ATE475667T1 - Templat-fixierte peptidomimetika - Google Patents

Templat-fixierte peptidomimetika

Info

Publication number
ATE475667T1
ATE475667T1 AT07701901T AT07701901T ATE475667T1 AT E475667 T1 ATE475667 T1 AT E475667T1 AT 07701901 T AT07701901 T AT 07701901T AT 07701901 T AT07701901 T AT 07701901T AT E475667 T1 ATE475667 T1 AT E475667T1
Authority
AT
Austria
Prior art keywords
tyr
template
dpro
cys
ala
Prior art date
Application number
AT07701901T
Other languages
English (en)
Inventor
Steven Demarco
Reshmi Mukherjee
Kerstin Moehle
John Robinson
Heiko Henze
Barbara Romagnoli
Daniel Obrecht
Frank Gombert
Christian Ludin
Jan Vrijbloed
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Application granted granted Critical
Publication of ATE475667T1 publication Critical patent/ATE475667T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Reversible Transmitting Devices (AREA)
AT07701901T 2007-02-28 2007-02-28 Templat-fixierte peptidomimetika ATE475667T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2007/000101 WO2008104090A1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics

Publications (1)

Publication Number Publication Date
ATE475667T1 true ATE475667T1 (de) 2010-08-15

Family

ID=37891752

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07701901T ATE475667T1 (de) 2007-02-28 2007-02-28 Templat-fixierte peptidomimetika

Country Status (20)

Country Link
US (7) US8399611B2 (de)
EP (1) EP2132221B1 (de)
JP (1) JP5140686B2 (de)
KR (1) KR101479148B1 (de)
CN (1) CN101641372B (de)
AT (1) ATE475667T1 (de)
AU (1) AU2007348171B2 (de)
BR (1) BRPI0721259C1 (de)
CA (1) CA2679414C (de)
DE (1) DE602007008150D1 (de)
DK (1) DK2132221T3 (de)
EA (1) EA017583B1 (de)
ES (1) ES2349879T3 (de)
IL (1) IL200312A (de)
MX (1) MX2009008843A (de)
NO (1) NO342598B1 (de)
NZ (1) NZ579875A (de)
PL (1) PL2132221T3 (de)
PT (1) PT2132221E (de)
WO (1) WO2008104090A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
CA2676865C (en) 2007-01-29 2018-09-25 Polyphor Ltd. Template - fixed peptidomimetics
MX2009008843A (es) * 2007-02-28 2009-08-28 Polyphor Ltd Peptidomimeticos fijados a un patron.
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
WO2011066869A1 (en) * 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
RU2638802C2 (ru) 2011-05-16 2017-12-15 Джензим Корпорейшн Применение антагонистов cxcr4
BR112013031575B1 (pt) * 2011-06-07 2021-03-16 Polyphor Ag Composto peptídico ciclado de estrutura principal, composição farmacêutica, uso de um composto, e, processo para a manufatura de um composto
SG11201400354PA (en) * 2011-10-07 2014-09-26 Polyphor Ag Template -fixed peptidomimetics as inhibitors of fpr1
MX355396B (es) * 2012-06-06 2018-04-18 Polyphor Ag Peptido - mimeticos de la horquilla beta.
ES2639165T3 (es) * 2012-08-08 2017-10-25 Polyphor Ag Combinaciones con un péptido de esqueleto ciclado
US20210024594A1 (en) 2018-02-08 2021-01-28 StemRIM Inc. Therapeutic Agent for Psoriasis
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
WO2020071520A1 (ja) * 2018-10-05 2020-04-09 株式会社ステムリム 間葉系幹細胞の動員活性を有するペプチド
CA3199171A1 (en) 2020-11-19 2022-05-27 Spexis Ag Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2025068346A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4, pd-1 and fak inhibitors for treating cancer
WO2025068348A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4 and pd-1 inhibitors for treating cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878804B1 (en) * 1999-08-30 2005-04-12 University Of Zurich Synthesis of template-fixed β-hairpin loop mimetics
US7253146B2 (en) * 2001-02-23 2007-08-07 Polyphor Ltd Template-fixed peptidomimetics with antimicrobial activity
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
US7109230B2 (en) * 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
AU2002342618C1 (en) 2002-08-20 2008-10-30 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2003232254A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed peptidomimetics as medicaments against hiv and cancer
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
US7681235B2 (en) 2003-05-19 2010-03-16 Radware Ltd. Dynamic network protection
EP1689863B1 (de) 2003-11-15 2014-05-28 Polyphor Ltd. Matrizen-fixierter beta-hairpinloopmimetika und deren verwendung in phagen- display
EP1856140B1 (de) 2005-02-17 2013-12-25 Polyphor Ltd. Matrixfixierte beta-haarnadelförmige peptidomimetika mit proteasehemmender wirkung
EP1879911B1 (de) 2005-05-02 2011-08-17 Polyphor Ltd. Farbstoffkonjugate von schablonenfixierten peptidomimetika
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
CA2676865C (en) 2007-01-29 2018-09-25 Polyphor Ltd. Template - fixed peptidomimetics
MX2009008843A (es) * 2007-02-28 2009-08-28 Polyphor Ltd Peptidomimeticos fijados a un patron.
CA2733117C (en) 2008-08-08 2016-03-22 Polyphor Ag Template-fixed peptidomimetics
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
AU2009350857A1 (en) 2009-08-05 2012-02-02 Polyphor Ag Conformationally constrained, fully synthetic macrocyclic compounds
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
WO2011066869A1 (en) 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
US8629112B2 (en) 2010-02-05 2014-01-14 Frank Otto Gombert Template-fixed peptidomimetics with CXCR7 modulating activity
WO2012016595A1 (en) 2010-08-05 2012-02-09 Polyphor Ag β-HAIRPIN PEPTIDOMIMETICS
BR112013031575B1 (pt) 2011-06-07 2021-03-16 Polyphor Ag Composto peptídico ciclado de estrutura principal, composição farmacêutica, uso de um composto, e, processo para a manufatura de um composto
SG11201400354PA (en) 2011-10-07 2014-09-26 Polyphor Ag Template -fixed peptidomimetics as inhibitors of fpr1
EP2836485B1 (de) 2012-03-17 2018-01-10 Polyphor Ag Konformationseingeschränkte vollsynthetische makrocyclische verbindungen
MX355396B (es) 2012-06-06 2018-04-18 Polyphor Ag Peptido - mimeticos de la horquilla beta.
ES2639165T3 (es) 2012-08-08 2017-10-25 Polyphor Ag Combinaciones con un péptido de esqueleto ciclado
MX366993B (es) 2012-08-08 2019-08-02 Polyphor Ag Combinaciones con un peptido ciclado con la estructura de la base.
EP2978772B1 (de) 2013-03-30 2018-06-27 Polyphor AG Beta-hairpin-peptidmimetika
KR102279428B1 (ko) 2013-03-30 2021-07-20 폴리포 리미티드 Beta- 헤어핀 펩타이드 모방체
LT3087094T (lt) 2013-12-27 2022-09-26 Spexis Ag Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai
JP6499182B2 (ja) 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体

