WO2004072243A3 - Inhibiteurs macrocycliques de la serine protease de l'hepatite c - Google Patents

Inhibiteurs macrocycliques de la serine protease de l'hepatite c Download PDF

Info

Publication number
WO2004072243A3
WO2004072243A3 PCT/US2004/003479 US2004003479W WO2004072243A3 WO 2004072243 A3 WO2004072243 A3 WO 2004072243A3 US 2004003479 W US2004003479 W US 2004003479W WO 2004072243 A3 WO2004072243 A3 WO 2004072243A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
present
hepatitis
serine protease
relates
Prior art date
Application number
PCT/US2004/003479
Other languages
English (en)
Other versions
WO2004072243A2 (fr
Inventor
Zenwei Miao
Ying Sun
Frank Wu
Suanne Nakajima
Guoyou Xu
Yat Sun Or
Zhe Wang
Original Assignee
Enanta Pharm Inc
Zenwei Miao
Ying Sun
Frank Wu
Suanne Nakajima
Guoyou Xu
Yat Sun Or
Zhe Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/384,120 external-priority patent/US20040180815A1/en
Application filed by Enanta Pharm Inc, Zenwei Miao, Ying Sun, Frank Wu, Suanne Nakajima, Guoyou Xu, Yat Sun Or, Zhe Wang filed Critical Enanta Pharm Inc
Priority to CNA2004800092686A priority Critical patent/CN1771050A/zh
Priority to EP04709020A priority patent/EP1590442A4/fr
Priority to AU2004211637A priority patent/AU2004211637C1/en
Priority to JP2006503381A priority patent/JP2007524576A/ja
Priority to CA002515216A priority patent/CA2515216A1/fr
Publication of WO2004072243A2 publication Critical patent/WO2004072243A2/fr
Publication of WO2004072243A3 publication Critical patent/WO2004072243A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des composés de la formule (I, II ou III), ou un sel, un ester ou un promédicament pharmaceutiquement acceptable de ceux-ci, dans laquelle W représente un système de noyau hétérocyclique substitué ou non substitué. Ces composés inhibent l'activité de la sérine protéase, en particulier celle de la protéase du virus de l'hépatite C (VHC) NS3-NS4A. En conséquence, ces composés, qui interfèrent avec le cycle de vie du virus de l'hépatite C, sont également utiles en tant qu'antiviraux. L'invention concerne également des compositions pharmaceutiques comprenant les composés précités à administrer au patient souffrant d'une infection du VHC. L'invention concerne en outre des procédés de traitement d'une infection du VHC chez un patient par administration d'une composition pharmaceutique comprenant lesdits composés.
PCT/US2004/003479 2003-02-07 2004-02-06 Inhibiteurs macrocycliques de la serine protease de l'hepatite c WO2004072243A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CNA2004800092686A CN1771050A (zh) 2003-02-07 2004-02-06 丙型肝炎丝氨酸蛋白酶的大环抑制剂
EP04709020A EP1590442A4 (fr) 2003-02-07 2004-02-06 Inhibiteurs macrocycliques de la serine protease de l'hepatite c
AU2004211637A AU2004211637C1 (en) 2003-02-07 2004-02-06 Macrocyclic hepatitis C serine protease inhibitors
JP2006503381A JP2007524576A (ja) 2003-02-07 2004-02-06 大環状のｃ型肝炎セリンプロテアーゼ阻害剤
CA002515216A CA2515216A1 (fr) 2003-02-07 2004-02-06 Inhibiteurs macrocycliques de la serine protease de l'hepatite c

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US36094703A 2003-02-07 2003-02-07
US10/360,947 2003-02-07
US36585403A 2003-02-13 2003-02-13
US10/365,854 2003-02-13
US10/384,120 US20040180815A1 (en) 2003-03-07 2003-03-07 Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
US10/384,120 2003-03-07

Publications (2)

Publication Number Publication Date
WO2004072243A2 WO2004072243A2 (fr) 2004-08-26
WO2004072243A3 true WO2004072243A3 (fr) 2005-11-03

Family

ID=32872697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/003479 WO2004072243A2 (fr) 2003-02-07 2004-02-06 Inhibiteurs macrocycliques de la serine protease de l'hepatite c

Country Status (7)

