MX343205B - Peptidomiméticos de horquilla beta como antagonistas de cxc4. - Google Patents

Peptidomiméticos de horquilla beta como antagonistas de cxc4.

Info

Publication number
MX343205B
MX343205B MX2013014229A MX2013014229A MX343205B MX 343205 B MX343205 B MX 343205B MX 2013014229 A MX2013014229 A MX 2013014229A MX 2013014229 A MX2013014229 A MX 2013014229A MX 343205 B MX343205 B MX 343205B
Authority
MX
Mexico
Prior art keywords
cys11
xaa14
xaa13
xaa8
xaa7
Prior art date
Application number
MX2013014229A
Other languages
English (en)
Other versions
MX2013014229A (es
Inventor
Obrecht Daniel
Otto Gombert Frank
Zimmermann Johann
Original Assignee
Polyphor Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ag filed Critical Polyphor Ag
Publication of MX2013014229A publication Critical patent/MX2013014229A/es
Publication of MX343205B publication Critical patent/MX343205B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Abstract

La presente invención se refiere a los peptidomiméticos de ß-horquilla del ciclo fórmula general (Tyr1-His2-Xaa3-Cys4-Ser5-Al a6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-DPro15-Pro16-), disulfuro de enlace entre Cys4 y Cys11 y sales farmacéuticamente aceptables de los mismos, Xaa3, Xaa7, Xaa8, Xaa13 y Xaa14 siendo residuos de aminoácidos de ciertos tipos que se definen en la descripción y las reivindicaciones, tienen propiedades farmacológicas favorables y pueden usarse para la prevención de infecciones por VIH en individuos saludables o para desacelerar y detener la progresión viral en pacientes infectados o en lugares en donde está mediada por el cáncer o como resultado de la actividad del receptor CXCR4 o en lugares en donde es mediada por enfermedades inmunológicas o como resultado de la actividad del receptor CXCP4, o para el tratamiento de inmunosupresión, o durante las recolecciones de aféresis de células madre de sangre periférica y/o como agentes para inducir la movilización de las células madre para regular la reparación de tejidos. Estos peptidomiméticos pueden ser fabricados por un proceso que se basa en una estrategia sintética mezclada en fase sólida y en solución.
MX2013014229A 2011-06-07 2012-06-06 Peptidomiméticos de horquilla beta como antagonistas de cxc4. MX343205B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2011059402 2011-06-07
PCT/EP2012/060763 WO2012168336A1 (en) 2011-06-07 2012-06-06 Beta - hairpin peptidomimetics as cxc4 antagonists

Publications (2)

Publication Number Publication Date
MX2013014229A MX2013014229A (es) 2014-01-23
MX343205B true MX343205B (es) 2016-10-28

Family

ID=46208595

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014229A MX343205B (es) 2011-06-07 2012-06-06 Peptidomiméticos de horquilla beta como antagonistas de cxc4.

Country Status (12)

Country Link
US (2) US9079939B2 (es)
JP (1) JP5957521B2 (es)
KR (1) KR102091456B1 (es)
CN (1) CN103703018B (es)
AU (1) AU2012266355B2 (es)
BR (1) BR112013031575B1 (es)
CA (1) CA2838037C (es)
ES (1) ES2552944T3 (es)
IL (1) IL229535B (es)
MX (1) MX343205B (es)
SG (1) SG195055A1 (es)
WO (1) WO2012168336A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
KR101479148B1 (ko) 2007-02-28 2015-01-05 폴리포 리미티드 주형 고정된 펩타이드 모방체
JP6047231B2 (ja) 2012-06-06 2016-12-21 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ β−ヘアピンペプチド模倣薬
KR20230129388A (ko) 2020-11-19 2023-09-08 스펙시스 아게 암 치료를 위한 펩타이드 cxcr4 억제제 및 탁산을 포함하는 약제학적 조합물
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08504837A (ja) 1993-10-14 1996-05-28 生化学工業株式会社 新規ポリペプチドおよびこれから調製される抗ｈｉｖ剤
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
KR101479148B1 (ko) * 2007-02-28 2015-01-05 폴리포 리미티드 주형 고정된 펩타이드 모방체
CL2008001467A1 (es) * 2007-05-30 2008-12-05 Lilly Co Eli Peptidos cilindricos antagonistas de cxcr4 ciclado por lactamas: composicion farmaceutica que los comprenden; y su uso para tratar artitis reumatica, fibrosis pulmonar, infeccion por vih o cancer.
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity

Also Published As

Publication number Publication date
WO2012168336A1 (en) 2012-12-13
NZ618110A (en) 2014-12-24
MX2013014229A (es) 2014-01-23
AU2012266355B2 (en) 2016-06-09
KR102091456B1 (ko) 2020-03-23
JP2014516999A (ja) 2014-07-17
AU2012266355A1 (en) 2013-12-12
US20150266924A1 (en) 2015-09-24
US9556231B2 (en) 2017-01-31
CN103703018B (zh) 2016-10-26
IL229535A0 (en) 2014-01-30
CA2838037A1 (en) 2012-12-13
BR112013031575A2 (pt) 2017-03-21
BR112013031575B1 (pt) 2021-03-16
ES2552944T3 (es) 2015-12-03
SG195055A1 (en) 2013-12-30
JP5957521B2 (ja) 2016-07-27
US20140213509A1 (en) 2014-07-31
IL229535B (en) 2018-07-31
CA2838037C (en) 2019-09-17
KR20140041689A (ko) 2014-04-04
CN103703018A (zh) 2014-04-02
US9079939B2 (en) 2015-07-14

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