YU62903A - Postupak za tretiranje demijelinacionih bolesti ili stanja - Google Patents

Postupak za tretiranje demijelinacionih bolesti ili stanja

Info

Publication number
YU62903A
YU62903A YU62903A YUP62903A YU62903A YU 62903 A YU62903 A YU 62903A YU 62903 A YU62903 A YU 62903A YU P62903 A YUP62903 A YU P62903A YU 62903 A YU62903 A YU 62903A
Authority
YU
Yugoslavia
Prior art keywords
treatment
conditions
demyelinating diseases
treating
compounds
Prior art date
Application number
YU62903A
Other languages
English (en)
Inventor
Craig P. Smith
Michel P. Rathbone
Margaret Petty
David Rampe
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of YU62903A publication Critical patent/YU62903A/sh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

N-(piridinil)-1il-indol-1-amini formule I, predstavljaju jedinstvenu kombinaciju svojstava blokiranja i kalijumovih i natrijumovih kanala. Ova jedinjenja su korisna u tretmanu demijelinacionih bolesti i stanja, kao što su multipla skleroza, povreda kičmene moždine, traumatska povreda mozga i moždani udar. Ova jedinjenja su takođe korisna u rehabilitaciji od moždanog udara, tretmanu iritacije i disfunkcije bešike i u tretmanu neuropatskog bola i bola izazvanog hemokinom.[N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
YU62903A 2001-02-15 2002-02-14 Postupak za tretiranje demijelinacionih bolesti ili stanja YU62903A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26884601P 2001-02-15 2001-02-15
GBGB0119435.6A GB0119435D0 (en) 2001-02-15 2001-08-09 Method of treating of demyelinating diseases or conditions

Publications (1)

Publication Number Publication Date
YU62903A true YU62903A (sh) 2006-05-25

Family

ID=23024747

Family Applications (1)

Application Number Title Priority Date Filing Date
YU62903A YU62903A (sh) 2001-02-15 2002-02-14 Postupak za tretiranje demijelinacionih bolesti ili stanja

Country Status (39)

Country Link
US (10) US6967210B2 (sh)
EP (1) EP1368031A2 (sh)
JP (3) JP2004518711A (sh)
KR (3) KR100951542B1 (sh)
CN (2) CN1529598A (sh)
AP (1) AP1749A (sh)
AR (1) AR035750A1 (sh)
AU (3) AU2002247200B9 (sh)
BR (1) BR0207272A (sh)
CA (1) CA2438712A1 (sh)
CO (1) CO5390085A1 (sh)
CR (1) CR7023A (sh)
CZ (1) CZ20032172A3 (sh)
EA (2) EA011319B1 (sh)
EC (1) ECSP024218A (sh)
EE (1) EE200300363A (sh)
GB (1) GB0119435D0 (sh)
HK (1) HK1080361B (sh)
HR (1) HRP20030652A2 (sh)
HU (1) HUP0303203A3 (sh)
IL (2) IL157341A0 (sh)
MA (1) MA26152A1 (sh)
ME (1) MEP21208A (sh)
MX (1) MXPA03006110A (sh)
MY (1) MY157745A (sh)
NO (1) NO20033622L (sh)
NZ (4) NZ527011A (sh)
OA (1) OA12549A (sh)
PA (1) PA8540101A1 (sh)
PE (1) PE20040175A1 (sh)
PL (1) PL363638A1 (sh)
SG (1) SG134170A1 (sh)
SK (1) SK10392003A3 (sh)
TR (4) TR200800693T2 (sh)
TW (1) TWI325319B (sh)
UA (2) UA80394C2 (sh)
WO (1) WO2002064126A2 (sh)
YU (1) YU62903A (sh)
ZA (1) ZA200306124B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
AU2003301184A1 (en) * 2002-12-20 2004-07-22 Dynogen Pharmaceuticals Inc METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS
WO2004066990A2 (en) * 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channel modulators
BRPI0408608A (pt) * 2003-03-21 2006-03-07 Dynogen Pharmaceuticals Inc uso de moduladores da subunidade (alfa)2(delta) de canal de cálcio e moduladores de músculo liso para tratamento de sintoma de um distúrbio do trato urinário inferior
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
GB0510164D0 (en) * 2005-04-28 2005-06-22 Paradigm Therapeutics Ltd Ion channel
FR2892021B1 (fr) * 2005-10-19 2008-01-04 Urogene Traitement de l'incontinence urinaire d'effort et mixte
FR2892022B1 (fr) * 2005-10-19 2008-01-04 Urogene Sa Traitement des symptomes de l'irritation de la vessie
US8420593B1 (en) * 2006-06-16 2013-04-16 Landon C. G. Miller Compositions and methods for regulating membrane potential
DE102008044844B4 (de) * 2008-08-28 2018-08-30 Siemens Healthcare Gmbh Verfahren zur Ermittlung einer Schwächungskarte zur Verwendung in der Positronenemissionstomographie und von Homogenitätsinformationen des Magnetresonanzmagnetfeldes
KR101862539B1 (ko) * 2010-03-26 2018-05-31 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
WO2012009204A1 (en) * 2010-07-15 2012-01-19 The Trustees Of Columbia University In The City Of New York Methods for diagnosing and treating concussive disorders
US20130030025A1 (en) * 2011-01-28 2013-01-31 Wessel Thomas C Use of potassium channel blockers to treat cerebral palsy
TWI592156B (zh) * 2011-10-04 2017-07-21 艾可達醫療公司 使用胺基吡啶以治療與中風有關之感覺動作損傷之方法
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
EP3727587A4 (en) 2017-12-22 2022-02-23 Massachusetts Institute Of Technology COMPOSITIONS AND METHODS FOR THERAPY OF WILLIAMS SYNDROME (WS)
EP4281118A1 (en) * 2021-01-20 2023-11-29 Rush University Medical Center Improved treatment for globoid cell leukodsytrophy or krabbe disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
EP0415103B1 (en) * 1989-08-02 1995-02-01 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
DE4325491A1 (de) * 1993-07-29 1995-02-02 Boehringer Ingelheim Kg Verwendung von zentral wirksamen alpha-2-Agonisten zur Hemmung des Postaggressionsstoffwechsels
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
EP0731108A1 (en) * 1995-03-10 1996-09-11 Boehringer Mannheim Gmbh Method of manufacturing a therapeutic agent for the regeneration of oligodendrocytes
FR2754147B1 (fr) 1996-10-03 2000-02-04 Mbh Technologies Sa Installation et procede pour le traitement de carcasses
DE69912250T2 (de) * 1998-01-29 2004-07-29 Bristol-Myers Squibb Co., Wallingford Phosphorylierte derivate des diaryl 1,3,4 oxadiazolon
WO2001004091A1 (en) * 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions

Also Published As

Publication number Publication date
US7230015B2 (en) 2007-06-12
NZ527011A (en) 2005-07-29
EP1368031A2 (en) 2003-12-10
WO2002064126A2 (en) 2002-08-22
KR20090005254A (ko) 2009-01-12
HRP20030652A2 (en) 2005-06-30
NO20033622L (no) 2003-10-06
UA88773C2 (ru) 2009-11-25
KR100951540B1 (ko) 2010-04-09
PE20040175A1 (es) 2004-03-29
MA26152A1 (fr) 2004-07-01
IL157341A (en) 2010-11-30
US6967210B2 (en) 2005-11-22
HK1080361B (zh) 2009-10-30
CN100522164C (zh) 2009-08-05
GB0119435D0 (en) 2001-10-03
EE200300363A (et) 2003-10-15
KR20090005255A (ko) 2009-01-12
CN1529598A (zh) 2004-09-15
AU2002247200B2 (en) 2007-12-13
CO5390085A1 (es) 2004-04-30
TR200800693T2 (tr) 2008-07-21
AU2008201179A1 (en) 2008-04-03
AP1749A (en) 2007-06-13
MEP21208A (en) 2010-06-10
ECSP024218A (es) 2003-09-24
NZ539159A (en) 2006-11-30
AU2008201179B2 (en) 2009-08-20
US20090209594A1 (en) 2009-08-20
US20090281147A1 (en) 2009-11-12
NZ556697A (en) 2009-01-31
AU2009238332A1 (en) 2009-12-10
CZ20032172A3 (cs) 2004-01-14
JP2009185045A (ja) 2009-08-20
EA011319B1 (ru) 2009-02-27
MXPA03006110A (es) 2005-07-01
TR200301330T2 (tr) 2004-12-21
CN1679564A (zh) 2005-10-12
MY157745A (en) 2016-07-15
TR200800692T2 (tr) 2008-03-21
CR7023A (es) 2003-11-17
HK1080361A1 (en) 2006-04-28
IL157341A0 (en) 2004-02-19
US20040157889A1 (en) 2004-08-12
NZ544720A (en) 2007-08-31
US20040157888A1 (en) 2004-08-12
OA12549A (en) 2006-06-05
US7534803B2 (en) 2009-05-19
SG134170A1 (en) 2007-08-29
US20050234105A1 (en) 2005-10-20
JP2010120958A (ja) 2010-06-03
AR035750A1 (es) 2004-07-07
NO20033622D0 (no) 2003-08-14
PA8540101A1 (es) 2003-09-05
ZA200306124B (en) 2004-11-08
EA200600896A1 (ru) 2006-08-25
US20030105150A1 (en) 2003-06-05
US7179821B2 (en) 2007-02-20
KR20040014459A (ko) 2004-02-14
BR0207272A (pt) 2004-02-10
JP2004518711A (ja) 2004-06-24
AP2003002834A0 (en) 2003-09-30
US20050159456A1 (en) 2005-07-21
CA2438712A1 (en) 2002-08-22
HUP0303203A2 (hu) 2003-12-29
EA200300882A1 (ru) 2003-12-25
US20090209595A1 (en) 2009-08-20
WO2002064126A3 (en) 2003-02-20
US20060025452A1 (en) 2006-02-02
UA80394C2 (en) 2007-09-25
TR200800691T2 (tr) 2008-03-21
EA012409B1 (ru) 2009-10-30
KR100951542B1 (ko) 2010-04-09
PL363638A1 (en) 2004-11-29
HUP0303203A3 (en) 2007-11-28
US20090270458A1 (en) 2009-10-29
AU2002247200B9 (en) 2008-07-10
SK10392003A3 (sk) 2004-01-08
TWI325319B (en) 2010-06-01

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