YU49123B - POSTUPAK ZA DOBIJANJE (-) CIS-6(S)-FENIL-5(R)[4-(2-pirolidin-1-IL ETOKSI)fenil]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL D-TARTARATA - Google Patents

POSTUPAK ZA DOBIJANJE (-) CIS-6(S)-FENIL-5(R)[4-(2-pirolidin-1-IL ETOKSI)fenil]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL D-TARTARATA

Info

Publication number
YU49123B
YU49123B YU57896A YU57896A YU49123B YU 49123 B YU49123 B YU 49123B YU 57896 A YU57896 A YU 57896A YU 57896 A YU57896 A YU 57896A YU 49123 B YU49123 B YU 49123B
Authority
YU
Yugoslavia
Prior art keywords
phenyl
pyrrolidin
ethoxy
cis
solution
Prior art date
Application number
YU57896A
Other languages
English (en)
Other versions
YU57896A (sh
Inventor
K. Charles Chiu
Morgan Meltz
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU57896A publication Critical patent/YU57896A/sh
Publication of YU49123B publication Critical patent/YU49123B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Postupak za dobijanje (-)Cis-6(S)-Fenil-5(R)[4-(2-pirolidin-1-il etoksi)fenil]-5,6,7,8-tetrahidronaftalen-2-ol D-tartarata, naznačen time, što obuhvata: a) rastvaranje racemata ili parcijalno optički obogaćenog cis-6-fenil-5[4-(2-pirolidin-1-il-etoksi)fenil]-5,6,7,8-tetrahidronaftalen-2-ol u ključalom vodenom etanolu radi stvaranja rastvora; b) dodavanje iste molarne količine D-vinske kiseline rastvorene u vodenom etanolu u navedeni rastvor radi dobijanja drugog rastvora; c) hlađenje navedenog drugog rastvora; i d) skupljanje proizvoda dobijenog u prethodnoj fazi.
YU57896A 1995-11-02 1996-11-01 POSTUPAK ZA DOBIJANJE (-) CIS-6(S)-FENIL-5(R)[4-(2-pirolidin-1-IL ETOKSI)fenil]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL D-TARTARATA YU49123B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US612595P 1995-11-02 1995-11-02

Publications (2)

Publication Number Publication Date
YU57896A YU57896A (sh) 1998-12-23
YU49123B true YU49123B (sh) 2004-03-12

Family

ID=21719433

Family Applications (1)

Application Number Title Priority Date Filing Date
YU57896A YU49123B (sh) 1995-11-02 1996-11-01 POSTUPAK ZA DOBIJANJE (-) CIS-6(S)-FENIL-5(R)[4-(2-pirolidin-1-IL ETOKSI)fenil]-5,6,7,8-TETRAHIDRONAFTALEN-2-OL D-TARTARATA

Country Status (43)

Country Link
US (1) US5948809A (sh)
EP (1) EP0876359B1 (sh)
JP (1) JP3088020B2 (sh)
KR (1) KR19990067280A (sh)
CN (1) CN1067065C (sh)
AP (1) AP713A (sh)
AR (1) AR004078A1 (sh)
AT (1) ATE248827T1 (sh)
AU (1) AU708841B2 (sh)
BG (1) BG63943B1 (sh)
BR (1) BR9611436A (sh)
CA (1) CA2236673C (sh)
CO (1) CO4770967A1 (sh)
CZ (1) CZ287341B6 (sh)
DE (1) DE69629837T2 (sh)
DK (1) DK0876359T3 (sh)
DZ (1) DZ2114A1 (sh)
EG (1) EG21095A (sh)
ES (1) ES2203713T3 (sh)
GT (1) GT199600085A (sh)
HR (1) HRP960503B1 (sh)
HU (1) HU227521B1 (sh)
IL (1) IL124027A (sh)
IS (1) IS1855B (sh)
MA (1) MA23998A1 (sh)
NO (1) NO310358B1 (sh)
NZ (1) NZ318498A (sh)
OA (1) OA11009A (sh)
PE (1) PE17698A1 (sh)
PL (1) PL188633B1 (sh)
PT (1) PT876359E (sh)
RO (1) RO119829B1 (sh)
RU (1) RU2162465C2 (sh)
SI (1) SI0876359T1 (sh)
SK (1) SK282172B6 (sh)
TN (1) TNSN96134A1 (sh)
TR (1) TR199800783T2 (sh)
TW (2) TW581766B (sh)
UA (1) UA51676C2 (sh)
UY (1) UY24362A1 (sh)
WO (1) WO1997016434A1 (sh)
YU (1) YU49123B (sh)
ZA (1) ZA969212B (sh)

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PE20000646A1 (es) * 1998-06-16 2000-08-05 Pfizer Prod Inc Terapia de combinacion para la fragilidad musculoesqueletica
CA2335112A1 (en) * 1998-06-16 1999-12-23 Hua Zhu Ke Therapeutic combinations for musculoskeletal frailty
EP0966968B1 (en) * 1998-06-16 2004-05-06 Pfizer Products Inc. Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin E2
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
CO5271697A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
CO5271696A1 (es) * 2000-01-12 2003-04-30 Pfizer Prod Inc Procedimiento para reducir la morbilidad y el riesgo de mortalidad
CO5251465A1 (es) 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
HUP0300419A3 (en) 2000-04-07 2005-07-28 Pfizer Prod Inc Estrogen agonist/antagonist metabolites, pharmaceutical compositions containing them and their use
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
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CZ20032959A3 (cs) 2001-05-01 2004-01-14 Pfizer Products Inc. Způsob přípravy farmaceutické kompozice s nízkou dávkou léčiva mající rovnoměrnou distribuci a účinnost léčiva
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PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
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EP1765461A1 (en) * 2004-06-21 2007-03-28 Pharmacia & Upjohn Company LLC Pyk2 inhibitors for stimulation of osteoblast function
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EP1899310B1 (en) 2005-06-22 2010-09-29 Pfizer Products Inc. Stereoselective hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride
CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
EP2424839A4 (en) 2009-04-29 2012-10-17 Glenmark Generics Ltd PROCESS FOR THE PREPARATION OF LASOFOXIFEN TARTRATE
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
CN103113323B (zh) * 2013-02-05 2015-11-11 南京华威医药科技开发有限公司 酒石酸拉索昔芬中间体的制备方法
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Also Published As

Publication number Publication date
IL124027A (en) 2001-10-31
DE69629837T2 (de) 2004-05-06
BR9611436A (pt) 1999-03-23
BG102474A (en) 1999-06-30
CN1067065C (zh) 2001-06-13
TR199800783T2 (xx) 1998-08-21
JPH11502866A (ja) 1999-03-09
TW518327B (en) 2003-01-21
EP0876359A1 (en) 1998-11-11
AU708841B2 (en) 1999-08-12
DZ2114A1 (fr) 2002-07-22
HU227521B1 (en) 2011-07-28
ATE248827T1 (de) 2003-09-15
UA51676C2 (uk) 2002-12-16
DK0876359T3 (da) 2003-11-24
JP3088020B2 (ja) 2000-09-18
PE17698A1 (es) 1998-04-18
CZ132098A3 (cs) 1999-03-17
PL326498A1 (en) 1998-09-28
NZ318498A (en) 1999-06-29
NO310358B1 (no) 2001-06-25
CZ287341B6 (en) 2000-10-11
SK54298A3 (en) 1999-07-12
CA2236673C (en) 2002-03-19
EP0876359B1 (en) 2003-09-03
AU6998496A (en) 1997-05-22
TW581766B (en) 2004-04-01
GT199600085A (es) 1998-04-04
SI0876359T1 (en) 2003-12-31
HUP9900087A3 (en) 1999-11-29
UY24362A1 (es) 1997-04-24
KR19990067280A (ko) 1999-08-16
HRP960503A2 (en) 1998-04-30
US5948809A (en) 1999-09-07
DE69629837D1 (de) 2003-10-09
YU57896A (sh) 1998-12-23
AP713A (en) 1998-12-28
AR004078A1 (es) 1998-09-30
ZA969212B (en) 1998-05-04
AP9600880A0 (en) 1997-01-31
HRP960503B1 (en) 2001-12-31
RU2162465C2 (ru) 2001-01-27
IS4718A (is) 1998-04-16
CA2236673A1 (en) 1997-05-09
HUP9900087A2 (hu) 1999-05-28
RO119829B1 (ro) 2005-04-29
NO981962L (no) 1998-04-30
ES2203713T3 (es) 2004-04-16
WO1997016434A1 (en) 1997-05-09
IS1855B (is) 2003-02-21
CN1201458A (zh) 1998-12-09
BG63943B1 (bg) 2003-07-31
CO4770967A1 (es) 1999-04-30
PT876359E (pt) 2003-12-31
EG21095A (en) 2000-10-31
TNSN96134A1 (fr) 1998-12-31
SK282172B6 (sk) 2001-11-06
OA11009A (en) 2003-03-03
PL188633B1 (pl) 2005-03-31
NO981962D0 (no) 1998-04-30
MA23998A1 (fr) 1997-07-01
MX9803544A (es) 1998-09-30

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