CO5251441A1 - Compuestos esteroides que contienen un anillo de ciclopropano - Google Patents

Compuestos esteroides que contienen un anillo de ciclopropano

Info

Publication number
CO5251441A1
CO5251441A1 CO00092012A CO00092012A CO5251441A1 CO 5251441 A1 CO5251441 A1 CO 5251441A1 CO 00092012 A CO00092012 A CO 00092012A CO 00092012 A CO00092012 A CO 00092012A CO 5251441 A1 CO5251441 A1 CO 5251441A1
Authority
CO
Colombia
Prior art keywords
alkyl
hydrogen
halogen
alkenyl
compounds containing
Prior art date
Application number
CO00092012A
Other languages
English (en)
Inventor
Dirk Leysen
Louw Jaap Van Der
Roberta Buma Bursi
De Gooyer Marcel Evert
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5251441A1 publication Critical patent/CO5251441A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)

Abstract

Un compuesto CARACTERIZADO porque satisface la fórmula estructural: <EMI FILE="00092012_1" ID="1" IMF=JPEG > Donde R1 es O, (H, H), (H, OR), NOR, siendo R hidrógeno, (C1-6)alquilo, (C1-6)acilo; R2 es hidrógeno, o (C1-6)alquilo; R3 es hidrógeno; o R3 es (C1-6)alquilo, (C2-6)alquenilo, o (C2-6)alquinilo, cada uno opcionalmente sustituido por halógeno; R4 es hidrógeno, (C1-6)alquilo, o (C2-6)alquenilo, R5 es (C1-6)alquilo; R6 es hidrógeno, halógeno, o (C1-4)alquilo R7 es hidrógeno, o (C1-6)alquilo;R8 es hidrógeno, hidroxilo, (C1-6)alcoxi, halógeno, o (C1-6)alquilo;R9, y R10 son independientemente hidrógeno; o R9 y R10 son independientemente (C1-6)alquilo, (C2-6)alquenilo, (C3-6)cicloalquilo, (C5-6)cicloalquenilo, o (C2-6)alquinilo, cada uno opcionalmente sustituido por (C1-4)alcoxi, o halógeno; R11 es hidrógeno, SO3H (C1-15)acilo; y Las líneas de puntos indican enlaces opcionales, seleccionados entre un doble enlace ?4, ?5(10), ó ?11, o un sistema dieno ?4,9 ó ?4,11.
CO00092012A 1999-12-02 2000-12-01 Compuestos esteroides que contienen un anillo de ciclopropano CO5251441A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99204080 1999-12-02

Publications (1)

Publication Number Publication Date
CO5251441A1 true CO5251441A1 (es) 2003-02-28

Family

ID=8240955

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00092012A CO5251441A1 (es) 1999-12-02 2000-12-01 Compuestos esteroides que contienen un anillo de ciclopropano

Country Status (27)

Country Link
US (1) US6706700B2 (es)
EP (1) EP1237904B1 (es)
JP (1) JP2003515543A (es)
CN (1) CN1166680C (es)
AR (1) AR026655A1 (es)
AT (1) ATE317396T1 (es)
AU (1) AU778017B2 (es)
CA (1) CA2390226A1 (es)
CO (1) CO5251441A1 (es)
CY (1) CY1106086T1 (es)
CZ (1) CZ301376B6 (es)
DE (1) DE60025958T2 (es)
DK (1) DK1237904T3 (es)
ES (1) ES2258037T3 (es)
HK (1) HK1047596B (es)
HU (1) HUP0203611A3 (es)
IL (1) IL149424A (es)
MX (1) MXPA02004939A (es)
NO (1) NO322422B1 (es)
NZ (1) NZ518753A (es)
PE (1) PE20011033A1 (es)
PL (1) PL202999B1 (es)
RU (1) RU2242479C2 (es)
SK (1) SK287095B6 (es)
TW (1) TWI275593B (es)
WO (1) WO2001040255A2 (es)
ZA (1) ZA200203536B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60004377T2 (de) * 1999-04-06 2004-06-09 Akzo Nobel N.V. Oral wirksame 7-alpha-alkyl androgene
MXPA04007049A (es) * 2002-01-21 2004-10-14 Akzo Nobel Nv Proceso para la preparacion de 7a-metilesteroides.
US20080293683A1 (en) * 2007-05-24 2008-11-27 University Of Kansas Medical Center Hormone Replacement Therapy
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
DK2764008T3 (en) * 2011-10-07 2016-11-07 Estetra Sprl A process for the preparation of estetrol
ES2877186T3 (es) 2015-06-18 2021-11-16 Estetra Sprl Comprimido orodispersable que contiene estetrol
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
TN2017000499A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
CN111621141B (zh) * 2020-06-12 2022-04-08 广西大学 一种缓释型二氧化氯-水性聚氨酯抗菌膜及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3086027A (en) 1960-01-22 1963-04-16 Lilly Co Eli 19-nor-4, 9(10)-steroids and process
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE19537626A1 (de) 1995-10-10 1997-04-17 Jenapharm Gmbh Steroide mit einer 14, 15-Methylengruppe
DE19827522A1 (de) * 1998-06-22 1999-12-23 Jenapharm Gmbh 14,15-Cyclopropanosteroide der 19-Nor-Androstanreihe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
CA2359218A1 (en) 1999-03-08 2000-09-14 Akzo Nobel N.V. 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens

Also Published As

Publication number Publication date
SK287095B6 (sk) 2009-12-07
DK1237904T3 (da) 2006-06-06
CZ301376B6 (cs) 2010-02-03
CA2390226A1 (en) 2001-06-07
CZ20021894A3 (cs) 2002-08-14
PL202999B1 (pl) 2009-08-31
PL355689A1 (en) 2004-05-17
WO2001040255A3 (en) 2001-11-15
NO322422B1 (no) 2006-10-02
HUP0203611A3 (en) 2004-07-28
MXPA02004939A (es) 2003-05-23
AR026655A1 (es) 2003-02-19
CN1166680C (zh) 2004-09-15
PE20011033A1 (es) 2001-10-11
TWI275593B (en) 2007-03-11
EP1237904A2 (en) 2002-09-11
HK1047596A1 (en) 2003-02-28
NO20022564L (no) 2002-05-30
ES2258037T3 (es) 2006-08-16
AU2838301A (en) 2001-06-12
DE60025958D1 (de) 2006-04-20
SK7582002A3 (en) 2002-09-10
AU778017B2 (en) 2004-11-11
ZA200203536B (en) 2003-08-04
DE60025958T2 (de) 2006-07-27
JP2003515543A (ja) 2003-05-07
IL149424A (en) 2007-05-15
EP1237904B1 (en) 2006-02-08
IL149424A0 (en) 2002-11-10
NZ518753A (en) 2004-05-28
HK1047596B (zh) 2006-04-21
CY1106086T1 (el) 2011-06-08
HUP0203611A2 (hu) 2003-03-28
CN1402735A (zh) 2003-03-12
ATE317396T1 (de) 2006-02-15
WO2001040255A2 (en) 2001-06-07
US6706700B2 (en) 2004-03-16
NO20022564D0 (no) 2002-05-30
RU2242479C2 (ru) 2004-12-20
US20030100543A1 (en) 2003-05-29

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