008-08-08 2014-06-19 Polyphor Ag Template-fixed peptidomimetics
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
EP2427476B1 (en) 2009-05-07 2018-08-08 Polyphor Ag Beta-hairpin peptidomimetics having cxcr4 antagonizing activity
DK2462147T3 (en) 2009-08-05 2015-02-23 Polyphor Ag Conformationally limited fully synthetic macrocyclic compounds
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
US8716242B2 (en) 2009-12-04 2014-05-06 Polyphor Ag β-hairpin peptidomimetics
AU2010344997B2 (en) 2010-02-05 2015-09-10 Polyphor Ag Template - fixed peptidomimetics with CXCR7 modulating activity
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
WO2012016595A1 (en) 2010-08-05 2012-02-09 Polyphor Ag β-HAIRPIN PEPTIDOMIMETICS
CN103703018B (zh) 2011-06-07 2016-10-26 波利弗尔股份公司 作为CXC4拮抗剂的β-发夹肽模拟物
EP2764010B9 (en) 2011-10-07 2017-01-18 Polyphor AG Template-fixed peptidomimetics as inhibitors of fpr1
CN104284891B (zh) 2012-03-17 2018-04-17 波利弗尔股份公司 构象受限的全合成大环化合物
WO2013182240A1 (en) 2012-06-06 2013-12-12 Polyphor Ag Beta-hairpin peptidomimetics
EA030524B1 (ru) 2012-08-08 2018-08-31 Полифор Аг КОМБИНАЦИЯ β-ШПИЛЕЧНОГО ПЕПТИДОМИМЕТИКА И АНТИБИОТИКА
US9775877B2 (en) 2012-08-08 2017-10-03 Polyphor Ag Combinations with a backbone-cyclized peptide
MX366089B (es) 2013-03-30 2019-06-27 Polyphor Ag Peptidomimeticos beta-horquilla.
PT2978771T (pt) 2013-03-30 2019-10-31 Polyphor Ag Peptidomiméticos em formato de gancho beta
CN105873939B (zh) 2013-12-27 2021-08-27 波利弗尔股份公司 作为选择性弹性蛋白酶抑制剂的β-发夹肽模拟物
HRP20221046T1 (hr) 2013-12-27 2023-01-20 Spexis Ag Beta-ukosni peptidomimetici kao selektivni inhibitori elastaze

Also Published As

Publication number Publication date
KR101479148B1 (ko) 2015-01-05
CN101641372A (zh) 2010-02-03
JP2010519331A (ja) 2010-06-03
CN101641372B (zh) 2012-11-28
HK1138011A1 (en) 2010-08-13
DE602007008150D1 (de) 2010-09-09
US8399611B2 (en) 2013-03-19
US9879047B2 (en) 2018-01-30
BRPI0721259A2 (pt) 2013-01-15
DK2132221T3 (da) 2010-11-22
NZ579875A (en) 2012-02-24
US20200399317A1 (en) 2020-12-24
BRPI0721259C1 (pt) 2021-05-25
BRPI0721259B8 (pt) 2020-09-15
PL2132221T3 (pl) 2011-04-29
EP2132221B1 (en) 2010-07-28
CA2679414C (en) 2014-10-28
JP5140686B2 (ja) 2013-02-06
US11421001B2 (en) 2022-08-23
NO342598B1 (no) 2018-06-18
AU2007348171B2 (en) 2012-09-06
ES2349879T3 (es) 2011-01-12
US20100048463A1 (en) 2010-02-25
AU2007348171A1 (en) 2008-09-04
ATE475667T1 (de) 2010-08-15
CA2679414A1 (en) 2008-09-04
KR20100014596A (ko) 2010-02-10
PT2132221E (pt) 2010-10-26
US20130150299A1 (en) 2013-06-13
US20150080317A1 (en) 2015-03-19
US20190100558A1 (en) 2019-04-04
US20170096453A1 (en) 2017-04-06
US20180127467A1 (en) 2018-05-10
EA200901178A1 (ru) 2010-04-30
MX2009008843A (es) 2009-08-28
IL200312A (en) 2014-11-30
US8921325B2 (en) 2014-12-30
US10144765B2 (en) 2018-12-04
IL200312A0 (en) 2010-04-29
EP2132221A1 (en) 2009-12-16
US9556234B2 (en) 2017-01-31
EA017583B1 (ru) 2013-01-30
BRPI0721259B1 (pt) 2020-04-07
WO2008104090A1 (en) 2008-09-04
US10787486B2 (en) 2020-09-29

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