PE20010205A1 - Derivados 3-sustituido de 2-carboxiciclopropil glicina como agonistas de glutamato - Google Patents
Derivados 3-sustituido de 2-carboxiciclopropil glicina como agonistas de glutamatoInfo
- Publication number
- PE20010205A1 PE20010205A1 PE2000000525A PE0005252000A PE20010205A1 PE 20010205 A1 PE20010205 A1 PE 20010205A1 PE 2000000525 A PE2000000525 A PE 2000000525A PE 0005252000 A PE0005252000 A PE 0005252000A PE 20010205 A1 PE20010205 A1 PE 20010205A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxyclopropyl
- glycine
- alkyl
- lil
- substituted derivatives
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000928 excitatory amino acid agonist Substances 0.000 title abstract 2
- 239000004471 Glycine Substances 0.000 title 1
- DHMQDGOQFOQNFH-CNRUNOGKSA-N 2-amino-2-tritioacetic acid Chemical compound [3H]C(N)C(O)=O DHMQDGOQFOQNFH-CNRUNOGKSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical compound [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 102000006239 metabotropic receptors Human genes 0.000 abstract 1
- 108020004083 metabotropic receptors Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS 3-SUSTITUIDO DE 2-CARBOXICICLOPROPIL GLICINA DE FORMULA I, DONDE: R1 ES HALO-ALQUILO C1-C10, HALO-ALQUENILO C2-C10, (CH2)nY, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-TETRAZO-5-LIL, 5-FENILTETRAZO-1-LIL, PO3H2; n ES 1-2, Y ES OH, CN, N3, OR3; R5, R6, R7, R8, R9 SON ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, 1H-TETRAZO-5-LIL, CARBOXI-ALQUILO C1-C4, 1H-TETRAZO-5-LIL-ALQUILO C1-C4; p ES 0-3. SON COMPUESTOS PREFERIDOS (2SR, 1`SR, 2'SR, 3'SR)-2-[(3'(2''-HIDROXIETIL)-2'-CARBOXI)CICLOPROPIL]GLICINA, (2SR, 1RS, 2'RS, 3'RS)-2-[3'-MERCAPTOMETIL-2'-CARBOXICICLOPROPIL]GLICINA, (2S,1'S,2'R,3'R)-2-(3'-HIDROXIMETIL-2'-CARBOXICICLOPROPIL)GLICINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS COMPUESTOS I SON AGONISTAS DE GLUTAMATO EN LOS RECEPTORES METABOTROPICOS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO CENTRAL COMO ENFERMEDADES NEUROLOGICAS, NEURODEGENERATIVAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99500090 | 1999-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010205A1 true PE20010205A1 (es) | 2001-03-16 |
Family
ID=8242502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000525A PE20010205A1 (es) | 1999-06-03 | 2000-05-31 | Derivados 3-sustituido de 2-carboxiciclopropil glicina como agonistas de glutamato |
Country Status (6)
Country | Link |
---|---|
US (1) | US6498180B1 (es) |
EP (1) | EP1189873A1 (es) |
AU (1) | AU5073600A (es) |
CO (1) | CO5180545A1 (es) |
PE (1) | PE20010205A1 (es) |
WO (1) | WO2000075101A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2849025B1 (fr) * | 2002-12-20 | 2005-10-14 | Rhodia Chimie Sa | Esters d'allyle substitue par un groupe difluoromethylene, leur procede de synthese et leur utilisation |
US7125871B2 (en) * | 2000-05-31 | 2006-10-24 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
US7081481B2 (en) * | 2000-05-31 | 2006-07-25 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CN101801930B (zh) * | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
JP5366269B2 (ja) | 2007-09-14 | 2013-12-11 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換4−(アリル−x−フェニル)−1h−ピリジン−2−オン |
US8785486B2 (en) | 2007-11-14 | 2014-07-22 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
SG10201402250TA (en) | 2009-05-12 | 2014-07-30 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
WO2012062750A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JP6416125B2 (ja) * | 2013-02-04 | 2018-10-31 | プレクストン・セラピューティクス・ソシエテ・アノニム | mGluR3の正のアロステリックモジュレーター |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
EA201891617A3 (ru) | 2014-01-21 | 2019-04-30 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3481975B2 (ja) * | 1992-09-08 | 2003-12-22 | サントリー株式会社 | (2s,1’s,2’r)−2−(2−カルボキシ−3−置換オキシメチルシクロプロピル)グリシン及びその製造法 |
JPH08301825A (ja) | 1995-03-07 | 1996-11-19 | Suntory Ltd | 3’−置換−(2−カルボキシシクロプロピル)グリシン |
IT1276153B1 (it) | 1995-11-17 | 1997-10-27 | Roberto Pellicciari | Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato |
WO1998000391A1 (fr) | 1996-06-28 | 1998-01-08 | Nippon Chemiphar Co., Ltd. | Derives de cyclopropylglycine et agoniste du recepteur du l-glutamate du type a regulation metabolique |
ES2131463B1 (es) * | 1997-04-08 | 2000-03-01 | Lilly Sa | Derivados de ciclopropilglicina con propiedades farmaceuticas. |
-
2000
- 2000-05-26 EP EP00935144A patent/EP1189873A1/en not_active Withdrawn
- 2000-05-26 WO PCT/EP2000/004903 patent/WO2000075101A1/en not_active Application Discontinuation
- 2000-05-26 US US09/979,322 patent/US6498180B1/en not_active Expired - Fee Related
- 2000-05-26 AU AU50736/00A patent/AU5073600A/en not_active Abandoned
- 2000-05-31 PE PE2000000525A patent/PE20010205A1/es not_active Application Discontinuation
- 2000-06-02 CO CO00041548A patent/CO5180545A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU5073600A (en) | 2000-12-28 |
EP1189873A1 (en) | 2002-03-27 |
US6498180B1 (en) | 2002-12-24 |
CO5180545A1 (es) | 2002-07-30 |
WO2000075101A1 (en) | 2000-12-14 |
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Legal Events
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