PE20000558A1 - Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente - Google Patents
Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamenteInfo
- Publication number
- PE20000558A1 PE20000558A1 PE1999000413A PE00041399A PE20000558A1 PE 20000558 A1 PE20000558 A1 PE 20000558A1 PE 1999000413 A PE1999000413 A PE 1999000413A PE 00041399 A PE00041399 A PE 00041399A PE 20000558 A1 PE20000558 A1 PE 20000558A1
- Authority
- PE
- Peru
- Prior art keywords
- acidal
- acid
- preparation
- derivatives
- methylen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE R- o S-NORBENZOMORFANOS DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C8, ALCOXI C1-C8, HIDROXI, HALOGENO; CARACTERIZADO PORQUE UN DERIVADO METILADO DE 4-METILEN-PIPERIDINA DE FORMULA 2 DE PREFERENCIA (+ o -)-2-(3-METOXIFENIL)METIL-3,3-DIMETIL-4-METILEN-PIPERIDINA, QUE REACCIONA CON UN ACIDO TAL COMO ACIDO CLORHIDRICO, ACIDO BROMHIDRICO O ACIDO SULFURICO FORMANDOSE UNA SAL; REACCIONA CON DE 2 A 12 EQUIVALENTES DE HALOGENURO DE ALUMINIO III, DE PREFERENCIA TRIBROMURO DE ALUMINIO O TRICLORURO DE ALUMINIO EN UN MEDIO DE REACCION TAL COMO UN HIDROCARBURO HALOGENADO ALIFATICO O AROMATICO O UNA AMIDA DE ACIDO O MEZCLAS DE LOS DISOLVENTES MENCIONADOS (ALCANO MONO- O POLICLORADO, BENCENO O UNO DE SUS DERIVADOS CLORADOS O UNA AMIDA DE UN ACIDO CARBOXILICO C1-C3 EN EL RADICAL CARBOXILICO) DE PREFERENCIA DICLOROMETANO, 1,2-DICLOROETANO, CLOROBENCENO O DIMETILACETAMIDA A UNA TEMPERATURA ENTRE 0°C-150°C Y DESPUES DE EFECTUADA LA TRANSFORMACION SE AISLA EL PRODUCTO DE LA REACCION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19822822A DE19822822A1 (de) | 1998-05-20 | 1998-05-20 | Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000558A1 true PE20000558A1 (es) | 2000-06-28 |
Family
ID=7868527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000413A PE20000558A1 (es) | 1998-05-20 | 1999-05-17 | Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6124459A (es) |
| EP (1) | EP1080076B1 (es) |
| JP (1) | JP4526185B2 (es) |
| KR (1) | KR20010043703A (es) |
| CN (1) | CN1113058C (es) |
| AR (1) | AR016040A1 (es) |
| AT (1) | ATE254605T1 (es) |
| AU (1) | AU753563B2 (es) |
| BG (1) | BG104964A (es) |
| BR (1) | BR9910603A (es) |
| CA (1) | CA2330669C (es) |
| CO (1) | CO5060460A1 (es) |
| DE (2) | DE19822822A1 (es) |
| DK (1) | DK1080076T3 (es) |
| EA (1) | EA003059B1 (es) |
| EE (1) | EE04305B1 (es) |
| EG (1) | EG21526A (es) |
| ES (1) | ES2211093T3 (es) |
| HK (1) | HK1035728A1 (es) |
| HR (1) | HRP20000793A2 (es) |
| HU (1) | HUP0102034A3 (es) |
| ID (1) | ID27014A (es) |
| IL (1) | IL138998A0 (es) |
| MY (1) | MY120806A (es) |
| NO (1) | NO317302B1 (es) |
| NZ (1) | NZ508845A (es) |
| PE (1) | PE20000558A1 (es) |
| PL (1) | PL343935A1 (es) |
| PT (1) | PT1080076E (es) |
| SI (1) | SI1080076T1 (es) |
| SK (1) | SK283996B6 (es) |
| TR (1) | TR200003360T2 (es) |
| TW (1) | TW455582B (es) |
| UA (1) | UA59448C2 (es) |
| UY (1) | UY25515A1 (es) |
| WO (1) | WO1999059976A1 (es) |
| YU (1) | YU71400A (es) |
| ZA (1) | ZA200005740B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405149B1 (en) * | 1998-12-21 | 2008-07-29 | Megica Corporation | Post passivation method for semiconductor chip or wafer |
| US10130615B2 (en) * | 2014-09-17 | 2018-11-20 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| CN107089948B (zh) * | 2017-04-28 | 2020-07-17 | 云南大学 | 吗吩衍生物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE34235B1 (en) * | 1969-06-04 | 1975-03-19 | Acf Chemiefarma Nv | 6,7-benzomorphans and their preparation |
| US4255579A (en) * | 1974-05-20 | 1981-03-10 | Sterling Drug Inc. | 11-Substituted hexahydro-2,6-methano-3-benzazocines |
| US3932422A (en) * | 1974-05-20 | 1976-01-13 | Sterling Drug Inc. | 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones |
| DE19528472A1 (de) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
-
1998
- 1998-05-20 DE DE19822822A patent/DE19822822A1/de not_active Withdrawn
-
1999
- 1999-05-07 ID IDW20002394A patent/ID27014A/id unknown
- 1999-05-07 EE EEP200000674A patent/EE04305B1/xx not_active IP Right Cessation
- 1999-05-07 CN CN99806339A patent/CN1113058C/zh not_active Expired - Fee Related
- 1999-05-07 JP JP2000549595A patent/JP4526185B2/ja not_active Expired - Fee Related
- 1999-05-07 DE DE59907804T patent/DE59907804D1/de not_active Expired - Lifetime
- 1999-05-07 DK DK99924901T patent/DK1080076T3/da active
- 1999-05-07 PT PT99924901T patent/PT1080076E/pt unknown
- 1999-05-07 AU AU41399/99A patent/AU753563B2/en not_active Ceased
- 1999-05-07 EA EA200001212A patent/EA003059B1/ru not_active IP Right Cessation
- 1999-05-07 PL PL99343935A patent/PL343935A1/xx not_active IP Right Cessation
- 1999-05-07 SI SI9930488T patent/SI1080076T1/xx unknown
- 1999-05-07 CA CA002330669A patent/CA2330669C/en not_active Expired - Fee Related
- 1999-05-07 EP EP99924901A patent/EP1080076B1/de not_active Expired - Lifetime
- 1999-05-07 SK SK1731-2000A patent/SK283996B6/sk unknown
- 1999-05-07 WO PCT/EP1999/003142 patent/WO1999059976A1/de not_active Application Discontinuation
- 1999-05-07 NZ NZ508845A patent/NZ508845A/xx unknown
- 1999-05-07 KR KR1020007012923A patent/KR20010043703A/ko not_active Application Discontinuation
- 1999-05-07 HU HU0102034A patent/HUP0102034A3/hu unknown
- 1999-05-07 ES ES99924901T patent/ES2211093T3/es not_active Expired - Lifetime
- 1999-05-07 BR BR9910603-5A patent/BR9910603A/pt not_active IP Right Cessation
- 1999-05-07 TR TR2000/03360T patent/TR200003360T2/xx unknown
- 1999-05-07 YU YU71400A patent/YU71400A/sh unknown
- 1999-05-07 AT AT99924901T patent/ATE254605T1/de not_active IP Right Cessation
- 1999-05-07 IL IL13899899A patent/IL138998A0/xx unknown
- 1999-05-17 EG EG56999A patent/EG21526A/xx active
- 1999-05-17 PE PE1999000413A patent/PE20000558A1/es not_active Application Discontinuation
- 1999-05-17 US US09/313,001 patent/US6124459A/en not_active Expired - Lifetime
- 1999-05-18 UY UY25515A patent/UY25515A1/es not_active IP Right Cessation
- 1999-05-18 CO CO99030491A patent/CO5060460A1/es unknown
- 1999-05-18 TW TW088108090A patent/TW455582B/zh not_active IP Right Cessation
- 1999-05-19 AR ARP990102374A patent/AR016040A1/es not_active Suspension/Interruption
- 1999-05-19 MY MYPI99001967A patent/MY120806A/en unknown
- 1999-07-05 UA UA2000127360A patent/UA59448C2/uk unknown
-
2000
- 2000-10-17 ZA ZA200005740A patent/ZA200005740B/xx unknown
- 2000-11-17 BG BG104964A patent/BG104964A/xx active Pending
- 2000-11-17 HR HR20000793A patent/HRP20000793A2/hr not_active Application Discontinuation
- 2000-11-17 NO NO20005818A patent/NO317302B1/no unknown
-
2001
- 2001-09-12 HK HK01106427A patent/HK1035728A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |