AR069830A1 - Factor viii y factor de von willebrand recombinantes modificados y metodos de uso de los mismos - Google Patents
Factor viii y factor de von willebrand recombinantes modificados y metodos de uso de los mismosInfo
- Publication number
- AR069830A1 AR069830A1 ARP080104914A ARP080104914A AR069830A1 AR 069830 A1 AR069830 A1 AR 069830A1 AR P080104914 A ARP080104914 A AR P080104914A AR P080104914 A ARP080104914 A AR P080104914A AR 069830 A1 AR069830 A1 AR 069830A1
- Authority
- AR
- Argentina
- Prior art keywords
- factor
- methods
- coagulation
- protein
- survival
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229960000301 factor viii Drugs 0.000 title 1
- 230000015271 coagulation Effects 0.000 abstract 5
- 238000005345 coagulation Methods 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 230000004083 survival effect Effects 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000001742 protein purification Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Materials Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Métodos para incrementar la sobrevida de una proteína de coagulacion por inhibicion de la interaccion con un receptor de depuracion. También se proveen métodos para preparar composiciones que inhiben a los receptores de depuracion de las proteínas de la coagulacion. Asimismo se proporcionan proteínas de la coagulacion conjugadas, inclusive composiciones y formulaciones con las mismas. Reivindicacion 1: Un método para incrementar la sobrevida de una proteína de la coagulacion mediante inhibicion de la interaccion con un receptor de depuracion, donde dicho método comprende los pasos de: (a) modificar una proteína de la coagulacion con un polímero soluble en agua, y (b) administrarle a un mamífero que lo necesita una cantidad eficaz para uso terapéutico de una composicion que comprende al factor de coagulacion modificado; en donde dicha modificacion incrementa la sobrevida de la proteína en la circulacion sanguínea de un mamífero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98697507P | 2007-11-09 | 2007-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069830A1 true AR069830A1 (es) | 2010-02-24 |
Family
ID=40227950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104914A AR069830A1 (es) | 2007-11-09 | 2008-11-10 | Factor viii y factor de von willebrand recombinantes modificados y metodos de uso de los mismos |
Country Status (10)
Country | Link |
---|---|
US (3) | US8173597B2 (es) |
EP (1) | EP2222329A1 (es) |
JP (2) | JP2011503101A (es) |
KR (1) | KR20100095441A (es) |
AR (1) | AR069830A1 (es) |
AU (1) | AU2008323768A1 (es) |
BR (1) | BRPI0820271A2 (es) |
CA (1) | CA2704234A1 (es) |
GB (1) | GB2467700A (es) |
WO (1) | WO2009062100A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2748662A1 (en) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase-cleavable bioprotective moiety |
CA2748314C (en) | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
WO2010146362A2 (en) * | 2009-06-16 | 2010-12-23 | The University Of Bath | Materials and methods relating to glycosylation |
WO2011028229A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
EP2536753B1 (en) * | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
WO2012088123A1 (en) * | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Polymer-factor vii moiety conjugates |
EP2714093A1 (en) * | 2011-05-27 | 2014-04-09 | Baxter International Inc. | Therapeutic proteins with increased half-life and methods of preparing same |
HUE039317T2 (hu) | 2011-06-10 | 2018-12-28 | Baxalta GmbH | Koagulációs betegség kezelése rekombináns VWF adagolásával |
JP6352806B2 (ja) | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー/エス | 新規のグルカゴン類似体 |
AU2012318303B2 (en) | 2011-10-18 | 2015-09-03 | Csl Behring Gmbh | Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of Factor VIII |
KR20140083036A (ko) * | 2011-10-18 | 2014-07-03 | 체에스엘 베링 게엠베하 | 인자 viii의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도 |
PT2804623T (pt) | 2012-01-12 | 2019-11-18 | Bioverativ Therapeutics Inc | Polipéptidos quiméricos do fator viii e suas utilizações |
CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
LT3564260T (lt) | 2012-02-15 | 2023-01-10 | Bioverativ Therapeutics Inc. | Viii faktoriaus kompozicijos ir jų gamybos bei panaudojimo būdai |
CN104411716B (zh) | 2012-04-24 | 2018-09-07 | 诺和诺德股份有限公司 | 适用于治疗血友病的化合物 |
BR112015000267B1 (pt) | 2012-07-11 | 2023-01-24 | Bioverativ Therapeutics Inc. | Proteínas quiméricas, e composição farmacêutica |
CN103804451A (zh) * | 2012-11-14 | 2014-05-21 | 沈阳药科大学 | 一种由葫芦素b水解制备葫芦素d的方法 |
CN105307672B (zh) | 2013-04-18 | 2021-01-05 | 诺和诺德股份有限公司 | 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 |
NZ713904A (en) * | 2013-06-28 | 2022-02-25 | Bioverativ Therapeutics Inc | Thrombin cleavable linker with xten and its uses thereof |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