Country Link
EP (1) EP1590442A4 (fr)
JP (1) JP2007524576A (fr)
KR (1) KR100940619B1 (fr)
CN (1) CN1771050A (fr)
AU (1) AU2004211637C1 (fr)
CA (1) CA2515216A1 (fr)
WO (1) WO2004072243A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227742B1 (en) 1996-10-18 2012-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7601709B2 (en) 2003-02-07 2009-10-13 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
US7176208B2 (en) 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
WO2004113365A2 (fr) * 2003-06-05 2004-12-29 Enanta Pharmaceuticals, Inc. Inhibiteurs de la tripeptide hepatite c serine protease
US7273851B2 (en) 2003-06-05 2007-09-25 Enanta Pharmaceuticals, Inc. Tri-peptide hepatitis C serine protease inhibitors
US7125845B2 (en) 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
DE602004031298D1 (de) 2003-09-26 2011-03-17 Schering Corp Makrocyclische inhibitoren der ns3-serinprotease des hepatitis-c-virus
EP1692157B1 (fr) 2003-10-10 2013-04-17 Vertex Pharmaceuticals Incorporated Inhibiteurs de serine proteases, en particulier la ns3-ns4a protease du hcv
NZ548740A (en) 2004-01-30 2010-06-25 Medivir Ab HCV NS-3 Serine protease inhibitors
JP2008505849A (ja) * 2004-02-04 2008-02-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド セリンプロテアーゼ、特に、ｈｃｖ、ｎｓ３−ｎｓ４ａプロテアーゼの阻害剤
DK1718608T3 (da) 2004-02-20 2013-10-14 Boehringer Ingelheim Int Virale polymeraseinhibitorer
US7385028B2 (en) * 2004-12-22 2008-06-10 Ambrx, Inc Derivatization of non-natural amino acids and polypeptides
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2006096652A2 (fr) * 2005-03-08 2006-09-14 Boehringer Ingelheim International Gmbh Preparation de composes macrocycliques
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7470664B2 (en) * 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
SG166791A1 (en) 2005-07-25 2010-12-29 Intermune Inc Novel macrocyclic inhibitors of hepatitis c virus replication
ES2373685T3 (es) 2005-07-29 2012-02-07 Tibotec Pharmaceuticals Inhibidores macrocíclicos del virus de la hepatitis c.
TWI383980B (zh) 2005-07-29 2013-02-01 Tibotec Pharm Ltd Ｃ型肝炎病毒之大環抑制劑
TWI393723B (zh) 2005-07-29 2013-04-21 Tibotec Pharm Ltd Ｃ型肝炎病毒之大環抑制劑（九）
MY142972A (en) 2005-07-29 2011-01-31 Tibotec Pharm Ltd Macrocyclic inhibitors of hepatitis c virus
PE20070343A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Inhibidores macrociclicos del virus de la hepatitis c
BRPI0614620A2 (pt) 2005-07-29 2011-04-12 Tibotec Pharm Ltd compostos inibidores macrocìclicos do vìrus da hepatite c, uso dos mesmos, processo para preparar os referidos compostos, combinação e composição farmacêutica
CA2617096C (fr) 2005-07-29 2013-12-24 Tibotec Pharmaceuticals Ltd. Inhibiteurs macrocycliques du virus de l'hepatite c
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
CN101277950B (zh) 2005-08-02 2013-03-27 弗特克斯药品有限公司 丝氨酸蛋白酶抑制剂
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
PL1934179T4 (pl) 2005-08-19 2014-03-31 Vertex Pharma Sposoby i związki pośrednie
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
DE602006019323D1 (de) 2005-10-11 2011-02-10 Intermune Inc Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2392590A3 (fr) 2005-11-11 2012-03-14 Vertex Pharmaceuticals Incorporated Variantes du virus de l'hépatite C
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US9526769B2 (en) 2006-06-06 2016-12-27 Enanta Pharmaceuticals, Inc. Macrocylic oximyl hepatitis C protease inhibitors
US8268776B2 (en) 2006-06-06 2012-09-18 Enanta Pharmaceuticals, Inc. Macrocylic oximyl hepatitis C protease inhibitors
US20070281884A1 (en) * 2006-06-06 2007-12-06 Ying Sun Macrocyclic oximyl hepatitis C protease inhibitors
PE20080992A1 (es) * 2006-06-26 2008-08-06 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c
RU2008152171A (ru) 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) Новые ингибиторы вирусной репликации гепатита с
DE602007004220D1 (de) 2006-07-07 2010-02-25 Leuven K U Res & Dev Neue pyridazinverbindung und ihre verwendung
CN101484444B (zh) * 2006-07-07 2012-11-21 吉里德科学公司 哒嗪化合物及其用途
US7935670B2 (en) 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR101512477B1 (ko) 2006-07-13 2015-04-15 아칠리온 파르마세우티칼스 인코포레이티드 바이러스 복제 억제제로서 사용되는 4-아미노-4-옥소부타노일 펩티드
WO2008019303A2 (fr) * 2006-08-04 2008-02-14 Enanta Pharmaceuticals, Inc. Inhibiteurs de sérine protéases de l'hépatite c macrocycliques de type pyridazinonyle
US7718612B2 (en) * 2007-08-02 2010-05-18 Enanta Pharmaceuticals, Inc. Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
