PE17698A1 - PROCEDIMIENTO DE PREPARACION DEL D-TARTRATO DE (-)-cis-6(S)-FENIL-5-(R)-(4-(2-PIRROLIDIN -1-ILETOXI)FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL - Google Patents

PROCEDIMIENTO DE PREPARACION DEL D-TARTRATO DE (-)-cis-6(S)-FENIL-5-(R)-(4-(2-PIRROLIDIN -1-ILETOXI)FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL

Info

Publication number
PE17698A1
PE17698A1 PE1996000753A PE00075396A PE17698A1 PE 17698 A1 PE17698 A1 PE 17698A1 PE 1996000753 A PE1996000753 A PE 1996000753A PE 00075396 A PE00075396 A PE 00075396A PE 17698 A1 PE17698 A1 PE 17698A1
Authority
PE
Peru
Prior art keywords
phenyl
cis
tetrahidronaftalen
iletoxi
pirrolidin
Prior art date
Application number
PE1996000753A
Other languages
English (en)
Inventor
Morgan Meltz
Charles K Chiu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE17698A1 publication Critical patent/PE17698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

CARACTERIZADO PORQUE COMPRENDE: A) DISOLVER cis-6(S)-FENIL-5(R)-[4-(2-PIRROLIDIN-1-ILETOXI)FENIL]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL, EN ETANOL ACUOSO EN EBULLICION, PARA FORMAR UNA DISOLUCION; B) ANADIR A DICHA DISOLUCION UNA CANTIDAD MOLAR IGUAL DE ACIDO D-TARTARICO DISUELTO EN ETANOL ACUOSO, PARA FORMAR UNA SEGUNDA DISOLUCION; C) ENFRIAR DICHA SEGUNDA DISOLUCION; Y D) RECOGER EL PRODUCTO FORMADO EN EL PASO (C). EN EL PROCEDIMIENTO, LAS CARACTERISTICAS DEL ENFRIAMIENTO, LOGRAN UN ALTO RENDIMIENTO Y PUREZA EN LA OBTENCION DE LA SAL DEL ISOMERO (-)-CIS, QUE ES UN COMPUESTO AGONISTA DE ESTROGENO, UTIL EN EL TRATAMIENTO DE LA HIPERLIPIDEMIA, ENTRE OTROS
PE1996000753A 1995-11-02 1996-10-30 PROCEDIMIENTO DE PREPARACION DEL D-TARTRATO DE (-)-cis-6(S)-FENIL-5-(R)-(4-(2-PIRROLIDIN -1-ILETOXI)FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL PE17698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US612595P 1995-11-02 1995-11-02

Publications (1)

Publication Number Publication Date
PE17698A1 true PE17698A1 (es) 1998-04-18

Family

ID=21719433

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000753A PE17698A1 (es) 1995-11-02 1996-10-30 PROCEDIMIENTO DE PREPARACION DEL D-TARTRATO DE (-)-cis-6(S)-FENIL-5-(R)-(4-(2-PIRROLIDIN -1-ILETOXI)FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL

Country Status (43)

Country Link
US (1) US5948809A (es)
EP (1) EP0876359B1 (es)
JP (1) JP3088020B2 (es)
KR (1) KR19990067280A (es)
CN (1) CN1067065C (es)
AP (1) AP713A (es)
AR (1) AR004078A1 (es)
AT (1) ATE248827T1 (es)
AU (1) AU708841B2 (es)
BG (1) BG63943B1 (es)
BR (1) BR9611436A (es)
CA (1) CA2236673C (es)
CO (1) CO4770967A1 (es)
CZ (1) CZ287341B6 (es)
DE (1) DE69629837T2 (es)
DK (1) DK0876359T3 (es)
DZ (1) DZ2114A1 (es)
EG (1) EG21095A (es)
ES (1) ES2203713T3 (es)
GT (1) GT199600085A (es)
HR (1) HRP960503B1 (es)
HU (1) HU227521B1 (es)
IL (1) IL124027A (es)
IS (1) IS1855B (es)
MA (1) MA23998A1 (es)
NO (1) NO310358B1 (es)
NZ (1) NZ318498A (es)
OA (1) OA11009A (es)
PE (1) PE17698A1 (es)
PL (1) PL188633B1 (es)
PT (1) PT876359E (es)
RO (1) RO119829B1 (es)
RU (1) RU2162465C2 (es)
SI (1) SI0876359T1 (es)
SK (1) SK282172B6 (es)
TN (1) TNSN96134A1 (es)
TR (1) TR199800783T2 (es)
TW (2) TW581766B (es)
UA (1) UA51676C2 (es)
UY (1) UY24362A1 (es)
WO (1) WO1997016434A1 (es)
YU (1) YU49123B (es)
ZA (1) ZA969212B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
GB9703109D0 (en) * 1997-02-14 1997-04-02 Smith & Nephew Compositions
PE20000646A1 (es) * 1998-06-16 2000-08-05 Pfizer Prod Inc Terapia de combinacion para la fragilidad musculoesqueletica
CA2335112A1 (en) * 1998-06-16 1999-12-23 Hua Zhu Ke Therapeutic combinations for musculoskeletal frailty
EP0966968B1 (en) * 1998-06-16 2004-05-06 Pfizer Products Inc. Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin E2
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
CO5271697A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
CO5271696A1 (es) * 2000-01-12 2003-04-30 Pfizer Prod Inc Procedimiento para reducir la morbilidad y el riesgo de mortalidad
CO5251465A1 (es) 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
HUP0300419A3 (en) 2000-04-07 2005-07-28 Pfizer Prod Inc Estrogen agonist/antagonist metabolites, pharmaceutical compositions containing them and their use
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
ES2274854T3 (es) 2000-05-08 2007-06-01 Pfizer Products Inc. Resolucion enzimatica de moduladores selectivos del receptor de estrogeno.
IL145838A (en) * 2000-10-16 2008-11-03 Pfizer Prod Inc Use of an estrogen agonist / antagonist to produce a drug for the treatment of vaginitis
IL145876A0 (en) 2000-10-17 2002-07-25 Pfizer Prod Inc Methods and kits for improving vascular health
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
AU2756602A (en) * 2001-04-25 2002-10-31 Pfizer Products Inc. Methods and kits for treating depression or preventing deterioration of cognitive function
CZ20032959A3 (cs) 2001-05-01 2004-01-14 Pfizer Products Inc. Způsob přípravy farmaceutické kompozice s nízkou dávkou léčiva mající rovnoměrnou distribuci a účinnost léčiva
CN1599606A (zh) * 2001-07-31 2005-03-23 辉瑞产品公司 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法
RU2317104C2 (ru) * 2001-09-24 2008-02-20 Импиэриэл Инноувейшнс Лимитид Способ модификации пищевого поведения и применение pyy или его агониста в качестве средства для модификации пищевого поведения
HUP0500025A3 (en) * 2002-03-28 2005-10-28 Pfizer Prod Inc Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization
PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
EP1765461A1 (en) * 2004-06-21 2007-03-28 Pharmacia & Upjohn Company LLC Pyk2 inhibitors for stimulation of osteoblast function
BRPI0512245A (pt) * 2004-06-30 2008-02-19 Lilly Co Eli composto, composição farmacêutica, e, uso do composto
EP1899310B1 (en) 2005-06-22 2010-09-29 Pfizer Products Inc. Stereoselective hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride
CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
EP2424839A4 (en) 2009-04-29 2012-10-17 Glenmark Generics Ltd PROCESS FOR THE PREPARATION OF LASOFOXIFEN TARTRATE
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
CN103113323B (zh) * 2013-02-05 2015-11-11 南京华威医药科技开发有限公司 酒石酸拉索昔芬中间体的制备方法
RU2019114079A (ru) 2016-10-11 2020-11-13 Дьюк Юниверсити Лечение er+ рака молочной железы лазофоксифеном
WO2019199891A1 (en) 2018-04-10 2019-10-17 Duke University Lasofoxifene treatment of breast cancer
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234090A (en) * 1962-09-10 1966-02-08 Ciba Geigy Corp Pharmaceutical compositions comprising saturated basic ethers
US3522319A (en) * 1964-01-23 1970-07-28 Ciba Geigy Corp Phenol substituted tetrahydronaphthalenes useful as estrogenics
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis

Also Published As

Publication number Publication date
IL124027A (en) 2001-10-31
DE69629837T2 (de) 2004-05-06
BR9611436A (pt) 1999-03-23
BG102474A (en) 1999-06-30
CN1067065C (zh) 2001-06-13
TR199800783T2 (xx) 1998-08-21
JPH11502866A (ja) 1999-03-09
TW518327B (en) 2003-01-21
EP0876359A1 (en) 1998-11-11
AU708841B2 (en) 1999-08-12
DZ2114A1 (fr) 2002-07-22
HU227521B1 (en) 2011-07-28
ATE248827T1 (de) 2003-09-15
UA51676C2 (uk) 2002-12-16
DK0876359T3 (da) 2003-11-24
JP3088020B2 (ja) 2000-09-18
CZ132098A3 (cs) 1999-03-17
PL326498A1 (en) 1998-09-28
NZ318498A (en) 1999-06-29
NO310358B1 (no) 2001-06-25
CZ287341B6 (en) 2000-10-11
SK54298A3 (en) 1999-07-12
CA2236673C (en) 2002-03-19
EP0876359B1 (en) 2003-09-03
AU6998496A (en) 1997-05-22
TW581766B (en) 2004-04-01
GT199600085A (es) 1998-04-04
SI0876359T1 (en) 2003-12-31
HUP9900087A3 (en) 1999-11-29
UY24362A1 (es) 1997-04-24
KR19990067280A (ko) 1999-08-16
HRP960503A2 (en) 1998-04-30
US5948809A (en) 1999-09-07
DE69629837D1 (de) 2003-10-09
YU57896A (sh) 1998-12-23
AP713A (en) 1998-12-28
AR004078A1 (es) 1998-09-30
YU49123B (sh) 2004-03-12
ZA969212B (en) 1998-05-04
AP9600880A0 (en) 1997-01-31
HRP960503B1 (en) 2001-12-31
RU2162465C2 (ru) 2001-01-27
IS4718A (is) 1998-04-16
CA2236673A1 (en) 1997-05-09
HUP9900087A2 (hu) 1999-05-28
RO119829B1 (ro) 2005-04-29
NO981962L (no) 1998-04-30
ES2203713T3 (es) 2004-04-16
WO1997016434A1 (en) 1997-05-09
IS1855B (is) 2003-02-21
CN1201458A (zh) 1998-12-09
BG63943B1 (bg) 2003-07-31
CO4770967A1 (es) 1999-04-30
PT876359E (pt) 2003-12-31
EG21095A (en) 2000-10-31
TNSN96134A1 (fr) 1998-12-31
SK282172B6 (sk) 2001-11-06
OA11009A (en) 2003-03-03
PL188633B1 (pl) 2005-03-31
NO981962D0 (no) 1998-04-30
MA23998A1 (fr) 1997-07-01
MX9803544A (es) 1998-09-30

Similar Documents

Publication Publication Date Title
PE17698A1 (es) PROCEDIMIENTO DE PREPARACION DEL D-TARTRATO DE (-)-cis-6(S)-FENIL-5-(R)-(4-(2-PIRROLIDIN -1-ILETOXI)FENIL)-5,6,7,8-TETRAHIDRONAFTALEN-2-OL
MA21722A1 (fr) Derives de 2 - aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation .
ES8506677A1 (es) Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
NO904022L (no) Fremgangsmaate for fremstilling av nye n-aryl- og n-heteroarylamid- og -urinstoffderivater.
KR920021507A (ko) 인돌 유도체
HUP9602868A2 (hu) Új 1,7,7-trimetil-biciklo[2.2.1]heptán-származékok
MX9200777A (es) 4-[(2-benzotiazolil)metilamino]-alfa-[(3,4-difluorofenoxi)metil]-1-pip eridetanol.
KR910002865A (ko) 피라노벤즈옥사디아졸 화합물 및 그 광학적 분할방법
TNSN91001A1 (en) Hemi-hydrate
DE69419416T2 (de) Gaba-erge modulation des augenwachstums
AU656674B2 (en) New thiochroman compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
PT97541A (pt) Processo para a preparacao de indoles substituidos
ES515895A0 (es) "un procedimiento para la preparacion de un compuesto de imidazol".
JPS5681557A (en) Preparation of optically active alpha-methyl-beta- mercaptopropionic acid derivative
PT82547B (pt) Processo de preparacao de acidos hexenoicos e de composicoes farmaceuticas que os contem
KR900011720A (ko) 글리신 유도체 및 그의 제조방법
HU886767D0 (en) Process for the preparation of new 20,21-dinor-eburnamenine derivatives, new intermediates thereof, as well as pharmaceutical compositions containing said compounds as active ingredients
IE840167L (en) Pyrrole-2-acetylamino acid derivatives
DE69608699T2 (de) Fluorsubstituierte benzoylpropionsaürederivate
DK0643055T3 (da) Fremgangsmåde til fremstilling af 5-amino-2,2-dialkyl-1,3-dioxaner
ITMI931418A1 (it) Enantiomeri farmacologicamente attivi
DK0725785T3 (da) Fremgangsmåde til fremstilling af rufloxacin af deraf
CO4410182A1 (es) Proceso para mejorar la pureza enantiomerica de aldehidos
JO1870B1 (en) CO2 derivatives - pyridinyl benzimidazole innovative
KR960701832A (ko) Ng-모노알킬-l-아르기닌 및 관련 화합물의 제조 방법(process for preparing ng-monoalkyl-l-arginine and related compounds)

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed