PE20070221A1 - Inhibidores macrociclicos del virus de la hepatitis c - Google Patents

Inhibidores macrociclicos del virus de la hepatitis c

Info

Publication number
PE20070221A1
PE20070221A1 PE2006000917A PE2006000917A PE20070221A1 PE 20070221 A1 PE20070221 A1 PE 20070221A1 PE 2006000917 A PE2006000917 A PE 2006000917A PE 2006000917 A PE2006000917 A PE 2006000917A PE 20070221 A1 PE20070221 A1 PE 20070221A1
Authority
PE
Peru
Prior art keywords
hepatitis
virus
metoxyquinolin
diazatriciclo
iloxi
Prior art date
Application number
PE2006000917A
Other languages
English (en)
Spanish (es)
Inventor
Kenneth Simmen
Kock Herman De
Pierre Raboisson
Lili Hu
David Mcgowan
Dominique Surleraux
Abdellah Tahri
De Vreken Wim Van
Sandrine Vendeville
Original Assignee
Medivir Ab
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37036843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070221(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medivir Ab, Tibotec Pharm Ltd filed Critical Medivir Ab
Publication of PE20070221A1 publication Critical patent/PE20070221A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
PE2006000917A 2005-07-29 2006-07-26 Inhibidores macrociclicos del virus de la hepatitis c PE20070221A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05107067 2005-07-29
EP05107413 2005-08-11

Publications (1)

Publication Number Publication Date
PE20070221A1 true PE20070221A1 (es) 2007-04-16

Family

ID=37036843

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000917A PE20070221A1 (es) 2005-07-29 2006-07-26 Inhibidores macrociclicos del virus de la hepatitis c

Country Status (28)

Country Link
US (1) US7989471B2 (fr)
EP (1) EP1912995B1 (fr)
JP (1) JP5426163B2 (fr)
KR (1) KR101074673B1 (fr)
CN (1) CN101233137B (fr)
AP (1) AP2473A (fr)
AR (1) AR055104A1 (fr)
AT (1) ATE517902T1 (fr)
AU (1) AU2006274858B2 (fr)
BR (1) BRPI0614670A2 (fr)
CA (1) CA2617095C (fr)
DK (1) DK1912995T3 (fr)
EA (1) EA014646B1 (fr)
GT (1) GT200600341A (fr)
HK (1) HK1116772A1 (fr)
IL (1) IL188283A (fr)
JO (1) JO2768B1 (fr)
MX (1) MX2008001395A (fr)
MY (1) MY152153A (fr)
NO (1) NO20081071L (fr)
NZ (1) NZ564541A (fr)
PE (1) PE20070221A1 (fr)
SG (1) SG163613A1 (fr)
SI (1) SI1912995T1 (fr)
SV (1) SV2008002639A (fr)
TW (1) TWI412534B (fr)
UY (1) UY29705A1 (fr)
WO (1) WO2007014919A1 (fr)

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PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20090024834A (ko) * 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
WO2008008776A2 (fr) 2006-07-11 2008-01-17 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
EA017448B1 (ru) 2006-07-13 2012-12-28 Ачиллион Фармасьютикалз, Инк. 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2008070358A2 (fr) * 2006-11-16 2008-06-12 Phenomix Corporation Inhibiteurs de la sérine protéase de l'hépatite c et utilisations de ceux-ci
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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EP2118091B1 (fr) * 2007-02-08 2015-04-15 Janssen Sciences Ireland UC Inhibiteurs macrocycliques du virus de l'hépatite c (vhc) substitués par pyrimidine
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US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
WO2009064955A1 (fr) 2007-11-14 2009-05-22 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques à radical tétrazolyle de la sérine protéase du virus de l'hépatite c
WO2009079353A1 (fr) 2007-12-14 2009-06-25 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques contenant du triazole des protéases à sérine du vhc
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
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US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
SI2364309T1 (sl) 2008-12-10 2015-03-31 Achillion Pharmaceuticals, Inc. Novi 4-amino-4-oksobutanoil peptidi kot inhibitorji virusne replikacije
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8377962B2 (en) * 2009-04-08 2013-02-19 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
CN101987825B (zh) * 2009-07-31 2014-04-02 上海开拓者医药发展有限公司 一种2-氨基-3-甲基-4-甲氧基苯乙酮的制备方法
AR077712A1 (es) 2009-08-05 2011-09-14 Idenix Pharmaceuticals Inc Inhibidores de serina proteasa macrociclica
AU2011352145A1 (en) 2010-12-30 2013-07-18 Abbvie Inc. Phenanthridine macrocyclic hepatitis C serine protease inhibitors
MX2013007677A (es) 2010-12-30 2013-07-30 Abbvie Inc Inhibidores macrociclicos de serina proteasa de hepatitis.
WO2012109398A1 (fr) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Inhibiteurs macrocycliques de sérine protéase, compositions pharmaceutiques les contenant et leur utilisation pour le traitement des infections par le vhc
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MX355102B (es) * 2012-01-11 2018-04-05 Abbvie Ireland Unlimited Co Procesos para hacer los inhibidores de la proteasa del hcv.
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MX360452B (es) 2012-10-19 2018-11-01 Bristol Myers Squibb Co Inhibidores del virus de la hepatitis c.
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014071007A1 (fr) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2014070974A1 (fr) 2012-11-05 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2014137869A1 (fr) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
EA201591722A1 (ru) 2013-03-14 2016-02-29 Ачиллион Фармасьютикалз, Инк. Новые способы получения совапревира
US9006423B2 (en) 2013-03-15 2015-04-14 Achillion Pharmaceuticals Inc. Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2014145600A1 (fr) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. Polymorphes de sel de sodium d'ach-0142684, composition les comprenant, et leur procédé de fabrication
KR20160005686A (ko) 2013-03-15 2016-01-15 아칠리온 파르마세우티칼스 인코포레이티드 소바프레비르 다형체들 및 이의 제조 방법
EP3089757A1 (fr) 2014-01-03 2016-11-09 AbbVie Inc. Formes galéniques antivirales solides
MA41812A (fr) * 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

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Also Published As

Publication number Publication date
US7989471B2 (en) 2011-08-02
IL188283A (en) 2016-12-29
TWI412534B (zh) 2013-10-21
SV2008002639A (es) 2008-07-23
EP1912995A1 (fr) 2008-04-23
EA200800484A1 (ru) 2008-06-30
EA014646B1 (ru) 2010-12-30
NZ564541A (en) 2010-03-26
AU2006274858B2 (en) 2012-05-24
CA2617095A1 (fr) 2007-02-08
KR20080041651A (ko) 2008-05-13
AP2473A (en) 2012-09-24
TW200745165A (en) 2007-12-16
JO2768B1 (en) 2014-03-15
MY152153A (en) 2014-08-15
EP1912995B1 (fr) 2011-07-27
GT200600341A (es) 2007-02-26
IL188283A0 (en) 2008-04-13
JP2009502882A (ja) 2009-01-29
US20100240698A1 (en) 2010-09-23
UY29705A1 (es) 2007-05-31
MX2008001395A (es) 2008-04-16
DK1912995T3 (da) 2011-10-24
CN101233137A (zh) 2008-07-30
BRPI0614670A2 (pt) 2011-04-12
AU2006274858A1 (en) 2007-02-08
WO2007014919A1 (fr) 2007-02-08
KR101074673B1 (ko) 2011-10-19
JP5426163B2 (ja) 2014-02-26
HK1116772A1 (en) 2009-01-02
ATE517902T1 (de) 2011-08-15
NO20081071L (no) 2008-04-25
CA2617095C (fr) 2014-05-13
SG163613A1 (en) 2010-08-30
CN101233137B (zh) 2014-05-07
AR055104A1 (es) 2007-08-08
SI1912995T1 (sl) 2011-11-30

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