AR059282A1 - Derivados del acido 1,3-dihidro-2h-benzo[f]isoindol acetico, metodo de preparacion, composiciones farmaceuticas que los contienen y usos terapeuticos como agonistas de receptores ep4. - Google Patents
Derivados del acido 1,3-dihidro-2h-benzo[f]isoindol acetico, metodo de preparacion, composiciones farmaceuticas que los contienen y usos terapeuticos como agonistas de receptores ep4.Info
- Publication number
- AR059282A1 AR059282A1 ARP070100429A ARP070100429A AR059282A1 AR 059282 A1 AR059282 A1 AR 059282A1 AR P070100429 A ARP070100429 A AR P070100429A AR P070100429 A ARP070100429 A AR P070100429A AR 059282 A1 AR059282 A1 AR 059282A1
- Authority
- AR
- Argentina
- Prior art keywords
- benzo
- derivatives
- dihidro
- isoindol
- agonists
- Prior art date
Links
- VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 title 1
- QKDLQFSLLCQTOH-UHFFFAOYSA-N Trichodonin Natural products C1C(O)C2C3(COC(=O)C)C(C=O)C(C)(C)CCC3OC(=O)C22C(=O)C(=C)C1C2 QKDLQFSLLCQTOH-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- -1 1,3-dihydro-2H-benzo [f] isoindole compound Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- Psychology (AREA)
Abstract
Reivindicacion 1: Un compuesto de 1,3-dihidro-2H-benzo[f]isoindol caracterizado porque es de la formula (1) o uno de sus derivados farmacéuticamente aceptables, en la que, R1 y R2 representan independientemente alquilo C1-4, R3, R4, R5 y R6 representan independientemente H o F, con la condicion de que, al menos uno de R3 y R4 representa H, al menos uno de R5 y R6 representa H, y al menos uno de R3, R4, R5 y R6 representa F; y X e Y representan independientemente CH2 o C=O, con la condicion de que al menos uno de X e Y representa C=O.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0602237A GB0602237D0 (en) | 2006-02-03 | 2006-02-03 | Novel compounds |
GB0608976A GB0608976D0 (en) | 2006-05-05 | 2006-05-05 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
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AR059282A1 true AR059282A1 (es) | 2008-03-19 |
Family
ID=37944208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100429A AR059282A1 (es) | 2006-02-03 | 2007-02-01 | Derivados del acido 1,3-dihidro-2h-benzo[f]isoindol acetico, metodo de preparacion, composiciones farmaceuticas que los contienen y usos terapeuticos como agonistas de receptores ep4. |
Country Status (19)
Country | Link |
---|---|
US (1) | US8252833B2 (es) |
EP (2) | EP2457897A1 (es) |
JP (2) | JP5250427B2 (es) |
KR (1) | KR20080097417A (es) |
AR (1) | AR059282A1 (es) |
AU (1) | AU2007211484A1 (es) |
BR (1) | BRPI0708024A2 (es) |
CA (1) | CA2640277A1 (es) |
CR (1) | CR10207A (es) |
EA (1) | EA200870224A1 (es) |
ES (1) | ES2390491T3 (es) |
IL (1) | IL192934A0 (es) |
MA (1) | MA30209B1 (es) |
NO (1) | NO20083448L (es) |
PE (1) | PE20070949A1 (es) |
SG (1) | SG169380A1 (es) |
TW (1) | TW200808722A (es) |
UY (1) | UY30121A1 (es) |
WO (1) | WO2007088190A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2027087A2 (en) * | 2006-05-18 | 2009-02-25 | MannKind Corporation | Intracellular kinase inhibitors |
GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
GB0620619D0 (en) * | 2006-10-17 | 2006-11-29 | Glaxo Group Ltd | Novel compounds |
GB0623203D0 (en) * | 2006-11-21 | 2007-01-03 | Glaxo Group Ltd | Novel compounds |
WO2008136519A1 (ja) | 2007-05-08 | 2008-11-13 | National University Corporation, Hamamatsu University School Of Medicine | Ep4アゴニストを含有してなる細胞傷害性t細胞の活性化剤 |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
CN103012111B (zh) * | 2012-09-12 | 2016-01-13 | 衢州学院 | 一种2,4,5-三氟苯乙酸的制备方法 |
CN110003129B (zh) * | 2019-04-18 | 2021-04-06 | 济南立德医药技术有限公司 | 一种佐米曲普坦中间体的制备方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT947165B (it) | 1971-05-17 | 1973-05-21 | Grefco | Composizioni e processo per la eliminazione selettiva di prodot ti oleosi dall acqua |
JPH10265454A (ja) | 1997-01-27 | 1998-10-06 | Ono Pharmaceut Co Ltd | 3,7−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
AUPO713297A0 (en) | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
US6043275A (en) | 1998-04-16 | 2000-03-28 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
TWI249520B (en) | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
US6586468B1 (en) | 1998-09-14 | 2003-07-01 | Ono Pharmaceutical Co., Ltd. | ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient |
AUPP608898A0 (en) | 1998-09-23 | 1998-10-15 | Fujisawa Pharmaceutical Co., Ltd. | New use of prostaglandin E2 antagonists |
US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
EP1148877A4 (en) | 1998-10-15 | 2003-01-22 | Merck & Co Inc | METHOD FOR INHIBITING BONE RESORPTION |
ES2274378T3 (es) * | 1999-08-10 | 2007-05-16 | Glaxo Group Limited | Ligando del receptor ep4 y uso contra dolor neuropatico, cancer de colon,hiv y migraña. |
GB0030541D0 (en) | 2000-12-14 | 2001-01-31 | Glaxo Group Ltd | Medical uses |
GB0031295D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
GB0031315D0 (en) | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
GB0031302D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
GB0103269D0 (en) * | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
DE60307607T2 (de) | 2002-03-18 | 2007-08-09 | Pfizer Products Inc., Groton | Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten |
NZ535748A (en) | 2002-04-12 | 2007-06-29 | Pfizer | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases |
CA2483555A1 (en) | 2002-06-10 | 2003-12-18 | Applied Research Systems Ars Holding N.V. | Gamma lactams as prostaglandin agonists and use thereof |
CA2491156A1 (en) | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company Llc | Inhibitors of hcv ns5b polymerase |
WO2004037813A1 (en) | 2002-10-25 | 2004-05-06 | Merck Frosst Canada & Co. | Pyrrolidin-2-on derivatives as ep4 receptor agonists |
US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
DK1603893T3 (da) | 2003-01-29 | 2008-09-08 | Asterand Uk Ltd | EP4 -Receptorantagonister |
BRPI0414130B8 (pt) | 2003-09-03 | 2021-05-25 | Askat Inc | compostos de fenilamida ou piridilamida, seu uso e composições farmacêuticas que os compreendem. |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
EP1723132A1 (en) | 2004-02-12 | 2006-11-22 | Asterand Uk Limited | Ep2 receptor agonists |
AU2005238291A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Inc. | Substituted methyl aryl or heteroaryl amide compounds |
WO2005105733A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Japan Inc. | Ortho substituted aryl or heteroaryl amide compounds |
WO2005116010A1 (en) | 2004-05-26 | 2005-12-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
US8013159B2 (en) | 2005-05-19 | 2011-09-06 | Merck Canada Inc. | Quinoline derivatives as EP4 antagonists |
GB0602900D0 (en) * | 2006-02-13 | 2006-03-22 | Glaxo Group Ltd | Novel Compounds |
-
2007
- 2007-01-30 UY UY30121A patent/UY30121A1/es not_active Application Discontinuation
- 2007-02-01 ES ES07704313T patent/ES2390491T3/es active Active
- 2007-02-01 CA CA002640277A patent/CA2640277A1/en not_active Abandoned
- 2007-02-01 WO PCT/EP2007/050992 patent/WO2007088190A1/en active Application Filing
- 2007-02-01 EP EP12154482A patent/EP2457897A1/en not_active Withdrawn
- 2007-02-01 AR ARP070100429A patent/AR059282A1/es not_active Application Discontinuation
- 2007-02-01 PE PE2007000114A patent/PE20070949A1/es not_active Application Discontinuation
- 2007-02-01 US US12/278,019 patent/US8252833B2/en not_active Expired - Fee Related
- 2007-02-01 KR KR1020087018920A patent/KR20080097417A/ko not_active Application Discontinuation
- 2007-02-01 EP EP07704313A patent/EP1979316B1/en active Active
- 2007-02-01 EA EA200870224A patent/EA200870224A1/ru unknown
- 2007-02-01 AU AU2007211484A patent/AU2007211484A1/en not_active Abandoned
- 2007-02-01 SG SG201100788-7A patent/SG169380A1/en unknown
- 2007-02-01 JP JP2008552809A patent/JP5250427B2/ja not_active Expired - Fee Related
- 2007-02-01 TW TW096103620A patent/TW200808722A/zh unknown
- 2007-02-01 BR BRPI0708024-7A patent/BRPI0708024A2/pt not_active IP Right Cessation
-
2008
- 2008-07-21 IL IL192934A patent/IL192934A0/en unknown
- 2008-08-06 MA MA31159A patent/MA30209B1/fr unknown
- 2008-08-07 NO NO20083448A patent/NO20083448L/no not_active Application Discontinuation
- 2008-08-14 CR CR10207A patent/CR10207A/es unknown
-
2013
- 2013-01-04 JP JP2013000193A patent/JP2013082734A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP2457897A1 (en) | 2012-05-30 |
US20110201663A1 (en) | 2011-08-18 |
EP1979316A1 (en) | 2008-10-15 |
US8252833B2 (en) | 2012-08-28 |
IL192934A0 (en) | 2009-02-11 |
AU2007211484A1 (en) | 2007-08-09 |
NO20083448L (no) | 2008-10-23 |
KR20080097417A (ko) | 2008-11-05 |
BRPI0708024A2 (pt) | 2011-05-17 |
MA30209B1 (fr) | 2009-02-02 |
ES2390491T3 (es) | 2012-11-13 |
EP1979316B1 (en) | 2012-07-11 |
CA2640277A1 (en) | 2007-08-09 |
UY30121A1 (es) | 2007-08-31 |
EA200870224A1 (ru) | 2009-02-27 |
JP2013082734A (ja) | 2013-05-09 |
JP2009525309A (ja) | 2009-07-09 |
PE20070949A1 (es) | 2007-11-22 |
JP5250427B2 (ja) | 2013-07-31 |
CR10207A (es) | 2008-09-22 |
WO2007088190A1 (en) | 2007-08-09 |
SG169380A1 (en) | 2011-03-30 |
TW200808722A (en) | 2008-02-16 |
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