EA200901178A1 - Закрепленные на матрице пептидомиметики - Google Patents

Закрепленные на матрице пептидомиметики

Info

Publication number
EA200901178A1
EA200901178A1 EA200901178A EA200901178A EA200901178A1 EA 200901178 A1 EA200901178 A1 EA 200901178A1 EA 200901178 A EA200901178 A EA 200901178A EA 200901178 A EA200901178 A EA 200901178A EA 200901178 A1 EA200901178 A1 EA 200901178A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tyr
dpro
cys
ala
peptidomycetics
Prior art date
Application number
EA200901178A
Other languages
English (en)
Other versions
EA017583B1 (ru
Inventor
Стивен Дж. Демарко
Решми Мухерджи
Керстин Меле
Джон Энтони Робинсон
Хайко Хенце
Барбара Романьоли
Даниель Обрехт
Франк Гомберт
Кристиан Лудин
Ян Вим Врейблуд
Original Assignee
Полифор Лтд.
Универзитет Цюрих
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Полифор Лтд., Универзитет Цюрих filed Critical Полифор Лтд.
Publication of EA200901178A1 publication Critical patent/EA200901178A1/ru
Publication of EA017583B1 publication Critical patent/EA017583B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Reversible Transmitting Devices (AREA)

Abstract

Закреплённые на матрице β-шпилечные пептидомиметики цикло(-Tyr-His-X-Cys-Ser-Ala-Pro-Dab-Arg-Tyr-Cys-Tyr-Arg-Gln-Lys-Pro-Pro), дисульфидная связь между Cys4 и Cys11 и их фармацевтически приемлемые соли, где Х представляет собой Ala или Tyr, имеют антагонистические свойства в отношении CXCR4 и могут применяться для предотвращения ВИЧ инфекций у здоровых людей или замедления и прекращения развития вируса у инфицированных пациентов; или когда рак опосредован или является результатом активности рецептора CXCR4; или когда иммунологические заболевания опосредованы или являются результатом активности рецептора CXCR4; или для лечения иммуносупрессии; или в частности для мобилизации стволовых клеток периферической крови и/или мезенхимальных стволовых клеток (МСК) и/или других стволовых клеток, удержание которых зависит от CXCR4 рецептора. Эти β-шпилечные пептидомиметики могут быть произведены с помощью способа, который основан на стратегии смешанного твердо-жидкофазного синтеза, применяя методы, которые хорошо известны специалистам в пептидной химии.
EA200901178A 2007-02-28 2007-02-28 Закрепленные на матрице пептидомиметики EA017583B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2007/000101 WO2008104090A1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics

Publications (2)

Publication Number Publication Date
EA200901178A1 true EA200901178A1 (ru) 2010-04-30
EA017583B1 EA017583B1 (ru) 2013-01-30

Family

ID=37891752

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901178A EA017583B1 (ru) 2007-02-28 2007-02-28 Закрепленные на матрице пептидомиметики

Country Status (21)

Country Link
US (7) US8399611B2 (ru)
EP (1) EP2132221B1 (ru)
JP (1) JP5140686B2 (ru)
KR (1) KR101479148B1 (ru)
CN (1) CN101641372B (ru)
AT (1) ATE475667T1 (ru)
AU (1) AU2007348171B2 (ru)
BR (1) BRPI0721259C1 (ru)
CA (1) CA2679414C (ru)
DE (1) DE602007008150D1 (ru)
DK (1) DK2132221T3 (ru)
EA (1) EA017583B1 (ru)
ES (1) ES2349879T3 (ru)
HK (1) HK1138011A1 (ru)
IL (1) IL200312A (ru)
MX (1) MX2009008843A (ru)
NO (1) NO342598B1 (ru)
NZ (1) NZ579875A (ru)
PL (1) PL2132221T3 (ru)
PT (1) PT2132221E (ru)
WO (1) WO2008104090A1 (ru)

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WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
ES2425575T3 (es) 2007-01-29 2013-10-16 Polyphor Ltd. Peptidomiméticos fijados a una matriz
WO2008104090A1 (en) 2007-02-28 2008-09-04 Polyphor Ag Template-fixed peptidomimetics
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
US8716242B2 (en) 2009-12-04 2014-05-06 Polyphor Ag β-hairpin peptidomimetics
JP2014513727A (ja) 2011-05-16 2014-06-05 ジェンザイム・コーポレーション Ｃｘｃｒ４拮抗薬の使用
AU2012266355B2 (en) * 2011-06-07 2016-06-09 Polyphor Ag Beta - hairpin peptidomimetics as CXC4 antagonists
CN103842373B (zh) * 2011-10-07 2018-12-21 波利弗尔股份公司 模板-固定的肽模拟物作为fpr1的抑制物
IN2014KN02752A (ru) * 2012-06-06 2015-05-08 Polyphor Ag
BR112015002727B1 (pt) * 2012-08-08 2022-09-06 Polyphor Ag Combinação, composição farmacêutica, kit, e, usos de uma combinação, e de uma composição farmacêutica
EP3862017A4 (en) * 2018-10-05 2022-08-03 Stemrim Inc. PEPTIDE WITH MESENCHYMAL STEM CELL MOBILIZATION ACTIVITY
KR20230129388A (ko) 2020-11-19 2023-09-08 스펙시스 아게 암 치료를 위한 펩타이드 cxcr4 억제제 및 탁산을 포함하는 약제학적 조합물
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer

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BR9917475B1 (pt) * 1999-08-30 2013-07-23 processo para a manufatura de compostos, e, modificação do processo.
BRPI0207502B1 (pt) * 2001-02-23 2018-10-09 Polyphor Ltd compostos, enanciômeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
US20040009890A1 (en) * 2002-01-07 2004-01-15 Erickson John W. Broad spectrum inhibitors
BRPI0215855B1 (pt) 2002-08-20 2016-12-13 Polyphor Ltd peptídeos cíclicos ligados à matriz com ação antimicrobiana
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2003232253A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
WO2004096838A1 (en) 2003-05-02 2004-11-11 Polyphor Ag Template-fixed peptidomimetics as medicaments against hiv and cancer
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CA2545590C (en) 2003-11-15 2013-08-20 Polyphor Ltd. Template fixed beta-hairpin loop mimetics and their use in phage display
EP1856140B1 (en) 2005-02-17 2013-12-25 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2006117011A1 (en) 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
ES2425575T3 (es) 2007-01-29 2013-10-16 Polyphor Ltd. Peptidomiméticos fijados a una matriz
WO2008104090A1 (en) 2007-02-28 2008-09-04 Polyphor Ag Template-fixed peptidomimetics
WO2010015287A2 (en) 2008-08-08 2010-02-11 Polyphor Ag Template-fixed peptidomimetics
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
EP2462147B8 (en) 2009-08-05 2015-03-18 Polyphor AG Conformationally constrained, fully synthetic macrocyclic compounds
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
US8716242B2 (en) 2009-12-04 2014-05-06 Polyphor Ag β-hairpin peptidomimetics
AU2010344997B2 (en) 2010-02-05 2015-09-10 Polyphor Ag Template - fixed peptidomimetics with CXCR7 modulating activity
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
WO2012016595A1 (en) 2010-08-05 2012-02-09 Polyphor Ag β-HAIRPIN PEPTIDOMIMETICS
AU2012266355B2 (en) 2011-06-07 2016-06-09 Polyphor Ag Beta - hairpin peptidomimetics as CXC4 antagonists
CN103842373B (zh) 2011-10-07 2018-12-21 波利弗尔股份公司 模板-固定的肽模拟物作为fpr1的抑制物
DK2836485T3 (en) 2012-03-17 2018-04-23 Polyphor Ag CONFORMITY LIMITED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS
IN2014KN02752A (ru) 2012-06-06 2015-05-08 Polyphor Ag
RS56350B1 (sr) 2012-08-08 2017-12-29 Polyphor Ag Kombinacije sa peptidom sa ciklizovanim osnovnim lancem
BR112015002727B1 (pt) 2012-08-08 2022-09-06 Polyphor Ag Combinação, composição farmacêutica, kit, e, usos de uma combinação, e de uma composição farmacêutica
EA034926B1 (ru) 2013-03-30 2020-04-07 Полифор Аг Бета-шпилечные пептидомиметики
ES2691895T3 (es) 2013-03-30 2018-11-29 Polyphor Ag Peptidomiméticos en horquilla beta
MX2016008468A (es) 2013-12-27 2016-09-26 Polyphor Ag Peptidomimeticos de horquilla beta como inhibidores de elastasa selectivos.
MX2016008318A (es) 2013-12-27 2016-10-13 Polyphor Ag Peptidomimeticos de horquilla beta como inhibidores de elastasa selectivos.

Also Published As

Publication number Publication date
CA2679414C (en) 2014-10-28
ATE475667T1 (de) 2010-08-15
US8399611B2 (en) 2013-03-19
US8921325B2 (en) 2014-12-30
CA2679414A1 (en) 2008-09-04
KR20100014596A (ko) 2010-02-10
BRPI0721259B1 (pt) 2020-04-07
NO20093064L (no) 2009-09-28
JP2010519331A (ja) 2010-06-03
JP5140686B2 (ja) 2013-02-06
CN101641372A (zh) 2010-02-03
HK1138011A1 (en) 2010-08-13
WO2008104090A1 (en) 2008-09-04
MX2009008843A (es) 2009-08-28
US20190100558A1 (en) 2019-04-04
US20100048463A1 (en) 2010-02-25
EP2132221B1 (en) 2010-07-28
KR101479148B1 (ko) 2015-01-05
IL200312A0 (en) 2010-04-29
AU2007348171A1 (en) 2008-09-04
US10144765B2 (en) 2018-12-04
NZ579875A (en) 2012-02-24
US20130150299A1 (en) 2013-06-13
DE602007008150D1 (de) 2010-09-09
NO342598B1 (no) 2018-06-18
US20150080317A1 (en) 2015-03-19
CN101641372B (zh) 2012-11-28
BRPI0721259C1 (pt) 2021-05-25
EA017583B1 (ru) 2013-01-30
PT2132221E (pt) 2010-10-26
AU2007348171B2 (en) 2012-09-06
ES2349879T3 (es) 2011-01-12
BRPI0721259A2 (pt) 2013-01-15
IL200312A (en) 2014-11-30
US9556234B2 (en) 2017-01-31
US20180127467A1 (en) 2018-05-10
BRPI0721259B8 (pt) 2020-09-15
US9879047B2 (en) 2018-01-30
EP2132221A1 (en) 2009-12-16
PL2132221T3 (pl) 2011-04-29
DK2132221T3 (da) 2010-11-22
US20170096453A1 (en) 2017-04-06
US20200399317A1 (en) 2020-12-24
US11421001B2 (en) 2022-08-23
US10787486B2 (en) 2020-09-29

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