MX355396B - Peptido - mimeticos de la horquilla beta. - Google Patents
Peptido - mimeticos de la horquilla beta.Info
- Publication number
- MX355396B MX355396B MX2014014840A MX2014014840A MX355396B MX 355396 B MX355396 B MX 355396B MX 2014014840 A MX2014014840 A MX 2014014840A MX 2014014840 A MX2014014840 A MX 2014014840A MX 355396 B MX355396 B MX 355396B
- Authority
- MX
- Mexico
- Prior art keywords
- cys11
- xaa14
- xaa15
- xaa13
- xaa6
- Prior art date
Links
- 239000000816 peptidomimetic Substances 0.000 title abstract 3
- 108010061299 CXCR4 Receptors Proteins 0.000 abstract 2
- 102000012000 CXCR4 Receptors Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101100022915 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-11 gene Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000002617 apheresis Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula general ciclo (-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr1 0-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), el enlace disulfuro entre Cys4 y Cys11, y las sales aceptables farmacéuticamente del mismo, con Xaa3 es Try; Try(Me); o Tyr (CF3), Try(Me) es ácido (2S)-2-amino-(4-metoxifenil)-3-propionico, Tyr (CF3) es ácido (2S)-2-amino-(4-trifluorometoxifenil)-3-propionico, Xaa6 es Ala; o Acc Acc es ácido 1-aminociclopropano-carboxílico, Xaa8 es Orn (iPr), Orn(iPr) es ácido (2S)-Nw-isopropil-2,5-diaminopentanoico, Xaa13 es Gln; o Glu, Xaa14 es Lys (iPr), Lys(iPr) es ácido (2S)-Nw-isopropil-2,6-diaminohexanoico, Xaa15 es DPro; o DLys(iPr) , Dlys (iPr) es ácido (2R)-Nw-isopropil-2,6-diaminohexan oico, con la provisión de que si Xaa6 es Ala, entonces Xaa15 es DLys (iPr).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/060766 WO2013182240A1 (en) | 2012-06-06 | 2012-06-06 | Beta-hairpin peptidomimetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014014840A MX2014014840A (es) | 2015-02-12 |
| MX355396B true MX355396B (es) | 2018-04-18 |
Family
ID=46208596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014840A MX355396B (es) | 2012-06-06 | 2012-06-06 | Peptido - mimeticos de la horquilla beta. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9617308B2 (es) |
| EP (1) | EP2859012B1 (es) |
| JP (1) | JP6047231B2 (es) |
| CN (1) | CN104603145B (es) |
| AU (1) | AU2012381808B2 (es) |
| CA (1) | CA2875733C (es) |
| ES (1) | ES2647076T3 (es) |
| IL (1) | IL235946B (es) |
| IN (1) | IN2014KN02752A (es) |
| MX (1) | MX355396B (es) |
| SG (1) | SG11201407837WA (es) |
| WO (1) | WO2013182240A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007348171B2 (en) | 2007-02-28 | 2012-09-06 | Polyphor Ltd. | Template-fixed peptidomimetics |
| MX355396B (es) * | 2012-06-06 | 2018-04-18 | Polyphor Ag | Peptido - mimeticos de la horquilla beta. |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| TN2017000084A1 (en) | 2014-09-11 | 2018-07-04 | Bristol Myers Squibb Co | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| BR112018073642A2 (pt) | 2016-05-19 | 2019-02-26 | Bristol-Myers Squibb Company | imunomoduladores para imagiologia tep |
| CN109922818B (zh) * | 2016-09-06 | 2024-02-20 | 主线生物科学公司 | Cxcr4拮抗剂及使用方法 |
| EP3535280B1 (en) | 2016-11-07 | 2022-03-16 | Bristol-Myers Squibb Company | Immunomodulators |
| KR102735038B1 (ko) | 2017-06-23 | 2024-11-28 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-1의 길항제로서 작용하는 면역조정제 |
| WO2019050564A1 (en) * | 2017-09-05 | 2019-03-14 | Mainline Biosciences | CXCR4 SELECTIVE BINDING CONJUGATE WITH HIGH AFFINITY AND METHOD OF USING THE SAME |
| US11123437B2 (en) | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| EP3692053A1 (en) | 2017-10-03 | 2020-08-12 | Bristol-Myers Squibb Company | Immunomodulators |
| JP2023510737A (ja) | 2020-01-06 | 2023-03-15 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| WO2021150258A1 (en) * | 2020-01-26 | 2021-07-29 | Mainline Biosciences Llc | Isotopically labelled selective cxcr4 binding peptide conjugate and methods for making and using the same |
| KR20220161407A (ko) | 2020-03-30 | 2022-12-06 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제 |
| JP2023549921A (ja) | 2020-11-19 | 2023-11-29 | スペクシス アーゲー | がんを治療するためのペプチドｃｘｃｒ４阻害剤およびタキサンを含む医薬組み合わせ |
| WO2022184320A2 (en) | 2021-03-03 | 2022-09-09 | Spexis Ag | Medical use of cyclic peptides |
| WO2023285677A1 (en) | 2021-07-16 | 2023-01-19 | Spexis Ag | Pharmaceutical combinations for treating cancer |
| WO2023285681A1 (en) | 2021-07-16 | 2023-01-19 | Spexis Ag | Pharmaceutical combinations for treating cancer |
| WO2025068348A1 (en) | 2023-09-27 | 2025-04-03 | Spexis Ag | Pharmaceutical combination of cxcr4 and pd-1 inhibitors for treating cancer |
| WO2025068346A1 (en) | 2023-09-27 | 2025-04-03 | Spexis Ag | Pharmaceutical combination of cxcr4, pd-1 and fak inhibitors for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212288A (en) * | 1990-02-20 | 1993-05-18 | Syntex (U.S.A.) Inc. | Temporary minimal protection synthesis of serine-containing polypeptides |
| WO2004096839A1 (en) * | 2003-05-02 | 2004-11-11 | Polyphor Ag | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity |
| US8628750B2 (en) * | 2006-02-27 | 2014-01-14 | Technische Universitat Munchen | Cancer imaging and treatment |
| AU2007348171B2 (en) * | 2007-02-28 | 2012-09-06 | Polyphor Ltd. | Template-fixed peptidomimetics |
| WO2010127704A1 (en) * | 2009-05-07 | 2010-11-11 | Polyphor Ag | Beta-hairpin peptidomimetics having cxcr4 antagonizing activity |
| WO2011066869A1 (en) * | 2009-12-04 | 2011-06-09 | Polyphor Ag | Beta-hairpin peptidomimetics |
| SG195055A1 (en) * | 2011-06-07 | 2013-12-30 | Polyphor Ag | Beta - hairpin peptidomimetics as cxc4 antagonists |
| MX355396B (es) * | 2012-06-06 | 2018-04-18 | Polyphor Ag | Peptido - mimeticos de la horquilla beta. |
-
2012
- 2012-06-06 MX MX2014014840A patent/MX355396B/es active IP Right Grant
- 2012-06-06 JP JP2015515399A patent/JP6047231B2/ja not_active Expired - Fee Related
- 2012-06-06 WO PCT/EP2012/060766 patent/WO2013182240A1/en not_active Ceased
- 2012-06-06 SG SG11201407837WA patent/SG11201407837WA/en unknown
- 2012-06-06 EP EP12725830.9A patent/EP2859012B1/en active Active
- 2012-06-06 CA CA2875733A patent/CA2875733C/en active Active
- 2012-06-06 ES ES12725830.9T patent/ES2647076T3/es active Active
- 2012-06-06 US US14/406,108 patent/US9617308B2/en not_active Expired - Fee Related
- 2012-06-06 IN IN2752KON2014 patent/IN2014KN02752A/en unknown
- 2012-06-06 AU AU2012381808A patent/AU2012381808B2/en not_active Ceased
- 2012-06-06 CN CN201280074311.1A patent/CN104603145B/zh not_active Expired - Fee Related
-
2014
- 2014-11-27 IL IL235946A patent/IL235946B/en active IP Right Grant
-
2017
- 2017-02-27 US US15/444,045 patent/US10363284B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150218219A1 (en) | 2015-08-06 |
| US20170165319A1 (en) | 2017-06-15 |
| JP2015521204A (ja) | 2015-07-27 |
| NZ702470A (en) | 2016-12-23 |
| HK1207867A1 (en) | 2016-02-12 |
| IL235946A0 (en) | 2015-01-29 |
| US10363284B2 (en) | 2019-07-30 |
| IN2014KN02752A (es) | 2015-05-08 |
| AU2012381808A1 (en) | 2015-01-22 |
| MX2014014840A (es) | 2015-02-12 |
| CN104603145A (zh) | 2015-05-06 |
| EP2859012A1 (en) | 2015-04-15 |
| US9617308B2 (en) | 2017-04-11 |
| CN104603145B (zh) | 2018-05-18 |
| IL235946B (en) | 2019-06-30 |
| CA2875733A1 (en) | 2013-12-12 |
| AU2012381808B2 (en) | 2017-04-27 |
| CA2875733C (en) | 2019-09-10 |
| SG11201407837WA (en) | 2014-12-30 |
| EP2859012B1 (en) | 2017-08-09 |
| JP6047231B2 (ja) | 2016-12-21 |
| ES2647076T3 (es) | 2017-12-19 |
| WO2013182240A1 (en) | 2013-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |