PE20011033A1 - Compuestos esteroides con un anillo ciclopropano con actividad androgenica - Google Patents
Compuestos esteroides con un anillo ciclopropano con actividad androgenicaInfo
- Publication number
- PE20011033A1 PE20011033A1 PE2000001285A PE0012852000A PE20011033A1 PE 20011033 A1 PE20011033 A1 PE 20011033A1 PE 2000001285 A PE2000001285 A PE 2000001285A PE 0012852000 A PE0012852000 A PE 0012852000A PE 20011033 A1 PE20011033 A1 PE 20011033A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- androgenic activity
- steroid compounds
- compounds
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
Abstract
SE REFIERE A COMPUESTOS ESTEROIDES CON UN ANILLO CICLOPROPANO DE FORMULA I DONDE R1 ES O, (H,H), (H,OR), NOR; R ES H, ALQUILO C1-C6, ACILO C1-C6; R2 ES H, ALQUILO C1-C6; R3 ES H o R3 ES ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ALQUENILO C2-C6; R5 ES ALQUILO C1-C6; R6 ES H, HALOGENO, ALQUILO C1-C4; R7 ES H, ALQUILO C1-C6; R8 ES H, OH, ALCOXI C1-C6, ENTRE OTROS; R9 Y R10 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C6, CICLOALQUENILO C5-C6, ALQUINILO C2-C6, ENTRE OTROS; R11 ES H, SO3H, ACILO C1-C15; LAS LINEAS PUNTEADAS INDICAN ENLACES OPCIONALES. UN COMPUESTO PREFERIDO ES 7O,14ß,-15ß,17O)-17-(HIDROXIMETIL)-7-METIL-14,15-METILENESTR-4-EN-3-ONA. LOS COMPUESTOS I TIENEN ACTIVIDAD ANDROGENICA Y PUEDEN UTILIZARSE EN LA ANTICONCEPCION MASCULINA Y EN LA TERAPIA DE SUSTITUCION DE HORMONAS MASCULINAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204080 | 1999-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011033A1 true PE20011033A1 (es) | 2001-10-11 |
Family
ID=8240955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001285A PE20011033A1 (es) | 1999-12-02 | 2000-12-01 | Compuestos esteroides con un anillo ciclopropano con actividad androgenica |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6706700B2 (es) |
| EP (1) | EP1237904B1 (es) |
| JP (1) | JP2003515543A (es) |
| CN (1) | CN1166680C (es) |
| AR (1) | AR026655A1 (es) |
| AT (1) | ATE317396T1 (es) |
| AU (1) | AU778017B2 (es) |
| CA (1) | CA2390226A1 (es) |
| CO (1) | CO5251441A1 (es) |
| CY (1) | CY1106086T1 (es) |
| CZ (1) | CZ301376B6 (es) |
| DE (1) | DE60025958T2 (es) |
| DK (1) | DK1237904T3 (es) |
| ES (1) | ES2258037T3 (es) |
| HK (1) | HK1047596B (es) |
| HU (1) | HUP0203611A3 (es) |
| IL (1) | IL149424A (es) |
| MX (1) | MXPA02004939A (es) |
| NO (1) | NO322422B1 (es) |
| NZ (1) | NZ518753A (es) |
| PE (1) | PE20011033A1 (es) |
| PL (1) | PL202999B1 (es) |
| RU (1) | RU2242479C2 (es) |
| SK (1) | SK287095B6 (es) |
| TW (1) | TWI275593B (es) |
| WO (1) | WO2001040255A2 (es) |
| ZA (1) | ZA200203536B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60004377T2 (de) * | 1999-04-06 | 2004-06-09 | Akzo Nobel N.V. | Oral wirksame 7-alpha-alkyl androgene |
| MXPA04007049A (es) * | 2002-01-21 | 2004-10-14 | Akzo Nobel Nv | Proceso para la preparacion de 7a-metilesteroides. |
| US20080293683A1 (en) * | 2007-05-24 | 2008-11-27 | University Of Kansas Medical Center | Hormone Replacement Therapy |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| DK2764008T3 (en) * | 2011-10-07 | 2016-11-07 | Estetra Sprl | A process for the preparation of estetrol |
| ES2877186T3 (es) | 2015-06-18 | 2021-11-16 | Estetra Sprl | Comprimido orodispersable que contiene estetrol |
| GEP20217243B (en) | 2015-06-18 | 2021-04-26 | Sprl Estetra | Orodispersible dosage unit containing an estetrol component |
| LT3310346T (lt) | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| TN2017000499A1 (en) | 2015-06-18 | 2019-04-12 | Mithra Pharmaceuticals S A | Orodispersible dosage unit containing an estetrol component |
| KR20220144885A (ko) | 2016-08-05 | 2022-10-27 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| CN111621141B (zh) * | 2020-06-12 | 2022-04-08 | 广西大学 | 一种缓释型二氧化氯-水性聚氨酯抗菌膜及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3086027A (en) | 1960-01-22 | 1963-04-16 | Lilly Co Eli | 19-nor-4, 9(10)-steroids and process |
| IE60780B1 (en) * | 1987-01-23 | 1994-08-10 | Akzo Nv | New 11-aryl steroid derivatives |
| DE19537626A1 (de) | 1995-10-10 | 1997-04-17 | Jenapharm Gmbh | Steroide mit einer 14, 15-Methylengruppe |
| DE19827522A1 (de) * | 1998-06-22 | 1999-12-23 | Jenapharm Gmbh | 14,15-Cyclopropanosteroide der 19-Nor-Androstanreihe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| CA2359218A1 (en) | 1999-03-08 | 2000-09-14 | Akzo Nobel N.V. | 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens |
-
2000
- 2000-11-29 ES ES00993259T patent/ES2258037T3/es not_active Expired - Lifetime
- 2000-11-29 CA CA002390226A patent/CA2390226A1/en not_active Abandoned
- 2000-11-29 HU HU0203611A patent/HUP0203611A3/hu unknown
- 2000-11-29 AT AT00993259T patent/ATE317396T1/de not_active IP Right Cessation
- 2000-11-29 JP JP2001541010A patent/JP2003515543A/ja active Pending
- 2000-11-29 PL PL355689A patent/PL202999B1/pl not_active IP Right Cessation
- 2000-11-29 CN CNB008164959A patent/CN1166680C/zh not_active Expired - Fee Related
- 2000-11-29 SK SK758-2002A patent/SK287095B6/sk not_active IP Right Cessation
- 2000-11-29 NZ NZ518753A patent/NZ518753A/en unknown
- 2000-11-29 RU RU2002117440/04A patent/RU2242479C2/ru not_active IP Right Cessation
- 2000-11-29 US US10/148,820 patent/US6706700B2/en not_active Expired - Fee Related
- 2000-11-29 EP EP00993259A patent/EP1237904B1/en not_active Expired - Lifetime
- 2000-11-29 AU AU28383/01A patent/AU778017B2/en not_active Ceased
- 2000-11-29 CZ CZ20021894A patent/CZ301376B6/cs not_active IP Right Cessation
- 2000-11-29 WO PCT/EP2000/012009 patent/WO2001040255A2/en active IP Right Grant
- 2000-11-29 DE DE60025958T patent/DE60025958T2/de not_active Expired - Lifetime
- 2000-11-29 DK DK00993259T patent/DK1237904T3/da active
- 2000-11-29 IL IL149424A patent/IL149424A/en not_active IP Right Cessation
- 2000-11-29 MX MXPA02004939A patent/MXPA02004939A/es active IP Right Grant
- 2000-11-30 AR ARP000106304A patent/AR026655A1/es active IP Right Grant
- 2000-12-01 PE PE2000001285A patent/PE20011033A1/es not_active Application Discontinuation
- 2000-12-01 CO CO00092012A patent/CO5251441A1/es not_active Application Discontinuation
- 2000-12-02 TW TW089125707A patent/TWI275593B/zh not_active IP Right Cessation
-
2002
- 2002-05-03 ZA ZA200203536A patent/ZA200203536B/en unknown
- 2002-05-30 NO NO20022564A patent/NO322422B1/no not_active IP Right Cessation
- 2002-12-18 HK HK02109169.4A patent/HK1047596B/zh not_active IP Right Cessation
-
2006
- 2006-04-10 CY CY20061100500T patent/CY1106086T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20011033A1 (es) | Compuestos esteroides con un anillo ciclopropano con actividad androgenica | |
| PE20010112A1 (es) | Compuestos no esteroides como moduladores del receptor glucocorticoide | |
| PE20010330A1 (es) | Androgenos oralmente activos | |
| PE55998A1 (es) | Derivados 19-nor-pregneno substituidos | |
| DK0538443T3 (da) | Fremgangsmåde og formuleringer til kontraception og til behandling af godartede gynækologiske forstyrrelser | |
| HUP0000968A2 (hu) | A 17alfa-helyzetben fluorozott alkilláncot tartalmazó antigesztagén szteroidok | |
| AR029600A1 (es) | Un derivado del acido fenoxiacetico, una composicion farmaceutica que lo contiene y agente util para la prevencion de enfermedades, uso de un derivado del acido fenoxiacetico para la fabricacion de una composicion farmaceutica para los tratamientos de dichas enfermedades y el procedimiento de fabric | |
| HUP0300335A2 (hu) | 8béta-hidrokarbil-szubsztituált ösztratriének mint szelektív hatású ösztrogének, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| PE20040587A1 (es) | Moduladores triciclicos de receptor nuclear de hormonas esteroideas | |
| ES472147A1 (es) | Procedimiento para la preparacion de nuevos esteroido-17- alcohilcarbonatos. | |
| IL106519A0 (en) | 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives,their preparation and pharmaceutical compositions containing them | |
| HUP9901136A2 (hu) | N,N-dimetil-2-(aril-tio)-benzil-amin-származékok és sóik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények | |
| ES8606879A1 (es) | Un procedimiento para la preparacion de derivados esteroida-les | |
| ES8401067A1 (es) | Procedimiento analogo para preparar un derivado de tropil benzoato. | |
| NZ221012A (en) | 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and pharmaceutical preparations containing these | |
| GB9610031D0 (en) | Chemical compounds | |
| NO20021079D0 (no) | Ikke-aromatiske östrogene steroider med en hydrogensubstituent i posisjon 11 | |
| ES441783A1 (es) | Procedimiento para la preparacion de 1-alfa-hidroxiesteroi- des. | |
| PE20020472A1 (es) | Uso de un inhibidor del receptor de progesterona para inhibir la fijacion de factores de crecimiento en celulas tumorales | |
| PE20001489A1 (es) | ESTEROIDE (14ß,17O)-17-(HIDROXIMETILO) CON ACTIVIDAD ANDROGENA | |
| PE20011121A1 (es) | Composicion farmaceutica que comprende un compuesto ciclico con un grupo sulfamato | |
| WO2001053321A3 (en) | Use of trilostane and its derivatives, optionally in combination with tamoxifen or raloxifene in the treatment of estrogen-dependent cancers e.g. breast, prostate and uterus cancers | |
| MX9802126A (es) | Compuestos heterociclicos novedosos. | |
| IL79465A0 (en) | Androstane derivatives,their preparation and pharmaceutical compositions containing them | |
| AR034194A1 (es) | Un compuesto esteroide, su uso, una composicion farmaceutica que lo comprende y un kit para la anticoncepcion masculina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |