UY25515A1 - Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente - Google Patents

Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente

Info

Publication number
UY25515A1
UY25515A1 UY25515A UY25515A UY25515A1 UY 25515 A1 UY25515 A1 UY 25515A1 UY 25515 A UY25515 A UY 25515A UY 25515 A UY25515 A UY 25515A UY 25515 A1 UY25515 A1 UY 25515A1
Authority
UY
Uruguay
Prior art keywords
derivatives
preparation
norbenzomorphan
improved procedure
methylene
Prior art date
Application number
UY25515A
Other languages
English (en)
Inventor
Matthias Grauert
Hanfried Baltes
Schnaubelt Jürgen
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of UY25515A1 publication Critical patent/UY25515A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un nuevo procedimiento para la preparación de derivados de norbenzomorfanos de fórmula general (I) (figura 1), donde R1 es H, alquilo C1-8, alcoxi C1-8, hidroxi o halógeno; caracterizado por hacer reaccionar un derivado de 4-metilen-piperidina (como por ejemplo (+)-2-(3-metoxifenil)metil-3,3-dimetil-4-metilen-pirifina) con un ácido para dar la sal de adición, la que se hace reaccionar con un halogenuro de aluminio (III), preferiblemente tribromuro de aluminio o tricloruro de aluminio. Ejemplo no limitante de productos obtenidos según la invención: (-)-4'-metoxi-5,9,9-trimetil-6,7-benzomorfano-tartrato ((-)-5aTA).
UY25515A 1998-05-20 1999-05-18 Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente UY25515A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19822822A DE19822822A1 (de) 1998-05-20 1998-05-20 Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten

Publications (1)

Publication Number Publication Date
UY25515A1 true UY25515A1 (es) 1999-12-13

Family

ID=7868527

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25515A UY25515A1 (es) 1998-05-20 1999-05-18 Procedimiento mejorado para la preparacion de derivados de norbenzomorfano, valiosos farmaceuticamente

Country Status (38)

Country Link
US (1) US6124459A (es)
EP (1) EP1080076B1 (es)
JP (1) JP4526185B2 (es)
KR (1) KR20010043703A (es)
CN (1) CN1113058C (es)
AR (1) AR016040A1 (es)
AT (1) ATE254605T1 (es)
AU (1) AU753563B2 (es)
BG (1) BG104964A (es)
BR (1) BR9910603A (es)
CA (1) CA2330669C (es)
CO (1) CO5060460A1 (es)
DE (2) DE19822822A1 (es)
DK (1) DK1080076T3 (es)
EA (1) EA003059B1 (es)
EE (1) EE04305B1 (es)
EG (1) EG21526A (es)
ES (1) ES2211093T3 (es)
HK (1) HK1035728A1 (es)
HR (1) HRP20000793A2 (es)
HU (1) HUP0102034A3 (es)
ID (1) ID27014A (es)
IL (1) IL138998A0 (es)
MY (1) MY120806A (es)
NO (1) NO317302B1 (es)
NZ (1) NZ508845A (es)
PE (1) PE20000558A1 (es)
PL (1) PL343935A1 (es)
PT (1) PT1080076E (es)
SI (1) SI1080076T1 (es)
SK (1) SK283996B6 (es)
TR (1) TR200003360T2 (es)
TW (1) TW455582B (es)
UA (1) UA59448C2 (es)
UY (1) UY25515A1 (es)
WO (1) WO1999059976A1 (es)
YU (1) YU71400A (es)
ZA (1) ZA200005740B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405149B1 (en) * 1998-12-21 2008-07-29 Megica Corporation Post passivation method for semiconductor chip or wafer
US10130615B2 (en) * 2014-09-17 2018-11-20 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
CN107089948B (zh) * 2017-04-28 2020-07-17 云南大学 吗吩衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US4255579A (en) * 1974-05-20 1981-03-10 Sterling Drug Inc. 11-Substituted hexahydro-2,6-methano-3-benzazocines
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
HUP0102034A2 (hu) 2001-12-28
TR200003360T2 (tr) 2001-06-21
CN1301256A (zh) 2001-06-27
HUP0102034A3 (en) 2002-02-28
PT1080076E (pt) 2004-04-30
HRP20000793A2 (en) 2001-10-31
CO5060460A1 (es) 2001-07-30
AU753563B2 (en) 2002-10-24
SK17312000A3 (sk) 2001-06-11
UA59448C2 (uk) 2003-09-15
NZ508845A (en) 2002-11-26
EP1080076B1 (de) 2003-11-19
YU71400A (sh) 2003-04-30
PE20000558A1 (es) 2000-06-28
CA2330669C (en) 2008-07-15
DE59907804D1 (de) 2003-12-24
US6124459A (en) 2000-09-26
EP1080076A1 (de) 2001-03-07
EA200001212A1 (ru) 2001-04-23
EE200000674A (et) 2002-04-15
IL138998A0 (en) 2001-11-25
EE04305B1 (et) 2004-06-15
BR9910603A (pt) 2001-01-16
CA2330669A1 (en) 1999-11-25
ATE254605T1 (de) 2003-12-15
TW455582B (en) 2001-09-21
MY120806A (en) 2005-11-30
EG21526A (en) 2001-11-28
ES2211093T3 (es) 2004-07-01
KR20010043703A (ko) 2001-05-25
AR016040A1 (es) 2001-05-30
SK283996B6 (sk) 2004-07-07
NO317302B1 (no) 2004-10-04
PL343935A1 (en) 2001-09-10
JP2002515491A (ja) 2002-05-28
DK1080076T3 (da) 2004-03-22
ZA200005740B (en) 2001-10-17
WO1999059976A1 (de) 1999-11-25
HK1035728A1 (en) 2001-12-07
AU4139999A (en) 1999-12-06
NO20005818L (no) 2000-11-17
EA003059B1 (ru) 2002-12-26
BG104964A (en) 2001-07-31
JP4526185B2 (ja) 2010-08-18
ID27014A (id) 2001-02-22
SI1080076T1 (en) 2004-04-30
DE19822822A1 (de) 1999-11-25
CN1113058C (zh) 2003-07-02
NO20005818D0 (no) 2000-11-17

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Legal Events

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VENC Patent expired

Effective date: 20190518