JP2010500978A (ja) 2006-08-17 2010-01-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) * 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN101668538A (zh) * 2007-01-08 2010-03-10 芬诺密克斯公司 大环类丙型肝炎蛋白酶抑制剂
PT2118098E (pt) * 2007-02-01 2014-12-09 Janssen R & D Ireland Formas polimórficas de um inibidor macrocíclico do hcv
WO2008106130A2 (fr) 2007-02-26 2008-09-04 Achillion Pharmaceuticals, Inc. Peptides substitués par une amine tertiaire utiles comme inhibiteurs de la réplication du virus de l'hépatite c
ATE548044T1 (de) 2007-05-04 2012-03-15 Vertex Pharma Kombinationstherapie zur behandlung von hiv- infektionen
JP5465666B2 (ja) 2007-06-29 2014-04-09 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
KR20100038417A (ko) 2007-06-29 2010-04-14 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
US8242140B2 (en) 2007-08-03 2012-08-14 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
WO2009070692A1 (fr) 2007-11-29 2009-06-04 Enanta Pharmaceuticals, Inc. Inhibiteurs de sérine protéase de l'hépatite c macrocycliques, dérivés de la proline, substitués en c5
US8030307B2 (en) 2007-11-29 2011-10-04 Enanta Pharmaceuticals, Inc. Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease
JP5529036B2 (ja) 2007-12-05 2014-06-25 エナンタ ファーマシューティカルズ インコーポレイテッド フッ素化トリペプチドｈｃｖセリンプロテアーゼ阻害剤
AU2008338273B2 (en) 2007-12-19 2014-10-02 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
AR070413A1 (es) * 2008-02-04 2010-04-07 Idenix Pharmaceuticals Inc Inhibidores macrociclicos de proteasa de serina
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2009148923A1 (fr) 2008-05-29 2009-12-10 Bristol-Myers Squibb Company Inhibiteurs du virus de l’hépatite c
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) * 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN102245599B (zh) 2008-12-10 2014-05-14 艾其林医药公司 作为病毒复制抑制剂的新的4-氨基-4-氧代丁酰基肽
KR20110096557A (ko) * 2008-12-10 2011-08-30 아칠리온 파르마세우티칼스 인코포레이티드 바이러스 복제의 억제제로서 4-아미노-4-옥소부타노일 펩티드 사이클릭 유사체
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MX2011007195A (es) 2009-01-07 2013-07-12 Scynexis Inc Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih).
JP5639155B2 (ja) 2009-05-13 2014-12-10 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルスインヒビターとしての大環状化合物
US8389560B2 (en) 2009-09-15 2013-03-05 Taigen Biotechnology Co., Ltd. HCV protease inhibitors
JP2013528217A (ja) * 2010-06-07 2013-07-08 アッヴィ・インコーポレイテッド 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
RS54638B1 (en) 2010-09-21 2016-08-31 Enanta Pharmaceuticals, Inc. HCV SERIN PROTEASE INHIBITORS DERIVED FROM MACROCYCLIC PROLINE
CA2821340A1 (fr) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques de phenanthridine de serine protease d'hepatite c
WO2012092409A2 (fr) 2010-12-30 2012-07-05 Enanta Phararmaceuticals, Inc Inhibiteurs macrocycliques de sérine protéase d'hépatite c
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20150074051A (ko) * 2012-10-19 2015-07-01 브리스톨-마이어스 스큅 컴퍼니 C형 간염 바이러스 억제제
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (fr) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2014071007A1 (fr) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
SG11201507469RA (en) 2013-03-14 2015-10-29 Achillion Pharmaceuticals Inc Processes for producing sovaprevir
WO2014145600A1 (fr) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. Polymorphes de sel de sodium d'ach-0142684, composition les comprenant, et leur procédé de fabrication
WO2014144087A1 (fr) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. Polymorphes de sovaprévir et leurs procédés de fabrication
US9006423B2 (en) 2013-03-15 2015-04-14 Achillion Pharmaceuticals Inc. Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2015103490A1 (fr) 2014-01-03 2015-07-09 Abbvie, Inc. Formes galéniques antivirales solides
EP2899207A1 (fr) 2014-01-28 2015-07-29 Amikana.Biologics Nouveau procédé pour tester l'inhibition de la protéase du HCV
CN105130916B (zh) * 2015-09-30 2019-03-01 江西师范大学 一种高效制备nh-1,2,3三唑化合物的方法
TWI846654B (zh) 2018-11-06 2024-06-21 美商富曼西公司 經取代之甲苯基殺真菌劑
WO2021127273A1 (fr) * 2019-12-20 2021-06-24 Gb004, Inc. Dérivés de 1-((6-oxo-1,6-dihydropyridazin-4-yl)méthyl)pipérazine et de 1-((6-oxo-1,6-dihydropyrimidin-4-yl)méthyl)pipérazine utilisés en tant que modulateurs de la prolyl hydroxylase, de l'hif-1 alpha et de la pgk dans le traitement de maladies inflammatoires, du cancer ou d'infections
UY39189A (es) 2020-05-06 2021-12-31 Fmc Corp Fungicidas de tolilo sustituido y sus mezclas

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437362A1 (fr) * 1999-04-06 2004-07-14 Boehringer Ingelheim (Canada) Ltd. Peptides macrocycliques actifs contre le protéase ns3 du virus de l'hépatite C

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867185B2 (en) * 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437362A1 (fr) * 1999-04-06 2004-07-14 Boehringer Ingelheim (Canada) Ltd. Peptides macrocycliques actifs contre le protéase ns3 du virus de l'hépatite C

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1590442A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Also Published As

Publication number Publication date
KR20050111585A (ko) 2005-11-25
AU2004211637B2 (en) 2009-08-13
AU2004211637A1 (en) 2004-08-26
CA2515216A1 (fr) 2004-08-26
JP2007524576A (ja) 2007-08-30
EP1590442A4 (fr) 2007-07-18
CN1771050A (zh) 2006-05-10
WO2004072243A2 (fr) 2004-08-26
EP1590442A2 (fr) 2005-11-02
AU2004211637C1 (en) 2010-08-19
KR100940619B1 (ko) 2010-02-05

Similar Documents

Publication Publication Date Title
WO2004072243A3 (fr) Inhibiteurs macrocycliques de la serine protease de l'hepatite c
WO2004093798A3 (fr) Composes macrocycliques de quinoxalinyle inhibant les serine proteases de l'hepatite c
WO2004113365A3 (fr) Inhibiteurs de la tripeptide hepatite c serine protease
WO2008002924A3 (fr) Inhibiteurs macrocycliques quinoxalinyliques des protéases à sérine du virus de l'hépatite c
WO2005007681A3 (fr) Inhibiteurs de serines proteases, en particulier de la protease ns3-ns4a du vhc
WO2005037860A3 (fr) Inhibiteurs de serine proteases, en particulier la ns3-ns4a protease du hcv
WO2005077969A3 (fr) Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a
WO2009053828A3 (fr) Inhibiteurs p3-hydroxyamino macrocycliques des sérine protéases de l'hépatite c
WO2007143694A3 (fr) Inhibiteurs oximyles macrocycliques de la protéase de l'hépatite c
WO2008021960A3 (fr) Inhibiteurs triazolyle macrocycliques de la sérine protéase de l'hépatite c
TW200510391A (en) Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
WO2005035525A3 (fr) Inhibiteurs des serines proteases, en particulier de la protease ns3-ns4a du virus de l'hepatite c (vhc)
WO2008022006A3 (fr) Inhibiteurs de protéase du virus de l'hépatite c arylalcoxyle
WO2008019303A3 (fr) Inhibiteurs de sérine protéases de l'hépatite c macrocycliques de type pyridazinonyle
WO2009076173A3 (fr) Composés à base de tripeptides fluorés inhibant la sérine protéase du vhc
WO2008021871A3 (fr) Inhibiteurs triazolyle acyclique de la sérine protéase de l'hépatite c
WO2008019266A3 (fr) Inhibiteurs de sérine protéase de l'hépatite c dérivés de pyridazinone acycliques
WO2008019289A3 (fr) Inhibiteurs de sérine protéases de l'hépatite c macrocycliques de type tétrazolyle
WO2008021956A3 (fr) Inhibiteurs d'acylamino-hétéroaryle de la protéase du virus de l'hépatite c
MX2010006209A (es) Derivados de quinoxalinilo.
WO2008021733A3 (fr) Inhibiteurs acycliques tétrazolylés de la sérine protéase de l'hépaptite c
HK1065322A1 (en) Bridged bicyclic serine protease inhibitors
MX2010005262A (es) Compuestos que contienen quinoxalina como inhibidores del virus de hepatitis c.
WO2009076166A3 (fr) Inhibiteurs oximyles de la sérine protéase de vhc
MX2010006518A (es) Inhibidores de serina proteasa de hepatitis c de oximil macrociclica.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2515216

Country of ref document: CA

Ref document number: 2004709020

Country of ref document: EP

Ref document number: 2006503381

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020057014600

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2004211637

Country of ref document: AU

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2004211637

Country of ref document: AU

Date of ref document: 20040206

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004211637

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 20048092686

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2004709020

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020057014600

Country of ref document: KR