PE20030399A1 - Formas de administracion de propiverina o sus sales farmaceuticamente aceptables con liberacion prolongada de la sustancia activa - Google Patents

Formas de administracion de propiverina o sus sales farmaceuticamente aceptables con liberacion prolongada de la sustancia activa

Info

Publication number
PE20030399A1
PE20030399A1 PE2002000989A PE2002000989A PE20030399A1 PE 20030399 A1 PE20030399 A1 PE 20030399A1 PE 2002000989 A PE2002000989 A PE 2002000989A PE 2002000989 A PE2002000989 A PE 2002000989A PE 20030399 A1 PE20030399 A1 PE 20030399A1
Authority
PE
Peru
Prior art keywords
hours
prolonged release
administration
propiverine
forms
Prior art date
Application number
PE2002000989A
Other languages
English (en)
Inventor
Thomas Gramatte
Peter Gruber
Peter Guldner
Wolfgang Wehner
Dirk Pamperin
Jan Ploen
Steffen Scheithauer
Michael Heschel
Original Assignee
Apogepha Arzneimittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogepha Arzneimittel Gmbh filed Critical Apogepha Arzneimittel Gmbh
Publication of PE20030399A1 publication Critical patent/PE20030399A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

SE REFIERE A UNA COMPOSICION PARA ADMINISTRACION ORAL CON LIBERACION PROLONGADA, QUE COMPRENDE: i)DE 4 mg A 60 mg DE PROPIVERINA O LA CANTIDAD EQUIVALENTE DE UNA DE SUS SALES O UNA MEZCLA DE LAS MISMAS; ii)UNA O VARIAS SUSTANCIAS ACIDAS QUE TIENEN UN VALOR pKa INFERIOR A 6,65, PREFERENTEMENTE DE 1,8 A 6,5; TAL COMO: ACIDO CITRICO, ACIDO TARTARICO; Y, iii)UNA SUSTANCIA RETARDANTE, TAL COMO POLIMEROS Y COPOLIMEROS DE DERIVADOS DE ACIDO ACRILICO Y/O METACRILICO. PRESENTANDO DICHA COMPOSICION LAS SIGUIENTES TASAS DE LIBERACION DE PROPIVERINA IN VITRO MEDIDAS EN 750 ml DE HCl 0,1 N, DURANTE LA PRIMERA HORA Y A CONTINUACION MEDIDAS EN 750 ml BUFFER USP, pH IGUAL A 5,8 USANDO EL METODO DE CANASTILLA GIRATORIA Ph. Eur. A 100 rpm Y 37 °C: DE 0% A 20% AL CABO DE UNA HORA; DE 10% A 45% AL CABO DE 3 HORAS; DE 30% A 75% AL CABO DE 5 HORAS; DE 40% A 85% AL CABO DE 7 HORAS; DE 45% A 95% AL CABO DE 9 HORAS Y MAYOR A 60% AL CABO DE 12 HORAS
PE2002000989A 2001-10-09 2002-10-04 Formas de administracion de propiverina o sus sales farmaceuticamente aceptables con liberacion prolongada de la sustancia activa PE20030399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10149674A DE10149674A1 (de) 2001-10-09 2001-10-09 Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung

Publications (1)

Publication Number Publication Date
PE20030399A1 true PE20030399A1 (es) 2003-05-08

Family

ID=7701848

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000989A PE20030399A1 (es) 2001-10-09 2002-10-04 Formas de administracion de propiverina o sus sales farmaceuticamente aceptables con liberacion prolongada de la sustancia activa

Country Status (33)

