DK1912995T3 - Makrocykliske inhibitorer af hepatitis C virus - Google Patents

Makrocykliske inhibitorer af hepatitis C virus

Info

Publication number
DK1912995T3
DK1912995T3 DK06764264.5T DK06764264T DK1912995T3 DK 1912995 T3 DK1912995 T3 DK 1912995T3 DK 06764264 T DK06764264 T DK 06764264T DK 1912995 T3 DK1912995 T3 DK 1912995T3
Authority
DK
Denmark
Prior art keywords
hepatitis
virus
macrocyclic inhibitors
macrocyclic
inhibitors
Prior art date
Application number
DK06764264.5T
Other languages
English (en)
Inventor
Lili Hu
Pierre Jean-Marie Bernard Raboisson
Kock Herman Augustinus De
Sandrine Marie Helene Vendeville
Gowan David Craig Mc
Abdellah Tahri
Dominique Louis Nestor Ghislain Surleraux
Kenneth Alan Simmen
De Vreken Wim Van
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37036843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1912995(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1912995T3 publication Critical patent/DK1912995T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK06764264.5T 2005-07-29 2006-07-28 Makrocykliske inhibitorer af hepatitis C virus DK1912995T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107067 2005-07-29
EP05107413 2005-08-11
PCT/EP2006/064813 WO2007014919A1 (en) 2005-07-29 2006-07-28 Macrocylic inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
DK1912995T3 true DK1912995T3 (da) 2011-10-24

Family

ID=37036843

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06764264.5T DK1912995T3 (da) 2005-07-29 2006-07-28 Makrocykliske inhibitorer af hepatitis C virus

Country Status (28)

Country Link
US (1) US7989471B2 (da)
EP (1) EP1912995B1 (da)
JP (1) JP5426163B2 (da)
KR (1) KR101074673B1 (da)
CN (1) CN101233137B (da)
AP (1) AP2473A (da)
AR (1) AR055104A1 (da)
AT (1) ATE517902T1 (da)
AU (1) AU2006274858B2 (da)
BR (1) BRPI0614670A2 (da)
CA (1) CA2617095C (da)
DK (1) DK1912995T3 (da)
EA (1) EA014646B1 (da)
GT (1) GT200600341A (da)
HK (1) HK1116772A1 (da)
IL (1) IL188283A (da)
JO (1) JO2768B1 (da)
MX (1) MX2008001395A (da)
MY (1) MY152153A (da)
NO (1) NO20081071L (da)
NZ (1) NZ564541A (da)
PE (1) PE20070221A1 (da)
SG (1) SG163613A1 (da)
SI (1) SI1912995T1 (da)
SV (1) SV2008002639A (da)
TW (1) TWI412534B (da)
UY (1) UY29705A1 (da)
WO (1) WO2007014919A1 (da)

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EP2049474B1 (en) 2006-07-11 2015-11-04 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2008008502A1 (en) 2006-07-13 2008-01-17 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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AU2008205116A1 (en) * 2007-01-08 2008-07-17 Phenomix Corporation Macrocyclic hepatitis C protease inhibitors
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US8937080B2 (en) 2007-02-08 2015-01-20 Medivir Ab Pyrimidine substituted macrocyclic HCV inhibitors
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CA2719008A1 (en) 2008-03-20 2009-09-24 Enanta Pharmaceuticals, Inc. Fluorinated macrocyclic compounds as hepatitis c virus inhibitors
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2364309E (pt) 2008-12-10 2015-01-14 Achillion Pharmaceuticals Inc Novos péptidos 4-amino-4-oxobutanoil como inibidores de replicação viral
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
CN101987825B (zh) * 2009-07-31 2014-04-02 上海开拓者医药发展有限公司 一种2-氨基-3-甲基-4-甲氧基苯乙酮的制备方法
WO2011017389A1 (en) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
EP2658858A4 (en) 2010-12-30 2014-06-25 Enanta Pharm Inc MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE
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US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
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CN107964006A (zh) * 2012-01-11 2018-04-27 艾伯维公司 用于制备hcv蛋白酶抑制剂的方法
US20140100364A1 (en) 2012-10-08 2014-04-10 Abbvie Inc. Compounds Useful For Making HCV Protease Inhibitors
PT2909205T (pt) 2012-10-19 2017-02-06 Bristol Myers Squibb Co Derivados de carbamato de hexadecahidrociclopropa(e)pirrolo(1,2- a)(1,4)diazaciclopentadecinilo substituídos com 9-metilo como inibidores da protease não estrutural 3 (ns3) para o tratamento de infeções por vírus da hepatite c
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
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US9006423B2 (en) 2013-03-15 2015-04-14 Achillion Pharmaceuticals Inc. Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
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WO2014145600A1 (en) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof
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Also Published As

Publication number Publication date
IL188283A (en) 2016-12-29
AU2006274858A1 (en) 2007-02-08
NO20081071L (no) 2008-04-25
SI1912995T1 (sl) 2011-11-30
JO2768B1 (en) 2014-03-15
SG163613A1 (en) 2010-08-30
CN101233137B (zh) 2014-05-07
KR101074673B1 (ko) 2011-10-19
SV2008002639A (es) 2008-07-23
IL188283A0 (en) 2008-04-13
BRPI0614670A2 (pt) 2011-04-12
NZ564541A (en) 2010-03-26
TWI412534B (zh) 2013-10-21
JP2009502882A (ja) 2009-01-29
AU2006274858B2 (en) 2012-05-24
KR20080041651A (ko) 2008-05-13
PE20070221A1 (es) 2007-04-16
EA014646B1 (ru) 2010-12-30
US20100240698A1 (en) 2010-09-23
GT200600341A (es) 2007-02-26
CA2617095A1 (en) 2007-02-08
MX2008001395A (es) 2008-04-16
AP2473A (en) 2012-09-24
EP1912995B1 (en) 2011-07-27
TW200745165A (en) 2007-12-16
US7989471B2 (en) 2011-08-02
UY29705A1 (es) 2007-05-31
CA2617095C (en) 2014-05-13
WO2007014919A1 (en) 2007-02-08
MY152153A (en) 2014-08-15
CN101233137A (zh) 2008-07-30
AR055104A1 (es) 2007-08-08
EP1912995A1 (en) 2008-04-23
HK1116772A1 (en) 2009-01-02
ATE517902T1 (de) 2011-08-15
JP5426163B2 (ja) 2014-02-26
EA200800484A1 (ru) 2008-06-30

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