PE130999A1 - 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba - Google Patents

4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba

Info

Publication number
PE130999A1
PE130999A1 PE1998001100A PE00110098A PE130999A1 PE 130999 A1 PE130999 A1 PE 130999A1 PE 1998001100 A PE1998001100 A PE 1998001100A PE 00110098 A PE00110098 A PE 00110098A PE 130999 A1 PE130999 A1 PE 130999A1
Authority
PE
Peru
Prior art keywords
alkyl
naftiridin
oxo
cycloalkyl
leaguards
Prior art date
Application number
PE1998001100A
Other languages
English (en)
Spanish (es)
Inventor
Pamela Albaugh
Robert W Desimone
Gang Liu
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of PE130999A1 publication Critical patent/PE130999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PE1998001100A 1997-08-25 1998-11-13 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba PE130999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25

Publications (1)

Publication Number Publication Date
PE130999A1 true PE130999A1 (es) 1999-12-16

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001100A PE130999A1 (es) 1997-08-25 1998-11-13 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba

Country Status (24)

Country Link
EP (1) EP1007526A1 (fr)
JP (1) JP2001514181A (fr)
KR (1) KR20010023313A (fr)
CN (1) CN1268136A (fr)
AP (1) AP2000001742A0 (fr)
AU (1) AU753800B2 (fr)
BG (1) BG104192A (fr)
BR (1) BR9811362A (fr)
CA (1) CA2301599C (fr)
EG (1) EG21717A (fr)
HU (1) HUP0003258A3 (fr)
IL (1) IL134291A0 (fr)
IS (1) IS5382A (fr)
LV (1) LV12539B (fr)
NO (1) NO20000822L (fr)
NZ (1) NZ502548A (fr)
OA (1) OA11293A (fr)
PE (1) PE130999A1 (fr)
PL (1) PL338783A1 (fr)
SI (1) SI20270A (fr)
SK (1) SK2162000A3 (fr)
TW (1) TW574221B (fr)
WO (1) WO1999010347A1 (fr)
YU (1) YU10500A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE289593T1 (de) * 1999-05-06 2005-03-15 Neurogen Corp Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden
WO2000071528A1 (fr) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides et leur utilisation en tant que ligands des recepteurs cerebraux gaba
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
EA200300449A1 (ru) 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
US6841558B2 (en) 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
WO2002030426A1 (fr) 2000-10-12 2002-04-18 Merck & Co., Inc. Azanaphthalenylcarboxamides et polyazanaphthalenylcarboxamides utiles en tant qu'inhibiteurs de la vih integrase
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CN1494422A (zh) * 2001-03-01 2004-05-05 �Ʒ� Gabaa反相激动剂与烟碱受体不完全激动剂、雌激素、选择性雌激素调节剂、或维生素e联合用于认知障碍的用途
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
US7279487B2 (en) 2002-01-17 2007-10-09 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
EP1496836B1 (fr) 2002-03-15 2008-09-24 Merck & Co., Inc. N-(benzyl substitue)-8-hydroxy-1,6-naphthyridine-7- carboxamides utiles en tant qu'inhibiteurs d'integrase de hiv
WO2004106336A1 (fr) * 2003-05-27 2004-12-09 Pfizer Products Inc. Procede de preparation et de purification de 1,5-naphtyridine-3-carboxyamides
WO2004106334A2 (fr) * 2003-05-28 2004-12-09 Pfizer Products Inc. Procede de preparation de 1,5-naphtyridine-3-carboxyamides par amidation directe d'esters
DK2074123T3 (da) * 2006-10-16 2013-01-14 Bionomics Ltd Nye anxiolytiske forbindelser
WO2008066750A1 (fr) * 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Procédés de traitement du retard mental, du syndrome de down, du syndrome de l'x fragile et de l'autisme

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
NO20000822L (no) 2000-04-13
YU10500A (sh) 2002-10-18
AP2000001742A0 (en) 2000-02-24
BG104192A (en) 2001-05-31
EP1007526A1 (fr) 2000-06-14
SK2162000A3 (en) 2001-03-12
PL338783A1 (en) 2000-11-20
LV12539A (en) 2000-10-20
CA2301599A1 (fr) 1999-03-04
AU9117398A (en) 1999-03-16
WO1999010347A1 (fr) 1999-03-04
JP2001514181A (ja) 2001-09-11
OA11293A (en) 2002-11-19
EG21717A (en) 2002-02-27
SI20270A (sl) 2000-12-31
TW574221B (en) 2004-02-01
NZ502548A (en) 2002-06-28
BR9811362A (pt) 2000-08-22
IS5382A (is) 2000-02-22
IL134291A0 (en) 2001-04-30
AU753800B2 (en) 2002-10-31
HUP0003258A2 (en) 2001-03-28
NO20000822D0 (no) 2000-02-18
CN1268136A (zh) 2000-09-27
LV12539B (en) 2001-01-20
KR20010023313A (ko) 2001-03-26
CA2301599C (fr) 2003-03-25
HUP0003258A3 (en) 2001-05-28

Similar Documents

Publication Publication Date Title
PE130999A1 (es) 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba
DK0613458T3 (da) Acykliske ethylendiaminderivater som substans P receptorantagonister
PE91798A1 (es) Pirrolicarboxanilidas condensadas: utiles como ligandos receptores
AR062299A1 (es) Derivados de bencimidazol
DK0641328T3 (da) Broforbundne, azabicykliske derivater som substans P-antagonister
MX9702601A (es) AGONISTAS beta-ADRENERGICOS HETEROCICLICOS.
PE46899A1 (es) Derivados de n-fenil-sulfonamida
PE109598A1 (es) Pirrolcarboxamidas condensadas, utiles como ligandos de receptores cerebrales gaba
PE20020917A1 (es) Derivados de imidazol como bloqueadores del receptor n-metil-d-aspartato
ES2059327T3 (es) Derivados de tetrahidronaftaleno y de indano, obtencion de los mismos y utilizacion en preparados farmaceuticos.
NO940927L (no) Kondenserte tricykliske nitrogenholdige heterocykler som substans-P-reseptor-antagonister
PE20030417A1 (es) Derivados de urea como antagonistas del receptor vainilloide
RU2004126613A (ru) Замещенные индолы в качестве агонистов альфа-1
HUP0000079A2 (hu) Indán- és dihidroindolszármazékok
PE20010205A1 (es) Derivados 3-sustituido de 2-carboxiciclopropil glicina como agonistas de glutamato
ATE428694T1 (de) N-ä1h-indol-5-ylünaphthalin-1-sulphonamid- derivate und verwandte verbindungen als serotonin 5-ht6 rezeptor antagonisten zur behandlung von erkrankungen des zentralen nervensystems
PE20060457A1 (es) Derivados de difenil eter como antagonistas de los receptores 5ht2
RU2004139099A (ru) 1-(аминоалкил)-3-сульфонилиндольные и -индазольные производные в качестве лигандов 5-гидрокситриптамина-6
ES2130135T3 (es) Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central.
RU2006105782A (ru) Производные 1-сульфонилиндола, их получение и их применение в качестве лигандов 5-нт-6
DE60003899D1 (de) Aryl-annellierte disubstituierte pyridine : nk3 rezeptor-liganden
HUP0001165A2 (hu) NK1 és NK2 antagonista hatású acil-amino-alkil-amid-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra
PE20021018A1 (es) DERIVADOS DE ß - CARBOLINA
PE20000548A1 (es) Derivados de diaza-espiro[3.5]nonano
DE69912419D1 (de) Phenylsulfonamid-phenylethylamine nützlich als dopamin-rezeptoren

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed