AR029600A1 - Un derivado del acido fenoxiacetico, una composicion farmaceutica que lo contiene y agente util para la prevencion de enfermedades, uso de un derivado del acido fenoxiacetico para la fabricacion de una composicion farmaceutica para los tratamientos de dichas enfermedades y el procedimiento de fabric - Google Patents

Un derivado del acido fenoxiacetico, una composicion farmaceutica que lo contiene y agente util para la prevencion de enfermedades, uso de un derivado del acido fenoxiacetico para la fabricacion de una composicion farmaceutica para los tratamientos de dichas enfermedades y el procedimiento de fabric

Info

Publication number
AR029600A1
AR029600A1 ARP990103315A ARP990103315A AR029600A1 AR 029600 A1 AR029600 A1 AR 029600A1 AR P990103315 A ARP990103315 A AR P990103315A AR P990103315 A ARP990103315 A AR P990103315A AR 029600 A1 AR029600 A1 AR 029600A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
phenoxyacetic acid
pharmaceutical composition
acid derivative
Prior art date
Application number
ARP990103315A
Other languages
English (en)
Inventor
Nobuyuki Tanaka
Tetsuro Tamai
Akihito Hirabayashi
Hideyuki Muranaka
Masaaki Sato
Masuo Akahanae
Harunobu Mukaiyama
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of AR029600A1 publication Critical patent/AR029600A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Maintenance And Inspection Apparatuses For Elevators (AREA)

Abstract

Un derivado del ácido fenoxiacético representado por la formula general: 1 donde R1 representa un grupo hidroxi, un grupo alcoxi, inferior, un grupo aralcoxi, un grupo amino o un grupo mono- o di (alquil inferior ) amino; uno de R2 y R3 es un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo inferior, o un grupo alcoxi inferior, mientras que el otro es un átomo de hidrogeno; r4 representa un átomo de halogeno, un grupo alquilo inferior, un grupo halo (alquilo inferior), un grupo hidroxi, un grupo alcoxi inferior, un grupo aralcoxi, un grupo ciano, un grupo nitro, un grupo amino, un grupo mono- o di (alquil inferior) amino, un grupo carbamoílo, un grupo mono o di (alquil inferior) carbamoílo o un grupo representado por la formula : -NHCOR5 (donde R5 representa un átomo de hidrogeno o un grupo alquilo inferior; el átomo de carbono marcado con (R) representa un átomo de carbono en configuracion R y el átomo de carbono marcado con (S) representa un átomo de carbono en configuracion (S) y sus sales farmacéuticamente aceptables, que tienen excelentes efectos estimulantes de los beta 3 - adrenoceptores y que son utiles como agentes para la prevencion o el tratamiento de la obesidad, la hiperglicemia, las enfermedades causadas por hipermotilidad intestinal, polaquiuria, incontinencia urinaria o depresion, o las enfermedades causadas por cálculos biliares o hipermotilidad del tracto biliar.
ARP990103315A 1998-07-08 1999-07-07 Un derivado del acido fenoxiacetico, una composicion farmaceutica que lo contiene y agente util para la prevencion de enfermedades, uso de un derivado del acido fenoxiacetico para la fabricacion de una composicion farmaceutica para los tratamientos de dichas enfermedades y el procedimiento de fabric AR029600A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22850198 1998-07-08

Publications (1)

Publication Number Publication Date
AR029600A1 true AR029600A1 (es) 2003-07-10

Family

ID=16877446

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103315A AR029600A1 (es) 1998-07-08 1999-07-07 Un derivado del acido fenoxiacetico, una composicion farmaceutica que lo contiene y agente util para la prevencion de enfermedades, uso de un derivado del acido fenoxiacetico para la fabricacion de una composicion farmaceutica para los tratamientos de dichas enfermedades y el procedimiento de fabric

Country Status (28)

Country Link
US (1) US6538152B1 (es)
EP (1) EP1095932B1 (es)
JP (2) JP4132010B2 (es)
KR (1) KR100516277B1 (es)
CN (1) CN1242983C (es)
AR (1) AR029600A1 (es)
AT (1) ATE267161T1 (es)
AU (1) AU771200B2 (es)
BR (1) BR9911871B1 (es)
CA (1) CA2336853C (es)
CO (1) CO5070574A1 (es)
CZ (1) CZ302727B6 (es)
DE (1) DE69917459T2 (es)
DK (1) DK1095932T3 (es)
ES (1) ES2221390T3 (es)
HK (1) HK1039480A1 (es)
HU (1) HUP0103008A3 (es)
IL (1) IL140498A (es)
MY (1) MY126489A (es)
NO (1) NO327770B1 (es)
NZ (1) NZ509203A (es)
PE (1) PE20000758A1 (es)
PL (1) PL197453B1 (es)
PT (1) PT1095932E (es)
SA (1) SA99200411B1 (es)
TW (1) TW432040B (es)
WO (1) WO2000002846A1 (es)
ZA (1) ZA200100135B (es)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
AUPQ585000A0 (en) * 2000-02-28 2000-03-16 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
ES2314092T3 (es) 2001-09-13 2009-03-16 Kissei Pharmaceutical Co., Ltd. Cristales de un derivado de hidroxinorefredina.
UA79498C2 (en) * 2002-09-05 2007-06-25 Kissei Pharmaceutical Intermediates for preparation of phenoxy-acetic derivates and processes of their preparation
AU2003284700B2 (en) 2002-11-07 2009-05-28 Astellas Pharma Inc. Remedy for overactive bladder comprising acetic acid anlide derivatives as the active ingredient
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
EP1620085B1 (en) * 2003-05-05 2008-07-23 Kissei Pharmaceutical Co., Ltd. Use of phenoxyacetic acid derivatives for treating hyperactive bladder
DE10351271A1 (de) * 2003-10-31 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Behandlung der Stressinkontinenz und/oder Mischinkontinenz
KR20060124603A (ko) * 2003-11-03 2006-12-05 베링거 인겔하임 인터내셔날 게엠베하 베타-3-아드레날린 수용체 효능제 및 알파 길항제 및/또는5-알파-리덕타제 억제제를 함유하는 약제학적 조성물
DE10352132A1 (de) * 2003-11-04 2005-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten
DE10356112A1 (de) * 2003-11-27 2005-06-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem in den Prostglandinstoffwechsel eingreifendem Wirkstoff
JP4808613B2 (ja) * 2004-03-24 2011-11-02 キッセイ薬品工業株式会社 頻尿または尿失禁の予防または治療用医薬
WO2005092321A1 (ja) * 2004-03-24 2005-10-06 Kissei Pharmaceutical Co., Ltd. 頻尿または尿失禁の予防または治療用医薬組成物
DE102004050952A1 (de) * 2004-10-18 2006-04-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Behandlung von Beschwerden, die mit krankhaften Veränderungen oder Irritationen der Prostata verbunden sind
EP1804778A1 (de) * 2004-10-18 2007-07-11 Boehringer Ingelheim International GmbH Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts
CA2585037A1 (en) 2004-10-26 2006-05-04 Kissei Pharmaceutical Co., Ltd. Synthesis of phenoxyacetic acid derivatives
TWI356699B (en) 2004-11-10 2012-01-21 Kissei Pharmaceutical Agent for treating interstitial cystitis and agent
LT5282B (lt) 2005-02-28 2005-10-25 Kissei Pharmaceutical Co., Ltd. Tarpiniai junginiai fenoksiacto rūgšties darinių gamyboje ir jų panaudojimo būdas
JPWO2006123517A1 (ja) * 2005-04-26 2008-12-25 キッセイ薬品工業株式会社 ヒドロキシノルエフェドリン誘導体塩酸塩の結晶多形
EP1878718A4 (en) * 2005-04-26 2010-07-28 Kissei Pharmaceutical CRYSTAL OF A HYDROXYNOREPHEDRINE DERIVATIVY HYDROCHLORIDE 1/4 HYDRATE
JPWO2007026630A1 (ja) * 2005-08-29 2009-03-05 キッセイ薬品工業株式会社 涙液の減少に伴う疾患の予防又は治療剤
EP1769792A1 (de) 2005-09-30 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co.KG Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden
JPWO2007083640A1 (ja) * 2006-01-18 2009-06-11 杏林製薬株式会社 頻尿及び尿失禁の予防又は治療剤
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
JP5849947B2 (ja) 2010-03-29 2016-02-03 アステラス製薬株式会社 放出制御医薬組成物
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

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AU4320297A (en) * 1996-09-26 1998-04-17 Kissei Pharmaceutical Co. Ltd. 2-amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives
ID24062A (id) * 1997-07-25 2000-07-06 Kissei Pharmaceutical Turunan-turunan asam aminoetilfenoksiasetat dan obat untuk mengurangi nyeri dan membantu penyingkiran dalam litiasis saluran air kencing

Also Published As

Publication number Publication date
ZA200100135B (en) 2001-12-10
KR20010071772A (ko) 2001-07-31
JP4871321B2 (ja) 2012-02-08
CZ302727B6 (cs) 2011-09-29
EP1095932A1 (en) 2001-05-02
DK1095932T3 (da) 2004-09-20
US6538152B1 (en) 2003-03-25
HUP0103008A2 (hu) 2001-12-28
NO20010078L (no) 2001-03-08
NO327770B1 (no) 2009-09-21
HK1039480A1 (en) 2002-04-26
CA2336853A1 (en) 2000-01-20
CA2336853C (en) 2009-03-10
BR9911871A (pt) 2001-03-27
ES2221390T3 (es) 2004-12-16
HUP0103008A3 (en) 2002-12-28
PL197453B1 (pl) 2008-04-30
AU4397399A (en) 2000-02-01
PE20000758A1 (es) 2000-09-04
CZ200173A3 (cs) 2002-01-16
DE69917459T2 (de) 2005-05-12
JP2008273965A (ja) 2008-11-13
EP1095932B1 (en) 2004-05-19
DE69917459D1 (de) 2004-06-24
CN1308603A (zh) 2001-08-15
NZ509203A (en) 2003-03-28
KR100516277B1 (ko) 2005-09-21
CN1242983C (zh) 2006-02-22
SA99200411B1 (ar) 2006-09-09
PL345730A1 (en) 2002-01-02
PT1095932E (pt) 2004-09-30
BR9911871B1 (pt) 2010-10-19
WO2000002846A1 (en) 2000-01-20
CO5070574A1 (es) 2001-08-28
EP1095932A4 (en) 2002-10-16
AU771200B2 (en) 2004-03-18
MY126489A (en) 2006-10-31
NO20010078D0 (no) 2001-01-05
IL140498A0 (en) 2002-02-10
TW432040B (en) 2001-05-01
JP4132010B2 (ja) 2008-08-13
ATE267161T1 (de) 2004-06-15
IL140498A (en) 2004-06-20

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