Also Published As

Publication number Publication date
EP2132221B1 (de) 2010-07-28
US20190100558A1 (en) 2019-04-04
BRPI0721259B1 (pt) 2020-04-07
US10787486B2 (en) 2020-09-29
US10144765B2 (en) 2018-12-04
CA2679414A1 (en) 2008-09-04
US9879047B2 (en) 2018-01-30
CN101641372A (zh) 2010-02-03
NO20093064L (no) 2009-09-28
NZ579875A (en) 2012-02-24
AU2007348171A1 (en) 2008-09-04
US11421001B2 (en) 2022-08-23
IL200312A0 (en) 2010-04-29
EA017583B1 (ru) 2013-01-30
WO2008104090A1 (en) 2008-09-04
AU2007348171B2 (en) 2012-09-06
ES2349879T3 (es) 2011-01-12
PT2132221E (pt) 2010-10-26
BRPI0721259A2 (pt) 2013-01-15
US20180127467A1 (en) 2018-05-10
BRPI0721259B8 (pt) 2020-09-15
JP5140686B2 (ja) 2013-02-06
US20170096453A1 (en) 2017-04-06
CN101641372B (zh) 2012-11-28
DE602007008150D1 (de) 2010-09-09
JP2010519331A (ja) 2010-06-03
IL200312A (en) 2014-11-30
US20130150299A1 (en) 2013-06-13
DK2132221T3 (da) 2010-11-22
US20150080317A1 (en) 2015-03-19
HK1138011A1 (en) 2010-08-13
US9556234B2 (en) 2017-01-31
KR101479148B1 (ko) 2015-01-05
US8399611B2 (en) 2013-03-19
EP2132221A1 (de) 2009-12-16
MX2009008843A (es) 2009-08-28
PL2132221T3 (pl) 2011-04-29
EA200901178A1 (ru) 2010-04-30
US20100048463A1 (en) 2010-02-25
US20200399317A1 (en) 2020-12-24
US8921325B2 (en) 2014-12-30
KR20100014596A (ko) 2010-02-10
NO342598B1 (no) 2018-06-18
CA2679414C (en) 2014-10-28
BRPI0721259C1 (pt) 2021-05-25

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