Country Link
US (1) US7943176B2 (es)
EP (1) EP1435915B1 (es)
JP (1) JP4192096B2 (es)
KR (1) KR100723964B1 (es)
CN (1) CN100473382C (es)
AR (1) AR036768A1 (es)
AT (1) ATE401865T1 (es)
AU (1) AU2002346973B8 (es)
CA (1) CA2462482C (es)
CY (1) CY1108426T1 (es)
DE (2) DE10149674A1 (es)
DK (1) DK1435915T3 (es)
EA (1) EA008862B1 (es)
EG (1) EG25542A (es)
ES (2) ES2311068T3 (es)
HK (1) HK1067310A1 (es)
HR (1) HRP20040323C1 (es)
HU (1) HU227878B1 (es)
IL (2) IL160977A0 (es)
IS (1) IS2571B (es)
JO (1) JO2555B1 (es)
ME (2) ME00327B (es)
MX (1) MXPA04003132A (es)
MY (1) MY142403A (es)
PE (1) PE20030399A1 (es)
PL (1) PL208229B1 (es)
PT (1) PT1435915E (es)
RS (1) RS50924B (es)
SI (1) SI1435915T1 (es)
TW (1) TWI315204B (es)
UA (1) UA75727C2 (es)
WO (1) WO2003030869A1 (es)
ZA (1) ZA200402437B (es)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
DE10209982A1 (de) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
CA2543689A1 (en) * 2003-10-31 2005-05-12 Hexal Ag Pharmaceutical actve-ingredient-containing formulation with coating
DE10353196A1 (de) * 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
DE10353186A1 (de) * 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
WO2005046697A1 (ja) * 2003-11-14 2005-05-26 Ajinomoto Co., Inc. フェニルアラニン誘導体の徐放性経口投与製剤
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
JP4895819B2 (ja) * 2004-10-29 2012-03-14 大鵬薬品工業株式会社 プロピベリン含有経口粉粒状製剤及びその製造法
WO2006096439A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
JP2008531714A (ja) * 2005-03-04 2008-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 不安障害の治療用及び／又は予防用の医薬組成物
PT2559430E (pt) 2005-03-22 2015-10-09 Stada Arzneimittel Ag Ibuprofeno solubilizado
JP2008534531A (ja) * 2005-03-29 2008-08-28 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 調節物質の送達に影響を及ぼすマトリックスを有するペレットを有する多粒子の医薬剤形
EP1863453A2 (en) * 2005-03-29 2007-12-12 Evonik Röhm GmbH Multiparticulate pharmaceutical form comprising pellets with a substance having a modular effect in relation to active ingredient release
US20060264511A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of drug-induced sexual dysfunction
JP2009503020A (ja) * 2005-08-03 2009-01-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肥満症の治療におけるフリバンセリンの使用
CA2626134C (en) * 2005-10-29 2013-12-24 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
KR101413613B1 (ko) * 2006-01-27 2014-07-10 앱탈리스 파마테크, 인코포레이티드 약 염기성 선택성 세로토닌 5-ｈｔ3 차단제와 유기산을 포함하는 약물 전달 시스템
BRPI0707325A2 (pt) * 2006-01-27 2011-05-03 Eurand Inc formulação de dosagem de liberação multiparticulada e método para preparação da mesma
CA2882048C (en) 2006-02-03 2020-03-24 Proventiv Therapeutics, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
JP2009536176A (ja) * 2006-05-09 2009-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 閉経後の性的欲求障害の治療のためのフリバンセリンの使用
ES2497494T3 (es) 2006-06-21 2014-09-23 Opko Renal, Llc Método de tratamiento y prevención del hiperparatiroidismo secundario
JP2009541443A (ja) 2006-06-30 2009-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 尿失禁及び関連疾患の治療のためのフリバンセリン
EP2043648A1 (en) * 2006-07-14 2009-04-08 Boehringer Ingelheim International GmbH Use of flibanserin for the treatment of sexual disorders in females
CL2007002214A1 (es) * 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
EA200900264A1 (ru) 2006-08-14 2009-08-28 Бёрингер Ингельхайм Интернациональ Гмбх Композиции флибансерина и способ их приготовления
AU2007287639A1 (en) * 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
EP2056792B1 (en) 2006-08-31 2023-06-07 Adare Pharmaceuticals, Inc. Drug delivery systems comprising solid solutions of weakly basic drugs
CA2678367C (en) * 2007-03-02 2014-07-08 Farnam Companies, Inc. Sustained release compositions using wax-like materials
AU2008226947B2 (en) 2007-03-08 2014-07-17 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
JP2010522714A (ja) * 2007-03-28 2010-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規な医薬組成物
WO2009047644A2 (en) 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
KR20190028822A (ko) 2007-04-25 2019-03-19 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
PE20091188A1 (es) 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen
CN101877971A (zh) * 2008-01-10 2010-11-03 赢创罗姆有限公司 具有活性物质在结肠中增强的释放的包衣药物或营养制剂
US8133506B2 (en) * 2008-03-12 2012-03-13 Aptalis Pharmatech, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
TWI519322B (zh) * 2008-04-15 2016-02-01 愛戴爾製藥股份有限公司 包含弱鹼性藥物及控制釋放劑型之組合物
ES2477552T3 (es) * 2008-09-08 2014-07-17 The Board Of Trustees Of The Leland Stanford Junior University Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos
WO2010062308A1 (en) 2008-10-28 2010-06-03 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase and methods of use thereof
CA2686480A1 (en) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh New salts
US20110003005A1 (en) * 2009-07-06 2011-01-06 Gopi Venkatesh Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions
PT2552484T (pt) 2010-03-29 2020-04-03 Opko Ireland Global Holdings Ltd Métodos e composições para redução dos níveis de parafróides
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
US20120289547A1 (en) * 2011-05-10 2012-11-15 Theravida, Inc. Combinations of propiverine and salivary stimulants for the treatment of overactive bladder
CN102579404A (zh) * 2012-01-17 2012-07-18 广州科的信医药技术有限公司 一种盐酸丙哌维林缓释胶囊及其制备方法
CN102743756A (zh) * 2012-07-24 2012-10-24 兆科药业（广州）有限公司 一种盐酸丙哌维林与α受体拮抗剂复方制剂
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10751287B2 (en) * 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
EP3193925A2 (en) 2014-08-07 2017-07-26 OPKO Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin d
EP3331502B1 (en) 2015-08-07 2021-05-26 Santa Farma Ilaç Sanayi A.S. Controlled release propiverine formulations
IL290855B1 (en) 2016-03-28 2024-02-01 Eirgen Pharma Ltd Treatment methods using vitamin D
WO2020101586A1 (en) 2018-11-16 2020-05-22 Santa Farma İlaç Sanayi̇ A.Ş. Controlled release propiverine formulations
TR201918013A2 (tr) * 2019-11-19 2021-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Propi̇veri̇n veya propi̇veri̇ni̇n farmasöti̇k olarak kabul edi̇lebi̇li̇r bi̇r tuzunu i̇çeren pellet kompozi̇syonu
EP4061369A4 (en) * 2019-11-19 2024-04-10 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi PHARMACEUTICAL FORM COMPRISING AN ACIDIC SUBSTANCE
CN112152871B (zh) * 2020-08-14 2021-09-24 上海纽盾科技股份有限公司 网络安全设备的人工智能测试方法、装置及系统
EP4251154A1 (en) 2020-11-27 2023-10-04 Santa Farma Ilac Sanayii A.S. Sustained release formulation compositions comprising propiverine
WO2023128906A1 (en) * 2021-12-30 2023-07-06 Santa Farma Ilac Sanayii A.S. Release of propiverine compositions in gastric conditions

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD139212A1 (de) 1978-10-09 1979-12-19 Christian Starke Verfahren zur herstellung eines neuen arzneimittels aus alpha,alpha-diphenyl-alpha-alkoxyessigsaeure-1-methylpiperidyl-4-ester-derivaten
DE3000979A1 (de) 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
DE3124090A1 (de) 1981-06-19 1983-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale dipyridamolformen
DE3126703A1 (de) 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach Bromhexin-retardform und verfahren zu ihrer herstellung
GB8616669D0 (en) 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
JPS63154619A (ja) 1986-12-17 1988-06-27 Kowa Yakuhin Kogyo Kk 頻尿および残尿感治療剤
US5178868A (en) * 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
SE8803822D0 (sv) 1988-10-26 1988-10-26 Novel dosage form
US5368861A (en) 1989-10-26 1994-11-29 Nippon Shinyaku Co., Ltd. Gastric preparation with sustained release
US5399359A (en) 1994-03-04 1995-03-21 Edward Mendell Co., Inc. Controlled release oxybutynin formulations
WO1996012477A1 (en) 1994-10-21 1996-05-02 Leiras Oy Controlled release oral delivery system containing oxybutynin
US5674895A (en) 1995-05-22 1997-10-07 Alza Corporation Dosage form comprising oxybutynin
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
US5811126A (en) 1995-10-02 1998-09-22 Euro-Celtique, S.A. Controlled release matrix for pharmaceuticals
ZA97976B (en) 1996-04-05 1997-08-18 Alza Corp Uniform drug delivery theraphy.
JP2002511777A (ja) 1996-10-28 2002-04-16 ゼネラル ミルズ，インコーポレイテッド 調放性粒子の埋包およびカプセル化
US5788987A (en) 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
HUP0100437A3 (en) 1998-08-27 2002-08-28 Pharmacia And Upjohn Ab Therapeutic formulation for administering tolterodine with controlled release
US6180136B1 (en) 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
BR9916972B1 (pt) 1999-01-29 2010-05-18 composições farmacêuticas de liberação retardada melhorada, bem como seu processo de produção.
EP1064938A1 (en) 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmaceutical dosage forms for controlled release producing at least a timed pulse
JP2001039873A (ja) 1999-08-02 2001-02-13 Nichiban Co Ltd 経皮吸収型排尿障害治療剤
CA2388159A1 (en) 1999-10-29 2001-05-10 Merck & Co., Inc. Osmotic controlled release drug delivery device
AU1303201A (en) 1999-11-10 2001-06-06 Takeda Chemical Industries Ltd. Alkoxyiminoalkanoic acid derivatives
JP2001048783A (ja) 2000-01-01 2001-02-20 Lead Chemical Co Ltd 経皮吸収型頻尿・尿失禁治療剤
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
JP2003523382A (ja) * 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
DE10016356B4 (de) * 2000-04-03 2007-06-21 Beisel, Günther Mittel mit verbesserter Retardwirkung und Verfahren zu dessen Herstellung
CA2403670C (en) * 2001-01-31 2010-02-09 Rohm Gmbh & Co. Kg Multiparticulate drug form comprising at least two differently coated pellet forms
PL200270B1 (pl) 2001-02-27 2008-12-31 Roehm Gmbh Sposób wytwarzania środka powlekającego i wiążącego, środki wytwarzane tym sposobem, postać leku zawierająca taki środek oraz zastosowanie środków
ITMI20011446A1 (it) * 2001-07-06 2003-01-06 Altergon Sa Composizioni farmaceutiche di principi attivi suscettibili di somministrazione illecita
DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung

Also Published As

Publication number Publication date
SI1435915T1 (sl) 2008-12-31
RS50924B (sr) 2010-08-31
HRPK20040323B3 (en) 2005-12-31
HUP0401714A3 (en) 2006-01-30
ZA200402437B (en) 2004-09-06
IS2571B (is) 2010-01-15
US20080317848A2 (en) 2008-12-25
US20040258749A1 (en) 2004-12-23
PL208229B1 (pl) 2011-04-29
ES2299287B1 (es) 2009-10-14
EG25542A (en) 2012-02-14
AU2002346973B2 (en) 2006-10-12
AR036768A1 (es) 2004-09-29
JP2005505589A (ja) 2005-02-24
HU227878B1 (en) 2012-05-29
HK1067310A1 (en) 2005-04-08
JO2555B1 (en) 2010-09-05
KR20050034589A (ko) 2005-04-14
CN1638737A (zh) 2005-07-13
ES2311068T3 (es) 2009-02-01
CY1108426T1 (el) 2014-04-09
HRP20040323A2 (en) 2004-08-31
TWI315204B (en) 2009-10-01
YU28104A (sh) 2006-08-17
MY142403A (en) 2010-11-30
CN100473382C (zh) 2009-04-01
WO2003030869A1 (de) 2003-04-17
MEP44308A (en) 2011-02-10
AU2002346973B8 (en) 2006-11-09
IL160977A0 (en) 2004-08-31
MXPA04003132A (es) 2005-01-25
PT1435915E (pt) 2008-10-30
KR100723964B1 (ko) 2007-06-04
CA2462482C (en) 2010-02-16
ES2299287A1 (es) 2008-05-16
US7943176B2 (en) 2011-05-17
HUP0401714A2 (hu) 2004-12-28
IL160977A (en) 2008-11-26
PL368301A1 (en) 2005-03-21
JP4192096B2 (ja) 2008-12-03
EP1435915B1 (de) 2008-07-23
IS7192A (is) 2004-03-19
EP1435915A1 (de) 2004-07-14
DK1435915T3 (da) 2008-11-24
ME00327B (me) 2011-02-10
EA200400471A1 (ru) 2004-10-28
UA75727C2 (en) 2006-05-15
ATE401865T1 (de) 2008-08-15
HRP20040323C1 (hr) 2013-11-08
CA2462482A1 (en) 2003-04-17
DE50212546D1 (de) 2008-09-04
EA008862B1 (ru) 2007-08-31
DE10149674A1 (de) 2003-04-24

