ES8606879A1 - Un procedimiento para la preparacion de derivados esteroida-les - Google Patents

Un procedimiento para la preparacion de derivados esteroida-les

Info

Publication number
ES8606879A1
ES8606879A1 ES543646A ES543646A ES8606879A1 ES 8606879 A1 ES8606879 A1 ES 8606879A1 ES 543646 A ES543646 A ES 543646A ES 543646 A ES543646 A ES 543646A ES 8606879 A1 ES8606879 A1 ES 8606879A1
Authority
ES
Spain
Prior art keywords
steroids
alkyl
alkylidene
unsaturated
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543646A
Other languages
English (en)
Other versions
ES543646A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8606879A1 publication Critical patent/ES8606879A1/es
Publication of ES543646A0 publication Critical patent/ES543646A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS ESTEROIDALES Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 2-4. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA NR2R3R4, EN LAS QUE X E Y PUEDEN SER VARIOS RADICALES, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA INHIBICION DE LA RESORCION INTESTINAL DE COLESTEROL.
ES543646A 1983-08-25 1985-05-30 Un procedimiento para la preparacion de derivados esteroida-les Expired ES8606879A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464483 1983-08-25

Publications (2)

Publication Number Publication Date
ES8606879A1 true ES8606879A1 (es) 1986-05-01
ES543646A0 ES543646A0 (es) 1986-05-01

Family

ID=4279973

Family Applications (2)

Application Number Title Priority Date Filing Date
ES535391A Granted ES535391A0 (es) 1983-08-25 1984-08-24 Procedimiento para la preparacion de derivados esteroidales
ES543646A Expired ES8606879A1 (es) 1983-08-25 1985-05-30 Un procedimiento para la preparacion de derivados esteroida-les

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES535391A Granted ES535391A0 (es) 1983-08-25 1984-08-24 Procedimiento para la preparacion de derivados esteroidales

Country Status (21)

Country Link
US (1) US4680290A (es)
EP (1) EP0135762B1 (es)
JP (1) JPS6061595A (es)
KR (1) KR850001767A (es)
AR (1) AR240834A1 (es)
AT (1) ATE37883T1 (es)
AU (1) AU574706B2 (es)
CA (1) CA1252778A (es)
DE (1) DE3474552D1 (es)
DK (1) DK347584A (es)
ES (2) ES535391A0 (es)
FI (1) FI842830A (es)
GR (1) GR80196B (es)
HU (1) HU189929B (es)
IL (1) IL72725A (es)
MC (1) MC1618A1 (es)
NO (1) NO161679C (es)
NZ (1) NZ209275A (es)
PH (1) PH19849A (es)
PT (1) PT79130B (es)
ZA (1) ZA846430B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1241947A (en) * 1985-05-31 1988-09-13 Pierre R. Proulx Conjugated polyene sterol derivatives as membrane probes
US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5026882A (en) * 1988-12-23 1991-06-25 Smithkline Beecham Corporation Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
US5215972A (en) * 1989-11-22 1993-06-01 Hoffmann-La Roche Inc. Steroids
CA2028759A1 (en) * 1989-11-22 1991-05-23 Jean-Marie Cassal Steroids
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
CA2204902A1 (en) * 1994-11-30 1996-06-06 Fred I. Chasalow Phosphocholine drug derivatives
US6251939B1 (en) * 1995-06-07 2001-06-26 Promega Biosciences, Inc. Carbamate-based cationic lipids
AU705549B2 (en) * 1995-06-07 1999-05-27 Promega Biosciences, Inc. Phosphonic acid-based cationic lipids
JP2002514183A (ja) * 1996-09-17 2002-05-14 スーパージェン・インコーポレーテッド リン脂質薬剤誘導体
US5830432A (en) * 1997-03-31 1998-11-03 Amur Pharmacuticals, Inc. Phospholipid drug derivatives
EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
CA2395447A1 (en) 2000-01-28 2001-08-02 Robert Joseph Sarama Palatable arginine compounds and uses thereof for cardiovascular health
US20030045473A1 (en) * 2002-07-19 2003-03-06 Sarama Robert Joseph Compositions, kits, and methods for cardiovascular health
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
JP2010511648A (ja) * 2006-12-08 2010-04-15 ジャド テクノロジーズ ゲーエムベーハー 感染性疾患の治療及び予防のためのコレステリルアミン
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
WO2023122075A1 (en) * 2021-12-20 2023-06-29 Ohio State Innovation Foundation Compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248408A (en) * 1963-07-22 1966-04-26 Merck & Co Inc Purification of steroid phosphates

Also Published As

Publication number Publication date
EP0135762A2 (de) 1985-04-03
FI842830A0 (fi) 1984-07-13
AR240834A1 (es) 1991-02-28
AR240834A2 (es) 1991-02-28
DE3474552D1 (en) 1988-11-17
IL72725A (en) 1988-07-31
ES8602844A1 (es) 1985-12-01
HU189929B (en) 1986-08-28
EP0135762B1 (de) 1988-10-12
FI842830A (fi) 1985-02-26
PT79130A (en) 1984-09-01
AU574706B2 (en) 1988-07-14
NZ209275A (en) 1987-06-30
NO843406L (no) 1985-02-26
CA1252778A (en) 1989-04-18
US4680290A (en) 1987-07-14
EP0135762A3 (en) 1986-01-22
ATE37883T1 (de) 1988-10-15
IL72725A0 (en) 1984-11-30
GR80196B (en) 1985-01-02
AU3222584A (en) 1985-02-28
KR850001767A (ko) 1985-04-01
PH19849A (en) 1986-07-22
ES543646A0 (es) 1986-05-01
DK347584A (da) 1985-02-26
NO161679C (no) 1989-09-13
ES535391A0 (es) 1985-12-01
JPS6061595A (ja) 1985-04-09
ZA846430B (en) 1985-04-24
HUT34997A (en) 1985-05-28
MC1618A1 (fr) 1985-07-18
NO161679B (no) 1989-06-05
PT79130B (en) 1986-11-14
DK347584D0 (da) 1984-07-13

Similar Documents

Publication Publication Date Title
ES8606879A1 (es) Un procedimiento para la preparacion de derivados esteroida-les
FI925652A (fi) Foerfarande och sammansaettningar foer foerhindrande av befruktning och behandling av benigna gynekologiska stoerningar
SE9100341D0 (sv) Novel steroids
MD1233B1 (en) Erythromycin derivatives, process for their preparation and pharmaceutical composition on base thereof
HUT73773A (en) Nitric esters having an inflammatory anti-platelet aggregation activity pharmacological activity and process for their preparation
DK0491415T3 (da) Orale svangerskabsforebyggende midler med lavt østrogen
ES8502129A1 (es) Un procedimiento para la preparacion de compuestos de acidos biliares
ATE87473T1 (de) Arzneimittel zur inhibition von hautfalte.
IE44473L (en) 6,9,21-trihalo pregnanes
ES8502709A1 (es) Procedimiento para la preparacion de 1-alquil-androsta-1,4-dien-3,17-dionas
PT79839A (en) Process for the preparation of 6,6-ethylene-15,16-methylene-3-oxi-17alpha-pregn-4-ene-21,17-carbolactones and pharmaceutical compositions therewith
ES452226A1 (es) Procedimiento para la preparacion de delta15-esteroides.
ATE154031T1 (de) 8-en-19, 11 beta-überbrückte steroide, deren herstellung und diese enthaltende pharmazeutische präparate
GB1387911A (en) Pregnane acid derivatives
ATE175418T1 (de) 15,15-dialkylsubstituierte östradiolderivate
ZA97444B (en) Potentiating agents.
IE780933L (en) Pregnene derivatives
FR2097045A1 (en) 17-ethynylgon-4-en-3-ones - with progestomimetic activity useful as contraceptives and for gynaecological disorders
IE781545L (en) Benzimidazole-2-derivatives.
ES444959A1 (es) Procedimiento para la obtencion de bifenilileteres.
KR910009724A (ko) 방향족 스테로이드 5-α-리덕타제 억제제
ATE81508T1 (de) Herstellung von corticoiden aus steroidischen 17- cyanohydrinen.
TW249800B (en) Synthesis of novel xanthones and their pharmaceutical effects
TH14327A (th) สเตอรอยด์แคลไกลโคไซด์ สำหรับการรักษาอาการมีโคเรสเตอรอลสูงเกินไป
JPS5318565A (en) Novel nitrosourea derivatives and their preparation