PE20070949A1 - Compuestos derivados de acido benzo(f)isoindol-2-ilfenil acetico como agonistas del receptor de prostanoides ep4 - Google Patents
Compuestos derivados de acido benzo(f)isoindol-2-ilfenil acetico como agonistas del receptor de prostanoides ep4Info
- Publication number
- PE20070949A1 PE20070949A1 PE2007000114A PE2007000114A PE20070949A1 PE 20070949 A1 PE20070949 A1 PE 20070949A1 PE 2007000114 A PE2007000114 A PE 2007000114A PE 2007000114 A PE2007000114 A PE 2007000114A PE 20070949 A1 PE20070949 A1 PE 20070949A1
- Authority
- PE
- Peru
- Prior art keywords
- isoindol
- benzo
- acetic acid
- agonists
- prostanoid
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 102000011367 Prostanoid EP4 receptors Human genes 0.000 title 1
- 108050001693 Prostanoid EP4 receptors Proteins 0.000 title 1
- -1 ETHYLOXY Chemical class 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- Gynecology & Obstetrics (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE NAFTALENO DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO ALQUILO(C1-C4); R3, R4, R5 Y R6 SON CADA UNO H O F; X E Y SON CADA UNO CH2 O C=O. SON COMPUESTOS PREFERIDOS: ACIDO {4-[4,9-BIS(ETILOXI)-1,3-DIOXO-1,3-DIHIDRO-2H-BENZO[f]ISOINDOL-2-IL]-3-FLUOROFENIL}-ACETICO, ACIDO {4-[1,3-DIOXO-4,9-BIS(PROPILOXI)-1,3-DIHIDRO-2H-BENZO[f]ISOINDOL-2-IL]-3-FLUOROFENIL}-ACETICO, ACIDO {4-[4,9-BIS(1-METILETOXI)-1,3-DIOXO-1,3-DIHIDRO-2H-BENZO[f]ISOINDOL-2-IL]-3-FLUOROFENIL}-ACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR DE PROSTANOIDES EP4 SIENDO UTILES EN EL TRATAMIENTO DE DOLOR ARTICULAR CRONICO, LUMBALGIA, DOLOR NEUROPATICO, DERMATITIS
Applications Claiming Priority (2)
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GB0602237A GB0602237D0 (en) | 2006-02-03 | 2006-02-03 | Novel compounds |
GB0608976A GB0608976D0 (en) | 2006-05-05 | 2006-05-05 | Novel compounds |
Publications (1)
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PE20070949A1 true PE20070949A1 (es) | 2007-11-22 |
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PE2007000114A PE20070949A1 (es) | 2006-02-03 | 2007-02-01 | Compuestos derivados de acido benzo(f)isoindol-2-ilfenil acetico como agonistas del receptor de prostanoides ep4 |
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US (1) | US8252833B2 (es) |
EP (2) | EP1979316B1 (es) |
JP (2) | JP5250427B2 (es) |
KR (1) | KR20080097417A (es) |
AR (1) | AR059282A1 (es) |
AU (1) | AU2007211484A1 (es) |
BR (1) | BRPI0708024A2 (es) |
CA (1) | CA2640277A1 (es) |
CR (1) | CR10207A (es) |
EA (1) | EA200870224A1 (es) |
ES (1) | ES2390491T3 (es) |
IL (1) | IL192934A0 (es) |
MA (1) | MA30209B1 (es) |
NO (1) | NO20083448L (es) |
PE (1) | PE20070949A1 (es) |
SG (1) | SG169380A1 (es) |
TW (1) | TW200808722A (es) |
UY (1) | UY30121A1 (es) |
WO (1) | WO2007088190A1 (es) |
Families Citing this family (8)
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MX2008014450A (es) * | 2006-05-18 | 2009-03-09 | Mannkind Corp | Inhibidores de cinasa intracelular. |
GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
GB0620619D0 (en) * | 2006-10-17 | 2006-11-29 | Glaxo Group Ltd | Novel compounds |
GB0623203D0 (en) * | 2006-11-21 | 2007-01-03 | Glaxo Group Ltd | Novel compounds |
MX2009012043A (es) | 2007-05-08 | 2010-02-18 | Nat Univ Corp Hamamatsu | Activador de celulas t citotoxicas que comprende agonista ep4. |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
CN103012111B (zh) * | 2012-09-12 | 2016-01-13 | 衢州学院 | 一种2,4,5-三氟苯乙酸的制备方法 |
CN110003129B (zh) * | 2019-04-18 | 2021-04-06 | 济南立德医药技术有限公司 | 一种佐米曲普坦中间体的制备方法 |
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WO2000015608A1 (en) | 1998-09-14 | 2000-03-23 | Ono Pharmaceutical Co., Ltd. | φ-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
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GB0602900D0 (en) * | 2006-02-13 | 2006-03-22 | Glaxo Group Ltd | Novel Compounds |
-
2007
- 2007-01-30 UY UY30121A patent/UY30121A1/es not_active Application Discontinuation
- 2007-02-01 AR ARP070100429A patent/AR059282A1/es not_active Application Discontinuation
- 2007-02-01 EP EP07704313A patent/EP1979316B1/en active Active
- 2007-02-01 WO PCT/EP2007/050992 patent/WO2007088190A1/en active Application Filing
- 2007-02-01 BR BRPI0708024-7A patent/BRPI0708024A2/pt not_active IP Right Cessation
- 2007-02-01 AU AU2007211484A patent/AU2007211484A1/en not_active Abandoned
- 2007-02-01 JP JP2008552809A patent/JP5250427B2/ja not_active Expired - Fee Related
- 2007-02-01 CA CA002640277A patent/CA2640277A1/en not_active Abandoned
- 2007-02-01 SG SG201100788-7A patent/SG169380A1/en unknown
- 2007-02-01 ES ES07704313T patent/ES2390491T3/es active Active
- 2007-02-01 KR KR1020087018920A patent/KR20080097417A/ko not_active Application Discontinuation
- 2007-02-01 US US12/278,019 patent/US8252833B2/en not_active Expired - Fee Related
- 2007-02-01 PE PE2007000114A patent/PE20070949A1/es not_active Application Discontinuation
- 2007-02-01 TW TW096103620A patent/TW200808722A/zh unknown
- 2007-02-01 EP EP12154482A patent/EP2457897A1/en not_active Withdrawn
- 2007-02-01 EA EA200870224A patent/EA200870224A1/ru unknown
-
2008
- 2008-07-21 IL IL192934A patent/IL192934A0/en unknown
- 2008-08-06 MA MA31159A patent/MA30209B1/fr unknown
- 2008-08-07 NO NO20083448A patent/NO20083448L/no not_active Application Discontinuation
- 2008-08-14 CR CR10207A patent/CR10207A/es unknown
-
2013
- 2013-01-04 JP JP2013000193A patent/JP2013082734A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
BRPI0708024A2 (pt) | 2011-05-17 |
AU2007211484A1 (en) | 2007-08-09 |
CA2640277A1 (en) | 2007-08-09 |
EP1979316B1 (en) | 2012-07-11 |
KR20080097417A (ko) | 2008-11-05 |
ES2390491T3 (es) | 2012-11-13 |
AR059282A1 (es) | 2008-03-19 |
US20110201663A1 (en) | 2011-08-18 |
UY30121A1 (es) | 2007-08-31 |
JP2009525309A (ja) | 2009-07-09 |
JP2013082734A (ja) | 2013-05-09 |
NO20083448L (no) | 2008-10-23 |
JP5250427B2 (ja) | 2013-07-31 |
IL192934A0 (en) | 2009-02-11 |
EP2457897A1 (en) | 2012-05-30 |
US8252833B2 (en) | 2012-08-28 |
WO2007088190A1 (en) | 2007-08-09 |
EP1979316A1 (en) | 2008-10-15 |
EA200870224A1 (ru) | 2009-02-27 |
CR10207A (es) | 2008-09-22 |
MA30209B1 (fr) | 2009-02-02 |
TW200808722A (en) | 2008-02-16 |
SG169380A1 (en) | 2011-03-30 |
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