BG104192A - Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands - Google Patents

Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands

Info

Publication number
BG104192A
BG104192A BG104192A BG10419200A BG104192A BG 104192 A BG104192 A BG 104192A BG 104192 A BG104192 A BG 104192A BG 10419200 A BG10419200 A BG 10419200A BG 104192 A BG104192 A BG 104192A
Authority
BG
Bulgaria
Prior art keywords
substituted
carboxamides
naphthyridine
oxo
agonists
Prior art date
Application number
BG104192A
Other languages
Bulgarian (bg)
English (en)
Inventor
Pamela Albaugh
Robert Desimone
Gang Liu
Original Assignee
Neurogen Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corporation filed Critical Neurogen Corporation
Publication of BG104192A publication Critical patent/BG104192A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG104192A 1997-08-25 2000-02-25 Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands BG104192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (fr) 1997-08-25 1998-08-24 4-oxo-naphtyridine-3-carboxamides substitues comme ligands de recepteur de gaba du cerveau

Publications (1)

Publication Number Publication Date
BG104192A true BG104192A (en) 2001-05-31

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104192A BG104192A (en) 1997-08-25 2000-02-25 Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands

Country Status (24)

Country Link
EP (1) EP1007526A1 (fr)
JP (1) JP2001514181A (fr)
KR (1) KR20010023313A (fr)
CN (1) CN1268136A (fr)
AP (1) AP2000001742A0 (fr)
AU (1) AU753800B2 (fr)
BG (1) BG104192A (fr)
BR (1) BR9811362A (fr)
CA (1) CA2301599C (fr)
EG (1) EG21717A (fr)
HU (1) HUP0003258A3 (fr)
IL (1) IL134291A0 (fr)
IS (1) IS5382A (fr)
LV (1) LV12539B (fr)
NO (1) NO20000822L (fr)
NZ (1) NZ502548A (fr)
OA (1) OA11293A (fr)
PE (1) PE130999A1 (fr)
PL (1) PL338783A1 (fr)
SI (1) SI20270A (fr)
SK (1) SK2162000A3 (fr)
TW (1) TW574221B (fr)
WO (1) WO1999010347A1 (fr)
YU (1) YU10500A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE289593T1 (de) * 1999-05-06 2005-03-15 Neurogen Corp Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden
WO2000071528A1 (fr) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides et leur utilisation en tant que ligands des recepteurs cerebraux gaba
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
EA200300449A1 (ru) 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
US6841558B2 (en) 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
WO2002030426A1 (fr) 2000-10-12 2002-04-18 Merck & Co., Inc. Azanaphthalenylcarboxamides et polyazanaphthalenylcarboxamides utiles en tant qu'inhibiteurs de la vih integrase
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CN1494422A (zh) * 2001-03-01 2004-05-05 �Ʒ� Gabaa反相激动剂与烟碱受体不完全激动剂、雌激素、选择性雌激素调节剂、或维生素e联合用于认知障碍的用途
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
US7279487B2 (en) 2002-01-17 2007-10-09 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
EP1496836B1 (fr) 2002-03-15 2008-09-24 Merck & Co., Inc. N-(benzyl substitue)-8-hydroxy-1,6-naphthyridine-7- carboxamides utiles en tant qu'inhibiteurs d'integrase de hiv
WO2004106336A1 (fr) * 2003-05-27 2004-12-09 Pfizer Products Inc. Procede de preparation et de purification de 1,5-naphtyridine-3-carboxyamides
WO2004106334A2 (fr) * 2003-05-28 2004-12-09 Pfizer Products Inc. Procede de preparation de 1,5-naphtyridine-3-carboxyamides par amidation directe d'esters
DK2074123T3 (da) * 2006-10-16 2013-01-14 Bionomics Ltd Nye anxiolytiske forbindelser
WO2008066750A1 (fr) * 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Procédés de traitement du retard mental, du syndrome de down, du syndrome de l'x fragile et de l'autisme

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
NO20000822L (no) 2000-04-13
YU10500A (sh) 2002-10-18
AP2000001742A0 (en) 2000-02-24
EP1007526A1 (fr) 2000-06-14
SK2162000A3 (en) 2001-03-12
PL338783A1 (en) 2000-11-20
LV12539A (en) 2000-10-20
CA2301599A1 (fr) 1999-03-04
AU9117398A (en) 1999-03-16
WO1999010347A1 (fr) 1999-03-04
JP2001514181A (ja) 2001-09-11
OA11293A (en) 2002-11-19
EG21717A (en) 2002-02-27
SI20270A (sl) 2000-12-31
TW574221B (en) 2004-02-01
NZ502548A (en) 2002-06-28
BR9811362A (pt) 2000-08-22
IS5382A (is) 2000-02-22
IL134291A0 (en) 2001-04-30
AU753800B2 (en) 2002-10-31
HUP0003258A2 (en) 2001-03-28
NO20000822D0 (no) 2000-02-18
CN1268136A (zh) 2000-09-27
LV12539B (en) 2001-01-20
KR20010023313A (ko) 2001-03-26
CA2301599C (fr) 2003-03-25
PE130999A1 (es) 1999-12-16
HUP0003258A3 (en) 2001-05-28

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