EA200870224A1 - Бензо[f]изоиндол-2-илфенильные производные уксусной кислоты в качестве агонистов рецепторов ep - Google Patents

Бензо[f]изоиндол-2-илфенильные производные уксусной кислоты в качестве агонистов рецепторов ep

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Publication number
EA200870224A1
EA200870224A1 EA200870224A EA200870224A EA200870224A1 EA 200870224 A1 EA200870224 A1 EA 200870224A1 EA 200870224 A EA200870224 A EA 200870224A EA 200870224 A EA200870224 A EA 200870224A EA 200870224 A1 EA200870224 A1 EA 200870224A1
Authority
EA
Eurasian Patent Office
Prior art keywords
izinindol
ilphenyl
agonists
benzo
receptors
Prior art date
Application number
EA200870224A
Other languages
English (en)
Inventor
Эндрю Биллинтон
Николас Мон Клэйтон
Джерард Мартин Пол Гиблин
Марк Патрик Хили
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37944208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200870224(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0602237A external-priority patent/GB0602237D0/en
Priority claimed from GB0608976A external-priority patent/GB0608976D0/en
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA200870224A1 publication Critical patent/EA200870224A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Изобретение относится к соединению формулы (I) или его фармацевтически приемлемому производному, где R, R, R, R, R5, R, Х и Y являются такими, как определено в описании; способу получения таких соединений; фармацевтической композиции, содержащей такие соединения; и применению таких соединений в медицине.
EA200870224A 2006-02-03 2007-02-01 Бензо[f]изоиндол-2-илфенильные производные уксусной кислоты в качестве агонистов рецепторов ep EA200870224A1 (ru)

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GB0602237A GB0602237D0 (en) 2006-02-03 2006-02-03 Novel compounds
GB0608976A GB0608976D0 (en) 2006-05-05 2006-05-05 Novel compounds
PCT/EP2007/050992 WO2007088190A1 (en) 2006-02-03 2007-02-01 Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as ep4 receptor agonists

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GB0623203D0 (en) * 2006-11-21 2007-01-03 Glaxo Group Ltd Novel compounds
CN101686985A (zh) 2007-05-08 2010-03-31 国立大学法人浜松医科大学 含有ep4激动剂的细胞毒性t细胞的活化剂
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CN103012111B (zh) * 2012-09-12 2016-01-13 衢州学院 一种2,4,5-三氟苯乙酸的制备方法
CN110003129B (zh) * 2019-04-18 2021-04-06 济南立德医药技术有限公司 一种佐米曲普坦中间体的制备方法

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US8252833B2 (en) 2012-08-28
AU2007211484A1 (en) 2007-08-09
JP2009525309A (ja) 2009-07-09
JP2013082734A (ja) 2013-05-09
EP1979316A1 (en) 2008-10-15
CA2640277A1 (en) 2007-08-09
KR20080097417A (ko) 2008-11-05
MA30209B1 (fr) 2009-02-02
US20110201663A1 (en) 2011-08-18
BRPI0708024A2 (pt) 2011-05-17
ES2390491T3 (es) 2012-11-13
JP5250427B2 (ja) 2013-07-31
CR10207A (es) 2008-09-22
IL192934A0 (en) 2009-02-11
WO2007088190A1 (en) 2007-08-09
TW200808722A (en) 2008-02-16
EP1979316B1 (en) 2012-07-11
PE20070949A1 (es) 2007-11-22
UY30121A1 (es) 2007-08-31
AR059282A1 (es) 2008-03-19
NO20083448L (no) 2008-10-23
EP2457897A1 (en) 2012-05-30
SG169380A1 (en) 2011-03-30

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