EA200800484A1 - Макроциклические ингибиторы вируса гепатита с - Google Patents

Макроциклические ингибиторы вируса гепатита с

Info

Publication number
EA200800484A1
EA200800484A1 EA200800484A EA200800484A EA200800484A1 EA 200800484 A1 EA200800484 A1 EA 200800484A1 EA 200800484 A EA200800484 A EA 200800484A EA 200800484 A EA200800484 A EA 200800484A EA 200800484 A1 EA200800484 A1 EA 200800484A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optionally
ring
substituted
salkanediyl
nrr
Prior art date
Application number
EA200800484A
Other languages
English (en)
Other versions
EA014646B1 (ru
Inventor
Пьер Жан-Мари Бернар Рабуассон
Херман Аугустинус Де Кок
Сандрин Мари Элен Вендевилль
Лили Ху
Вим Ван Де Фрейкен
Дэвид Крейг Мак Гоуен
Абделлах Тахри
Доминик Луи Нестор Гилэйн Сюрлеро
Кеннет Алан Симмен
Original Assignee
Тиботек Фармасьютикалз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37036843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800484(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тиботек Фармасьютикалз Лтд. filed Critical Тиботек Фармасьютикалз Лтд.
Publication of EA200800484A1 publication Critical patent/EA200800484A1/ru
Publication of EA014646B1 publication Critical patent/EA014646B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Abstract

Предложены ингибиторы HCV формулы (I) и их N-оксиды, соли и стереохимически изомерные формы, где Rпредставляет собой арил или насыщенную, частично ненасыщенную или полностью ненасыщенную 5- или 6-членную моноциклическую или 9-12-членную бициклическую гетероциклическую кольцевую систему, содержащую один атом азота и необязательно от одного до трех атомов кислорода, серы и азота, где указанная кольцевая система может быть необязательно замещена; L представляет собой прямую связь, -О-, -O-Салкандиил-, -O-СО-, -O-С(=O)-NR- или -O-С(=O)-NR-Салкандиил-; Rпредставляет собой водород, -OR, -С(О)OR, -C(=O)R, -C(=O)NRR, -C(=O)NHR, -NRR, -NHR, -NHSONRR, -NRSORили -В(OR); Rи Rпредставляют собой водород или Cалкил; или Rи Rвместе могут образовывать Сциклоалкильное кольцо; n равен 3, 4, 5 или 6; р равен 1 или 2; арил представляет собой фенил, нафтил, индалил или 1,2,3,4-тетрагидронафтил, каждый из которых может быть необязательно замещен, Het представляет собой 5- или 6-членное насыщенное, частично ненасыщенное или полностью ненасыщенное гетероциклическое кольцо, содержащее 1-4 гетероатома, каждый независимо выбранный из азота, кислорода и серы, где кольцо необязательно конденсировано с бензольным кольцом, и где группа Het, в целом, может быть необязательно замещена; фармацевтические композиции, содержащие соединения (I), и способы получения соединений (I). Также предложены биодоступные комбинации ингибиторов HCV формулы (I) с ритонавиром.
EA200800484A 2005-07-29 2006-07-28 Макроциклические ингибиторы вируса гепатита с EA014646B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107067 2005-07-29
EP05107413 2005-08-11
PCT/EP2006/064813 WO2007014919A1 (en) 2005-07-29 2006-07-28 Macrocylic inhibitors of hepatitis c virus

Publications (2)

Publication Number Publication Date
EA200800484A1 true EA200800484A1 (ru) 2008-06-30
EA014646B1 EA014646B1 (ru) 2010-12-30

Family

ID=37036843

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800484A EA014646B1 (ru) 2005-07-29 2006-07-28 Макроциклические ингибиторы вируса гепатита с

Country Status (28)

Country Link
US (1) US7989471B2 (ru)
EP (1) EP1912995B1 (ru)
JP (1) JP5426163B2 (ru)
KR (1) KR101074673B1 (ru)
CN (1) CN101233137B (ru)
AP (1) AP2473A (ru)
AR (1) AR055104A1 (ru)
AT (1) ATE517902T1 (ru)
AU (1) AU2006274858B2 (ru)
BR (1) BRPI0614670A2 (ru)
CA (1) CA2617095C (ru)
DK (1) DK1912995T3 (ru)
EA (1) EA014646B1 (ru)
GT (1) GT200600341A (ru)
HK (1) HK1116772A1 (ru)
IL (1) IL188283A (ru)
JO (1) JO2768B1 (ru)
MX (1) MX2008001395A (ru)
MY (1) MY152153A (ru)
NO (1) NO20081071L (ru)
NZ (1) NZ564541A (ru)
PE (1) PE20070221A1 (ru)
SG (1) SG163613A1 (ru)
SI (1) SI1912995T1 (ru)
SV (1) SV2008002639A (ru)
TW (1) TWI412534B (ru)
UY (1) UY29705A1 (ru)
WO (1) WO2007014919A1 (ru)

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Also Published As

Publication number Publication date
IL188283A (en) 2016-12-29
AU2006274858A1 (en) 2007-02-08
NO20081071L (no) 2008-04-25
SI1912995T1 (sl) 2011-11-30
JO2768B1 (en) 2014-03-15
SG163613A1 (en) 2010-08-30
CN101233137B (zh) 2014-05-07
KR101074673B1 (ko) 2011-10-19
SV2008002639A (es) 2008-07-23
IL188283A0 (en) 2008-04-13
BRPI0614670A2 (pt) 2011-04-12
NZ564541A (en) 2010-03-26
TWI412534B (zh) 2013-10-21
JP2009502882A (ja) 2009-01-29
AU2006274858B2 (en) 2012-05-24
KR20080041651A (ko) 2008-05-13
PE20070221A1 (es) 2007-04-16
EA014646B1 (ru) 2010-12-30
US20100240698A1 (en) 2010-09-23
GT200600341A (es) 2007-02-26
CA2617095A1 (en) 2007-02-08
MX2008001395A (es) 2008-04-16
AP2473A (en) 2012-09-24
EP1912995B1 (en) 2011-07-27
TW200745165A (en) 2007-12-16
US7989471B2 (en) 2011-08-02
UY29705A1 (es) 2007-05-31
CA2617095C (en) 2014-05-13
WO2007014919A1 (en) 2007-02-08
DK1912995T3 (da) 2011-10-24
MY152153A (en) 2014-08-15
CN101233137A (zh) 2008-07-30
AR055104A1 (es) 2007-08-08
EP1912995A1 (en) 2008-04-23
HK1116772A1 (en) 2009-01-02
ATE517902T1 (de) 2011-08-15
JP5426163B2 (ja) 2014-02-26

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PC4A Registration of transfer of a eurasian patent by assignment
TC4A Change in name of a patent proprietor in a eurasian patent
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU