AR016040A1 - Procedimiento para la preparacion de r- o bien s-norbenzomorfanos - Google Patents

Procedimiento para la preparacion de r- o bien s-norbenzomorfanos

Info

Publication number
AR016040A1
AR016040A1 ARP990102374A ARP990102374A AR016040A1 AR 016040 A1 AR016040 A1 AR 016040A1 AR P990102374 A ARP990102374 A AR P990102374A AR P990102374 A ARP990102374 A AR P990102374A AR 016040 A1 AR016040 A1 AR 016040A1
Authority
AR
Argentina
Prior art keywords
preparation
reacted
general formula
norbenzomorphans
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Suspension/Interruption
Application number
ARP990102374A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR016040A1 publication Critical patent/AR016040A1/es
Suspension/Interruption legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparacion de R- o bien S-norbenzomorfanos de formula general 1, en la que R1 puede significar H, alquilo C1-8, alcoxi C1-8,hidroxi, halogeno, caracterizado porque un derivado de 4-metilen-piperidina de formula general 2 sehac e reaccionar con un ácido, proporcionado lacorrespondiente sal por adicion de ácido, y la sal se hace reaccionar en un medio de reaccion con un halogenuro de aluminio(III), preferiblemente tribromuro dealuminio o tricloruro de aluminio, a unatempera tura comprendida en un intervalo de 0 a 150*C y, después de efectuada la transformacion, se aísla el procductode reaccion. Los compuestos obtenidos por el procedimiento son valiosos farmacéuticamente.
ARP990102374A 1998-05-20 1999-05-19 Procedimiento para la preparacion de r- o bien s-norbenzomorfanos Suspension/Interruption AR016040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19822822A DE19822822A1 (de) 1998-05-20 1998-05-20 Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten

Publications (1)

Publication Number Publication Date
AR016040A1 true AR016040A1 (es) 2001-05-30

Family

ID=7868527

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102374A Suspension/Interruption AR016040A1 (es) 1998-05-20 1999-05-19 Procedimiento para la preparacion de r- o bien s-norbenzomorfanos

Country Status (38)

Country Link
US (1) US6124459A (es)
EP (1) EP1080076B1 (es)
JP (1) JP4526185B2 (es)
KR (1) KR20010043703A (es)
CN (1) CN1113058C (es)
AR (1) AR016040A1 (es)
AT (1) ATE254605T1 (es)
AU (1) AU753563B2 (es)
BG (1) BG104964A (es)
BR (1) BR9910603A (es)
CA (1) CA2330669C (es)
CO (1) CO5060460A1 (es)
DE (2) DE19822822A1 (es)
DK (1) DK1080076T3 (es)
EA (1) EA003059B1 (es)
EE (1) EE04305B1 (es)
EG (1) EG21526A (es)
ES (1) ES2211093T3 (es)
HK (1) HK1035728A1 (es)
HR (1) HRP20000793A2 (es)
HU (1) HUP0102034A3 (es)
ID (1) ID27014A (es)
IL (1) IL138998A0 (es)
MY (1) MY120806A (es)
NO (1) NO317302B1 (es)
NZ (1) NZ508845A (es)
PE (1) PE20000558A1 (es)
PL (1) PL343935A1 (es)
PT (1) PT1080076E (es)
SI (1) SI1080076T1 (es)
SK (1) SK283996B6 (es)
TR (1) TR200003360T2 (es)
TW (1) TW455582B (es)
UA (1) UA59448C2 (es)
UY (1) UY25515A1 (es)
WO (1) WO1999059976A1 (es)
YU (1) YU71400A (es)
ZA (1) ZA200005740B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405149B1 (en) * 1998-12-21 2008-07-29 Megica Corporation Post passivation method for semiconductor chip or wafer
WO2016044546A1 (en) * 2014-09-17 2016-03-24 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
CN107089948B (zh) * 2017-04-28 2020-07-17 云南大学 吗吩衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
US4255579A (en) * 1974-05-20 1981-03-10 Sterling Drug Inc. 11-Substituted hexahydro-2,6-methano-3-benzazocines
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
DK1080076T3 (da) 2004-03-22
PT1080076E (pt) 2004-04-30
AU753563B2 (en) 2002-10-24
ES2211093T3 (es) 2004-07-01
SI1080076T1 (en) 2004-04-30
NO20005818L (no) 2000-11-17
DE59907804D1 (de) 2003-12-24
HUP0102034A3 (en) 2002-02-28
BG104964A (en) 2001-07-31
UY25515A1 (es) 1999-12-13
EE04305B1 (et) 2004-06-15
KR20010043703A (ko) 2001-05-25
BR9910603A (pt) 2001-01-16
TW455582B (en) 2001-09-21
JP4526185B2 (ja) 2010-08-18
EP1080076B1 (de) 2003-11-19
AU4139999A (en) 1999-12-06
NZ508845A (en) 2002-11-26
YU71400A (sh) 2003-04-30
DE19822822A1 (de) 1999-11-25
HUP0102034A2 (hu) 2001-12-28
CA2330669A1 (en) 1999-11-25
HRP20000793A2 (en) 2001-10-31
NO317302B1 (no) 2004-10-04
PL343935A1 (en) 2001-09-10
ID27014A (id) 2001-02-22
ZA200005740B (en) 2001-10-17
CA2330669C (en) 2008-07-15
CN1301256A (zh) 2001-06-27
US6124459A (en) 2000-09-26
TR200003360T2 (tr) 2001-06-21
SK283996B6 (sk) 2004-07-07
EA003059B1 (ru) 2002-12-26
EP1080076A1 (de) 2001-03-07
NO20005818D0 (no) 2000-11-17
JP2002515491A (ja) 2002-05-28
ATE254605T1 (de) 2003-12-15
SK17312000A3 (sk) 2001-06-11
CN1113058C (zh) 2003-07-02
WO1999059976A1 (de) 1999-11-25
UA59448C2 (uk) 2003-09-15
IL138998A0 (en) 2001-11-25
EA200001212A1 (ru) 2001-04-23
PE20000558A1 (es) 2000-06-28
CO5060460A1 (es) 2001-07-30
EE200000674A (et) 2002-04-15
MY120806A (en) 2005-11-30
HK1035728A1 (en) 2001-12-07
EG21526A (en) 2001-11-28

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