AR035750A1 - Uso de n- (piridinilamino) indoles para la preparacion de medicamentos para el tratamiento de enfermedades o trastornos desmielinizantes - Google Patents

Uso de n- (piridinilamino) indoles para la preparacion de medicamentos para el tratamiento de enfermedades o trastornos desmielinizantes

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Publication number
AR035750A1
AR035750A1 ARP020100540A ARP020100540A AR035750A1 AR 035750 A1 AR035750 A1 AR 035750A1 AR P020100540 A ARP020100540 A AR P020100540A AR P020100540 A ARP020100540 A AR P020100540A AR 035750 A1 AR035750 A1 AR 035750A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
hydrogen
preparation
treatment
Prior art date
Application number
ARP020100540A
Other languages
English (en)
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of AR035750A1 publication Critical patent/AR035750A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Uso de un compuesto N-(piridinilamino) indoles de la fórmula (1) en la cual: m es 0, 1 o 2; n es 0, 1 o 2; p es 0 o 1; cada R es independientemente hidrógeno, halógeno, trifluorometilo, alquilo C1-6, alcoxi C1-6, benciloxi, hidroxi, nitro o amino; cada R1 es independientemente hidrógeno, alquilo C1-6, alquenilo C1-6, alcanoílo C1-6, halógeno, ciano -C(O)C-alquilo C1-6, alquilen C1-6-CN, alquilen C1-6-NR'R'', donde cada uno de R' y R'' es independientemente hidrógeno o alquilo C1-6; alquilen C1-6-OC(O)alquilo C1-6 o -CH(OH)R4, donde R4 es hidrógeno o alquilo C1-6; R2 es hidrógeno, alquilo C1-6, optativamente sustituido con halógeno, hidroxi o benciloxi, alquenilo C1-6, alquinilo C1-6, -CO2-alquilo C1-6, o -R5-NR'R'', donde R5 es alquileno C1-6, alquenileno C1-6, o alquinileno C1-6 y cada uno de R' y R'' es independientemente hidrógeno, alquilo C1-6 o, de lo contrario, el grupo -NR'R'' en su totalidad es 1-pirrolidinilo y R3 es hidrógeno, nitro, amino, halógeno, alcoxi C1-6, hidroxi o alquilo C1-6, o una sal farmacéuticamente aceptable del mismo para la preparación de un medicamento para el tratamiento de las Enfermedades Desmielinizantes a un paciente que lo necesita.
ARP020100540A 2001-02-15 2002-02-15 Uso de n- (piridinilamino) indoles para la preparacion de medicamentos para el tratamiento de enfermedades o trastornos desmielinizantes AR035750A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26884601P 2001-02-15 2001-02-15

Publications (1)

Publication Number Publication Date
AR035750A1 true AR035750A1 (es) 2004-07-07

Family

ID=23024747

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100540A AR035750A1 (es) 2001-02-15 2002-02-15 Uso de n- (piridinilamino) indoles para la preparacion de medicamentos para el tratamiento de enfermedades o trastornos desmielinizantes

Country Status (39)

Country Link
US (10) US6967210B2 (es)
EP (1) EP1368031A2 (es)
JP (3) JP2004518711A (es)
KR (3) KR100951542B1 (es)
CN (2) CN1529598A (es)
AP (1) AP1749A (es)
AR (1) AR035750A1 (es)
AU (3) AU2002247200B9 (es)
BR (1) BR0207272A (es)
CA (1) CA2438712A1 (es)
CO (1) CO5390085A1 (es)
CR (1) CR7023A (es)
CZ (1) CZ20032172A3 (es)
EA (2) EA011319B1 (es)
EC (1) ECSP024218A (es)
EE (1) EE200300363A (es)
GB (1) GB0119435D0 (es)
HK (1) HK1080361B (es)
HR (1) HRP20030652A2 (es)
HU (1) HUP0303203A3 (es)
IL (2) IL157341A0 (es)
MA (1) MA26152A1 (es)
ME (1) MEP21208A (es)
MX (1) MXPA03006110A (es)
MY (1) MY157745A (es)
NO (1) NO20033622L (es)
NZ (4) NZ544720A (es)
OA (1) OA12549A (es)
PA (1) PA8540101A1 (es)
PE (1) PE20040175A1 (es)
PL (1) PL363638A1 (es)
SG (1) SG134170A1 (es)
SK (1) SK10392003A3 (es)
TR (4) TR200800693T2 (es)
TW (1) TWI325319B (es)
UA (2) UA80394C2 (es)
WO (1) WO2002064126A2 (es)
YU (1) YU62903A (es)
ZA (1) ZA200306124B (es)

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GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
AU2003301184A1 (en) * 2002-12-20 2004-07-22 Dynogen Pharmaceuticals Inc METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS
JP2006515327A (ja) * 2003-01-30 2006-05-25 ダイノジェン ファーマシューティカルズ, インコーポレイテッド ナトリウムチャネル調節因子を用いた下部尿路障害を処置するための方法
DE602004003172T2 (de) * 2003-03-21 2007-09-27 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
GB0510164D0 (en) * 2005-04-28 2005-06-22 Paradigm Therapeutics Ltd Ion channel
FR2892021B1 (fr) * 2005-10-19 2008-01-04 Urogene Traitement de l'incontinence urinaire d'effort et mixte
FR2892022B1 (fr) * 2005-10-19 2008-01-04 Urogene Sa Traitement des symptomes de l'irritation de la vessie
US8420593B1 (en) * 2006-06-16 2013-04-16 Landon C. G. Miller Compositions and methods for regulating membrane potential
DE102008044844B4 (de) * 2008-08-28 2018-08-30 Siemens Healthcare Gmbh Verfahren zur Ermittlung einer Schwächungskarte zur Verwendung in der Positronenemissionstomographie und von Homogenitätsinformationen des Magnetresonanzmagnetfeldes
WO2011118364A1 (en) * 2010-03-26 2011-09-29 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device
WO2012009204A1 (en) * 2010-07-15 2012-01-19 The Trustees Of Columbia University In The City Of New York Methods for diagnosing and treating concussive disorders
WO2012103471A1 (en) * 2011-01-28 2012-08-02 Acorda Therapeutics, Inc. Use of potassium channel blockers to treat cerebral palsy
TWI592156B (zh) * 2011-10-04 2017-07-21 艾可達醫療公司 使用胺基吡啶以治療與中風有關之感覺動作損傷之方法
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
EP3727587A4 (en) 2017-12-22 2022-02-23 Massachusetts Institute Of Technology COMPOSITIONS AND METHODS FOR THERAPY OF WILLIAMS SYNDROME (WS)
US20240082184A1 (en) * 2021-01-20 2024-03-14 Rush University Medical Center Improved treatment for globoid cell leukodsytrophy or krabbe disease

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DE3852335T2 (de) * 1987-04-24 1995-05-11 Hoechst Roussel Pharma N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
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ES2068294T3 (es) * 1989-08-02 1995-04-16 Hoechst Roussel Pharma 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos.
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
DE4325491A1 (de) * 1993-07-29 1995-02-02 Boehringer Ingelheim Kg Verwendung von zentral wirksamen alpha-2-Agonisten zur Hemmung des Postaggressionsstoffwechsels
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US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
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GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions

Also Published As

Publication number Publication date
US20050159456A1 (en) 2005-07-21
US20090209594A1 (en) 2009-08-20
KR100951540B1 (ko) 2010-04-09
CR7023A (es) 2003-11-17
HRP20030652A2 (en) 2005-06-30
ECSP024218A (es) 2003-09-24
EA200300882A1 (ru) 2003-12-25
AU2002247200B2 (en) 2007-12-13
US20090270458A1 (en) 2009-10-29
KR20090005254A (ko) 2009-01-12
HK1080361B (zh) 2009-10-30
KR20040014459A (ko) 2004-02-14
IL157341A0 (en) 2004-02-19
EA200600896A1 (ru) 2006-08-25
US7230015B2 (en) 2007-06-12
US20040157889A1 (en) 2004-08-12
AU2009238332A1 (en) 2009-12-10
MY157745A (en) 2016-07-15
TR200800692T2 (tr) 2008-03-21
NO20033622D0 (no) 2003-08-14
US20040157888A1 (en) 2004-08-12
US20060025452A1 (en) 2006-02-02
WO2002064126A2 (en) 2002-08-22
US20050234105A1 (en) 2005-10-20
CA2438712A1 (en) 2002-08-22
AP1749A (en) 2007-06-13
CO5390085A1 (es) 2004-04-30
US7534803B2 (en) 2009-05-19
AU2002247200B9 (en) 2008-07-10
TR200301330T2 (tr) 2004-12-21
BR0207272A (pt) 2004-02-10
JP2004518711A (ja) 2004-06-24
UA80394C2 (en) 2007-09-25
KR100951542B1 (ko) 2010-04-09
US6967210B2 (en) 2005-11-22
NZ556697A (en) 2009-01-31
GB0119435D0 (en) 2001-10-03
JP2009185045A (ja) 2009-08-20
PL363638A1 (en) 2004-11-29
CN1679564A (zh) 2005-10-12
HK1080361A1 (en) 2006-04-28
SG134170A1 (en) 2007-08-29
IL157341A (en) 2010-11-30
WO2002064126A3 (en) 2003-02-20
AU2008201179B2 (en) 2009-08-20
NO20033622L (no) 2003-10-06
MA26152A1 (fr) 2004-07-01
KR20090005255A (ko) 2009-01-12
EA011319B1 (ru) 2009-02-27
HUP0303203A3 (en) 2007-11-28
CN100522164C (zh) 2009-08-05
YU62903A (sh) 2006-05-25
US20090281147A1 (en) 2009-11-12
MEP21208A (en) 2010-06-10
PE20040175A1 (es) 2004-03-29
AP2003002834A0 (en) 2003-09-30
HUP0303203A2 (hu) 2003-12-29
EE200300363A (et) 2003-10-15
US7179821B2 (en) 2007-02-20
US20090209595A1 (en) 2009-08-20
MXPA03006110A (es) 2005-07-01
EA012409B1 (ru) 2009-10-30
AU2008201179A1 (en) 2008-04-03
SK10392003A3 (sk) 2004-01-08
TWI325319B (en) 2010-06-01
UA88773C2 (ru) 2009-11-25
CN1529598A (zh) 2004-09-15
NZ539159A (en) 2006-11-30
EP1368031A2 (en) 2003-12-10
NZ527011A (en) 2005-07-29
JP2010120958A (ja) 2010-06-03
US20030105150A1 (en) 2003-06-05
NZ544720A (en) 2007-08-31
TR200800693T2 (tr) 2008-07-21
OA12549A (en) 2006-06-05
ZA200306124B (en) 2004-11-08
CZ20032172A3 (cs) 2004-01-14
PA8540101A1 (es) 2003-09-05
TR200800691T2 (tr) 2008-03-21

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