ITMI931418A1 - Enantiomeri farmacologicamente attivi - Google Patents
Enantiomeri farmacologicamente attiviInfo
- Publication number
- ITMI931418A1 ITMI931418A1 IT93MI001418A ITMI931418A ITMI931418A1 IT MI931418 A1 ITMI931418 A1 IT MI931418A1 IT 93MI001418 A IT93MI001418 A IT 93MI001418A IT MI931418 A ITMI931418 A IT MI931418A IT MI931418 A1 ITMI931418 A1 IT MI931418A1
- Authority
- IT
- Italy
- Prior art keywords
- pharmacologically active
- active enantiomers
- formula
- enantiomers
- alk
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Enantiomeri farmacologicamente attivi di formula (FORMULA IA) in cui Alk è alchile a 1-3C,loro sali con acidi fisiologicamente accettabili, metodo per prepararli e composizioni farmaceutiche che li contengono.
Priority Applications (39)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001418A IT1268414B1 (it) | 1993-07-01 | 1993-07-01 | Enantiomeri farmacologicamente attivi |
DE69405999T DE69405999T2 (de) | 1993-07-01 | 1994-06-21 | Pharmazeutisch wirksame enantiomere |
CN94193226A CN1046281C (zh) | 1993-07-01 | 1994-06-21 | 药理活性的对映体及其制备方法 |
SI9430110T SI0707587T1 (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers |
EP94919660A EP0707587B1 (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers |
AT94919660T ATE158796T1 (de) | 1993-07-01 | 1994-06-21 | Pharmazeutisch wirksame enantiomere |
PCT/EP1994/002061 WO1995001354A1 (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers |
JP07503250A JP3096065B2 (ja) | 1993-07-01 | 1994-06-21 | 医薬的に活性な鏡像体 |
PL94312419A PL181831B1 (pl) | 1993-07-01 | 1994-06-21 | Farmakologicznie aktywne enancjomery PL PL PL PL PL |
ES94919660T ES2111309T3 (es) | 1993-07-01 | 1994-06-21 | Enantiomeros farmacologicamente activos. |
NZ268014A NZ268014A (en) | 1993-07-01 | 1994-06-21 | 1,2,4-triazol [4,3-a]pyridin-3(2h)ones; enantiomers of such compounds and a method for their preparation |
RO95-02315A RO116899B1 (ro) | 1993-07-01 | 1994-06-21 | DERIVATI DE 1,2,4-TRIAZOL[4,3-a]-PIRIDINONA SI PROCEDEU PENTRU PREPARAREA ACESTORA |
CZ19953485A CZ289526B6 (cs) | 1993-07-01 | 1994-06-21 | (S) nebo (R) Enantiomer piperazinylové sloučeniny a způsob jeho přípravy |
GEAP19943025A GEP19991791B (en) | 1993-07-01 | 1994-06-21 | Pharmacologically Active Enantiomers and Process for its Production |
SK1664-95A SK281060B6 (sk) | 1993-07-01 | 1994-06-21 | Farmakologicky účinné enantioméry, spôsob ich prípravy, medziprodukty tohto postupu |
US08/564,276 US5741907A (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers |
AU70729/94A AU689478B2 (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers of triazolone compounds |
DK94919660.4T DK0707587T3 (da) | 1993-07-01 | 1994-06-21 | Farmakologisk aktive enantiomerer |
CA002166470A CA2166470C (en) | 1993-07-01 | 1994-06-21 | Pharmacologically active enantiomers |
UA96010331A UA53607C2 (uk) | 1993-07-01 | 1994-06-21 | Фармакологічно активні енантіомери, спосіб їх отримання, проміжна сполука для їх отримання та спосіб її отримання |
KR1019950705994A KR100306018B1 (ko) | 1993-07-01 | 1994-06-21 | 약리학적 활성을 갖는 에난티오머 |
BR9406996A BR9406996A (pt) | 1993-07-01 | 1994-06-21 | Enanciômero processo para preparar o mesmo processo para ciclizar um composto e composto intermediário |
HU9503876A HU221631B1 (hu) | 1993-07-01 | 1994-06-21 | Gyógyászatilag aktív 1,2,4-triazo [4,3-a]piridin enantiomerek és eljárás ezek, valamint piperazin-intermedierek előállítására |
