IN2014KN02752A - - Google Patents
Info
- Publication number
- IN2014KN02752A IN2014KN02752A IN2752KON2014A IN2014KN02752A IN 2014KN02752 A IN2014KN02752 A IN 2014KN02752A IN 2752KON2014 A IN2752KON2014 A IN 2752KON2014A IN 2014KN02752 A IN2014KN02752 A IN 2014KN02752A
- Authority
- IN
- India
- Prior art keywords
- cys11
- xaa14
- xaa15
- xaa13
- xaa8
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
β-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8, Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/060766 WO2013182240A1 (en) | 2012-06-06 | 2012-06-06 | Beta-hairpin peptidomimetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN02752A true IN2014KN02752A (en) | 2015-05-08 |
Family
ID=46208596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2752KON2014 IN2014KN02752A (en) | 2012-06-06 | 2012-06-06 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9617308B2 (en) |
| EP (1) | EP2859012B1 (en) |
| JP (1) | JP6047231B2 (en) |
| CN (1) | CN104603145B (en) |
| AU (1) | AU2012381808B2 (en) |
| CA (1) | CA2875733C (en) |
| ES (1) | ES2647076T3 (en) |
| HK (1) | HK1207867A1 (en) |
| IL (1) | IL235946B (en) |
| IN (1) | IN2014KN02752A (en) |
| MX (1) | MX355396B (en) |
| SG (1) | SG11201407837WA (en) |
| WO (1) | WO2013182240A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2349879T3 (en) | 2007-02-28 | 2011-01-12 | Polyphor Ltd. | PEPTIDOMYMETICS SET ON PATTERN. |
| JP6047231B2 (en) * | 2012-06-06 | 2016-12-21 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | β-hairpin peptidomimetics |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| CA2960778C (en) | 2014-09-11 | 2023-03-07 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| MX2018014028A (en) | 2016-05-19 | 2019-04-04 | Squibb Bristol Myers Co | Pet-imaging immunomodulators. |
| JP7100639B2 (en) * | 2016-09-06 | 2022-07-13 | メインライン バイオサエンシズ | CXCR4 antagonist and usage |
| KR102526034B1 (en) | 2016-11-07 | 2023-04-25 | 브리스톨-마이어스 스큅 컴퍼니 | immunomodulator |
| US11066445B2 (en) | 2017-06-23 | 2021-07-20 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of PD-1 |
| CN111183146A (en) * | 2017-09-05 | 2020-05-19 | 主线生物科学公司 | Conjugates that bind CXCR4 with high affinity selectivity and methods of use thereof |
| US11123437B2 (en) | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| KR20200058506A (en) | 2017-10-03 | 2020-05-27 | 브리스톨-마이어스 스큅 컴퍼니 | Immunomodulators |
| EP4097120A4 (en) * | 2020-01-26 | 2024-05-01 | Mainline Biosciences (Shanghai) Co., Ltd. | Isotopically labelled selective cxcr4 binding peptide conjugate and methods for making and using the same |
| MX2023005829A (en) | 2020-11-19 | 2023-08-21 | Spexis Ag | Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer. |
| WO2022184320A2 (en) | 2021-03-03 | 2022-09-09 | Spexis Ag | Medical use of cyclic peptides |
| WO2023285681A1 (en) | 2021-07-16 | 2023-01-19 | Spexis Ag | Pharmaceutical combinations for treating cancer |
| WO2023285677A1 (en) | 2021-07-16 | 2023-01-19 | Spexis Ag | Pharmaceutical combinations for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212288A (en) * | 1990-02-20 | 1993-05-18 | Syntex (U.S.A.) Inc. | Temporary minimal protection synthesis of serine-containing polypeptides |
| AU2003232253A1 (en) * | 2003-05-02 | 2004-11-23 | Polyphor Ag | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity |
| JP5308829B2 (en) * | 2006-02-27 | 2013-10-09 | テクニッシュ ユニべルシタット ミュンヘン | Cancer imaging and treatment |
| ES2349879T3 (en) * | 2007-02-28 | 2011-01-12 | Polyphor Ltd. | PEPTIDOMYMETICS SET ON PATTERN. |
| EP2427476B1 (en) | 2009-05-07 | 2018-08-08 | Polyphor Ag | Beta-hairpin peptidomimetics having cxcr4 antagonizing activity |
| WO2011066869A1 (en) | 2009-12-04 | 2011-06-09 | Polyphor Ag | Beta-hairpin peptidomimetics |
| WO2012168336A1 (en) * | 2011-06-07 | 2012-12-13 | Polyphor Ag | Beta - hairpin peptidomimetics as cxc4 antagonists |
| JP6047231B2 (en) * | 2012-06-06 | 2016-12-21 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | β-hairpin peptidomimetics |
-
2012
- 2012-06-06 JP JP2015515399A patent/JP6047231B2/en not_active Expired - Fee Related
- 2012-06-06 AU AU2012381808A patent/AU2012381808B2/en active Active
- 2012-06-06 CN CN201280074311.1A patent/CN104603145B/en active Active
- 2012-06-06 EP EP12725830.9A patent/EP2859012B1/en active Active
- 2012-06-06 ES ES12725830.9T patent/ES2647076T3/en active Active
- 2012-06-06 MX MX2014014840A patent/MX355396B/en active IP Right Grant
- 2012-06-06 SG SG11201407837WA patent/SG11201407837WA/en unknown
- 2012-06-06 IN IN2752KON2014 patent/IN2014KN02752A/en unknown
- 2012-06-06 CA CA2875733A patent/CA2875733C/en active Active
- 2012-06-06 US US14/406,108 patent/US9617308B2/en active Active
- 2012-06-06 WO PCT/EP2012/060766 patent/WO2013182240A1/en active Application Filing
-
2014
- 2014-11-27 IL IL235946A patent/IL235946B/en active IP Right Grant
-
2015
- 2015-08-31 HK HK15108479.6A patent/HK1207867A1/en unknown
-
2017
- 2017-02-27 US US15/444,045 patent/US10363284B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9617308B2 (en) | 2017-04-11 |
| AU2012381808B2 (en) | 2017-04-27 |
| WO2013182240A1 (en) | 2013-12-12 |
| IL235946B (en) | 2019-06-30 |
| JP2015521204A (en) | 2015-07-27 |
| US20150218219A1 (en) | 2015-08-06 |
| US10363284B2 (en) | 2019-07-30 |
| EP2859012A1 (en) | 2015-04-15 |
| AU2012381808A1 (en) | 2015-01-22 |
| IL235946A0 (en) | 2015-01-29 |
| HK1207867A1 (en) | 2016-02-12 |
| CA2875733C (en) | 2019-09-10 |
| CN104603145B (en) | 2018-05-18 |
| MX355396B (en) | 2018-04-18 |
| US20170165319A1 (en) | 2017-06-15 |
| CA2875733A1 (en) | 2013-12-12 |
| JP6047231B2 (en) | 2016-12-21 |
| CN104603145A (en) | 2015-05-06 |
| SG11201407837WA (en) | 2014-12-30 |
| NZ702470A (en) | 2016-12-23 |
| EP2859012B1 (en) | 2017-08-09 |
| MX2014014840A (en) | 2015-02-12 |
| ES2647076T3 (en) | 2017-12-19 |
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