Similar Documents

Publication Publication Date Title
PE20030399A1 (es) Formas de administracion de propiverina o sus sales farmaceuticamente aceptables con liberacion prolongada de la sustancia activa
AR037490A1 (es) Composiciones farmaceuticas solidas, proceso para su preparacion, kit para el tratamiento de la obesidad y uso de dichas composiciones en la elaboracion de medicamentos
ES2530719T3 (es) Formulaciones de oxicodona para ser administradas una vez al día
EA200700049A1 (ru) Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением
ES2194732T3 (es) Composiciones farmaceuticas orales de liberacion controlada de mesalazina.
ATE493973T1 (de) Irbesartan enthaltende pharmazeutische zusammensetzung
BRPI0015567B8 (pt) composto, composição farmacêutica, forma de unidade de dosagem, uso da composição farmacêutica e método para preparar uma composição farmacêutica
RU2005115855A (ru) Композиция трамадола продлонгированного высвобождением с 24-часовым действием
ES2525495T1 (es) Composición farmacéutica de liberación controlada que comprende éster de ácido fumárico
MX2007015480A (es) Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada.
NO20043871L (no) Legemiddelformuleringer med kontrollert frigjoring som inneholder et baererpeptid
BRPI0507735A (pt) composição para administração oral de cloridrato de tamsulosin e formulação de gránulo de liberação controlada compreendendo a mesma
AR029688A1 (es) Composiciones de liberacion retardada de matriz antibiotica de quinolona para administracion oral, y procedimiento para su fabricacion
EA200501901A1 (ru) Таблетка с основой, позволяющая осуществлять пролонгированное высвобождение триметазидина после введения оральным путём
NO20013060D0 (no) Kontrollert frigjörende farmasöytisk preparat med tilidinmesylat som virkestoff
NO20055601L (no) Farmasoytisk preparat i form av en hydrogel for transdermal administrasjon av aktive virkestoffer
HUP0203844A2 (hu) Növekedési hormon kibocsátó tulajdonságú vegyület, ezt tartalmazó gyógyszerkészítmény és alkalmazása
SE0102440D0 (sv) New compound
ATE253354T1 (de) Kapseln mit loratadin und pseudoephedrin enthaltenden zusammensetzungen
PE20080313A1 (es) Formulaciones de liberacion pulsada de fenilefrina y composiciones farmaceuticas
BR0311642A (pt) Formulação de divalproex de sódio de liberação aumentada
CA2415154A1 (en) Modified release formulations of selective serotonin re-uptake inhibitors
DK1255535T3 (da) Lægemiddelsammensætning med kontrolleret frisætning indeholdende tramadol-hydrochlorid
UY28457A1 (es) Nueva composición
TR200103473T2 (tr) Kristalli azabisiklo (2.2.2) oktan-3-amin sitratin polimorfları ve farmasötik kompozisyonları.

Legal Events

Date Code Title Description
FC Refusal