ROA200100015A RO121031B1 (ro) | 1993-07-01 | 1994-06-21 | Derivat de 3-clorfenil-piperazinonă şi procedeude preparare a acestuia |
RU96104371A RU2128180C1 (ru) | 1993-07-01 | 1994-06-21 | (s)- или (r)-энантиомеры, способы их получения, промежуточный продукт |
ZA944570A ZA944570B (en) | 1993-07-01 | 1994-06-24 | Pharmacologically active enantiomers |
FI956334A FI111943B (fi) | 1993-07-01 | 1995-12-29 | Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet |
NO955345A NO305957B1 (no) | 1993-07-01 | 1995-12-29 | Farmakologisk aktive enantiomerer |
LVP-96-17A LV11546B (en) | 1993-07-01 | 1996-01-26 | Pharmacologically active enantiomers |
BG100331A BG61815B1 (bg) | 1993-07-01 | 1996-02-01 | Фармакологично активни енантиомери |
US08/995,988 US5817815A (en) | 1993-07-01 | 1997-12-22 | Pharmacologically active enantiomers |
GR970403452T GR3025806T3 (en) | 1993-07-01 | 1997-12-30 | Pharmacologically active enantiomers |
US09/076,845 US5973150A (en) | 1993-07-01 | 1998-05-13 | Pharmacologically active enantiomers |
AU69041/98A AU718075B2 (en) | 1993-07-01 | 1998-05-27 | Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds |
CNB98116661XA CN1136201C (zh) | 1993-07-01 | 1998-07-29 | 药理活性的对映体及其制备方法 |
CNB981166601A CN1136200C (zh) | 1993-07-01 | 1998-07-29 | 药理活性的对映体及其制备方法 |
HK99103799A HK1018781A1 (en) | 1993-07-01 | 1999-09-02 | Pharmacologically active enantiomers |
HK99103792A HK1018777A1 (en) | 1993-07-01 | 1999-09-02 | Pharmacologically active enantiomers |
CZ20004132A CZ292867B6 (cs) | 1993-07-01 | 2000-11-07 | Způsob cyklizace anilinových derivátů |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93MI001418A IT1268414B1 (it) | 1993-07-01 | 1993-07-01 | Enantiomeri farmacologicamente attivi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI931418A0 ITMI931418A0 (it) | 1993-07-01 |
ITMI931418A1 true ITMI931418A1 (it) | 1995-01-01 |
IT1268414B1 IT1268414B1 (it) | 1997-02-27 |
Family
ID=11366510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93MI001418A IT1268414B1 (it) | 1993-07-01 | 1993-07-01 | Enantiomeri farmacologicamente attivi |
Country Status (30)
Country | Link |
---|---|
US (3) | US5741907A (it) |
EP (1) | EP0707587B1 (it) |
JP (1) | JP3096065B2 (it) |
KR (1) | KR100306018B1 (it) |
CN (3) | CN1046281C (it) |
AT (1) | ATE158796T1 (it) |
AU (1) | AU689478B2 (it) |
BG (1) | BG61815B1 (it) |
BR (1) | BR9406996A (it) |
CA (1) | CA2166470C (it) |
CZ (1) | CZ289526B6 (it) |
DE (1) | DE69405999T2 (it) |
DK (1) | DK0707587T3 (it) |
ES (1) | ES2111309T3 (it) |
FI (1) | FI111943B (it) |
GE (1) | GEP19991791B (it) |
GR (1) | GR3025806T3 (it) |
HK (2) | HK1018781A1 (it) |
HU (1) | HU221631B1 (it) |
IT (1) | IT1268414B1 (it) |
LV (1) | LV11546B (it) |
NO (1) | NO305957B1 (it) |
NZ (1) | NZ268014A (it) |
PL (1) | PL181831B1 (it) |
RO (2) | RO121031B1 (it) |
RU (1) | RU2128180C1 (it) |
SK (1) | SK281060B6 (it) |
UA (1) | UA53607C2 (it) |
WO (1) | WO1995001354A1 (it) |
ZA (1) | ZA944570B (it) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1268414B1 (it) * | 1993-07-01 | 1997-02-27 | Angelini Francesco Ist Ricerca | Enantiomeri farmacologicamente attivi |
JP2009018992A (ja) * | 2007-07-10 | 2009-01-29 | Sumitomo Chemical Co Ltd | 光学活性ミルタザピンの製造方法 |
RU2706700C1 (ru) | 2019-09-24 | 2019-11-20 | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3365453A (en) * | 1963-10-28 | 1968-01-23 | Sterling Drug Inc | 1-phenyl-4-lower-alkyl-2-piperazinones |
IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
US5303837A (en) * | 1991-03-05 | 1994-04-19 | Portola Packaging, Inc. | One-piece fitment and plug with tamper-evident band |
US5739334A (en) * | 1992-01-17 | 1998-04-14 | Istituto Ricerca Francesco Angelini S.P.A. | Alkyl derivatives of trazodone with CNS activity |
IT1258790B (it) * | 1992-01-17 | 1996-02-29 | Angelini Francesco Ist Ricerca | Alchil derivati del trazodone |
IT1268414B1 (it) * | 1993-07-01 | 1997-02-27 | Angelini Francesco Ist Ricerca | Enantiomeri farmacologicamente attivi |
US5399765A (en) * | 1994-05-23 | 1995-03-21 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
-
1993
- 1993-07-01 IT IT93MI001418A patent/IT1268414B1/it active IP Right Grant
-
1994
- 1994-06-21 BR BR9406996A patent/BR9406996A/pt not_active Application Discontinuation
- 1994-06-21 CZ CZ19953485A patent/CZ289526B6/cs not_active IP Right Cessation
- 1994-06-21 SK SK1664-95A patent/SK281060B6/sk not_active IP Right Cessation
- 1994-06-21 HU HU9503876A patent/HU221631B1/hu not_active IP Right Cessation
- 1994-06-21 RU RU96104371A patent/RU2128180C1/ru not_active IP Right Cessation
- 1994-06-21 DK DK94919660.4T patent/DK0707587T3/da active
- 1994-06-21 EP EP94919660A patent/EP0707587B1/en not_active Expired - Lifetime
- 1994-06-21 KR KR1019950705994A patent/KR100306018B1/ko not_active IP Right Cessation
- 1994-06-21 ES ES94919660T patent/ES2111309T3/es not_active Expired - Lifetime
- 1994-06-21 AT AT94919660T patent/ATE158796T1/de not_active IP Right Cessation
- 1994-06-21 CA CA002166470A patent/CA2166470C/en not_active Expired - Fee Related
- 1994-06-21 CN CN94193226A patent/CN1046281C/zh not_active Expired - Fee Related
- 1994-06-21 GE GEAP19943025A patent/GEP19991791B/en unknown
- 1994-06-21 NZ NZ268014A patent/NZ268014A/xx not_active IP Right Cessation
- 1994-06-21 RO ROA200100015A patent/RO121031B1/ro unknown
- 1994-06-21 US US08/564,276 patent/US5741907A/en not_active Expired - Fee Related
- 1994-06-21 DE DE69405999T patent/DE69405999T2/de not_active Expired - Fee Related
- 1994-06-21 AU AU70729/94A patent/AU689478B2/en not_active Ceased
- 1994-06-21 RO RO95-02315A patent/RO116899B1/ro unknown
- 1994-06-21 PL PL94312419A patent/PL181831B1/pl not_active IP Right Cessation
- 1994-06-21 UA UA96010331A patent/UA53607C2/uk unknown
- 1994-06-21 WO PCT/EP1994/002061 patent/WO1995001354A1/en active IP Right Grant
- 1994-06-21 JP JP07503250A patent/JP3096065B2/ja not_active Expired - Fee Related
- 1994-06-24 ZA ZA944570A patent/ZA944570B/xx unknown
-
1995
- 1995-12-29 FI FI956334A patent/FI111943B/fi active
- 1995-12-29 NO NO955345A patent/NO305957B1/no unknown
-
1996
- 1996-01-26 LV LVP-96-17A patent/LV11546B/en unknown
- 1996-02-01 BG BG100331A patent/BG61815B1/bg unknown
-
1997
- 1997-12-22 US US08/995,988 patent/US5817815A/en not_active Expired - Fee Related
- 1997-12-30 GR GR970403452T patent/GR3025806T3/el unknown
-
1998
- 1998-05-13 US US09/076,845 patent/US5973150A/en not_active Expired - Fee Related
- 1998-07-29 CN CNB981166601A patent/CN1136200C/zh not_active Expired - Fee Related
- 1998-07-29 CN CNB98116661XA patent/CN1136201C/zh not_active Expired - Fee Related
-
1999
- 1999-09-02 HK HK99103799A patent/HK1018781A1/xx not_active IP Right Cessation
- 1999-09-02 HK HK99103792A patent/HK1018777A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970724 |