CN116621991A (zh) | 2014-01-10 | 2023-08-22 | 比奥贝拉蒂治疗公司 | 因子viii嵌合蛋白及其用途 |
JP6665104B2 (ja) * | 2014-04-10 | 2020-03-13 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | 配合培地粉末製剤および細胞培養用液体培地の調製方法 |
JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー/エス | 医療用のglp−1/グルカゴン受容体コアゴニスト |
CA2953593C (en) * | 2014-07-02 | 2023-09-26 | Csl Limited | Modified von willebrand factor |
BR112017002090B1 (pt) | 2014-08-04 | 2021-06-01 | Csl Limited | Composição aquosa de fator viii de coagulação e método de estabilizar uma molécula de fviii |
CA2978374A1 (en) | 2015-03-06 | 2016-09-15 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
JP6851381B6 (ja) | 2016-01-07 | 2021-04-21 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 変異切断型フォンウィルブランド因子 |
CN108779165B (zh) * | 2016-01-07 | 2022-12-02 | 康诺贝林伦瑙有限公司 | 突变的冯·维勒布兰德因子 |
WO2017222337A1 (ko) | 2016-06-24 | 2017-12-28 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
DK3648788T3 (da) | 2017-07-07 | 2024-08-19 | Takeda Pharmaceuticals Co | Behandling af gastrointestinal blødning hos patienter med svær von willebrand-sygdom ved administration af rekombinant vwf |
CN111565741A (zh) * | 2017-07-07 | 2020-08-21 | 百深公司 | 通过施用重组vwf来治疗经历择期手术的患有严重冯维勒布兰德病的患者 |
SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
CN114072420B (zh) | 2019-07-04 | 2024-06-11 | 康诺贝林伦瑙有限公司 | 用于增加凝血因子viii的体外稳定性的截短的血管性血友病因子(vwf) |
JP2023500953A (ja) | 2019-11-11 | 2023-01-11 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第viii因子に対する寛容を誘導するためのポリペプチド |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
AU6029594A (en) * | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
EP1408119A1 (en) * | 2001-07-18 | 2004-04-14 | Suntory Limited | Method of screening abc protein promoter/inhibitor |
IL161251A0 (en) * | 2001-10-10 | 2004-09-27 | Neose Technologies Inc | Remodeling and glycoconjugation of peptides |
WO2004029280A2 (en) | 2002-09-24 | 2004-04-08 | Rico Buchli | Anti-hla assay and methods |
CA2788505C (en) * | 2003-02-26 | 2018-09-04 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
WO2004084949A2 (en) * | 2003-03-20 | 2004-10-07 | Xencor | Generating protein pro-drugs using reversible ppg linkages |
CA2530725A1 (en) * | 2003-03-28 | 2004-10-07 | Biopolymed Inc. | Biologically active material conjugated with biocompatible polymer with 1:1 complex, preparation method thereof and pharmaceutical composition comprising the same |
ES2512499T3 (es) * | 2003-04-08 | 2014-10-24 | Yeda Research And Development Co., Ltd. | Fármacos pegilados reversibles |
PT2644206T (pt) * | 2003-05-23 | 2019-07-10 | Nektar Therapeutics | Derivados de peg contendo duas cadeias de peg |
SI3130601T1 (sl) | 2004-11-12 | 2020-11-30 | Bayer Healthcare Llc | Usmerjena modifikacija FVIII |
WO2006071801A2 (en) * | 2004-12-27 | 2006-07-06 | Baxter International Inc | Polymer-von willebrand factor-conjugates |
KR101304157B1 (ko) * | 2005-06-16 | 2013-09-06 | 넥타르 테라퓨틱스 | 분해가능한 결합을 갖는 컨주게이트 및 이러한 컨주게이트제조에 유용한 고분자 시약 |
AU2007245190B2 (en) | 2006-03-31 | 2011-07-21 | Takeda Pharmaceutical Company Limited | Pegylated factor VIII |
CA2671676C (en) * | 2006-12-27 | 2014-04-22 | Baxter Healthcare Sa | Von willebrand factor-and factor viii-polymer conjugates having a releasable linkage |
-
2008
- 2008-11-07 WO PCT/US2008/082888 patent/WO2009062100A1/en active Application Filing
- 2008-11-07 CA CA2704234A patent/CA2704234A1/en not_active Abandoned
- 2008-11-07 AU AU2008323768A patent/AU2008323768A1/en not_active Abandoned
- 2008-11-07 BR BRPI0820271-0A patent/BRPI0820271A2/pt not_active IP Right Cessation
- 2008-11-07 JP JP2010533298A patent/JP2011503101A/ja active Pending
- 2008-11-07 GB GB1009493A patent/GB2467700A/en not_active Withdrawn
- 2008-11-07 EP EP08846717A patent/EP2222329A1/en not_active Withdrawn
- 2008-11-07 US US12/267,491 patent/US8173597B2/en active Active
- 2008-11-07 KR KR1020107012591A patent/KR20100095441A/ko not_active Application Discontinuation
- 2008-11-10 AR ARP080104914A patent/AR069830A1/es unknown
-
2012
- 2012-04-20 US US13/452,612 patent/US20120322737A1/en not_active Abandoned
-
2013
- 2013-04-11 US US13/861,235 patent/US20130296243A1/en not_active Abandoned
-
2014
- 2014-05-12 JP JP2014098520A patent/JP2014141532A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20130296243A1 (en) | 2013-11-07 |
EP2222329A1 (en) | 2010-09-01 |
US20090247459A1 (en) | 2009-10-01 |
WO2009062100A1 (en) | 2009-05-14 |
US8173597B2 (en) | 2012-05-08 |
CA2704234A1 (en) | 2009-05-14 |
JP2011503101A (ja) | 2011-01-27 |
JP2014141532A (ja) | 2014-08-07 |
AU2008323768A1 (en) | 2009-05-14 |
BRPI0820271A2 (pt) | 2015-05-26 |
GB2467700A (en) | 2010-08-11 |
KR20100095441A (ko) | 2010-08-30 |
US20120322737A1 (en) | 2012-12-20 |
GB201009493D0 (en) | 2010-07-21 |
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